The network for 'cellular response to hydrogen peroxide' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to hydrogen peroxide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

Homo sapiens
Name Description Probability Func Analog Organism
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.997
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.997
HBB hemoglobin, beta 0.964
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.928
PRDX1 peroxiredoxin 1 0.920
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.915
JUN jun proto-oncogene 0.888
HBA2 hemoglobin, alpha 2 0.856
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.769
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.755
MPDZ multiple PDZ domain protein 0.733
MAFG v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) 0.708
PRDX4 peroxiredoxin 4 0.696
BCL3 B-cell CLL/lymphoma 3 0.657
HBG2 hemoglobin, gamma G 0.645
SOD1 superoxide dismutase 1, soluble 0.615
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.599
DAXX death-domain associated protein 0.591
PLAU plasminogen activator, urokinase 0.539
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.448
EGFR epidermal growth factor receptor 0.420
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.414
TXN thioredoxin 0.404
ARHGAP1 Rho GTPase activating protein 1 0.387
DUSP1 dual specificity phosphatase 1 0.386
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.340
MAPT microtubule-associated protein tau 0.307
PRDX2 peroxiredoxin 2 0.300
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.300
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.292
CAV1 caveolin 1, caveolae protein, 22kDa 0.271
PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.267
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.262
IL4R interleukin 4 receptor 0.251
KLF6 Kruppel-like factor 6 0.239
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.234
RHOA ras homolog gene family, member A 0.229
GAB1 GRB2-associated binding protein 1 0.220
ACACA acetyl-CoA carboxylase alpha 0.208
PARK7 Parkinson disease (autosomal recessive, early onset) 7 0.194
MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) 0.193
PML promyelocytic leukemia 0.193
MET met proto-oncogene (hepatocyte growth factor receptor) 0.185
ATF3 activating transcription factor 3 0.185
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.172
TSC22D4 TSC22 domain family, member 4 0.160
RUNX1 runt-related transcription factor 1 0.158
TTR transthyretin 0.157
FOS FBJ murine osteosarcoma viral oncogene homolog 0.151
TNIP2 TNFAIP3 interacting protein 2 0.151
APOE apolipoprotein E 0.146
RING1 ring finger protein 1 0.144
PLAUR plasminogen activator, urokinase receptor 0.143
GPX4 glutathione peroxidase 4 (phospholipid hydroperoxidase) 0.139
SOCS1 suppressor of cytokine signaling 1 0.135
FBXO7 F-box protein 7 0.135
S100B S100 calcium binding protein B 0.123
EP300 E1A binding protein p300 0.121
HP haptoglobin 0.118
AR androgen receptor 0.110
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.107
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.103
FADD Fas (TNFRSF6)-associated via death domain 0.101
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.100
COL4A2 collagen, type IV, alpha 2 0.096
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.091
KAT2B K(lysine) acetyltransferase 2B 0.091
PLXNB1 plexin B1 0.090
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 0.086
CTSD cathepsin D 0.086
NCOR2 nuclear receptor corepressor 2 0.083
PGK1 phosphoglycerate kinase 1 0.082
KLF4 Kruppel-like factor 4 (gut) 0.079
IL6R interleukin 6 receptor 0.078
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.077
TSPO translocator protein (18kDa) 0.075
PGAM1 phosphoglycerate mutase 1 (brain) 0.074
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.074
LCAT lecithin-cholesterol acyltransferase 0.071
JUND jun D proto-oncogene 0.071
HBE1 hemoglobin, epsilon 1 0.070
TNIP1 TNFAIP3 interacting protein 1 0.070
PRDX6 peroxiredoxin 6 0.069
APOH apolipoprotein H (beta-2-glycoprotein I) 0.069
TPP1 tripeptidyl peptidase I 0.069
FOXO1 forkhead box O1 0.069
DUSP23 dual specificity phosphatase 23 0.069
PLAT plasminogen activator, tissue 0.069
KEAP1 kelch-like ECH-associated protein 1 0.067
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0.064
APOA1 apolipoprotein A-I 0.063
C3 complement component 3 0.060
CREBBP CREB binding protein 0.058
CCND2 cyclin D2 0.058
APOC3 apolipoprotein C-III 0.057
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.055
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.055
PRMT2 protein arginine methyltransferase 2 0.054
FAS Fas (TNF receptor superfamily, member 6) 0.054
HBD hemoglobin, delta 0.053
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
gst-6 Protein GST-6 0.017
CELE_T28F3.8 Protein T28F3.8 0.015
gst-13 Protein GST-13 0.013
C53B4.3 Protein C53B4.3 0.012
H43E16.1 Protein H43E16.1 0.011
dsc-4 Protein DSC-4 0.011
unc-112 Protein UNC-112 0.011
ugt-48 Protein UGT-48 0.010
lbp-7 Protein LBP-7 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Sod2 Superoxide dismutase 2 (Mn) 0.171
tefu telomere fusion 0.109
Sod Superoxide dismutase 0.101
kibra kibra ortholog 0.071
Aldh Aldehyde dehydrogenase 0.063
dj-1beta CG1349 gene product from transcript CG1349-RA 0.063
CG30410 CG30410 gene product from transcript CG30410-RB 0.061
CG13319 CG13319 gene product from transcript CG13319-RA 0.052
ash1 absent, small, or homeotic discs 1 0.051
XNP CG4548 gene product from transcript CG4548-RA 0.044
Trx-2 thioredoxin-2 0.041
PHGPx CG12013 gene product from transcript CG12013-RC 0.036
NLaz Neural Lazarillo 0.035
Thor CG8846 gene product from transcript CG8846-RA 0.033
Lnk CG17367 gene product from transcript CG17367-RC 0.031
Pink1 PTEN-induced putative kinase 1 0.031
CG6543 CG6543 gene product from transcript CG6543-RA 0.029
GLaz Glial Lazarillo 0.027
DJ-1alpha CG6646 gene product from transcript CG6646-RA 0.025
kay kayak 0.023
comm commissureless 0.021
CG8036 CG8036 gene product from transcript CG8036-RB 0.020
Mpk2 CG5475 gene product from transcript CG5475-RB 0.020
Trim9 CG31721 gene product from transcript CG31721-RB 0.020
Zw Zwischenferment 0.019
dys dysfusion 0.018
robo roundabout 0.018
CG14715 CG14715 gene product from transcript CG14715-RA 0.017
Cat Catalase 0.017
Rac1 CG2248 gene product from transcript CG2248-RA 0.016
Spn27A Serpin 27A 0.015
MTF-1 Metal response element-binding Transcription Factor-1 0.014
park parkin 0.014
Khc Kinesin heavy chain 0.014
rtGEF rho-type guanine exchange factor 0.013
fh frataxin homolog 0.013
Pvr PDGF- and VEGF-receptor related 0.013
TFAM mitochondrial transcription factor A 0.013
CG6783 CG6783 gene product from transcript CG6783-RC 0.012
Mekk1 CG7717 gene product from transcript CG7717-RB 0.011
CG9425 CG9425 gene product from transcript CG9425-RB 0.011
CG11858 CG11858 gene product from transcript CG11858-RA 0.011
ush u-shaped 0.011
Prx5 Peroxiredoxin 5 0.011
IP3K2 Inositol 1,4,5-triphosphate kinase 2 0.011
Lectin-galC1 Galactose-specific C-type lectin 0.011
Fkbp13 CG9847 gene product from transcript CG9847-RC 0.011
p38b CG7393 gene product from transcript CG7393-RA 0.010
l(3)82Fd CG32464 gene product from transcript CG32464-RR 0.010
lid little imaginal discs 0.010
foxo forkhead box, sub-group O 0.010
Pcmt Protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.010
CG13890 CG13890 gene product from transcript CG13890-RA 0.010
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Alas2 aminolevulinate, delta-, synthase 2 0.434
Hbb hemoglobin, beta 0.178
LOC100134871 beta globin minor gene 0.142
LOC689064 beta-globin 0.080
Hba-a2 hemoglobin alpha, adult chain 2 0.079
Jun Jun oncogene 0.059
Hbb-b1 hemoglobin, beta adult major chain 0.054
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.035
Gadd45a growth arrest and DNA-damage-inducible, alpha 0.035
Egr1 early growth response 1 0.034
Atf3 activating transcription factor 3 0.025
Zfp36 zinc finger protein 36 0.024
Gstp1 glutathione S-transferase pi 1 0.024
Vim vimentin 0.024
Oaz1 ornithine decarboxylase antizyme 1 0.023
Cd48 Cd48 molecule 0.023
Prdx2 peroxiredoxin 2 0.023
Btg2 BTG family, member 2 0.023
LOC287167 globin, alpha 0.023
Ptgs2 prostaglandin-endoperoxide synthase 2 0.022
Dusp1 dual specificity phosphatase 1 0.021
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.020
Junb jun B proto-oncogene 0.020
Ier3 immediate early response 3 0.019
Fos FBJ osteosarcoma oncogene 0.019
Rabac1 Rab acceptor 1 (prenylated) 0.018
S100a10 S100 calcium binding protein A10 0.017
Arih1 ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila) 0.017
Smad1 SMAD family member 1 0.017
Mdm2 Mdm2 p53 binding protein homolog (mouse) 0.016
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.016
Tp53 tumor protein p53 0.016
Klf9 Kruppel-like factor 9 0.016
Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 0.016
Hmox1 heme oxygenase (decycling) 1 0.015
Pebp1 phosphatidylethanolamine binding protein 1 0.015
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.015
Zyx zyxin 0.015
S100a11 S100 calcium binding protein A11 (calizzarin) 0.015
Gpx4 glutathione peroxidase 4 0.015
Mafk v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian) 0.015
S100a6 S100 calcium binding protein A6 0.014
Nup153 nucleoporin 153 0.014
Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 0.014
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.014
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.014
Ctsl1 cathepsin L1 0.014
Lgals3 lectin, galactoside-binding, soluble, 3 0.014
Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a 0.013
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.013
Il13ra1 interleukin 13 receptor, alpha 1 0.013
Plat plasminogen activator, tissue 0.013
Txnrd1 thioredoxin reductase 1 0.013
Chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.013
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.012
Atf4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.012
Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) 0.012
Prdx1 peroxiredoxin 1 0.012
PVR poliovirus receptor 0.012
Anxa4 annexin A4 0.012
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.012
Gabarapl1 GABA(A) receptor-associated protein like 1 0.012
Ypel5 yippee-like 5 (Drosophila) 0.012
Jak2 Janus kinase 2 0.012
Klf6 Kruppel-like factor 6 0.012
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.012
Ctdsp1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 0.012
Mgst2 microsomal glutathione S-transferase 2 0.012
Gja1 gap junction protein, alpha 1 0.012
Cox6a1 cytochrome c oxidase, subunit VIa, polypeptide 1 0.012
Rab11a RAB11a, member RAS oncogene family 0.011
Nqo1 NAD(P)H dehydrogenase, quinone 1 0.011
Fkbp4 FK506 binding protein 4 0.011
Tsc22d3 TSC22 domain family, member 3 0.011
Sod1 superoxide dismutase 1, soluble 0.011
Top2a topoisomerase (DNA) II alpha 0.011
Psmb5 proteasome (prosome, macropain) subunit, beta type 5 0.011
Sepp1 selenoprotein P, plasma, 1 0.011
Lgals5 lectin, galactose binding, soluble 5 0.011
Tor1aip2 torsin A interacting protein 2 0.011
Akr1a1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 0.011
Pawr PRKC, apoptosis, WT1, regulator 0.011
Idh1 isocitrate dehydrogenase 1 (NADP+), soluble 0.011
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.011
Tjp1 tight junction protein 1 0.011
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.011
Spry1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.011
RT1-EC2 RT1 class Ib, locus EC2 0.011
Pomp proteasome maturation protein 0.011
Htr5b 5-hydroxytryptamine (serotonin) receptor 5B 0.011
Ubb ubiquitin B 0.010
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.010
Cdkn1a cyclin-dependent kinase inhibitor 1A 0.010
Slc44a2 solute carrier family 44, member 2 0.010
Hdac7 histone deacetylase 7 0.010
Cp ceruloplasmin 0.010
Nploc4 nuclear protein localization 4 homolog (S. cerevisiae) 0.010
F3 coagulation factor III (thromboplastin, tissue factor) 0.010
Lgals1 lectin, galactoside-binding, soluble, 1 0.010
Icam1 intercellular adhesion molecule 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
TRX2 Trx2p 0.024
HAL5 Hal5p 0.013
MIG2 Mig2p 0.013
SSK2 Ssk2p 0.011
CTT1 Ctt1p 0.011
RPN4 Rpn4p 0.011