The network for 'regulation of actin filament bundle assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of actin filament bundle assembly

Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles.

Homo sapiens
Name Description Probability Func Analog Organism
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 1.000
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.999
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.990
FN1 fibronectin 1 0.974
RHOA ras homolog gene family, member A 0.920
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.849
BAIAP2 BAI1-associated protein 2 0.836
ZYX zyxin 0.832
FLNA filamin A, alpha 0.831
RHOC ras homolog gene family, member C 0.786
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.776
S100A8 S100 calcium binding protein A8 0.734
S100A6 S100 calcium binding protein A6 0.721
S100B S100 calcium binding protein B 0.706
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.698
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.558
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.457
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.450
S100A4 S100 calcium binding protein A4 0.442
S100A1 S100 calcium binding protein A1 0.403
PLEC plectin 0.378
LMNA lamin A/C 0.330
S100A11 S100 calcium binding protein A11 0.328
PFN1 profilin 1 0.326
S100A9 S100 calcium binding protein A9 0.322
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.319
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.317
CTGF connective tissue growth factor 0.317
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.281
ZNF746 zinc finger protein 746 0.279
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.253
EZR ezrin 0.248
PALLD palladin, cytoskeletal associated protein 0.245
SORBS3 sorbin and SH3 domain containing 3 0.242
FYN FYN oncogene related to SRC, FGR, YES 0.229
LRRK2 leucine-rich repeat kinase 2 0.219
ACTN1 actinin, alpha 1 0.218
MYH9 myosin, heavy chain 9, non-muscle 0.215
HP haptoglobin 0.200
LGALS1 lectin, galactoside-binding, soluble, 1 0.184
SH3KBP1 SH3-domain kinase binding protein 1 0.184
RHOG ras homolog gene family, member G (rho G) 0.175
EPS8 epidermal growth factor receptor pathway substrate 8 0.173
SPRY4 sprouty homolog 4 (Drosophila) 0.151
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.147
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.145
CYR61 cysteine-rich, angiogenic inducer, 61 0.145
ANXA2 annexin A2 0.144
ARHGAP1 Rho GTPase activating protein 1 0.137
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.133
VAV1 vav 1 guanine nucleotide exchange factor 0.127
SCHIP1 schwannomin interacting protein 1 0.125
MSN moesin 0.119
WIPF1 WAS/WASL interacting protein family, member 1 0.116
TSC2 tuberous sclerosis 2 0.102
A2M alpha-2-macroglobulin 0.101
SFN stratifin 0.100
SH3RF3 SH3 domain containing ring finger 3 0.098
CTTN cortactin 0.097
FLNB filamin B, beta 0.093
PXN paxillin 0.091
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 0.090
CYTH1 cytohesin 1 0.086
APOC1 apolipoprotein C-I 0.086
INPPL1 inositol polyphosphate phosphatase-like 1 0.085
SH3BGRL3 SH3 domain binding glutamic acid-rich protein like 3 0.082
SORBS2 sorbin and SH3 domain containing 2 0.078
VASP vasodilator-stimulated phosphoprotein 0.076
MYO10 myosin X 0.073
WASF1 WAS protein family, member 1 0.071
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.071
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.069
AREG amphiregulin 0.068
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.066
GAS7 growth arrest-specific 7 0.066
SPTBN1 spectrin, beta, non-erythrocytic 1 0.063
CSNK1E casein kinase 1, epsilon 0.061
HTT huntingtin 0.061
CD44 CD44 molecule (Indian blood group) 0.060
DLG5 discs, large homolog 5 (Drosophila) 0.058
HIPK2 homeodomain interacting protein kinase 2 0.057
IQGAP1 IQ motif containing GTPase activating protein 1 0.056
FXYD5 FXYD domain containing ion transport regulator 5 0.055
AGTPBP1 ATP/GTP binding protein 1 0.053
HCK hemopoietic cell kinase 0.053
EMP3 epithelial membrane protein 3 0.052
ENG endoglin 0.052
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.052
FAT1 FAT tumor suppressor homolog 1 (Drosophila) 0.051
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.050
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.050
ALB albumin 0.050
VCL vinculin 0.050
SH3BP2 SH3-domain binding protein 2 0.050
DCAF7 DDB1 and CUL4 associated factor 7 0.047
DNM2 dynamin 2 0.047
CAPG capping protein (actin filament), gelsolin-like 0.046
SMAD2 SMAD family member 2 0.046
NCF2 neutrophil cytosolic factor 2 0.046
DIAPH1 diaphanous homolog 1 (Drosophila) 0.046
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rho1 CG8416 gene product from transcript CG8416-RB 0.754
dsh dishevelled 0.263
drpr draper 0.233
Cdc42 CG12530 gene product from transcript CG12530-RA 0.225
