The network for 'positive regulation of protein tyrosine kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of protein tyrosine kinase activity

Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.

Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 1.000
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 1.000
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 1.000
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.000
VEGFA vascular endothelial growth factor A 0.999
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.998
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.979
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.974
CCR5 chemokine (C-C motif) receptor 5 0.952
BCAR1 breast cancer anti-estrogen resistance 1 0.868
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.862
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.860
AXL AXL receptor tyrosine kinase 0.825
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.747
ABI2 abl-interactor 2 0.687
NRP1 neuropilin 1 0.657
CCL2 chemokine (C-C motif) ligand 2 0.654
LRRK2 leucine-rich repeat kinase 2 0.639
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.556
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.535
CXCL9 chemokine (C-X-C motif) ligand 9 0.502
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.455
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.431
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.414
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.384
MUC1 mucin 1, cell surface associated 0.367
CCL5 chemokine (C-C motif) ligand 5 0.333
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.257
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.247
CCL8 chemokine (C-C motif) ligand 8 0.226
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.220
PLCG1 phospholipase C, gamma 1 0.215
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.214
NCK1 NCK adaptor protein 1 0.213
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.204
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.191
MAPT microtubule-associated protein tau 0.188
WASL Wiskott-Aldrich syndrome-like 0.187
DNM1 dynamin 1 0.185
PGF placental growth factor 0.171
BAIAP2 BAI1-associated protein 2 0.164
CCL4 chemokine (C-C motif) ligand 4 0.164
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.161
CXCL13 chemokine (C-X-C motif) ligand 13 0.155
XAB2 XPA binding protein 2 0.149
NCKAP1 NCK-associated protein 1 0.142
PTPRB protein tyrosine phosphatase, receptor type, B 0.136
DLG1 discs, large homolog 1 (Drosophila) 0.121
PDCD6IP programmed cell death 6 interacting protein 0.120
CCL13 chemokine (C-C motif) ligand 13 0.116
PTK2 PTK2 protein tyrosine kinase 2 0.106
SOS1 son of sevenless homolog 1 (Drosophila) 0.102
GAB2 GRB2-associated binding protein 2 0.097
IL1B interleukin 1, beta 0.096
TNK2 tyrosine kinase, non-receptor, 2 0.096
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.094
IL6 interleukin 6 (interferon, beta 2) 0.093
CCL11 chemokine (C-C motif) ligand 11 0.091
SSR1 signal sequence receptor, alpha 0.090
SH3D19 SH3 domain containing 19 0.087
IQGAP1 IQ motif containing GTPase activating protein 1 0.085
SPRR2A small proline-rich protein 2A 0.084
CXCL10 chemokine (C-X-C motif) ligand 10 0.081
NCF2 neutrophil cytosolic factor 2 0.080
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.079
CRMP1 collapsin response mediator protein 1 0.079
CCL19 chemokine (C-C motif) ligand 19 0.075
IDE insulin-degrading enzyme 0.072
CCR7 chemokine (C-C motif) receptor 7 0.070
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.066
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.065
GAB1 GRB2-associated binding protein 1 0.064
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.063
PDGFC platelet derived growth factor C 0.058
PRKCA protein kinase C, alpha 0.055
CCR1 chemokine (C-C motif) receptor 1 0.053
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.053
DLG2 discs, large homolog 2 (Drosophila) 0.051
ICAM1 intercellular adhesion molecule 1 0.050
ARRB1 arrestin, beta 1 0.050
CDH5 cadherin 5, type 2 (vascular endothelium) 0.050
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.048
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.047
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.047
MED28 mediator complex subunit 28 0.046
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.045
IL8 interleukin 8 0.043
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.043
SELE selectin E 0.043
IFNG interferon, gamma 0.042
KITLG KIT ligand 0.042
CAPRIN2 caprin family member 2 0.041
VCAM1 vascular cell adhesion molecule 1 0.041
ARRDC3 arrestin domain containing 3 0.040
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.040
LNX1 ligand of numb-protein X 1 0.040
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.040
INSR insulin receptor 0.040
SH3RF3 SH3 domain containing ring finger 3 0.038
DARC Duffy blood group, chemokine receptor 0.038
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Ras85D Ras oncogene at 85D 0.427
Rho1 CG8416 gene product from transcript CG8416-RB 0.191
Rala Ras-related protein 0.182
aop anterior open 0.172
ttk tramtrack 0.111
argos CG4531 gene product from transcript CG4531-RA 0.065
pnt pointed 0.062
trio CG18214 gene product from transcript CG18214-RA 0.054
Rac1 CG2248 gene product from transcript CG2248-RA 0.045
shg shotgun 0.037
N Notch 0.035
H Hairless 0.031
arm armadillo 0.029
drk downstream of receptor kinase 0.024
emc extra macrochaetae 0.023
mbc myoblast city 0.021
Su(H) Suppressor of Hairless 0.021
Rab5 Rab-protein 5 0.020
eya eyes absent 0.018
Egfr Epidermal growth factor receptor 0.016
spi spitz 0.015
rl rolled 0.015
bif bifocal 0.015
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.015
Hem HEM-protein 0.014
WASp CG1520 gene product from transcript CG1520-RA 0.013
Pvr PDGF- and VEGF-receptor related 0.012
rho rhomboid 0.012
Rel Relish 0.011
milt milton 0.011
MED24 Mediator complex subunit 24 0.011
Dl Delta 0.010
numb CG3779 gene product from transcript CG3779-RB 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Dab1 disabled homolog 1 (Drosophila) 0.975
Vangl1 vang-like 1 (van gogh, Drosophila) 0.726
Vangl2 vang-like 2 (van gogh, Drosophila) 0.709
Ret ret proto-oncogene 0.682
Nos3 nitric oxide synthase 3, endothelial cell 0.585
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.571
Cpeb3 cytoplasmic polyadenylation element binding protein 3 0.530
Pax2 paired box gene 2 0.398
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.362
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.337
Lhx1 LIM homeobox protein 1 0.233
Wnt3a wingless-related MMTV integration site 3A 0.217
Ntf3 neurotrophin 3 0.187
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.152
Csf1 colony stimulating factor 1 (macrophage) 0.149
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.128
Wnt4 wingless-related MMTV integration site 4 0.121
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.120
Phox2b paired-like homeobox 2b 0.117
Kl klotho 0.115
Reln reelin 0.110
Tgfb1 transforming growth factor, beta 1 0.108
Src Rous sarcoma oncogene 0.107
Apoe apolipoprotein E 0.107
Wnt10b wingless related MMTV integration site 10b 0.101
Lrp8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.099
Gdnf glial cell line derived neurotrophic factor 0.096
Sox10 SRY-box containing gene 10 0.095
Agtr1a angiotensin II receptor, type 1a 0.087
Tgfa transforming growth factor alpha 0.081
Chrd chordin 0.080
Kcne1l potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene 0.077
Fgf8 fibroblast growth factor 8 0.075
App amyloid beta (A4) precursor protein 0.069
Vldlr very low density lipoprotein receptor 0.063
Egfr epidermal growth factor receptor 0.063
Hoxd9 homeobox D9 0.062
Pou3f3 POU domain, class 3, transcription factor 3 0.061
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.060
Zfp651 zinc finger protein 651 0.060
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.060
Adra2a adrenergic receptor, alpha 2a 0.059
T brachyury 0.059
Pax8 paired box gene 8 0.055
Flt1 FMS-like tyrosine kinase 1 0.051
Fgfr1 fibroblast growth factor receptor 1 0.044
Vstm2b V-set and transmembrane domain containing 2B 0.041
Dll1 delta-like 1 (Drosophila) 0.041
Ptk7 PTK7 protein tyrosine kinase 7 0.041
Nog noggin 0.039
Hoxa11 homeobox A11 0.038
Isl1 ISL1 transcription factor, LIM/homeodomain 0.037
Phox2a paired-like homeobox 2a 0.037
Acan aggrecan 0.036
Musk muscle, skeletal, receptor tyrosine kinase 0.036
Porcn porcupine homolog (Drosophila) 0.036
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.035
Vdr vitamin D receptor 0.034
Hif1a hypoxia inducible factor 1, alpha subunit 0.033
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.032
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.031
Lama5 laminin, alpha 5 0.031
Pitx2 paired-like homeodomain transcription factor 2 0.029
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.028
Psen1 presenilin 1 0.027
Emx1 empty spiracles homolog 1 (Drosophila) 0.027
H2-Aa histocompatibility 2, class II antigen A, alpha 0.027
Foxf1a forkhead box F1a 0.027
Acvr1 activin A receptor, type 1 0.025
Ctnnb1 catenin (cadherin associated protein), beta 1 0.024
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.023
Ren1 renin 1 structural 0.022
Npas1 neuronal PAS domain protein 1 0.022
Smad3 MAD homolog 3 (Drosophila) 0.022
Fzd1 frizzled homolog 1 (Drosophila) 0.022
Tbx1 T-box 1 0.021
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.021
Pou3f1 POU domain, class 3, transcription factor 1 0.020
Emid2 EMI domain containing 2 0.020
Nptx1 neuronal pentraxin 1 0.020
Lhx6 LIM homeobox protein 6 0.019
Fgf18 fibroblast growth factor 18 0.018
Ntf5 neurotrophin 5 0.018
Gli3 GLI-Kruppel family member GLI3 0.018
Tnni2 troponin I, skeletal, fast 2 0.018
Fzd8 frizzled homolog 8 (Drosophila) 0.018
Vav2 vav 2 oncogene 0.018
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.018
Btbd17 BTB (POZ) domain containing 17 0.018
Ngf nerve growth factor 0.018
Wnt7a wingless-related MMTV integration site 7A 0.018
Sema3b sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.017
Nr2e1 nuclear receptor subfamily 2, group E, member 1 0.017
Fgf5 fibroblast growth factor 5 0.016
Wnt9a wingless-type MMTV integration site 9A 0.016
Tcirg1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 0.016
Shh sonic hedgehog 0.016
Sos1 son of sevenless homolog 1 (Drosophila) 0.016
Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.016
Il11 interleukin 11 0.016
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Strn striatin, calmodulin binding protein 0.053
Uhmk1 U2AF homology motif (UHM) kinase 1 0.034
Met met proto-oncogene 0.032
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.028
Gzmb granzyme B 0.028
Dnase1l3 deoxyribonuclease 1-like 3 0.026
Gnal guanine nucleotide binding protein, alpha stimulating, olfactory type 0.026
Elk3 ELK3, ETS-domain protein 0.024
Gzmk granzyme K 0.024
Tcrb T-cell receptor beta chain 0.022
Unc5b unc-5 homolog B (C. elegans) 0.021
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.020
Wasf1 WAS protein family, member 1 0.020
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.019
Fgfr2 fibroblast growth factor receptor 2 0.018
Flt1 FMS-related tyrosine kinase 1 0.018
Il2rb interleukin 2 receptor, beta 0.018
Cd3g CD3 molecule, gamma 0.018
Heph hephaestin 0.018
Gata6 GATA binding protein 6 0.017
Il1a interleukin 1 alpha 0.016
Csnk1g3 casein kinase 1, gamma 3 0.016
Gpr173 G-protein coupled receptor 173 0.015
Adam10 ADAM metallopeptidase domain 10 0.015
Lhx5 LIM homeobox 5 0.015
Taok1 TAO kinase 1 0.015
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.014
Lig3 ligase III, DNA, ATP-dependent 0.014
Tril TLR4 interactor with leucine-rich repeats 0.014
Ccr5 chemokine (C-C motif) receptor 5 0.014
Prp2 proline rich protein 2 0.014
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.014
Max MYC associated factor X 0.014
Dpep1 dipeptidase 1 (renal) 0.014
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.014
Gata4 GATA binding protein 4 0.014
Clic4 chloride intracellular channel 4 0.014
Olr837 olfactory receptor 837 0.014
Il1rap interleukin 1 receptor accessory protein 0.014
Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.013
Trib1 tribbles homolog 1 (Drosophila) 0.013
Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 0.013
Sox2 SRY (sex determining region Y)-box 2 0.013
Wipf1 WAS/WASL interacting protein family, member 1 0.013
Pdk4 pyruvate dehydrogenase kinase, isozyme 4 0.013
Soat1 sterol O-acyltransferase 1 0.013
Wasl Wiskott-Aldrich syndrome-like 0.013
Ltc4s leukotriene C4 synthase 0.013
Apob apolipoprotein B 0.013
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.012
Dctn4 dynactin 4 0.012
Nxph1 neurexophilin 1 0.012
Pllp plasma membrane proteolipid (plasmolipin) 0.012
Pde6d phosphodiesterase 6D, cGMP-specific, rod, delta 0.012
Bcl2l1 Bcl2-like 1 0.012
Arhgdib Rho, GDP dissociation inhibitor (GDI) beta 0.012
Igh-6 immunoglobulin heavy chain 6 0.012
Ptprc protein tyrosine phosphatase, receptor type, C 0.012
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.012
Ptprz1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.012
Ocln occludin 0.012
RGD1565043 similar to Rho guanine nucleotide exchange factor (GEF) 10 0.012
Tacr1 tachykinin receptor 1 0.012
Synrg synergin, gamma 0.012
Ptafr platelet-activating factor receptor 0.012
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.012
Slc30a1 solute carrier family 30 (zinc transporter), member 1 0.011
Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.011
Pax6 paired box 6 0.011
Tle4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 0.011
Cxcl10 chemokine (C-X-C motif) ligand 10 0.011
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.011
Clcn7 chloride channel 7 0.011
Muc1 mucin 1, cell surface associated 0.011
Cxcr4 chemokine (C-X-C motif) receptor 4 0.011
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.011
G6pc glucose-6-phosphatase, catalytic subunit 0.011
St6galnac3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.011
Azgp1 alpha-2-glycoprotein 1, zinc-binding 0.011
Ednrb endothelin receptor type B 0.011
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.011
Casp2 caspase 2 0.011
Dlg1 discs, large homolog 1 (Drosophila) 0.011
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.011
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.010
LOC287167 globin, alpha 0.010
Tgfbr1 transforming growth factor, beta receptor 1 0.010
Lhfpl2 lipoma HMGIC fusion partner-like 2 0.010
Padi1 peptidyl arginine deiminase, type I 0.010
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.010
Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase 0.010
Arih1 ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila) 0.010
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.010
Dpy19l1 dpy-19-like 1 (C. elegans) 0.010
RT1-M5 RT1 class Ib, locus M5 0.010
Acox3 acyl-Coenzyme A oxidase 3, pristanoyl 0.010
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.010
Gprc5b G protein-coupled receptor, family C, group 5, member B 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism