IMP
Process View
The network for 'negative regulation of leukocyte degranulation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
negative regulation of leukocyte degranulation
Any process that stops, prevents, or reduces the rate of leukocyte degranulation.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.226 | |
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.224 | |
| Fgr | Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog | 0.175 | |
| Ccl3 | chemokine (C-C motif) ligand 3 | 0.162 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.158 | |
| Mefv | Mediterranean fever | 0.102 | |
| Selp | selectin, platelet | 0.080 | |
| Fcrla | Fc receptor-like A | 0.058 | |
| Cxcl13 | chemokine (C-X-C motif) ligand 13 | 0.044 | |
| Cxcr2 | chemokine (C-X-C motif) receptor 2 | 0.044 | |
| Blk | B lymphoid kinase | 0.043 | |
| Klrb1b | killer cell lectin-like receptor subfamily B member 1B | 0.040 | |
| Ifng | interferon gamma | 0.039 | |
| Csf3r | colony stimulating factor 3 receptor (granulocyte) | 0.038 | |
| Cd180 | CD180 antigen | 0.038 | |
| Lgr4 | leucine-rich repeat-containing G protein-coupled receptor 4 | 0.037 | |
| Cxcr3 | chemokine (C-X-C motif) receptor 3 | 0.035 | |
| Clec4a2 | C-type lectin domain family 4, member a2 | 0.034 | |
| Trem3 | triggering receptor expressed on myeloid cells 3 | 0.034 | |
| Itgax | integrin alpha X | 0.033 | |
| Tgfb2 | transforming growth factor, beta 2 | 0.031 | |
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.031 | |
| Tnfsf14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.030 | |
| Cd22 | CD22 antigen | 0.029 | |
| Mb | myoglobin | 0.025 | |
| Slpi | secretory leukocyte peptidase inhibitor | 0.025 | |
| Prdm1 | PR domain containing 1, with ZNF domain | 0.024 | |
| Cd44 | CD44 antigen | 0.023 | |
| Il1r1 | interleukin 1 receptor, type I | 0.023 | |
| Il1b | interleukin 1 beta | 0.023 | |
| Cd33 | CD33 antigen | 0.022 | |
| Klrk1 | killer cell lectin-like receptor subfamily K, member 1 | 0.022 | |
| Tlr2 | toll-like receptor 2 | 0.021 | |
| Slfn4 | schlafen 4 | 0.021 | |
| Tnf | tumor necrosis factor | 0.020 | |
| Il18rap | interleukin 18 receptor accessory protein | 0.019 | |
| Fcgr1 | Fc receptor, IgG, high affinity I | 0.019 | |
| Ccl4 | chemokine (C-C motif) ligand 4 | 0.018 | |
| Tlr8 | toll-like receptor 8 | 0.018 | |
| Tlr4 | toll-like receptor 4 | 0.018 | |
| Klra2 | killer cell lectin-like receptor, subfamily A, member 2 | 0.018 | |
| Il1f9 | interleukin 1 family, member 9 | 0.018 | |
| Icos | inducible T-cell co-stimulator | 0.018 | |
| Il10ra | interleukin 10 receptor, alpha | 0.018 | |
| Cd40 | CD40 antigen | 0.017 | |
| Ccr6 | chemokine (C-C motif) receptor 6 | 0.017 | |
| Klrg1 | killer cell lectin-like receptor subfamily G, member 1 | 0.017 | |
| Il4 | interleukin 4 | 0.016 | |
| Ciita | class II transactivator | 0.016 | |
| Ctla4 | cytotoxic T-lymphocyte-associated protein 4 | 0.016 | |
| Clec4d | C-type lectin domain family 4, member d | 0.015 | |
| Cd7 | CD7 antigen | 0.015 | |
| Ncr1 | natural cytotoxicity triggering receptor 1 | 0.014 | |
| Tlr7 | toll-like receptor 7 | 0.014 | |
| Nkx2-3 | NK2 transcription factor related, locus 3 (Drosophila) | 0.014 | |
| Fcer2a | Fc receptor, IgE, low affinity II, alpha polypeptide | 0.014 | |
| Trem1 | triggering receptor expressed on myeloid cells 1 | 0.014 | |
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.014 | |
| Snai1 | snail homolog 1 (Drosophila) | 0.014 | |
| Pilrb1 | paired immunoglobin-like type 2 receptor beta 1 | 0.014 | |
| Fcgr4 | Fc receptor, IgG, low affinity IV | 0.014 | |
| Clec5a | C-type lectin domain family 5, member a | 0.013 | |
| Pilra | paired immunoglobin-like type 2 receptor alpha | 0.013 | |
| Pik3cg | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 0.013 | |
| Fpr1 | formyl peptide receptor 1 | 0.013 | |
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.013 | |
| H2-Ob | histocompatibility 2, O region beta locus | 0.012 | |
| Trpv1 | transient receptor potential cation channel, subfamily V, member 1 | 0.012 | |
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.012 | |
| Lair1 | leukocyte-associated Ig-like receptor 1 | 0.012 | |
| Ear2 | eosinophil-associated, ribonuclease A family, member 2 | 0.012 | |
| Irg1 | immunoresponsive gene 1 | 0.012 | |
| Nos2 | nitric oxide synthase 2, inducible | 0.012 | |
| Ccr9 | chemokine (C-C motif) receptor 9 | 0.012 | |
| Dock1 | dedicator of cytokinesis 1 | 0.012 | |
| Efna1 | ephrin A1 | 0.012 | |
| Emr4 | EGF-like module containing, mucin-like, hormone receptor-like sequence 4 | 0.012 | |
| Cd3e | CD3 antigen, epsilon polypeptide | 0.011 | |
| Cd300lb | CD300 antigen like family member B | 0.011 | |
| C5ar1 | complement component 5a receptor 1 | 0.011 | |
| Mmp8 | matrix metallopeptidase 8 | 0.011 | |
| Siglece | sialic acid binding Ig-like lectin E | 0.011 | |
| Gzmb | granzyme B | 0.011 | |
| Slamf6 | SLAM family member 6 | 0.010 | |
| Cd4 | CD4 antigen | 0.010 | |
| Csf2rb | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.010 | |
| Abcg3 | ATP-binding cassette, sub-family G (WHITE), member 3 | 0.010 | |
| Mmp9 | matrix metallopeptidase 9 | 0.010 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| C19orf50 | chromosome 19 open reading frame 50 | 0.952 | |
| TFF1 | trefoil factor 1 | 0.925 | |
| CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 0.797 | |
| APBA3 | amyloid beta (A4) precursor protein-binding, family A, member 3 | 0.697 | |
| PDZK1 | PDZ domain containing 1 | 0.325 | |
| MLLT4 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 0.299 | |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.124 | |
| HK3 | hexokinase 3 (white cell) | 0.101 | |
| LAIR1 | leukocyte-associated immunoglobulin-like receptor 1 | 0.095 | |
| LY86 | lymphocyte antigen 86 | 0.057 | |
| GIPC1 | GIPC PDZ domain containing family, member 1 | 0.047 | |
| RGS12 | regulator of G-protein signaling 12 | 0.041 | |
| IFT20 | intraflagellar transport 20 homolog (Chlamydomonas) | 0.037 | |
| KRT81 | keratin 81 | 0.036 | |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.031 | |
| SLC9A3R2 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 | 0.029 | |
| LILRA2 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 | 0.029 | |
| SLC9A3R1 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | 0.027 | |
| PIK3AP1 | phosphoinositide-3-kinase adaptor protein 1 | 0.021 | |
| CD300A | CD300a molecule | 0.021 | |
| GOPC | golgi-associated PDZ and coiled-coil motif containing | 0.019 | |
| FUT6 | fucosyltransferase 6 (alpha (1,3) fucosyltransferase) | 0.019 | |
| AOAH | acyloxyacyl hydrolase (neutrophil) | 0.018 | |
| CEACAM3 | carcinoembryonic antigen-related cell adhesion molecule 3 | 0.018 | |
| SLMAP | sarcolemma associated protein | 0.018 | |
| WAS | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 0.017 | |
| TBXAS1 | thromboxane A synthase 1 (platelet) | 0.016 | |
| SIGLEC1 | sialic acid binding Ig-like lectin 1, sialoadhesin | 0.015 | |
| SASH3 | SAM and SH3 domain containing 3 | 0.015 | |
| LTK | leukocyte receptor tyrosine kinase | 0.014 | |
| ASGR2 | asialoglycoprotein receptor 2 | 0.014 | |
| TNFSF8 | tumor necrosis factor (ligand) superfamily, member 8 | 0.014 | |
| FAM82A2 | family with sequence similarity 82, member A2 | 0.014 | |
| FOXF2 | forkhead box F2 | 0.013 | |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | 0.013 | |
| SLC11A1 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 | 0.013 | |
| IL19 | interleukin 19 | 0.012 | |
| PVRL2 | poliovirus receptor-related 2 (herpesvirus entry mediator B) | 0.012 | |
| OSCAR | osteoclast associated, immunoglobulin-like receptor | 0.012 | |
| IL10 | interleukin 10 | 0.012 | |
| CCDC33 | coiled-coil domain containing 33 | 0.011 | |
| CLEC4A | C-type lectin domain family 4, member A | 0.011 | |
| EMR1 | egf-like module containing, mucin-like, hormone receptor-like 1 | 0.011 | |
| IL2RB | interleukin 2 receptor, beta | 0.011 | |
| CD300LB | CD300 molecule-like family member b | 0.011 | |
| CSF3R | colony stimulating factor 3 receptor (granulocyte) | 0.011 | |
| HIP1R | huntingtin interacting protein 1 related | 0.011 | |
| CD33 | CD33 molecule | 0.011 | |
| CD300LF | CD300 molecule-like family member f | 0.011 | |
| TPM3 | tropomyosin 3 | 0.011 | |
| TJP1 | tight junction protein 1 (zona occludens 1) | 0.011 | |
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 | 0.011 | |
| EPOR | erythropoietin receptor | 0.010 | |
| EPHB2 | EPH receptor B2 | 0.010 | |
| SIGLEC7 | sialic acid binding Ig-like lectin 7 | 0.010 | |
| CXCR6 | chemokine (C-X-C motif) receptor 6 | 0.010 |