rok Rho-kinase 0.208
neur neuralized 0.207
crb crumbs 0.156
Rab7 Rab-protein 7 0.141
msn misshapen 0.116
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.094
mbc myoblast city 0.070
wupA wings up A 0.058
par-1 CG8201 gene product from transcript CG8201-RA 0.057
Atg1 Autophagy-specific gene 1 0.039
wun wunen 0.038
scb scab 0.033
katanin-60 katanin 60 0.031
cpb capping protein beta 0.030
Pvr PDGF- and VEGF-receptor related 0.030
if inflated 0.029
mew multiple edematous wings 0.029
htl heartless 0.028
dia diaphanous 0.027
Ephrin CG1862 gene product from transcript CG1862-RA 0.027
Lerp lysosomal enzyme receptor protein 0.026
milt milton 0.025
Rala Ras-related protein 0.025
csw corkscrew 0.025
baz bazooka 0.023
bsk basket 0.022
Cip4 CG15015 gene product from transcript CG15015-RA 0.021
kst karst 0.020
tos tosca 0.020
Abl Abl tyrosine kinase 0.020
CG4091 CG4091 gene product from transcript CG4091-RA 0.017
Miro Mitochondrial Rho 0.017
wts warts 0.017
pod1 CG4532 gene product from transcript CG4532-RF 0.016
frc fringe connection 0.015
CG5953 CG5953 gene product from transcript CG5953-RA 0.015
Hnf4 Hepatocyte nuclear factor 4 0.014
stck steamer duck 0.014
cindr CIN85 and CD2AP orthologue 0.014
Mtl Mig-2-like 0.014
gish gilgamesh 0.014
fkh fork head 0.013
Pde11 Phosphodiesterase 11 0.012
Myo31DF Myosin 31DF 0.012
Lrrk Leucine-rich repeat kinase 0.011
ttk tramtrack 0.011
wdb widerborst 0.011
unk unkempt 0.011
mbt mushroom bodies tiny 0.011
CG14869 CG14869 gene product from transcript CG14869-RB 0.010
mys myospheroid 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Rac1 RAS-related C3 botulinum substrate 1 0.986
Vangl2 vang-like 2 (van gogh, Drosophila) 0.875
Vangl1 vang-like 1 (van gogh, Drosophila) 0.774
Efnb2 ephrin B2 0.684
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.603
Ephb2 Eph receptor B2 0.572
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.550
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.549
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.468
Apc adenomatosis polyposis coli 0.410
Ctnnb1 catenin (cadherin associated protein), beta 1 0.359
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.321
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.257
Itga3 integrin alpha 3 0.242
Lama5 laminin, alpha 5 0.169
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.166
Ptk7 PTK7 protein tyrosine kinase 7 0.162
Zfp651 zinc finger protein 651 0.158
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.142
Nf1 neurofibromatosis 1 0.136
Wdr1 WD repeat domain 1 0.135
Wipf1 WAS/WASL interacting protein family, member 1 0.135
Plcg1 phospholipase C, gamma 1 0.120
Dnm1 dynamin 1 0.115
Bcl2 B-cell leukemia/lymphoma 2 0.110
Hspa1b heat shock protein 1B 0.108
Actb actin, beta 0.100
Sorbs3 sorbin and SH3 domain containing 3 0.099
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.099
Eng endoglin 0.098
Smad4 MAD homolog 4 (Drosophila) 0.097
Rictor RPTOR independent companion of MTOR, complex 2 0.096
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.092
Mapkap1 mitogen-activated protein kinase associated protein 1 0.090
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.088
Vasp vasodilator-stimulated phosphoprotein 0.082
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.081
Tead3 TEA domain family member 3 0.081
Axin1 axin 1 0.080
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.080
Gdnf glial cell line derived neurotrophic factor 0.080
Wnt2b wingless related MMTV integration site 2b 0.079
Rnd3 Rho family GTPase 3 0.077
Lrp5 low density lipoprotein receptor-related protein 5 0.075
Tead2 TEA domain family member 2 0.074
Pecam1 platelet/endothelial cell adhesion molecule 1 0.070
Nfe2l3 nuclear factor, erythroid derived 2, like 3 0.068
Apoe apolipoprotein E 0.067
Efnb1 ephrin B1 0.067
Ret ret proto-oncogene 0.066
Gli3 GLI-Kruppel family member GLI3 0.063
Lhx1 LIM homeobox protein 1 0.061
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.060
Wnt6 wingless-related MMTV integration site 6 0.060
Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha 0.060
Hic1 hypermethylated in cancer 1 0.058
Gli2 GLI-Kruppel family member GLI2 0.058
Rint1 RAD50 interactor 1 0.056
Pgr progesterone receptor 0.055
Rhoa ras homolog gene family, member A 0.055
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.054
Rtkn rhotekin 0.054
Col13a1 collagen, type XIII, alpha 1 0.052
Efna4 ephrin A4 0.052
Porcn porcupine homolog (Drosophila) 0.052
Trp73 transformation related protein 73 0.050
Mpz myelin protein zero 0.050
Kit kit oncogene 0.049
Cxadr coxsackie virus and adenovirus receptor 0.048
Fgf18 fibroblast growth factor 18 0.048
Fgfr4 fibroblast growth factor receptor 4 0.048
Msn moesin 0.048
Ptch1 patched homolog 1 0.048
Nkd2 naked cuticle 2 homolog (Drosophila) 0.048
Cttn cortactin 0.048
Ephb3 Eph receptor B3 0.047
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.047
Tsc2 tuberous sclerosis 2 0.046
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.046
Epha4 Eph receptor A4 0.043
Sema3b sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.042
Pou3f3 POU domain, class 3, transcription factor 3 0.042
Apaf1 apoptotic peptidase activating factor 1 0.041
Wnt10b wingless related MMTV integration site 10b 0.041
Amhr2 anti-Mullerian hormone type 2 receptor 0.041
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.041
Sox5 SRY-box containing gene 5 0.041
Enah enabled homolog (Drosophila) 0.040
Gata5 GATA binding protein 5 0.040
Tsc1 tuberous sclerosis 1 0.040
Sfrp1 secreted frizzled-related protein 1 0.039
Pax8 paired box gene 8 0.039
Fgf2 fibroblast growth factor 2 0.038
Itga6 integrin alpha 6 0.038
Acan aggrecan 0.038
Vav2 vav 2 oncogene 0.037
P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 0.037
Braf Braf transforming gene 0.036
Cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.036
Tmeff2 transmembrane protein with EGF-like and two follistatin-like domains 2 0.036
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Rattus norvegicus
Name Description Probability Func Analog Organism
Tagln transgelin 0.121
Arf6 ADP-ribosylation factor 6 0.088
Anxa2 annexin A2 0.072
Shank2 SH3 and multiple ankyrin repeat domains 2 0.065
Efhd2 EF-hand domain family, member D2 0.057
Rhoa ras homolog gene family, member A 0.051
Capn9 calpain 9 0.045
Chrna4 cholinergic receptor, nicotinic, alpha 4 0.040
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.038
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.034
Cd38 CD38 molecule 0.031
Socs3 suppressor of cytokine signaling 3 0.030
Fgfr2 fibroblast growth factor receptor 2 0.030
Myh9 myosin, heavy chain 9, non-muscle 0.030
Dlx5 distal-less homeobox 5 0.029
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.028
Gpr83 G protein-coupled receptor 83 0.026
Ppbp pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.026
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.025
Jak2 Janus kinase 2 0.024
Prl prolactin 0.024
Calcr calcitonin receptor 0.023
Ptbp1 polypyrimidine tract binding protein 1 0.023
Apoa5 apolipoprotein A-V 0.023
Wdr1 WD repeat domain 1 0.022
Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide 0.021
Cacna1g calcium channel, voltage-dependent, T type, alpha 1G subunit 0.021
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.021
Myl9 myosin, light chain 9, regulatory 0.020
Ncan neurocan 0.020
Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.020
Emp1 epithelial membrane protein 1 0.019
Cdc2l5 cell division cycle 2-like 5 (cholinesterase-related cell division controller) 0.019
Syngr2 synaptogyrin 2 0.018
Smad3 SMAD family member 3 0.017
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.017
Rac1 ras-related C3 botulinum toxin substrate 1 0.016
Calb1 calbindin 1 0.016
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.016
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.015
Ptprc protein tyrosine phosphatase, receptor type, C 0.015
Actg2 actin, gamma 2, smooth muscle, enteric 0.015
Nmur2 neuromedin U receptor 2 0.015
Glp1r glucagon-like peptide 1 receptor 0.014
Timp3 TIMP metallopeptidase inhibitor 3 0.014
Oxtr oxytocin receptor 0.014
Vip vasoactive intestinal peptide 0.014
Arpc1b actin related protein 2/3 complex, subunit 1B 0.014
Atp2c2 ATPase, Ca++ transporting, type 2C, member 2 0.013
Fgfr1 Fibroblast growth factor receptor 1 0.013
Tpm3 tropomyosin 3, gamma 0.013
Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 0.013
Gad1 glutamate decarboxylase 1 0.013
Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 0.013
Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 0.012
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.012
Nmbr neuromedin B receptor 0.012
Cnn1 calponin 1, basic, smooth muscle 0.012
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.012
Gmfg glia maturation factor, gamma 0.012
Flna filamin A, alpha 0.011
Homer1 homer homolog 1 (Drosophila) 0.011
Scnn1g sodium channel, nonvoltage-gated 1, gamma 0.011
Cd4 Cd4 molecule 0.011
Grm8 glutamate receptor, metabotropic 8 0.010
Acta1 actin, alpha 1, skeletal muscle 0.010
Nrgn neurogranin 0.010
Tpm4 tropomyosin 4 0.010
Syt8 synaptotagmin VIII 0.010
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.010
Cpne9 copine family member IX 0.010
Hoxb8 homeo box B8 0.010
Lmna lamin A 0.010
Smad9 SMAD family member 9 0.010
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.010
Map2 microtubule-associated protein 2 0.010
Hist1h1a histone cluster 1, H1a 0.010
Akt1 v-akt murine thymoma viral oncogene homolog 1 0.010
Clic4 chloride intracellular channel 4 0.010
Nlgn1 neuroligin 1 0.010
Cryab crystallin, alpha B 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism