The network for 'negative regulation of cellular response to growth factor stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cellular response to growth factor stimulus

Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.

Mus musculus
Name Description Probability Func Analog Organism
Lef1 lymphoid enhancer binding factor 1 0.965
Cdx2 caudal type homeobox 2 0.920
Smad7 MAD homolog 7 (Drosophila) 0.908
Nodal nodal 0.904
Gata4 GATA binding protein 4 0.817
Rarb retinoic acid receptor, beta 0.799
Onecut1 one cut domain, family member 1 0.760
Lum lumican 0.737
Fmod fibromodulin 0.703
Fgf10 fibroblast growth factor 10 0.674
Lhx1 LIM homeobox protein 1 0.663
Slit3 slit homolog 3 (Drosophila) 0.637
Wnt3a wingless-related MMTV integration site 3A 0.534
Pax8 paired box gene 8 0.501
Igf2 insulin-like growth factor 2 0.468
Nog noggin 0.466
Fbn1 fibrillin 1 0.461
Gdf1 growth differentiation factor 1 0.450
Rxra retinoid X receptor alpha 0.448
Acvr1 activin A receptor, type 1 0.422
Il6st interleukin 6 signal transducer 0.399
Ar androgen receptor 0.394
Rarg retinoic acid receptor, gamma 0.389
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.387
Fgf8 fibroblast growth factor 8 0.349
Bnc1 basonuclin 1 0.344
Tcf7 transcription factor 7, T-cell specific 0.325
Fgfr1 fibroblast growth factor receptor 1 0.322
Tgfb2 transforming growth factor, beta 2 0.311
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.305
Robo1 roundabout homolog 1 (Drosophila) 0.286
Gata6 GATA binding protein 6 0.284
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.264
Rara retinoic acid receptor, alpha 0.262
Mdm2 transformed mouse 3T3 cell double minute 2 0.254
Pax2 paired box gene 2 0.248
Smad3 MAD homolog 3 (Drosophila) 0.246
Foxf1a forkhead box F1a 0.244
Bmpr1a bone morphogenetic protein receptor, type 1A 0.238
Cyld cylindromatosis (turban tumor syndrome) 0.234
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.213
Wnt6 wingless-related MMTV integration site 6 0.208
Pax3 paired box gene 3 0.204
Chrd chordin 0.203
Smad6 MAD homolog 6 (Drosophila) 0.194
Mesp1 mesoderm posterior 1 0.193
Tbx3 T-box 3 0.192
Sox4 SRY-box containing gene 4 0.190
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.189
Thbs2 thrombospondin 2 0.186
Tal1 T-cell acute lymphocytic leukemia 1 0.185
Tbx2 T-box 2 0.183
Plin1 perilipin 1 0.180
Pitx2 paired-like homeodomain transcription factor 2 0.180
Fgf18 fibroblast growth factor 18 0.179
Tgfbr1 transforming growth factor, beta receptor I 0.176
Grb10 growth factor receptor bound protein 10 0.176
Wnt3 wingless-related MMTV integration site 3 0.175
Pparg peroxisome proliferator activated receptor gamma 0.174
Lepr leptin receptor 0.173
Cd59a CD59a antigen 0.173
Ank1 ankyrin 1, erythroid 0.171
Gdnf glial cell line derived neurotrophic factor 0.167
Pdgfa platelet derived growth factor, alpha 0.165
Ntf3 neurotrophin 3 0.164
Lrp1 low density lipoprotein receptor-related protein 1 0.164
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.162
Wnt4 wingless-related MMTV integration site 4 0.159
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.157
Skor1 SKI family transcriptional corepressor 1 0.156
Wnt11 wingless-related MMTV integration site 11 0.148
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.142
Gpc3 glypican 3 0.141
Wt1 Wilms tumor 1 homolog 0.138
Hes1 hairy and enhancer of split 1 (Drosophila) 0.134
Col1a1 collagen, type I, alpha 1 0.132
Axin2 axin2 0.130
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.128
Fgf2 fibroblast growth factor 2 0.123
Pou3f1 POU domain, class 3, transcription factor 1 0.122
Ptrf polymerase I and transcript release factor 0.115
Agtr1a angiotensin II receptor, type 1a 0.114
Hic1 hypermethylated in cancer 1 0.112
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.112
Gli2 GLI-Kruppel family member GLI2 0.111
Timp2 tissue inhibitor of metalloproteinase 2 0.111
Tcf15 transcription factor 15 0.106
Arvcf armadillo repeat gene deleted in velo-cardio-facial syndrome 0.105
Dag1 dystroglycan 1 0.104
Cd59b CD59b antigen 0.104
Ece1 endothelin converting enzyme 1 0.103
Efemp2 epidermal growth factor-containing fibulin-like extracellular matrix protein 2 0.102
Fzd7 frizzled homolog 7 (Drosophila) 0.102
Hoxd11 homeobox D11 0.101
Lamc1 laminin, gamma 1 0.101
Fzd8 frizzled homolog 8 (Drosophila) 0.101
Tgfbr2 transforming growth factor, beta receptor II 0.101
Ret ret proto-oncogene 0.101
Rnf11 ring finger protein 11 0.099
Twist1 twist homolog 1 (Drosophila) 0.098
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp2a bone morphogenetic protein 2a 0.065
bmp2b bone morphogenetic protein 2b 0.046
wnt11r wingless-type MMTV integration site family, member 11, related 0.045
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.039
dusp6 dual specificity phosphatase 6 0.035
lmo4a LIM domain only 4a 0.032
robo3 roundabout homolog 3 0.031
rbfox2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.031
skia nuclear oncoprotein skia 0.030
wnt11 wingless-type MMTV integration site family, member 11 0.025
irf6 interferon regulatory factor 6 0.023
tmem88a transmembrane protein 88 a 0.022
nkx2.2b NK2 transcription factor related 2b 0.021
tmem2 transmembrane protein 2 0.020
hdac4 histone deacetylase 4 0.018
bmp4 bone morphogenetic protein 4 0.018
tbx1 T-box 1 0.018
kif5bb kinesin family member 5B, b 0.017
fzd9b frizzled homolog 9b 0.016
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.015
fgf3 fibroblast growth factor 3 0.015
spry4 sprouty (Drosophila) homolog 4 0.014
gata2a GATA-binding protein 2a 0.014
gsk3b glycogen synthase kinase 3 beta 0.014
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.014
btg1 B-cell translocation gene 1 0.014
fn1 fibronectin 1 0.014
spns2 spinster homolog 2 (Drosophila) 0.013
zic5 zic family member 5 (odd-paired homolog, Drosophila) 0.013
ntla no tail a 0.013
wu:fi04c06 wu:fi04c06 0.013
si:ch211-173o4.2 si:ch211-173o4.2 0.012
col10a1 collagen, type X, alpha 1 0.012
msxd muscle segment homeobox D 0.012
fgf24 fibroblast growth factor 24 0.012
runx3 runt-related transcription factor 3 0.012
gpc4 glypican 4 0.012
hlxb9la homeo box HB9 like a 0.012
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.011
cyp24a1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.011
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.011
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.011
epyc epiphycan 0.011
cntfr ciliary neurotrophic factor receptor 0.011
wu:fj39b01 wu:fj39b01 0.011
sbf1 SET binding factor 1 0.011
irx7 iroquois homeobox protein 7 0.011
zbtb4 zinc finger and BTB domain containing 4 0.011
btbd6a BTB (POZ) domain containing 6a 0.011
ippk inositol 1,3,4,5,6-pentakisphosphate 2-kinase 0.011
tbx2b T-box 2b 0.010
f2rl1.2 coagulation factor II (thrombin) receptor-like 1.2 0.010
ctnnd2b catenin (cadherin-associated protein), delta 2b 0.010
robo1 roundabout homolog 1 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Mad Mothers against dpp 1.000
babo baboon 0.566
ci cubitus interruptus 0.123
shn schnurri 0.108
Dad Daughters against dpp 0.080
krz kurtz 0.079
hipk homeodomain interacting protein kinase 0.064
wun wunen 0.045
Akt1 CG4006 gene product from transcript CG4006-RA 0.038
CG31122 CG31122 gene product from transcript CG31122-RA 0.035
neuroligin CG13772 gene product from transcript CG13772-RA 0.031
Stat92E Signal-transducer and activator of transcription protein at 92E 0.028
pho pleiohomeotic 0.027
Sara Smad anchor for receptor activation 0.027
caz cabeza 0.025
kn knot 0.024
Rpn6 Proteasome p44.5 subunit 0.023
InR Insulin-like receptor 0.023
htl heartless 0.023
Snoo Sno oncogene 0.021
Timp Tissue inhibitor of metalloproteases 0.020
hrg hiiragi 0.020
robo roundabout 0.020
wit wishful thinking 0.020
Lasp CG3849 gene product from transcript CG3849-RB 0.020
Fak56D Focal Adhesion Kinase 0.019
Hcf Host cell factor 0.019
Su(H) Suppressor of Hairless 0.018
rl rolled 0.018
Acsl Acyl-CoA synthetase long-chain 0.017
Pak PAK-kinase 0.016
Sdc Syndecan 0.016
CG11347 CG11347 gene product from transcript CG11347-RE 0.015
LIMK1 LIM-kinase1 0.015
foxo forkhead box, sub-group O 0.015
flfl falafel 0.014
CG8090 CG8090 gene product from transcript CG8090-RB 0.014
CG31224 CG31224 gene product from transcript CG31224-RA 0.014
rst roughest 0.014
Gr39a Gustatory receptor 39a 0.012
Abl Abl tyrosine kinase 0.012
tkv thickveins 0.012
sog short gastrulation 0.011
iav inactive 0.011
cv-c crossveinless c 0.011
wnd wallenda 0.011
Met Methoprene-tolerant 0.011
Ubx Ultrabithorax 0.011
nompA no mechanoreceptor potential A 0.011
Pkn Protein kinase related to protein kinase N 0.010
Adar Adenosine deaminase acting on RNA 0.010
CG6961 CG6961 gene product from transcript CG6961-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.997
SMAD4 SMAD family member 4 0.992
SMAD1 SMAD family member 1 0.991
SMAD7 SMAD family member 7 0.939
PTK2 PTK2 protein tyrosine kinase 2 0.856
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.687
SMAD5 SMAD family member 5 0.659
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.570
MAGEF1 melanoma antigen family F, 1 0.543
ELN elastin 0.530
TGFBR1 transforming growth factor, beta receptor 1 0.522
TIMP3 TIMP metallopeptidase inhibitor 3 0.517
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.514
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.467
TBX5 T-box 5 0.448
PDCD6IP programmed cell death 6 interacting protein 0.437
ABI2 abl-interactor 2 0.400
SNX9 sorting nexin 9 0.389
ZFYVE9 zinc finger, FYVE domain containing 9 0.360
AR androgen receptor 0.359
PARVA parvin, alpha 0.283
INADL InaD-like (Drosophila) 0.278
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.276
CAV1 caveolin 1, caveolae protein, 22kDa 0.271
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.253
FBLN1 fibulin 1 0.245
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.235
DLG1 discs, large homolog 1 (Drosophila) 0.208
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.205
SDC2 syndecan 2 0.200
SMAD3 SMAD family member 3 0.198
TGFB1 transforming growth factor, beta 1 0.196
THBS2 thrombospondin 2 0.191
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.164
NCK2 NCK adaptor protein 2 0.161
SNX6 sorting nexin 6 0.158
YAP1 Yes-associated protein 1 0.152
LTBP2 latent transforming growth factor beta binding protein 2 0.139
CHRD chordin 0.139
COL1A1 collagen, type I, alpha 1 0.136
COL8A1 collagen, type VIII, alpha 1 0.132
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.130
FAP fibroblast activation protein, alpha 0.130
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.105
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.105
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.104
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.103
TESK1 testis-specific kinase 1 0.094
LPXN leupaxin 0.093
COL5A1 collagen, type V, alpha 1 0.093
SNX33 sorting nexin 33 0.087
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 0.086
WISP1 WNT1 inducible signaling pathway protein 1 0.083
SMAD6 SMAD family member 6 0.081
BGN biglycan 0.081
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.081
FHL2 four and a half LIM domains 2 0.080
RLN3 relaxin 3 0.079
VCAN versican 0.078
COMP cartilage oligomeric matrix protein 0.074
AEBP1 AE binding protein 1 0.073
IGFBP5 insulin-like growth factor binding protein 5 0.072
ENG endoglin 0.072
TGFB3 transforming growth factor, beta 3 0.072
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.071
INHBA inhibin, beta A 0.068
SH3D19 SH3 domain containing 19 0.067
BCAR1 breast cancer anti-estrogen resistance 1 0.067
AQP1 aquaporin 1 (Colton blood group) 0.067
COL6A1 collagen, type VI, alpha 1 0.065
LIMS1 LIM and senescent cell antigen-like domains 1 0.064
SNX2 sorting nexin 2 0.063
ZNF512B zinc finger protein 512B 0.062
CXXC5 CXXC finger protein 5 0.060
RNF11 ring finger protein 11 0.059
HIC1 hypermethylated in cancer 1 0.059
PCOLCE procollagen C-endopeptidase enhancer 0.057
TIMP2 TIMP metallopeptidase inhibitor 2 0.057
ANKRD13A ankyrin repeat domain 13A 0.056
TGFB2 transforming growth factor, beta 2 0.055
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.054
COL14A1 collagen, type XIV, alpha 1 0.053
MESDC2 mesoderm development candidate 2 0.052
RANBP3 RAN binding protein 3 0.051
DPT dermatopontin 0.051
LOX lysyl oxidase 0.051
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.049
SULF1 sulfatase 1 0.049
MXRA5 matrix-remodelling associated 5 0.048
MFAP4 microfibrillar-associated protein 4 0.048
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.047
ECM2 extracellular matrix protein 2, female organ and adipocyte specific 0.047
MIB1 mindbomb homolog 1 (Drosophila) 0.046
MFAP5 microfibrillar associated protein 5 0.046
DNM1 dynamin 1 0.046
PHC2 polyhomeotic homolog 2 (Drosophila) 0.046
WNT2 wingless-type MMTV integration site family member 2 0.045
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.045
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.045
GJA1 gap junction protein, alpha 1, 43kDa 0.045
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hsp90b1 heat shock protein 90, beta, member 1 0.015
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism