The network for 'pole plasm assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

pole plasm assembly

Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster.

Name Description Probability Func Analog Organism
Ctnnb1 catenin (cadherin associated protein), beta 1 1.000
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1.000
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 1.000
Apc adenomatosis polyposis coli 0.999
Stx1a syntaxin 1A (brain) 0.999
Dlg4 discs, large homolog 4 (Drosophila) 0.995
Gsk3b glycogen synthase kinase 3 beta 0.992
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.990
Snap25 synaptosomal-associated protein 25 0.979
Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha 0.976
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.958
Hif1a hypoxia inducible factor 1, alpha subunit 0.953
Fus fusion, derived from t(12;16) malignant liposarcoma (human) 0.937
Hspa8 heat shock protein 8 0.936
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.926
Vamp2 vesicle-associated membrane protein 2 0.926
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.920
Smad4 MAD homolog 4 (Drosophila) 0.919
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.899
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.874
Htt huntingtin 0.865
Ina internexin neuronal intermediate filament protein, alpha 0.778
Bmpr1a bone morphogenetic protein receptor, type 1A 0.761
Pten phosphatase and tensin homolog 0.756
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.747
Ccnd1 cyclin D1 0.740
Tsc1 tuberous sclerosis 1 0.709
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.693
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.676
Dlg2 discs, large homolog 2 (Drosophila) 0.670
Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform 0.668
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.668
Stx12 syntaxin 12 0.668
Cltc clathrin, heavy polypeptide (Hc) 0.667
Dlg1 discs, large homolog 1 (Drosophila) 0.637
Nf1 neurofibromatosis 1 0.629
Mtap2 microtubule-associated protein 2 0.618
Bicd2 bicaudal D homolog 2 (Drosophila) 0.612
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.596
Psen1 presenilin 1 0.590
Rb1 retinoblastoma 1 0.575
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.570
Set SET nuclear oncogene 0.568
Spnb2 spectrin beta 2 0.562
Ccdc64 coiled-coil domain containing 64 0.558
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.555
Prmt5 protein arginine N-methyltransferase 5 0.543
Cct6a chaperonin containing Tcp1, subunit 6a (zeta) 0.541
Prkce protein kinase C, epsilon 0.537
Smad1 MAD homolog 1 (Drosophila) 0.516
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.507
Eif5a eukaryotic translation initiation factor 5A 0.507
Khdrbs1 KH domain containing, RNA binding, signal transduction associated 1 0.498
Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 0.486
Thbs1 thrombospondin 1 0.456
Ppp2r2a protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform 0.453
Nrcam neuron-glia-CAM-related cell adhesion molecule 0.435
Kif5a kinesin family member 5A 0.434
Mael maelstrom homolog (Drosophila) 0.408
Pum1 pumilio 1 (Drosophila) 0.405
Kdm1a lysine (K)-specific demethylase 1A 0.400
Braf Braf transforming gene 0.394
Hnrnpd heterogeneous nuclear ribonucleoprotein D 0.379
Mdm2 transformed mouse 3T3 cell double minute 2 0.376
Cct2 chaperonin containing Tcp1, subunit 2 (beta) 0.373
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.373
Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.369
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.355
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.348
Arc activity regulated cytoskeletal-associated protein 0.343
Sult4a1 sulfotransferase family 4A, member 1 0.343
Src Rous sarcoma oncogene 0.340
Hnrnpk heterogeneous nuclear ribonucleoprotein K 0.340
Nudc nuclear distribution gene C homolog (Aspergillus) 0.332
Dnm1 dynamin 1 0.329
Rpgrip1l Rpgrip1-like 0.328
Ddx3x DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked 0.326
Bsn bassoon 0.307
Vcp valosin containing protein 0.306
2500003M10Rik RIKEN cDNA 2500003M10 gene 0.303
Trp53 transformation related protein 53 0.297
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.295
Eif4h eukaryotic translation initiation factor 4H 0.295
Clstn1 calsyntenin 1 0.289
Pafah1b2 platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 0.284
Srsf2 serine/arginine-rich splicing factor 2 0.280
Snrpd1 small nuclear ribonucleoprotein D1 0.279
Stxbp1 syntaxin binding protein 1 0.277
Hnrnpab heterogeneous nuclear ribonucleoprotein A/B 0.271
App amyloid beta (A4) precursor protein 0.265
Tsc2 tuberous sclerosis 2 0.265
Cdk4 cyclin-dependent kinase 4 0.260
Snrpb small nuclear ribonucleoprotein B 0.260
Aplp2 amyloid beta (A4) precursor-like protein 2 0.258
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.258
Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 0.253
Ewsr1 Ewing sarcoma breakpoint region 1 0.252
Msh2 mutS homolog 2 (E. coli) 0.252
Tbca tubulin cofactor A 0.249
Kif5c kinesin family member 5C 0.246
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
par-5 Protein PAR-5 0.893
glh-1 Protein GLH-1 0.646
Y65B4BR.5 Protein Y65B4BR.5 0.635
tba-2 Protein TBA-2 0.582
snr-4 Protein SNR-4 0.487
pas-3 Protein PAS-3 0.404
mcm-2 Protein MCM-2 0.369
pgl-1 Protein PGL-1 0.366
rars-1 Protein RARS-1 0.356
lbp-9 Protein LBP-9 0.355
par-2 Protein PAR-2 0.347
ucr-2.3 Protein UCR-2.3 0.332
glh-4 Protein GLH-4 0.310
tbb-2 Protein TBB-2 0.304
snr-3 Protein SNR-3 0.286
CELE_C01G10.8 Protein C01G10.8 0.254
R07E5.7 Protein R07E5.7 0.235
klp-15 Protein KLP-15 0.234
prg-2 Protein PRG-2 0.222
ina-1 Protein INA-1 0.205
prg-1 Protein PRG-1 0.203
CELE_C17H12.13 Protein C17H12.13 0.198
rpl-11.1 Protein RPL-11.1 0.198
rpl-25.2 Protein RPL-25.2 0.196
icd-1 Protein ICD-1 0.193
R12C12.6 Protein R12C12.6 0.187
pbs-4 Protein PBS-4 0.184
rpl-7 Protein RPL-7 0.183
tbb-1 Protein TBB-1 0.179
imb-3 Protein IMB-3 0.175
K06A5.1 Protein K06A5.1 0.167
xpo-2 Protein XPO-2 0.165
ife-1 Protein IFE-1 0.163
eef-1A.1 Protein EEF-1A.1 0.162
hsp-1 Protein HSP-1 0.157
arx-7 Protein ARX-7 0.156
rpt-3 Protein RPT-3 0.155
wago-4 Protein WAGO-4 0.142
rpl-6 Protein RPL-6 0.139
rec-8 Protein REC-8 0.138
cbd-1 Protein CBD-1 0.138
cgh-1 Protein CGH-1 0.136
rpa-2 Protein RPA-2 0.120
CELE_Y57G11C.3 Protein Y57G11C.3 0.116
CELE_Y54E10BR.5 Protein Y54E10BR.5 0.116
T28D9.1 Protein T28D9.1 0.115
npl-4.2 Protein NPL-4.2 0.112
pbs-6 Protein PBS-6 0.103
goa-1 Protein GOA-1 0.096
K07H8.3 Protein K07H8.3 0.096
CELE_C18C4.5 Protein C18C4.5 0.094
chc-1 Protein CHC-1 0.094
CELE_Y14H12B.2 Protein Y14H12B.2 0.092
gba-3 Protein GBA-3 0.092
zif-1 Protein ZIF-1 0.089
csnk-1 Protein CSNK-1 0.089
rpl-12 Protein RPL-12 0.088
btf-1 Protein BTF-1 0.086
pas-4 Protein PAS-4 0.086
K07C5.3 Protein K07C5.3 0.084
rpl-3 Protein RPL-3 0.083
rps-2 Protein RPS-2 0.082
rpl-4 Protein RPL-4 0.080
rpt-5 Protein RPT-5 0.079
rpl-2 Protein RPL-2 0.079
rps-6 Protein RPS-6 0.076
snr-2 Protein SNR-2 0.075
W08E12.7 Protein W08E12.7 0.074
unc-116 Protein UNC-116 0.074
rpl-15 Protein RPL-15 0.074
rpl-13 Protein RPL-13 0.072
pab-1 Protein PAB-1 0.071
rpb-8 Protein RPB-8 0.070
dnj-5 Protein DNJ-5 0.070
spk-1 Protein SPK-1 0.067
CELE_Y14H12B.1 Protein Y14H12B.1 0.067
pas-2 Protein PAS-2 0.067
gpb-1 Protein GPB-1 0.067
rho-1 Protein RHO-1 0.066
mog-2 Protein MOG-2 0.066
mac-1 Protein MAC-1 0.064
R186.7 Protein R186.7 0.064
hlh-30 Protein HLH-30 0.061
iff-1 Protein IFF-1 0.061
mcm-4 Protein MCM-4 0.061
cst-2 Protein CST-2 0.060
usp-14 Protein USP-14 0.059
csr-1 Protein CSR-1 0.059
CELE_Y18D10A.11 Protein Y18D10A.11 0.059
CELE_C16C10.4 Protein C16C10.4 0.059
cct-1 Protein CCT-1 0.059
F31C3.3 Protein F31C3.3 0.058
wago-1 Protein WAGO-1 0.058
F56D2.6 Protein F56D2.6 0.057
rack-1 Protein RACK-1 0.057
rla-0 Protein RLA-0 0.057
pqn-87 Protein PQN-87 0.056
perm-1 Protein PERM-1 0.055
klc-2 Protein KLC-2 0.055
F10G8.8 Protein F10G8.8 0.054
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Danio rerio
Name Description Probability Func Analog Organism
nanos3 nanos homolog 3 1.000
piwil1 piwi-like 1 (Drosophila) 0.999
piwil2 piwi-like 2 (Drosophila) 0.975
dazl daz-like gene 0.954
zgc:103482 zgc:103482 0.686
dlg2 discs, large (Drosophila) homolog 2 0.657
ilf2 interleukin enhancer binding factor 2 0.642
gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 0.630
org oogenesis-related gene 0.621
elavl2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) 0.607
ef1a elongation factor 1-alpha 0.557
dnd dead end 0.539
ca15b carbonic anhydrase XV b 0.517
brca2 breast cancer 2, early onset 0.512
fancl Fanconi anemia, complementation group L 0.400
rnf17 ring finger protein 17 0.336
vasa vasa homolog 0.328
eef1g eukaryotic translation elongation factor 1 gamma 0.320
snx6 sorting nexin 6 0.302
zorba Orb/CPEB-related RNA-binding protein 0.297
cltcb clathrin, heavy polypeptide b (Hc) 0.287
elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.271
eif4a1a eukaryotic translation initiation factor 4A, isoform 1A 0.268
ube2na ubiquitin-conjugating enzyme E2Na 0.261
spsb1 splA/ryanodine receptor domain and SOCS box containing 1 0.255
spsb4a splA/ryanodine receptor domain and SOCS box containing 4a 0.242
hk1 hexokinase 1 0.239
tdrd1 tudor domain containing 1 0.238
znf711 zinc finger protein 711 0.236
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.233
buc bucky ball 0.229
rpl3 ribosomal protein L3 0.226
rpl4 ribosomal protein L4 0.220
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.218
eif5a eukaryotic translation initiation factor 5A 0.214
khdrbs1a KH domain containing, RNA binding, signal transduction associated 1a 0.213
sfrs3b splicing factor, arginine/serine-rich 3b 0.210
snrpd3l small nuclear ribonucleoprotein D3 polypeptide, like 0.206
ck2b casein kinase 2 beta 0.205
zgc:193933 zgc:193933 0.203
smu1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 0.201
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.201
atp6v1h ATPase, H+ transporting, lysosomal, V1 subunit H 0.201
tdrd7 tudor domain containing 7 0.198
asz1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 0.197
hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 0.196
tpm4 tropomyosin 4 0.196
rps4x ribosomal protein S4, X-linked 0.193
rpl23a ribosomal protein L23a 0.192
si:ch1073-351m12.1 si:ch1073-351m12.1 0.189
psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.181
zgc:77366 zgc:77366 0.174
cntn1a contactin 1a 0.171
smarce1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.167
ncl nucleolin 0.162
pob partial optokinetic response b 0.161
tpt1 tumor protein, translationally-controlled 1 0.160
pfn2 profilin 2 0.157
gdf9 growth differentiation factor 9 0.153
flot1b flotillin 1b 0.150
actr10 actin-related protein 10 homolog (S. cerevisiae) 0.147
magoh mago-nashi homolog, proliferation-associated (Drosophila) 0.146
psen1 presenilin 1 0.143
mpz myelin protein zero 0.142
tubg1 tubulin, gamma 1 0.138
ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.138
usp5 ubiquitin specific protease 5 0.135
bactin1 bactin1 0.132
zgc:56005 zgc:56005 0.132
cct7 chaperonin containing TCP1, subunit 7 (eta) 0.131
LOC561889 granulito 0.130
dynlt3 dynein, light chain, Tctex-type 3 0.130
pak2a p21 (CDKN1A)-activated kinase 2a 0.128
g3bp1 GTPase activating protein (SH3 domain) binding protein 1 0.125
sf1 splicing factor 1 0.125
henmt1 HEN1 methyltransferase homolog 1 (Arabidopsis) 0.124
si:ch211-67f24.5 si:ch211-67f24.5 0.123
grcc10 gene rich cluster, C10 gene 0.123
zgc:112425 zgc:112425 0.122
rpl5b ribosomal protein L5b 0.122
stk25b serine/threonine kinase 25b 0.122
arf2 ADP-ribosylation factor 2 0.121
prkd1 protein kinase D1 0.121
arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.119
atp1b2a ATPase, Na+/K+ transporting, beta 2a polypeptide 0.117
acvr1b activin A receptor, type IB 0.116
rspo1 R-spondin homolog (Xenopus laevis) 0.116
esyt3 extended synaptotagmin-like protein 3 0.115
atp6v0ca ATPase, H+ transporting, lysosomal, V0 subunit c, a 0.114
api5 apoptosis inhibitor 5 0.113
hnrnpu heterogeneous nuclear ribonucleoprotein U 0.111
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.111
hspa8 heat shock protein 8 0.109
ewsr1b Ewing sarcoma breakpoint region 1b 0.107
sri sorcin 0.106
il13ra2 interleukin 13 receptor, alpha 2 0.106
hnrnpl2 heterogeneous nuclear ribonucleoprotein L2 0.104
celf1 cugbp, Elav-like family member 1 0.104
rap1b RAS related protein 1b 0.103
sybu syntabulin (syntaxin-interacting) 0.103
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Drosophila melanogaster
Name Description Probability Func Analog Organism
BicD Bicaudal D 1.000
par-1 CG8201 gene product from transcript CG8201-RA 1.000
sqd squid 1.000
aPKC atypical protein kinase C 0.999
baz bazooka 0.999
Khc Kinesin heavy chain 0.999
TER94 CG2331 gene product from transcript CG2331-RA 0.997
Cdc42 CG12530 gene product from transcript CG12530-RA 0.997
osk oskar 0.991
Lam Lamin 0.991
Dlic Dynein light intermediate chain 0.991
Dhc64C Dynein heavy chain 64C 0.991
sec5 CG8843 gene product from transcript CG8843-RA 0.990
vas vasa 0.985
glo glorund 0.981
Src64B Src oncogene at 64B 0.973
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.972
Hel25E Helicase at 25E 0.971
tsu tsunagi 0.971
stau staufen 0.970
SRPK CG8174 gene product from transcript CG8174-RA 0.964
vls valois 0.963
mago mago nashi 0.955
par-6 CG5884 gene product from transcript CG5884-RA 0.952
CG11188 CG11188 gene product from transcript CG11188-RA 0.944
CG6854 CG6854 gene product from transcript CG6854-RC 0.942
mael maelstrom 0.927
rok Rho-kinase 0.906
ecd ecdysoneless 0.899
tud tudor 0.897
tho2 CG31671 gene product from transcript CG31671-RA 0.895
piwi CG6122 gene product from transcript CG6122-RA 0.892
aret arrest 0.891
Dcp1 Decapping protein 1 0.888
sqh spaghetti squash 0.878
Atx2 Ataxin-2 0.867
Sop2 Suppressor of profilin 2 0.840
spn-E spindle E 0.825
egh egghead 0.818
me31B maternal expression at 31B 0.794
Nup154 Nucleoporin 154 0.793
slmb supernumerary limbs 0.785
CG10260 CG10260 gene product from transcript CG10260-RB 0.766
brat brain tumor 0.761
pita CG3941 gene product from transcript CG3941-RA 0.742
Tm1 Tropomyosin 1 0.735
shg shotgun 0.714
bcd bicoid 0.688
Pi3K21B CG2699 gene product from transcript CG2699-RA 0.643
spir spire 0.631
cpa capping protein alpha 0.612
Eip75B Ecdysone-induced protein 75B 0.599
alpha-Spec alpha Spectrin 0.592
Lis-1 Lissencephaly-1 0.566
bel belle 0.556
tral trailer hitch 0.536
aub aubergine 0.527
egg eggless 0.510
RpL10Ab Ribosomal protein L10Ab 0.500
hts hu li tai shao 0.495
krimp krimper 0.490
orb oo18 RNA-binding protein 0.461
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.457
mtrm matrimony 0.456
pum pumilio 0.448
CG17838 CG17838 gene product from transcript CG17838-RA 0.444
sax saxophone 0.443
mxc multi sex combs 0.435
Mi-2 CG8103 gene product from transcript CG8103-RA 0.407
nos nanos 0.400
Pabp2 CG2163 gene product from transcript CG2163-RA 0.395
CG4771 CG4771 gene product from transcript CG4771-RA 0.394
Chc Clathrin heavy chain 0.394
csul capsuleen 0.381
hb hunchback 0.357
psq pipsqueak 0.345
mirr mirror 0.344
grk gurken 0.336
lic licorne 0.327
ens ensconsin 0.315
Ets97D Ets at 97D 0.309
exu exuperantia 0.307
crb crumbs 0.293
dco discs overgrown 0.272
ttk tramtrack 0.236
Btk29A Btk family kinase at 29A 0.231
qm quemao 0.221
Rop Ras opposite 0.221
del deadlock 0.219
spn-F CG12114 gene product from transcript CG12114-RA 0.215
dap dacapo 0.211
lwr lesswright 0.209
jagn jagunal 0.209
lsn larsen 0.200
smt3 CG4494 gene product from transcript CG4494-RA 0.193
Rab5 Rab-protein 5 0.179
HtrA2 CG8464 gene product from transcript CG8464-RA 0.175
Fmr1 CG6203 gene product from transcript CG6203-RC 0.172
CG4415 CG4415 gene product from transcript CG4415-RA 0.169
CG4420 CG4420 gene product from transcript CG4420-RA 0.169
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Homo sapiens
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism