The network for 'establishment of planar polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment of planar polarity

Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.

Mus musculus
Name Description Probability Func Analog Organism
Vangl2 vang-like 2 (van gogh, Drosophila) 1.000
Dvl2 dishevelled 2, dsh homolog (Drosophila) 1.000
Ptk7 PTK7 protein tyrosine kinase 7 0.998
Wnt3a wingless-related MMTV integration site 3A 0.995
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.995
Gli3 GLI-Kruppel family member GLI3 0.982
Fgfr2 fibroblast growth factor receptor 2 0.963
Wnt5a wingless-related MMTV integration site 5A 0.957
Dlg4 discs, large homolog 4 (Drosophila) 0.935
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.894
Shh sonic hedgehog 0.884
Fzd1 frizzled homolog 1 (Drosophila) 0.883
Vangl1 vang-like 1 (van gogh, Drosophila) 0.878
Gli2 GLI-Kruppel family member GLI2 0.850
Sfrp2 secreted frizzled-related protein 2 0.828
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.801
Axin1 axin 1 0.790
Ctnnb1 catenin (cadherin associated protein), beta 1 0.764
Tbx3 T-box 3 0.727
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.725
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.724
Pax2 paired box gene 2 0.715
Foxc1 forkhead box C1 0.682
Fgfr1 fibroblast growth factor receptor 1 0.647
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.646
Gopc golgi associated PDZ and coiled-coil motif containing 0.621
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.595
Wnt4 wingless-related MMTV integration site 4 0.519
Tbx2 T-box 2 0.495
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.490
Sfrp1 secreted frizzled-related protein 1 0.480
Ret ret proto-oncogene 0.468
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.462
Gdnf glial cell line derived neurotrophic factor 0.447
Ntf3 neurotrophin 3 0.434
Lama5 laminin, alpha 5 0.425
Gpc3 glypican 3 0.423
Dll1 delta-like 1 (Drosophila) 0.417
Nog noggin 0.411
Itga3 integrin alpha 3 0.408
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.400
Pten phosphatase and tensin homolog 0.387
Fgfr3 fibroblast growth factor receptor 3 0.364
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.353
Trp63 transformation related protein 63 0.341
Fzd2 frizzled homolog 2 (Drosophila) 0.327
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.324
Tgfa transforming growth factor alpha 0.311
Rnd3 Rho family GTPase 3 0.297
Twist2 twist homolog 2 (Drosophila) 0.294
Hoxb6 homeobox B6 0.292
Sall4 sal-like 4 (Drosophila) 0.286
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.281
Foxf1a forkhead box F1a 0.278
Gli1 GLI-Kruppel family member GLI1 0.270
Lhx1 LIM homeobox protein 1 0.262
Sox11 SRY-box containing gene 11 0.255
Smad3 MAD homolog 3 (Drosophila) 0.254
Ric8 resistance to inhibitors of cholinesterase 8 homolog (C. elegans) 0.254
Grb10 growth factor receptor bound protein 10 0.251
Efna2 ephrin A2 0.248
Fzd7 frizzled homolog 7 (Drosophila) 0.244
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.230
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.228
Fjx1 four jointed box 1 (Drosophila) 0.218
Hoxd9 homeobox D9 0.214
T brachyury 0.214
Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila) 0.214
Lef1 lymphoid enhancer binding factor 1 0.209
Efna4 ephrin A4 0.203
Dact3 dapper homolog 3, antagonist of beta-catenin (xenopus) 0.203
Msx2 homeobox, msh-like 2 0.201
Fgf8 fibroblast growth factor 8 0.201
Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.198
Phox2a paired-like homeobox 2a 0.198
Ptch1 patched homolog 1 0.193
En1 engrailed 1 0.187
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.184
Lrp6 low density lipoprotein receptor-related protein 6 0.182
Fzd8 frizzled homolog 8 (Drosophila) 0.181
Zfp185 zinc finger protein 185 0.179
Myo6 myosin VI 0.178
Npr3 natriuretic peptide receptor 3 0.177
Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.174
Rarb retinoic acid receptor, beta 0.173
Lrp2 low density lipoprotein receptor-related protein 2 0.167
Nrcam neuron-glia-CAM-related cell adhesion molecule 0.166
Irx2 Iroquois related homeobox 2 (Drosophila) 0.165
Esr2 estrogen receptor 2 (beta) 0.161
Egfr epidermal growth factor receptor 0.161
Fgf18 fibroblast growth factor 18 0.160
Tead2 TEA domain family member 2 0.159
Wnt10b wingless related MMTV integration site 10b 0.153
Arhgap1 Rho GTPase activating protein 1 0.150
Smad6 MAD homolog 6 (Drosophila) 0.143
Hoxa5 homeobox A5 0.142
Wnt7b wingless-related MMTV integration site 7B 0.135
Plxna3 plexin A3 0.134
Dlg1 discs, large homolog 1 (Drosophila) 0.131
Lrp5 low density lipoprotein receptor-related protein 5 0.131
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
wnt11 wingless-type MMTV integration site family, member 11 0.011
lama1 laminin, alpha 1 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
fz frizzled 0.999
N Notch 0.998
Rac1 CG2248 gene product from transcript CG2248-RA 0.997
dsh dishevelled 0.996
ttk tramtrack 0.995
scrib scribbled 0.994
pk prickle 0.991
Rho1 CG8416 gene product from transcript CG8416-RB 0.984
rok Rho-kinase 0.983
stan starry night 0.981
in inturned 0.980
ft fat 0.975
wg wingless 0.973
rin rasputin 0.972
msn misshapen 0.963
ed echinoid 0.954
wdb widerborst 0.950
aop anterior open 0.944
Akt1 CG4006 gene product from transcript CG4006-RA 0.938
Pkn Protein kinase related to protein kinase N 0.929
hbs hibris 0.924
sano serrano 0.919
zip zipper 0.906
Vang Van Gogh 0.904
ru roughoid 0.903
cindr CIN85 and CD2AP orthologue 0.897
pyd polychaetoid 0.889
fw furrowed 0.887
arm armadillo 0.884
gish gilgamesh 0.880
crb crumbs 0.874
hep hemipterous 0.871
CG32556 CG32556 gene product from transcript CG32556-RB 0.863
CG42251 CG42251 gene product from transcript CG42251-RC 0.856
ovo CG6824 gene product from transcript CG6824-RE 0.840
rst roughest 0.787
fng fringe 0.782
Shc SHC-adaptor protein 0.765
mirr mirror 0.765
Fas2 Fasciclin 2 0.756
G-oalpha47A G protein oalpha 47A 0.745
dgo diego 0.736
Mob2 CG11711 gene product from transcript CG11711-RC 0.736
argos CG4531 gene product from transcript CG4531-RA 0.711
Mtl Mig-2-like 0.693
mwh multiple wing hairs 0.668
sca scabrous 0.667
POSH Plenty of SH3s 0.654
fry furry 0.640
fj four-jointed 0.617
frtz fritz 0.616
nej nejire 0.602
ds dachsous 0.574
Traf4 TNF-receptor-associated factor 4 0.543
CG31687 CG31687 gene product from transcript CG31687-RA 0.532
pbl pebble 0.501
Wnt4 Wnt oncogene analog 4 0.494
shg shotgun 0.486
trc tricornered 0.485
Cdc42 CG12530 gene product from transcript CG12530-RA 0.484
frc fringe connection 0.478
eyg eyegone 0.469
Peb Protein ejaculatory bulb 0.457
tsr twinstar 0.449
toe twin of eyg 0.434
trp transient receptor potential 0.428
fz2 frizzled 2 0.418
neur neuralized 0.416
RhoGAPp190 CG32555 gene product from transcript CG32555-RB 0.407
SoxN SoxNeuro 0.402
caup caupolican 0.383
aPKC atypical protein kinase C 0.363
edl ETS-domain lacking 0.334
tow target of wingless 0.315
ptc patched 0.313
ssh slingshot 0.310
Jra Jun-related antigen 0.301
svp seven up 0.294
Hop Hsp70/Hsp90 organizing protein homolog 0.289
Parp Poly-(ADP-ribose) polymerase 0.279
CG14168 CG14168 gene product from transcript CG14168-RA 0.276
yu CG3249 gene product from transcript CG3249-RA 0.269
CG15730 CG15730 gene product from transcript CG15730-RA 0.266
Egfr Epidermal growth factor receptor 0.265
14-3-3zeta CG17870 gene product from transcript CG17870-RB 0.255
raps rapsynoid 0.247
Or22a Odorant receptor 22a 0.239
Msi Male-specific insect derived growth factor 0.236
slou slouch 0.227
CG14905 CG14905 gene product from transcript CG14905-RA 0.224
insc inscuteable 0.217
amos absent MD neurons and olfactory sensilla 0.216
S6kII RPS6-protein kinase-II 0.211
Tollo CG6890 gene product from transcript CG6890-RA 0.205
trio CG18214 gene product from transcript CG18214-RA 0.201
kermit CG11546 gene product from transcript CG11546-RB 0.198
pain painless 0.197
tinc tincar 0.192
klu klumpfuss 0.189
nmo nemo 0.186
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Homo sapiens
Name Description Probability Func Analog Organism
ARHGAP1 Rho GTPase activating protein 1 0.983
RHOA ras homolog gene family, member A 0.959
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.947
GDA guanine deaminase 0.873
LRRK2 leucine-rich repeat kinase 2 0.650
TPBG trophoblast glycoprotein 0.632
AFF4 AF4/FMR2 family, member 4 0.558
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.543
AFF1 AF4/FMR2 family, member 1 0.513
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.459
RIN1 Ras and Rab interactor 1 0.415
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.413
APC adenomatous polyposis coli 0.389
PTN pleiotrophin 0.366
KRT5 keratin 5 0.361
EGFR epidermal growth factor receptor 0.356
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.336
CABLES1 Cdk5 and Abl enzyme substrate 1 0.315
TSG101 tumor susceptibility gene 101 0.276
PRKCZ protein kinase C, zeta 0.271
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.257
SEC23A Sec23 homolog A (S. cerevisiae) 0.253
INVS inversin 0.248
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.229
JUP junction plakoglobin 0.220
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.211
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.206
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.200
FZD1 frizzled homolog 1 (Drosophila) 0.186
PRPF3 PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) 0.181
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.178
NCKAP1 NCK-associated protein 1 0.171
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.168
SMAD2 SMAD family member 2 0.162
SATB2 SATB homeobox 2 0.160
EZR ezrin 0.154
AXIN1 axin 1 0.151
WNT3A wingless-type MMTV integration site family, member 3A 0.149
SOX4 SRY (sex determining region Y)-box 4 0.149
SORBS3 sorbin and SH3 domain containing 3 0.147
MYO6 myosin VI 0.139
CSNK1E casein kinase 1, epsilon 0.135
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.129
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.126
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.124
JAM2 junctional adhesion molecule 2 0.123
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.120
CEP164 centrosomal protein 164kDa 0.119
TTC30B tetratricopeptide repeat domain 30B 0.119
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.116
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.115
PRKCI protein kinase C, iota 0.113
MED29 mediator complex subunit 29 0.113
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.113
WNT5A wingless-type MMTV integration site family, member 5A 0.111
TYRP1 tyrosinase-related protein 1 0.109
JUB jub, ajuba homolog (Xenopus laevis) 0.107
LRP6 low density lipoprotein receptor-related protein 6 0.107
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.105
CSNK1D casein kinase 1, delta 0.105
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.103
CAV1 caveolin 1, caveolae protein, 22kDa 0.101
MED24 mediator complex subunit 24 0.101
WT1 Wilms tumor 1 0.100
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 0.100
BCL6 B-cell CLL/lymphoma 6 0.098
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.098
CFL1 cofilin 1 (non-muscle) 0.096
TJP2 tight junction protein 2 (zona occludens 2) 0.096
CAPN1 calpain 1, (mu/I) large subunit 0.095
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.094
MAP2K6 mitogen-activated protein kinase kinase 6 0.092
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.092
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 0.090
PTPRF protein tyrosine phosphatase, receptor type, F 0.089
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.089
GSK3B glycogen synthase kinase 3 beta 0.088
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.087
SH3RF3 SH3 domain containing ring finger 3 0.086
BAK1 BCL2-antagonist/killer 1 0.085
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.084
TRIP6 thyroid hormone receptor interactor 6 0.083
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.082
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.081
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.080
SMAD1 SMAD family member 1 0.075
MAPT microtubule-associated protein tau 0.075
ABI2 abl-interactor 2 0.073
WASF1 WAS protein family, member 1 0.072
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.071
CDH5 cadherin 5, type 2 (vascular endothelium) 0.069
HIPK3 homeodomain interacting protein kinase 3 0.067
SFN stratifin 0.064
CDK6 cyclin-dependent kinase 6 0.063
CCNT1 cyclin T1 0.062
IQGAP1 IQ motif containing GTPase activating protein 1 0.060
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.059
ERBB2IP erbb2 interacting protein 0.059
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.059
TGFBR1 transforming growth factor, beta receptor 1 0.057
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ednrb endothelin receptor type B 0.079
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.053
Baiap2 BAI1-associated protein 2 0.040
Myl9 myosin, light chain 9, regulatory 0.039
Nfia nuclear factor I/A 0.038
Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase 0.037
Fgfr1 Fibroblast growth factor receptor 1 0.037
Id3 inhibitor of DNA binding 3 0.037
Spon1 spondin 1, extracellular matrix protein 0.031
Lrfn2 leucine rich repeat and fibronectin type III domain containing 2 0.031
Boc biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein 0.030
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.030
Plagl1 pleiomorphic adenoma gene-like 1 0.029
Lrpap1 low density lipoprotein receptor-related protein associated protein 1 0.027
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.027
Arl5a ADP-ribosylation factor-like 5A 0.026
Gns glucosamine (N-acetyl)-6-sulfatase 0.024
Ssbp4 single stranded DNA binding protein 4 0.024
Fndc3b fibronectin type III domain containing 3B 0.024
Hspb7 heat shock protein family, member 7 (cardiovascular) 0.024
Paqr5 progestin and adipoQ receptor family member V 0.023
Sostdc1 sclerostin domain containing 1 0.023
Il6st interleukin 6 signal transducer 0.023
Cbx2 chromobox homolog 2 (Pc class homolog, Drosophila) 0.023
Add3 adducin 3 (gamma) 0.023
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.022
C1r complement component 1, r subcomponent 0.022
Marcks myristoylated alanine rich protein kinase C substrate 0.022
Gja1 gap junction protein, alpha 1 0.022
Lgals7 lectin, galactoside-binding, soluble, 7 0.022
Sox12 SRY (sex determining region Y)-box 12 0.021
RGD1559896 similar to RIKEN cDNA 2310022B05 0.021
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.021
Glud1 glutamate dehydrogenase 1 0.021
Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.021
Fam129b family with sequence similarity 129, member B 0.020
Golph3 golgi phosphoprotein 3 (coat-protein) 0.020
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.020
Plk5 polo-like kinase 5 0.020
Mcam melanoma cell adhesion molecule 0.020
Zfp278 zinc finger protein 278 0.020
Scamp2 secretory carrier membrane protein 2 0.020
Fam46b family with sequence similarity 46, member B 0.020
Bnc1 basonuclin 1 0.019
Tagln transgelin 0.019
Rgs19 regulator of G-protein signaling 19 0.019
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.019
Fgf23 fibroblast growth factor 23 0.019
Sorcs2 sortilin-related VPS10 domain containing receptor 2 0.019
Bmp4 bone morphogenetic protein 4 0.019
Lce1f late cornified envelope 1F 0.018
Ezr ezrin 0.018
Prph peripherin 0.018
Ppp4r1 protein phosphatase 4, regulatory subunit 1 0.018
Slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 0.018
Arf6 ADP-ribosylation factor 6 0.018
LOC688455 hypothetical protein LOC688455 0.018
Aifm3 apoptosis-inducing factor, mitochondrion-associated 3 0.018
Prkag3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 0.018
Thrb thyroid hormone receptor beta 0.018
Fzd1 frizzled homolog 1 (Drosophila) 0.018
M6pr mannose-6-phosphate receptor, cation dependent 0.018
Spata2L spermatogenesis associated 2-like 0.017
Eif2b2 eukaryotic translation initiation factor 2B, subunit 2 beta 0.017
Tpm1 tropomyosin 1, alpha 0.017
Sc65 synaptonemal complex protein SC65 0.017
Cd9 CD9 molecule 0.017
Cd82 Cd82 molecule 0.017
Efemp1 EGF-containing fibulin-like extracellular matrix protein 1 0.017
Tpm3 tropomyosin 3, gamma 0.017
Ube2q1 ubiquitin-conjugating enzyme E2Q family member 1 0.017
Acvr1 activin A receptor, type I 0.017
Spry1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.017
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.017
Lmcd1 LIM and cysteine-rich domains 1 0.017
Nrp1 neuropilin 1 0.017
Nradd neurotrophin receptor associated death domain 0.017
Galnt1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) 0.016
Cugbp2 CUG triplet repeat, RNA binding protein 2 0.016
Hoxb13 homeo box B13 0.016
Slc39a14 solute carrier family 39 (zinc transporter), member 14 0.016
Mapk1 mitogen activated protein kinase 1 0.016
Prx periaxin 0.016
Gpc3 glypican 3 0.016
Stxbp5 syntaxin binding protein 5 (tomosyn) 0.016
Tcfe2a transcription factor E2a 0.016
Kcng3 potassium voltage-gated channel, subfamily G, member 3 0.016
Arvcf armadillo repeat gene deleted in velo-cardio-facial syndrome 0.016
Jub jub, ajuba homolog (Xenopus laevis) 0.016
Cxcl12 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) 0.016
Matn3 matrilin 3 0.016
Kbtbd10 kelch repeat and BTB (POZ) domain containing 10 0.016
Ntf3 neurotrophin 3 0.016
Tead2 TEA domain family member 2 0.016
Krt7 keratin 7 0.016
Cpa4 carboxypeptidase A4 0.015
Ptk7 PTK7 protein tyrosine kinase 7 0.015
Ddah1 dimethylarginine dimethylaminohydrolase 1 0.015
Akirin2 akirin 2 0.015
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.015
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism