The network for 'bone remodeling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

bone remodeling

The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.

Mus musculus
Name Description Probability Func Analog Organism
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.983
Efnb2 ephrin B2 0.886
Kl klotho 0.814
Fgf10 fibroblast growth factor 10 0.777
Ctnnb1 catenin (cadherin associated protein), beta 1 0.695
Cd19 CD19 antigen 0.693
Casr calcium-sensing receptor 0.493
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.477
Cd247 CD247 antigen 0.473
Adam17 a disintegrin and metallopeptidase domain 17 0.454
Cdh6 cadherin 6 0.449
Psen1 presenilin 1 0.432
Tgfb2 transforming growth factor, beta 2 0.431
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.415
Sfrp2 secreted frizzled-related protein 2 0.391
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.387
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.383
Ltbp2 latent transforming growth factor beta binding protein 2 0.368
Ephb2 Eph receptor B2 0.335
Fgfr2 fibroblast growth factor receptor 2 0.326
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.324
Fyn Fyn proto-oncogene 0.321
Dok1 docking protein 1 0.305
Csf1 colony stimulating factor 1 (macrophage) 0.301
Fgf23 fibroblast growth factor 23 0.285
Il7 interleukin 7 0.283
Wnt5a wingless-related MMTV integration site 5A 0.281
Cd40 CD40 antigen 0.280
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.274
S1pr2 sphingosine-1-phosphate receptor 2 0.272
Pparg peroxisome proliferator activated receptor gamma 0.266
Adam12 a disintegrin and metallopeptidase domain 12 (meltrin alpha) 0.258
Sykb spleen tyrosine kinase 0.258
Pnpla2 patatin-like phospholipase domain containing 2 0.253
Ltb lymphotoxin B 0.250
Bnc1 basonuclin 1 0.237
Tgfa transforming growth factor alpha 0.227
Adrb2 adrenergic receptor, beta 2 0.213
Ephb3 Eph receptor B3 0.211
Bmp4 bone morphogenetic protein 4 0.206
Idua iduronidase, alpha-L- 0.194
S1pr3 sphingosine-1-phosphate receptor 3 0.194
Dock1 dedicator of cytokinesis 1 0.182
Pdgfb platelet derived growth factor, B polypeptide 0.179
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.172
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.170
Pthlh parathyroid hormone-like peptide 0.166
Tgfbr2 transforming growth factor, beta receptor II 0.163
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.163
Epha4 Eph receptor A4 0.159
Axin1 axin 1 0.154
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.152
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.150
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.144
Galnt3 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 0.143
Foxn1 forkhead box N1 0.142
Tcf7l2 transcription factor 7-like 2, T-cell specific, HMG-box 0.140
Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 0.139
Cel carboxyl ester lipase 0.136
Cxcr5 chemokine (C-X-C motif) receptor 5 0.135
Aire autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) 0.135
Slc16a8 solute carrier family 16 (monocarboxylic acid transporters), member 8 0.135
Drd2 dopamine receptor D2 0.132
Lat linker for activation of T cells 0.132
Efnb1 ephrin B1 0.132
Ern2 endoplasmic reticulum (ER) to nucleus signalling 2 0.130
Bmp1 bone morphogenetic protein 1 0.129
Egfr epidermal growth factor receptor 0.128
Foxc2 forkhead box C2 0.127
Zfp92 zinc finger protein 92 0.126
Zfpm2 zinc finger protein, multitype 2 0.126
Cd40lg CD40 ligand 0.123
Jag1 jagged 1 0.121
Ptprc protein tyrosine phosphatase, receptor type, C 0.118
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.117
Ptk2 PTK2 protein tyrosine kinase 2 0.116
Klk6 kallikrein related-peptidase 6 0.116
Grb2 growth factor receptor bound protein 2 0.116
Ikzf1 IKAROS family zinc finger 1 0.115
Mrc2 mannose receptor, C type 2 0.115
Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.114
Cx3cr1 chemokine (C-X3-C) receptor 1 0.113
Itgal integrin alpha L 0.113
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.111
Hoxb1 homeobox B1 0.111
Pomc pro-opiomelanocortin-alpha 0.110
Foxf1a forkhead box F1a 0.110
Sntb1 syntrophin, basic 1 0.109
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.108
Vdr vitamin D receptor 0.108
Hipk1 homeodomain interacting protein kinase 1 0.108
Ddr2 discoidin domain receptor family, member 2 0.106
Ptk7 PTK7 protein tyrosine kinase 7 0.104
Smo smoothened homolog (Drosophila) 0.103
Has2 hyaluronan synthase 2 0.103
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.102
Sfrp1 secreted frizzled-related protein 1 0.100
Foxc1 forkhead box C1 0.099
Gata6 GATA binding protein 6 0.098
Tox thymocyte selection-associated high mobility group box 0.098
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp4 bone morphogenetic protein 4 0.276
lef1 lymphocyte enhancer binding factor 1 0.113
mitfa microphthalmia-associated transcription factor a 0.111
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.106
spry4 sprouty (Drosophila) homolog 4 0.095
rag1 recombination activating gene 1 0.075
pea3 ETS-domain transcription factor pea3 0.066
sparc secreted acidic cysteine rich glycoprotein 0.054
bmp2a bone morphogenetic protein 2a 0.051
mespb mesoderm posterior b 0.050
ptch2 patched 2 0.048
kita kit receptor a 0.046
sc:d812 sc:d812 0.046
tyr tyrosinase 0.046
msxb muscle segment homeobox B 0.044
zgc:112329 zgc:112329 0.044
nipblb novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila) 0.040
sox9b SRY-box containing gene 9b 0.039
fgf17 fibroblast growth factor 17 0.039
ahr2 aryl hydrocarbon receptor 2 0.038
LOC100151531 zinc finger protein Gfi-1b-like 0.038
stmn4 stathmin-like 4 0.038
aldh1a3 aldehyde dehydrogenase 1 family, member A3 0.038
fgf4 fibroblast growth factor 4 0.036
vasa vasa homolog 0.035
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.035
frem3 Fras1 related extracellular matrix 3 0.034
comta catechol-O-methyltransferase a 0.034
mpx myeloid-specific peroxidase 0.033
lcp1 lymphocyte cytosolic plastin 1 0.033
plod1a procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a 0.032
dlx5a distal-less homeobox gene 5a 0.032
epha4a eph receptor A4a 0.032
mmp9 matrix metalloproteinase 9 0.031
lhx6 LIM homeobox 6 0.030
fn1 fibronectin 1 0.029
lhx3 LIM homeobox 3 0.029
lhcgr luteinizing hormone/choriogonadotropin receptor 0.028
piwil1 piwi-like 1 (Drosophila) 0.028
pmela premelanosome protein a 0.028
jag1b jagged 1b 0.027
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.027
ntn2 netrin 2 0.027
hapln1a hyaluronan and proteoglycan link protein 1a 0.026
lepr leptin receptor 0.026
ctsba cathepsin B, a 0.026
otomp otolith matrix protein 0.026
plod2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.025
ptch1 patched 1 0.025
esr1 estrogen receptor 1 0.025
traf4a tnf receptor-associated factor 4a 0.025
hbbe1.1 hemoglobin beta embryonic-1.1 0.025
pitx3 paired-like homeodomain transcription factor 3 0.024
tgfbi transforming growth factor, beta-induced 0.024
wu:fb80a07 wu:fb80a07 0.024
osr1 odd-skipped related 1 (Drosophila) 0.024
wnt7ba wingless-type MMTV integration site family, member 7Ba 0.024
col10a1 collagen, type X, alpha 1 0.024
gng13a guanine nucleotide binding protein (G protein), gamma 13a 0.023
pou1f1 POU domain, class 1, transcription factor 1 0.023
slco1f1 solute carrier organic anion transporter family, member 1F1 0.023
mlphb melanophilin b 0.023
col2a1a collagen type II, alpha-1a 0.023
fgf18a fibroblast growth factor 18a 0.022
mmp13a matrix metalloproteinase 13a 0.022
vipr2 vasoactive intestinal peptide receptor 2 0.022
sfrp1a secreted frizzled-related protein 1a 0.022
wu:fd52f12 wu:fd52f12 0.022
fras1 Fraser syndrome 1 0.022
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.022
si:ch211-212m21.5 si:ch211-212m21.5 0.022
slc25a37 solute carrier family 25, member 37 0.021
LOC793701 growth arrest-specific protein 7-like 0.021
irf8 interferon regulatory factor 8 0.021
cd63 Cd63 antigen 0.021
apoeb apolipoprotein Eb 0.021
kiss2 kisspeptin 2 0.021
slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.021
piwil2 piwi-like 2 (Drosophila) 0.021
tgfb2 transforming growth factor, beta 2 0.021
ihhb Indian hedgehog homolog b 0.020
fn1b fibronectin 1b 0.020
rpz rapunzel 0.020
gcm2 glial cells missing homolog 2 (Drosophila) 0.020
alas2 aminolevulinate, delta-, synthetase 2 0.020
fbp1b fructose-1,6-bisphosphatase 1b 0.020
lhb luteinizing hormone, beta polypeptide 0.020
LOC100148845 neurogenin-1-like 0.020
mesp2 mesoderm posterior 2 homolog (mouse) 0.019
si:ch211-191i18.3 si:ch211-191i18.3 0.019
gnrh3 gonadotropin-releasing hormone 3 0.019
cx43.4 connexin 43.4 0.019
tbx22 T-box 22 0.019
spi1l spleen focus forming virus (SFFV) proviral integration oncogene spi1 like 0.019
snai1a snail homolog 1a (Drosophila) 0.019
ptmab prothymosin, alpha b 0.019
frem2a Fras1 related extracellular matrix protein 2a 0.019
si:dkeyp-7c9.1 si:dkeyp-7c9.1 0.019
gpr126 G protein-coupled receptor 126 0.019
ctsc cathepsin C 0.019
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
JAG1 jagged 1 0.474
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.135
NRP1 neuropilin 1 0.115
TJP1 tight junction protein 1 (zona occludens 1) 0.053
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.048
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.030
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.019
ENG endoglin 0.018
EPOR erythropoietin receptor 0.018
EFNA1 ephrin-A1 0.018
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.015
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.013
PTK2 PTK2 protein tyrosine kinase 2 0.012
GAST gastrin 0.012
INSR insulin receptor 0.011
GLB1 galactosidase, beta 1 0.011
GAA glucosidase, alpha; acid 0.010
UBASH3B ubiquitin associated and SH3 domain containing B 0.010
CTSA cathepsin A 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.056
Nos3 nitric oxide synthase 3, endothelial cell 0.036
Col12a1 collagen, type XII, alpha 1 0.034
Jak1 Janus kinase 1 0.032
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.025
Lrp10 low-density lipoprotein receptor-related protein 10 0.024
Ccr5 chemokine (C-C motif) receptor 5 0.022
Gpnmb glycoprotein (transmembrane) nmb 0.021
Nmur2 neuromedin U receptor 2 0.019
Wt1 Wilms tumor 1 0.019
Adam10 ADAM metallopeptidase domain 10 0.018
RT1-Ba RT1 class II, locus Ba 0.018
Cd53 Cd53 molecule 0.018
Aspg asparaginase homolog (S. cerevisiae) 0.018
Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 0.017
Laptm5 lysosomal protein transmembrane 5 0.017
MGC112715 hypothetical protein LOC690899 0.017
Cpa3 carboxypeptidase A3, mast cell 0.017
Tgfbr3 transforming growth factor, beta receptor III 0.016
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.016
Plau plasminogen activator, urokinase 0.016
Spon1 spondin 1, extracellular matrix protein 0.016
Unc93b1 unc-93 homolog B1 (C. elegans) 0.015
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.015
Rhog ras homolog gene family, member G (rho G) 0.015
Tas2r105 taste receptor, type 2, member 105 0.015
Ptk2b PTK2B protein tyrosine kinase 2 beta 0.014
Cotl1 coactosin-like 1 (Dictyostelium) 0.014
Rcvrn recoverin 0.014
Cd37 CD37 molecule 0.014
Cd2 Cd2 molecule 0.014
Fkbp1a FK506 binding protein 1a 0.014
Rab10 RAB10, member RAS oncogene family 0.014
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.013
Bmp6 bone morphogenetic protein 6 0.013
Lyz2 lysozyme 2 0.013
Rtn4 reticulon 4 0.013
Efhd2 EF-hand domain family, member D2 0.013
RT1-DMa RT1 class II, locus DMa 0.013
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.012
Vcam1 vascular cell adhesion molecule 1 0.012
Slit3 slit homolog 3 (Drosophila) 0.012
Jtb jumping translocation breakpoint 0.012
Lamp2 lysosomal-associated membrane protein 2 0.012
Il1b interleukin 1 beta 0.012
Efnb1 ephrin B1 0.012
Lst1 leukocyte specific transcript 1 0.012
Clic4 chloride intracellular channel 4 0.012
LOC100365152 adaptor-related protein complex 1, gamma 2 subunit-like 0.012
ND4 NADH dehydrogenase subunit 4 0.011
Ctss cathepsin S 0.011
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.011
Cd200r1 CD200 receptor 1 0.011
Tmem49 transmembrane protein 49 0.011
Cd44 Cd44 molecule 0.011
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.011
Olr1654 olfactory receptor 1654 0.011
C1qb complement component 1, q subcomponent, B chain 0.011
Itgad integrin, alpha D 0.011
Ccl3 chemokine (C-C motif) ligand 3 0.011
Tlr7 toll-like receptor 7 0.011
Ccl6 chemokine (C-C motif) ligand 6 0.011
Dchs1 dachsous 1 (Drosophila) 0.011
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.011
Cfp complement factor properdin 0.010
Pctk3 PCTAIRE protein kinase 3 0.010
Cybrd1 cytochrome b reductase 1 0.010
Gpr182 G protein-coupled receptor 182 0.010
Agtr1a angiotensin II receptor, type 1a 0.010
Prkcb protein kinase C, beta 0.010
Inpp5d inositol polyphosphate-5-phosphatase D 0.010
Cd4 Cd4 molecule 0.010
Ctsb cathepsin B 0.010
LOC100361706 lambda-chain C1-region-like 0.010
Vipr2 vasoactive intestinal peptide receptor 2 0.010
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.010
Matk megakaryocyte-associated tyrosine kinase 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism