The network for 'regulation of ion homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of ion homeostasis

Any process that modulates the frequency, rate or extent of ion homeostasis.

Mus musculus
Name Description Probability Func Analog Organism
Ryr2 ryanodine receptor 2, cardiac 0.993
Ptk2 PTK2 protein tyrosine kinase 2 0.963
Scn5a sodium channel, voltage-gated, type V, alpha 0.952
Ldb3 LIM domain binding 3 0.944
Fyn Fyn proto-oncogene 0.922
Ntf3 neurotrophin 3 0.901
Ccr1 chemokine (C-C motif) receptor 1 0.888
Ccr2 chemokine (C-C motif) receptor 2 0.852
Drd2 dopamine receptor D2 0.804
Ifng interferon gamma 0.763
Gfra3 glial cell line derived neurotrophic factor family receptor alpha 3 0.760
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.758
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.721
Cav3 caveolin 3 0.719
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.704
Egfr epidermal growth factor receptor 0.691
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.654
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.645
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.627
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.625
Trp53 transformation related protein 53 0.621
Ccl3 chemokine (C-C motif) ligand 3 0.613
Ccl2 chemokine (C-C motif) ligand 2 0.600
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.588
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.581
Ncr1 natural cytotoxicity triggering receptor 1 0.581
C3ar1 complement component 3a receptor 1 0.563
Cxcr3 chemokine (C-X-C motif) receptor 3 0.500
Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like 0.489
Ikzf1 IKAROS family zinc finger 1 0.477
Bax BCL2-associated X protein 0.477
Cd7 CD7 antigen 0.472
Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 0.465
Vegfa vascular endothelial growth factor A 0.464
Gpr33 G protein-coupled receptor 33 0.463
Fgf7 fibroblast growth factor 7 0.458
Shh sonic hedgehog 0.454
Clec4d C-type lectin domain family 4, member d 0.453
Ednrb endothelin receptor type B 0.452
Bdnf brain derived neurotrophic factor 0.449
Cbl Casitas B-lineage lymphoma 0.448
Cd209b CD209b antigen 0.445
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.438
Itgax integrin alpha X 0.437
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.436
Ctsw cathepsin W 0.432
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.431
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.431
Gzma granzyme A 0.426
Pten phosphatase and tensin homolog 0.411
Gja1 gap junction protein, alpha 1 0.410
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.410
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.397
Flt3 FMS-like tyrosine kinase 3 0.397
Gclm glutamate-cysteine ligase, modifier subunit 0.393
Clec4e C-type lectin domain family 4, member e 0.379
Ttn titin 0.377
Src Rous sarcoma oncogene 0.367
Hrc histidine rich calcium binding protein 0.364
Rps3 ribosomal protein S3 0.350
Folr2 folate receptor 2 (fetal) 0.343
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.337
Pcdh12 protocadherin 12 0.326
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.322
Tspo2 translocator protein 2 0.319
Tbx5 T-box 5 0.314
Il2rb interleukin 2 receptor, beta chain 0.311
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.310
Nos3 nitric oxide synthase 3, endothelial cell 0.304
Msr1 macrophage scavenger receptor 1 0.304
Smyd1 SET and MYND domain containing 1 0.302
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.302
Pxn paxillin 0.301
Ch25h cholesterol 25-hydroxylase 0.301
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.301
Xcr1 chemokine (C motif) receptor 1 0.297
Epor erythropoietin receptor 0.294
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.291
Kl klotho 0.289
Clock circadian locomotor output cycles kaput 0.284
Chrd chordin 0.283
Kit kit oncogene 0.279
Cnr1 cannabinoid receptor 1 (brain) 0.278
Dok1 docking protein 1 0.277
Ccr6 chemokine (C-C motif) receptor 6 0.276
Cacna1s calcium channel, voltage-dependent, L type, alpha 1S subunit 0.271
Ptgir prostaglandin I receptor (IP) 0.270
Gclc glutamate-cysteine ligase, catalytic subunit 0.268
Il7r interleukin 7 receptor 0.267
Scn1a sodium channel, voltage-gated, type I, alpha 0.265
Ccr5 chemokine (C-C motif) receptor 5 0.264
Ccl22 chemokine (C-C motif) ligand 22 0.260
Gzmb granzyme B 0.258
Kitl kit ligand 0.255
Tlr2 toll-like receptor 2 0.253
Cd96 CD96 antigen 0.248
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.246
Cd247 CD247 antigen 0.245
Cd180 CD180 antigen 0.241
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.241
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
chat choline acetyltransferase 0.095
opn4a opsin 4a (melanopsin) 0.082
opn4l opsin 4, like 0.042
bdnf brain-derived neurotrophic factor 0.034
th2 tyrosine hydroxylase 2 0.024
pink1 PTEN induced putative kinase 1 0.023
wnt10a wingless-type MMTV integration site family, member 10a 0.020
zfyve26 zinc finger, FYVE domain containing 26 0.020
gcm2 glial cells missing homolog 2 (Drosophila) 0.020
spry2 sprouty homolog 2 0.019
twist1b twist1b 0.017
wnt4a wingless-type MMTV integration site family, member 4a 0.016
paqr7b progestin and adipoQ receptor family member VII, b 0.015
opn4x1 opsin 4x1 0.014
stac3 SH3 and cysteine rich domain 3 0.012
mpx myeloid-specific peroxidase 0.012
paqr8 progestin and adipoQ receptor family member VIII 0.012
col11a2 collagen type XI alpha-2 0.012
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.011
slc9a3.2 solute carrier family 9 (sodium/hydrogen exchanger), member 3.2 0.011
mc4r melanocortin 4 receptor 0.011
lhx6 LIM homeobox 6 0.011
avpl arginine vasopressin-like 0.010
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.010
spry4 sprouty (Drosophila) homolog 4 0.010
dusp6 dual specificity phosphatase 6 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
ninaE neither inactivation nor afterpotential E 0.775
inaD inactivation no afterpotential D 0.376
trp transient receptor potential 0.243
trpl trp-like 0.165
Rh5 Rhodopsin 5 0.137
Arr2 Arrestin 2 0.095
inaC inactivation no afterpotential C 0.056
Arr1 Arrestin 1 0.039
comt comatose 0.035
Rh3 Rhodopsin 3 0.029
ninaA neither inactivation nor afterpotential A 0.027
Rh6 Rhodopsin 6 0.027
ninaC neither inactivation nor afterpotential C 0.027
CG33960 CG33960 gene product from transcript CG33960-RB 0.022
Pp2B-14D Protein phosphatase 2B at 14D 0.020
myoglianin CG1838 gene product from transcript CG1838-RD 0.020
LIMK1 LIM-kinase1 0.018
CG4468 CG4468 gene product from transcript CG4468-RA 0.018
norpA no receptor potential A 0.018
Clk Clock 0.015
t tan 0.014
Wnt5 Wnt oncogene analog 5 0.014
trio CG18214 gene product from transcript CG18214-RA 0.013
mtt mangetout 0.013
inaF-D CG42563 gene product from transcript CG42563-RB 0.011
Dab Disabled 0.011
VGlut Vesicular glutamate transporter 0.010
CG42629 CG42629 gene product from transcript CG42629-RB 0.010
Gbeta76C G protein beta-subunit 76C 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 1.000
CCR5 chemokine (C-C motif) receptor 5 0.990
GSTM1 glutathione S-transferase mu 1 0.982
IL8 interleukin 8 0.981
SYK spleen tyrosine kinase 0.951
BAD BCL2-associated agonist of cell death 0.951
FGFR2 fibroblast growth factor receptor 2 0.937
CXCL9 chemokine (C-X-C motif) ligand 9 0.933
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.928
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.913
CCL5 chemokine (C-C motif) ligand 5 0.912
BTK Bruton agammaglobulinemia tyrosine kinase 0.909
GRB2 growth factor receptor-bound protein 2 0.868
CXCL2 chemokine (C-X-C motif) ligand 2 0.860
LCK lymphocyte-specific protein tyrosine kinase 0.858
GSTM2 glutathione S-transferase mu 2 (muscle) 0.857
BCL2 B-cell CLL/lymphoma 2 0.852
BCL2L1 BCL2-like 1 0.809
NCF1 neutrophil cytosolic factor 1 0.702
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.669
MPZL2 myelin protein zero-like 2 0.665
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.647
FYN FYN oncogene related to SRC, FGR, YES 0.632
CXCL3 chemokine (C-X-C motif) ligand 3 0.622
MPZL3 myelin protein zero-like 3 0.620
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.597
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.582
TJP1 tight junction protein 1 (zona occludens 1) 0.579
CCL4 chemokine (C-C motif) ligand 4 0.572
CAV1 caveolin 1, caveolae protein, 22kDa 0.537
DRD2 dopamine receptor D2 0.526
PDCD6IP programmed cell death 6 interacting protein 0.521
CREBBP CREB binding protein 0.513
IFNG interferon, gamma 0.486
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.473
SPRR2A small proline-rich protein 2A 0.466
FGFR1 fibroblast growth factor receptor 1 0.465
ZFYVE9 zinc finger, FYVE domain containing 9 0.459
CXCL10 chemokine (C-X-C motif) ligand 10 0.454
IL6 interleukin 6 (interferon, beta 2) 0.436
KIAA1683 KIAA1683 0.425
CXCL5 chemokine (C-X-C motif) ligand 5 0.424
CCL2 chemokine (C-C motif) ligand 2 0.424
AKAP12 A kinase (PRKA) anchor protein 12 0.413
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.403
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.394
CXCL11 chemokine (C-X-C motif) ligand 11 0.376
CCL8 chemokine (C-C motif) ligand 8 0.373
MPDZ multiple PDZ domain protein 0.373
CD22 CD22 molecule 0.365
GSTM4 glutathione S-transferase mu 4 0.351
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.325
DPP4 dipeptidyl-peptidase 4 0.325
MED28 mediator complex subunit 28 0.322
BAK1 BCL2-antagonist/killer 1 0.321
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.318
IL1B interleukin 1, beta 0.317
TGFBR1 transforming growth factor, beta receptor 1 0.316
BLNK B-cell linker 0.315
UBASH3B ubiquitin associated and SH3 domain containing B 0.315
CCL7 chemokine (C-C motif) ligand 7 0.308
CCL3 chemokine (C-C motif) ligand 3 0.304
ARRB2 arrestin, beta 2 0.304
CCL20 chemokine (C-C motif) ligand 20 0.302
HCK hemopoietic cell kinase 0.300
CXCL13 chemokine (C-X-C motif) ligand 13 0.299
CCR7 chemokine (C-C motif) receptor 7 0.298
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.289
SPTB spectrin, beta, erythrocytic 0.285
CCL22 chemokine (C-C motif) ligand 22 0.284
PRKCA protein kinase C, alpha 0.272
IL2RB interleukin 2 receptor, beta 0.269
NCF4 neutrophil cytosolic factor 4, 40kDa 0.265
PTEN phosphatase and tensin homolog 0.265
IL10 interleukin 10 0.263
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.258
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.254
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.249
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.243
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.242
RHOA ras homolog gene family, member A 0.239
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.236
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.226
YAP1 Yes-associated protein 1 0.224
ITK IL2-inducible T-cell kinase 0.220
NCF2 neutrophil cytosolic factor 2 0.219
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 0.213
MAPT microtubule-associated protein tau 0.211
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.210
VAV1 vav 1 guanine nucleotide exchange factor 0.199
DAXX death-domain associated protein 0.196
CCL13 chemokine (C-C motif) ligand 13 0.196
GCLC glutamate-cysteine ligase, catalytic subunit 0.194
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.192
PRKCB protein kinase C, beta 0.188
CXCR3 chemokine (C-X-C motif) receptor 3 0.187
ACTB actin, beta 0.187
CCL11 chemokine (C-C motif) ligand 11 0.187
KLHL3 kelch-like 3 (Drosophila) 0.181
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.179
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Rattus norvegicus
Name Description Probability Func Analog Organism
Lim2 lens intrinsic membrane protein 2 0.114
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.112
Chrm2 cholinergic receptor, muscarinic 2 0.087
Csf1 colony stimulating factor 1 (macrophage) 0.080
Il2rg interleukin 2 receptor, gamma 0.072
Clps colipase, pancreatic 0.069
Kcnmb1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 0.068
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.067
Ahsg alpha-2-HS-glycoprotein 0.067
Olr1278 olfactory receptor 1278 0.064
Phkg1 phosphorylase kinase, gamma 1 0.064
Testin testin gene 0.058
Rxrg retinoid X receptor gamma 0.056
Mag myelin-associated glycoprotein 0.055
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.051
Ppyr1 pancreatic polypeptide receptor 1 0.050
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.049
Zp1 zona pellucida glycoprotein 1 (sperm receptor) 0.049
Gdf9 growth differentiation factor 9 0.048
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.047
Ednra endothelin receptor type A 0.047
Trh thyrotropin releasing hormone 0.047
Hspa5 heat shock protein 5 0.046
Tnni1 troponin I type 1 (skeletal, slow) 0.046
Adora2a adenosine A2a receptor 0.043
Il9r interleukin 9 receptor 0.043
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.042
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.042
Npffr2 neuropeptide FF receptor 2 0.041
Acp5 acid phosphatase 5, tartrate resistant 0.041
Olr287 olfactory receptor 287 0.041
Prkab2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 0.040
Esr2 estrogen receptor 2 (ER beta) 0.039
Myh6 myosin, heavy chain 6, cardiac muscle, alpha 0.038
Cav3 caveolin 3 0.038
Oxt oxytocin, prepropeptide 0.038
Proc protein C 0.037
Pgam2 phosphoglycerate mutase 2 (muscle) 0.037
Atp2a3 ATPase, Ca++ transporting, ubiquitous 0.037
Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 0.037
Hoxb7 homeo box B7 0.037
Smr3a submaxillary gland androgen regulated protein 3A 0.036
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.036
Htr3a 5-hydroxytryptamine (serotonin) receptor 3a 0.036
Gja6 gap junction protein, alpha 6 0.036
Syt8 synaptotagmin VIII 0.036
Ifnb1 interferon beta 1, fibroblast 0.036
Calcrl calcitonin receptor-like 0.035
RGD1559588 similar to cell surface receptor FDFACT 0.035
Sirpa signal-regulatory protein alpha 0.035
Slc18a3 solute carrier family 18 (vesicular acetylcholine), member 3 0.035
Rftn2 raftlin family member 2 0.034
Vav1 vav 1 guanine nucleotide exchange factor 0.034
Ccl4 chemokine (C-C motif) ligand 4 0.033
Pde1c phosphodiesterase 1C 0.033
Apoa5 apolipoprotein A-V 0.033
Ly86 lymphocyte antigen 86 0.033
Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 0.033
LOC286980 putative pheromone receptor (Go-VN13B) 0.033
P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 0.033
Arhgap25 Rho GTPase activating protein 25 0.033
Cd38 CD38 molecule 0.032
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.032
Casp1 caspase 1 0.032
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.032
Clec11a C-type lectin domain family 11, member a 0.032
Mos Moloney sarcoma oncogene 0.032
Ton tonin 0.032
Rhobtb2 Rho-related BTB domain containing 2 0.031
F13a1 coagulation factor XIII, A1 polypeptide 0.031
Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.031
Slc4a1 solute carrier family 4 (anion exchanger), member 1 0.031
Slc22a25 solute carrier family 22, member 25 0.031
Bhlha15 basic helix-loop-helix family, member a15 0.031
Apcs amyloid P component, serum 0.030
Lbp lipopolysaccharide binding protein 0.030
Slc12a3 solute carrier family 12 (sodium/chloride transporters), member 3 0.030
Itpr1 inositol 1,4,5-triphosphate receptor, type 1 0.030
Fgf10 fibroblast growth factor 10 0.030
Ros1 c-ros oncogene 1 , receptor tyrosine kinase 0.030
Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.030
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.030
Serpind1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.030
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.030
Padi3 peptidyl arginine deiminase, type III 0.030
Gzmk granzyme K 0.030
Arrb2 arrestin, beta 2 0.030
Mbl1 mannose-binding lectin (protein A) 1 0.029
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.029
Irs1 insulin receptor substrate 1 0.029
Adra1a adrenergic, alpha-1A-, receptor 0.029
Ckm creatine kinase, muscle 0.029
Mca32 mast cell antigen 32 0.029
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.029
Ptgfr prostaglandin F receptor 0.029
Pzp pregnancy-zone protein 0.029
Slfn2 schlafen 2 0.029
Cacng7 calcium channel, voltage-dependent, gamma subunit 7 0.029
Actg2 actin, gamma 2, smooth muscle, enteric 0.028
Trhr thyrotropin releasing hormone receptor 0.028
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism