The network for 'response to peptidoglycan' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to peptidoglycan

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.

Mus musculus
Name Description Probability Func Analog Organism
Tlr4 toll-like receptor 4 0.998
Myd88 myeloid differentiation primary response gene 88 0.996
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.844
Cd44 CD44 antigen 0.697
Nlrp3 NLR family, pyrin domain containing 3 0.656
Mefv Mediterranean fever 0.519
Traf6 TNF receptor-associated factor 6 0.504
Irak4 interleukin-1 receptor-associated kinase 4 0.400
Clec4n C-type lectin domain family 4, member n 0.355
Ccl2 chemokine (C-C motif) ligand 2 0.326
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.210
Il1r1 interleukin 1 receptor, type I 0.176
Msr1 macrophage scavenger receptor 1 0.167
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.152
Irg1 immunoresponsive gene 1 0.148
Cd14 CD14 antigen 0.136
Il10 interleukin 10 0.127
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.120
Ticam1 toll-like receptor adaptor molecule 1 0.118
Fcgr4 Fc receptor, IgG, low affinity IV 0.116
Siglece sialic acid binding Ig-like lectin E 0.116
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.112
Cd300ld CD300 molecule-like family member d 0.102
Fpr1 formyl peptide receptor 1 0.096
Casp1 caspase 1 0.092
Pilrb1 paired immunoglobin-like type 2 receptor beta 1 0.081
Il1b interleukin 1 beta 0.080
Pycard PYD and CARD domain containing 0.077
Irak3 interleukin-1 receptor-associated kinase 3 0.074
Cd33 CD33 antigen 0.068
Klra2 killer cell lectin-like receptor, subfamily A, member 2 0.067
Clec4d C-type lectin domain family 4, member d 0.065
Plau plasminogen activator, urokinase 0.052
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.050
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.046
Trem3 triggering receptor expressed on myeloid cells 3 0.043
Il1rn interleukin 1 receptor antagonist 0.040
Mb myoglobin 0.038
Tnf tumor necrosis factor 0.036
Il1f9 interleukin 1 family, member 9 0.036
Clec4e C-type lectin domain family 4, member e 0.035
Il1a interleukin 1 alpha 0.034
Nos2 nitric oxide synthase 2, inducible 0.034
Nfam1 Nfat activating molecule with ITAM motif 1 0.032
Irak1 interleukin-1 receptor-associated kinase 1 0.032
Ccr1 chemokine (C-C motif) receptor 1 0.031
Fpr2 formyl peptide receptor 2 0.029
Aoah acyloxyacyl hydrolase 0.028
Mmp8 matrix metallopeptidase 8 0.027
Ticam2 toll-like receptor adaptor molecule 2 0.026
Ccr2 chemokine (C-C motif) receptor 2 0.025
Btk Bruton agammaglobulinemia tyrosine kinase 0.025
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.021
Pilra paired immunoglobin-like type 2 receptor alpha 0.020
Tcfec transcription factor EC 0.020
F7 coagulation factor VII 0.020
Trpv1 transient receptor potential cation channel, subfamily V, member 1 0.019
Cblb Casitas B-lineage lymphoma b 0.019
Gpr35 G protein-coupled receptor 35 0.017
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.017
Fpr3 formyl peptide receptor 3 0.017
Cd180 CD180 antigen 0.017
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.017
Tifa TRAF-interacting protein with forkhead-associated domain 0.016
Clec7a C-type lectin domain family 7, member a 0.016
Aim2 absent in melanoma 2 0.016
C130050O18Rik RIKEN cDNA C130050O18 gene 0.016
Ccl3 chemokine (C-C motif) ligand 3 0.016
Ly96 lymphocyte antigen 96 0.015
Clec5a C-type lectin domain family 5, member a 0.015
Mmp9 matrix metallopeptidase 9 0.015
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.014
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.014
Cd300lf CD300 antigen like family member F 0.014
Gbp5 guanylate binding protein 5 0.014
Slfn4 schlafen 4 0.014
Fcgr1 Fc receptor, IgG, high affinity I 0.014
Marco macrophage receptor with collagenous structure 0.012
Cd84 CD84 antigen 0.012
Tbxas1 thromboxane A synthase 1, platelet 0.012
Tlr8 toll-like receptor 8 0.012
Cysltr1 cysteinyl leukotriene receptor 1 0.012
Hcst hematopoietic cell signal transducer 0.011
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.011
B430306N03Rik RIKEN cDNA B430306N03 gene 0.011
F10 coagulation factor X 0.011
Slamf8 SLAM family member 8 0.011
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.011
Ms4a6d membrane-spanning 4-domains, subfamily A, member 6D 0.011
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.010
Lair1 leukocyte-associated Ig-like receptor 1 0.010
Tifab TRAF-interacting protein with forkhead-associated domain, family member B 0.010
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.010
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rel Relish 0.996
PGRP-LC Peptidoglycan recognition protein LC 0.982
AttA Attacin-A 0.973
ird5 immune response deficient 5 0.749
DptB Diptericin B 0.677
grass Gram-positive Specific Serine protease 0.668
PGRP-LF Peptidoglycan recognition protein LF 0.604
imd immune deficiency 0.585
PGRP-SA Peptidoglycan recognition protein SA 0.372
Dredd Death related ced-3/Nedd2-like protein 0.370
PGRP-SD CG7496 gene product from transcript CG7496-RA 0.362
Mtk Metchnikowin 0.360
Sp7 Serine protease 7 0.336
AttC Attacin-C 0.336
spz spatzle 0.314
Mpk2 CG5475 gene product from transcript CG5475-RB 0.297
pirk poor Imd response upon knock-in 0.279
Drs Drosomycin 0.240
CG32185 CG32185 gene product from transcript CG32185-RA 0.238
SPE Spatzle-Processing Enzyme 0.189
ird1 immune response deficient 1 0.174
PGRP-LB Peptidoglycan recognition protein LB 0.164
Myo31DF Myosin 31DF 0.147
Irc Immune-regulated catalase 0.144
CG15917 CG15917 gene product from transcript CG15917-RA 0.126
PGRP-SC1a CG14746 gene product from transcript CG14746-RA 0.109
CG9184 CG9184 gene product from transcript CG9184-RB 0.088
BG4 CG12297 gene product from transcript CG12297-RA 0.088
fon fondue 0.087
AGO2 Argonaute 2 0.084
Lmpt Limpet 0.083
Spn1 Serine protease inhibitor 1 0.064
IM18 Immune induced molecule 18 0.059
whd withered 0.056
Duox Dual oxidase 0.051
Spn27A Serpin 27A 0.048
PGRP-SC1b CG8577 gene product from transcript CG8577-RA 0.047
spirit Serine Protease Immune Response Integrator 0.047
psh persephone 0.045
p38b CG7393 gene product from transcript CG7393-RA 0.044
GNBP1 Gram-negative bacteria binding protein 1 0.044
l(3)mbn lethal (3) malignant blood neoplasm 0.041
eater CG6124 gene product from transcript CG6124-RB 0.041
CG10414 CG10414 gene product from transcript CG10414-RA 0.039
CG18594 CG18594 gene product from transcript CG18594-RA 0.036
bbg big bang 0.035
CG42863 CG42863 gene product from transcript CG42863-RB 0.029
modSP modular serine protease 0.028
Rab23 CG2108 gene product from transcript CG2108-RA 0.027
CG13641 CG13641 gene product from transcript CG13641-RA 0.025
Spn28D Serpin 28D 0.025
He Hemese 0.025
CG12004 CG12004 gene product from transcript CG12004-RC 0.025
CecC Cecropin C 0.022
Spn88Eb Serpin 88Eb 0.021
Cht11 CG3044 gene product from transcript CG3044-RA 0.021
CG15065 CG15065 gene product from transcript CG15065-RA 0.020
GNBP3 Gram-negative bacteria binding protein 3 0.019
upd2 unpaired 2 0.019
PGRP-SB1 CG9681 gene product from transcript CG9681-RA 0.019
CG10080 CG10080 gene product from transcript CG10080-RA 0.018
CG13422 CG13422 gene product from transcript CG13422-RA 0.018
proPO-A1 prophenol oxidase A1 0.018
Dpt Diptericin 0.017
Gadd45 CG11086 gene product from transcript CG11086-RA 0.016
Spargel CG9809 gene product from transcript CG9809-RB 0.015
CecB Cecropin B 0.015
TepIII Thiolester containing protein III 0.014
CG13890 CG13890 gene product from transcript CG13890-RA 0.014
Dro Drosocin 0.014
psidin phagocyte signaling impaired 0.013
upd3 unpaired 3 0.013
Glt Glutactin 0.013
CG18067 CG18067 gene product from transcript CG18067-RA 0.012
CG11836 CG11836 gene product from transcript CG11836-RB 0.011
gb genderblind 0.011
CG14567 CG14567 gene product from transcript CG14567-RA 0.011
CG8791 CG8791 gene product from transcript CG8791-RA 0.010
Naam Nicotinamide amidase 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
MYD88 myeloid differentiation primary response gene (88) 0.997
IRAK2 interleukin-1 receptor-associated kinase 2 0.994
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.993
IRAK1 interleukin-1 receptor-associated kinase 1 0.944
BIRC3 baculoviral IAP repeat containing 3 0.920
IRF7 interferon regulatory factor 7 0.879
TRAF6 TNF receptor-associated factor 6 0.786
STAT2 signal transducer and activator of transcription 2, 113kDa 0.764
PELI3 pellino homolog 3 (Drosophila) 0.706
ZC3H12A zinc finger CCCH-type containing 12A 0.622
IRAK3 interleukin-1 receptor-associated kinase 3 0.611
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.482
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.342
TLR2 toll-like receptor 2 0.283
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.213
CD14 CD14 molecule 0.206
BIRC2 baculoviral IAP repeat containing 2 0.201
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.198
RIPK2 receptor-interacting serine-threonine kinase 2 0.170
IL8 interleukin 8 0.147
IRF1 interferon regulatory factor 1 0.125
MAVS mitochondrial antiviral signaling protein 0.110
IL6R interleukin 6 receptor 0.107
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.094
CHN2 chimerin (chimaerin) 2 0.089
TLR4 toll-like receptor 4 0.085
TRIM21 tripartite motif containing 21 0.083
SIAH2 seven in absentia homolog 2 (Drosophila) 0.081
NLRC4 NLR family, CARD domain containing 4 0.080
SOD2 superoxide dismutase 2, mitochondrial 0.079
CXCL2 chemokine (C-X-C motif) ligand 2 0.077
SH3RF3 SH3 domain containing ring finger 3 0.072
NOD1 nucleotide-binding oligomerization domain containing 1 0.067
NOD2 nucleotide-binding oligomerization domain containing 2 0.064
IRAK4 interleukin-1 receptor-associated kinase 4 0.063
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.060
STAP2 signal transducing adaptor family member 2 0.057
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 0.056
ZNFX1 zinc finger, NFX1-type containing 1 0.056
CXCL3 chemokine (C-X-C motif) ligand 3 0.052
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.051
IL1B interleukin 1, beta 0.050
NCKAP1 NCK-associated protein 1 0.050
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.046
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.042
TRAF3 TNF receptor-associated factor 3 0.039
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.038
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.037
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.037
ICAM1 intercellular adhesion molecule 1 0.036
STAT1 signal transducer and activator of transcription 1, 91kDa 0.036
TRIM22 tripartite motif containing 22 0.036
OCRL oculocerebrorenal syndrome of Lowe 0.036
SH3RF1 SH3 domain containing ring finger 1 0.033
IRF8 interferon regulatory factor 8 0.033
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.032
FHOD1 formin homology 2 domain containing 1 0.032
ADAR adenosine deaminase, RNA-specific 0.031
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.031
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.030
NCF2 neutrophil cytosolic factor 2 0.030
IFI35 interferon-induced protein 35 0.027
ISG20 interferon stimulated exonuclease gene 20kDa 0.027
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.027
SPOP speckle-type POZ protein 0.027
CCL20 chemokine (C-C motif) ligand 20 0.026
ANG angiogenin, ribonuclease, RNase A family, 5 0.025
PYDC2 pyrin domain containing 2 0.024
TMEM173 transmembrane protein 173 0.022
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.022
IRF2 interferon regulatory factor 2 0.022
BCL3 B-cell CLL/lymphoma 3 0.021
CD40 CD40 molecule, TNF receptor superfamily member 5 0.021
PYCARD PYD and CARD domain containing 0.021
ZC3H12C zinc finger CCCH-type containing 12C 0.021
IL15RA interleukin 15 receptor, alpha 0.020
DTX3L deltex 3-like (Drosophila) 0.020
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.020
TOLLIP toll interacting protein 0.020
ELF4 E74-like factor 4 (ets domain transcription factor) 0.019
HLA-B major histocompatibility complex, class I, B 0.018
PELI1 pellino homolog 1 (Drosophila) 0.018
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.018
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.018
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.017
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.017
ARHGAP15 Rho GTPase activating protein 15 0.017
BCL2A1 BCL2-related protein A1 0.016
HCK hemopoietic cell kinase 0.016
STAU1 staufen, RNA binding protein, homolog 1 (Drosophila) 0.016
CD83 CD83 molecule 0.016
CCL4 chemokine (C-C motif) ligand 4 0.016
TYMP thymidine phosphorylase 0.016
ARFIP2 ADP-ribosylation factor interacting protein 2 0.016
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.016
DOCK8 dedicator of cytokinesis 8 0.016
IL1R1 interleukin 1 receptor, type I 0.015
STX11 syntaxin 11 0.015
TNIP2 TNFAIP3 interacting protein 2 0.015
TLR5 toll-like receptor 5 0.015
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.186
Junb jun B proto-oncogene 0.049
Bcl3 B-cell CLL/lymphoma 3 0.042
Xdh xanthine dehydrogenase 0.037
Ncf4 neutrophil cytosolic factor 4 0.035
Serpinb1a serine (or cysteine) proteinase inhibitor, clade B, member 1a 0.028
Stat3 signal transducer and activator of transcription 3 0.022
Hcls1 hematopoietic cell specific Lyn substrate 1 0.022
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.019
Tlr2 toll-like receptor 2 0.015
Nfkbie nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.014
Mcoln2 mucolipin 2 0.013
Tifa TRAF-interacting protein with forkhead-associated domain 0.012
Sbno2 strawberry notch homolog 2 (Drosophila) 0.012
Irak3 interleukin-1 receptor-associated kinase 3 0.011
Tnfaip8l2 tumor necrosis factor, alpha-induced protein 8-like 2 0.011
Unc93b1 unc-93 homolog B1 (C. elegans) 0.011
Il17ra interleukin 17 receptor A 0.010
RGD1305793 similar to hypothetical protein FLJ20154 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism