IMP

Process View

Homo sapiens

4 genes annotated in human

Multi-species View

inflammatory response to antigenic stimulus

GO:0002437

An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "inflammatory response to antigenic stimulus"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "inflammatory response to antigenic stimulus" (in gray)

Name	Description	Probability	Func Analog Organism
HLA-DRA	major histocompatibility complex, class II, DR alpha	1.000
PSMB2	proteasome (prosome, macropain) subunit, beta type, 2	0.956
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.804
IL1R1	interleukin 1 receptor, type I	0.742
PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5	0.716
GRAP2	GRB2-related adaptor protein 2	0.671
SYK	spleen tyrosine kinase	0.648
HLA-DMB	major histocompatibility complex, class II, DM beta	0.635
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.580
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.524	Human
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.388
POMP	proteasome maturation protein	0.366
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.358	Mouse
CCL5	chemokine (C-C motif) ligand 5	0.350
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.307
JAG1	jagged 1	0.286
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.233
ATXN1L	ataxin 1-like	0.231
PSMB5	proteasome (prosome, macropain) subunit, beta type, 5	0.228
PSMB1	proteasome (prosome, macropain) subunit, beta type, 1	0.227
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.201
PSMA6	proteasome (prosome, macropain) subunit, alpha type, 6	0.189
NOTCH1	notch 1	0.184	Mouse
UBASH3B	ubiquitin associated and SH3 domain containing B	0.165
MAML1	mastermind-like 1 (Drosophila)	0.161
IL1B	interleukin 1, beta	0.158	Rat
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.143
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.138	Human
IL1R2	interleukin 1 receptor, type II	0.123
PSMB7	proteasome (prosome, macropain) subunit, beta type, 7	0.123
HMGN2	high mobility group nucleosomal binding domain 2	0.117
IL1RN	interleukin 1 receptor antagonist	0.102	Rat
IL8	interleukin 8	0.093
PSMA7	proteasome (prosome, macropain) subunit, alpha type, 7	0.087
CCL4	chemokine (C-C motif) ligand 4	0.086
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.085
CFH	complement factor H	0.085
HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.084
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.083	Mouse
HMGB1	high mobility group box 1	0.079
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.078
IL1RAP	interleukin 1 receptor accessory protein	0.072
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.065
HMGB2	high mobility group box 2	0.063	Human
TRAF1	TNF receptor-associated factor 1	0.063
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.063	Mouse
CXCR4	chemokine (C-X-C motif) receptor 4	0.063
PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3	0.059
SLX1B	SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)	0.059
CFI	complement factor I	0.053
NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.053
BLNK	B-cell linker	0.052
HLA-DQA2	major histocompatibility complex, class II, DQ alpha 2	0.050
GAB1	GRB2-associated binding protein 1	0.049
NOTCH2NL	notch 2 N-terminal like	0.043
CCL20	chemokine (C-C motif) ligand 20	0.042
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.042
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.039
PSMA2	proteasome (prosome, macropain) subunit, alpha type, 2	0.038
TYROBP	TYRO protein tyrosine kinase binding protein	0.034
CCR1	chemokine (C-C motif) receptor 1	0.032
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.032
DLL1	delta-like 1 (Drosophila)	0.032
ANP32B	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B	0.032
IL4R	interleukin 4 receptor	0.031
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.031
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.031
CCR5	chemokine (C-C motif) receptor 5	0.030	Rat
CCL2	chemokine (C-C motif) ligand 2	0.030
CSNK1A1	casein kinase 1, alpha 1	0.030
PSMA4	proteasome (prosome, macropain) subunit, alpha type, 4	0.029
CXCL2	chemokine (C-X-C motif) ligand 2	0.029
SEC61G	Sec61 gamma subunit	0.027
HMGN1	high mobility group nucleosome binding domain 1	0.026
IL2RB	interleukin 2 receptor, beta	0.026
CD83	CD83 molecule	0.026
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	0.026
LNX1	ligand of numb-protein X 1	0.026
TLR2	toll-like receptor 2	0.025
SLAMF1	signaling lymphocytic activation molecule family member 1	0.025
CCL22	chemokine (C-C motif) ligand 22	0.025
CCR7	chemokine (C-C motif) receptor 7	0.025	Mouse
TRADD	TNFRSF1A-associated via death domain	0.025
CCR2	chemokine (C-C motif) receptor 2	0.025	Rat
CXCL9	chemokine (C-X-C motif) ligand 9	0.025
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.024
DERL2	Der1-like domain family, member 2	0.024
HNRNPA3	heterogeneous nuclear ribonucleoprotein A3	0.023
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.023
XIAP	X-linked inhibitor of apoptosis	0.022
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.022
IL10RA	interleukin 10 receptor, alpha	0.022
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.022
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.022
CXCR2	chemokine (C-X-C motif) receptor 2	0.022	Rat
CSF1R	colony stimulating factor 1 receptor	0.021
CIR1	corepressor interacting with RBPJ, 1	0.021
IL10	interleukin 10	0.021
CCL19	chemokine (C-C motif) ligand 19	0.021
PTMA	prothymosin, alpha	0.021
GPR109B	G protein-coupled receptor 109B	0.021
GPR18	G protein-coupled receptor 18	0.021
SMAD1	SMAD family member 1	0.021
IFNG	interferon, gamma	0.021
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.021
CXCR6	chemokine (C-X-C motif) receptor 6	0.020
TXN	thioredoxin	0.020
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.020
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.020
CXCL3	chemokine (C-X-C motif) ligand 3	0.020
IRF8	interferon regulatory factor 8	0.020
SNW1	SNW domain containing 1	0.019
LAPTM5	lysosomal protein transmembrane 5	0.019
CBX1	chromobox homolog 1	0.019
GZMK	granzyme K (granzyme 3; tryptase II)	0.019
CCR4	chemokine (C-C motif) receptor 4	0.019
CD1C	CD1c molecule	0.018
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.018
AQP9	aquaporin 9	0.018
CFB	complement factor B	0.018
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.017
PI3	peptidase inhibitor 3, skin-derived	0.017
CCR6	chemokine (C-C motif) receptor 6	0.017
CXCL10	chemokine (C-X-C motif) ligand 10	0.017
CLEC4E	C-type lectin domain family 4, member E	0.017
IGSF6	immunoglobulin superfamily, member 6	0.017
CCNB2	cyclin B2	0.017
RGS1	regulator of G-protein signaling 1	0.017
TNF	tumor necrosis factor	0.017
CTNNBL1	catenin, beta like 1	0.017
GPR65	G protein-coupled receptor 65	0.016
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.016
GFI1B	growth factor independent 1B transcription repressor	0.016
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.016
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.016
CCL8	chemokine (C-C motif) ligand 8	0.016
CCR9	chemokine (C-C motif) receptor 9	0.016
ORC6	origin recognition complex, subunit 6	0.016
IL6	interleukin 6 (interferon, beta 2)	0.015
IRF4	interferon regulatory factor 4	0.015
TNIP1	TNFAIP3 interacting protein 1	0.015
EPOR	erythropoietin receptor	0.015
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	0.015
PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	0.015
IL18R1	interleukin 18 receptor 1	0.015
IL21R	interleukin 21 receptor	0.014
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.014
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	0.014
CD40LG	CD40 ligand	0.014
LBR	lamin B receptor	0.014
CCL3	chemokine (C-C motif) ligand 3	0.014
IL2RA	interleukin 2 receptor, alpha	0.014
IL1A	interleukin 1, alpha	0.014
RUNX3	runt-related transcription factor 3	0.014
LCK	lymphocyte-specific protein tyrosine kinase	0.014
BCL2A1	BCL2-related protein A1	0.014
P2RY10	purinergic receptor P2Y, G-protein coupled, 10	0.014
CTSG	cathepsin G	0.014
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.014
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.014
CLEC7A	C-type lectin domain family 7, member A	0.013
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.013
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.013
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.013
SNIP1	Smad nuclear interacting protein 1	0.013
LTB	lymphotoxin beta (TNF superfamily, member 3)	0.013
CD53	CD53 molecule	0.013
OAZ1	ornithine decarboxylase antizyme 1	0.013
SHFM1	split hand/foot malformation (ectrodactyly) type 1	0.013
CYBB	cytochrome b-245, beta polypeptide	0.013
IL7R	interleukin 7 receptor	0.013
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.013
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.013
IL18RAP	interleukin 18 receptor accessory protein	0.013
ANP32A	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	0.013
CD33	CD33 molecule	0.013
CD72	CD72 molecule	0.013
CXCL13	chemokine (C-X-C motif) ligand 13	0.013
LDHB	lactate dehydrogenase B	0.013
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.013
CXCR3	chemokine (C-X-C motif) receptor 3	0.013
CXCL5	chemokine (C-X-C motif) ligand 5	0.012
GPR171	G protein-coupled receptor 171	0.012
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.012
SIRPB1	signal-regulatory protein beta 1	0.012
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.012
PLEK	pleckstrin	0.012
PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.012
STEAP4	STEAP family member 4	0.012
CFP	complement factor properdin	0.012
LY9	lymphocyte antigen 9	0.012
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.012
HMGA1	high mobility group AT-hook 1	0.012
CD14	CD14 molecule	0.012
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.012
CLEC10A	C-type lectin domain family 10, member A	0.012
CXCL11	chemokine (C-X-C motif) ligand 11	0.012
HLA-DQB2	major histocompatibility complex, class II, DQ beta 2	0.012
ARG1	arginase, liver	0.012
F13A1	coagulation factor XIII, A1 polypeptide	0.012
TRAT1	T cell receptor associated transmembrane adaptor 1	0.012
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.012
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.012
TLR7	toll-like receptor 7	0.012
FCAR	Fc fragment of IgA, receptor for	0.011
CD84	CD84 molecule	0.011
C1S	complement component 1, s subcomponent	0.011
NBPF10	neuroblastoma breakpoint family, member 10	0.011
CAMP	cathelicidin antimicrobial peptide	0.011
H2AFZ	H2A histone family, member Z	0.011
MXD1	MAX dimerization protein 1	0.011
CLEC5A	C-type lectin domain family 5, member A	0.011
GAB2	GRB2-associated binding protein 2	0.011
PRDM1	PR domain containing 1, with ZNF domain	0.011
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.011
TREM1	triggering receptor expressed on myeloid cells 1	0.011
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.011
OCLN	occludin	0.011
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.011
S100A12	S100 calcium binding protein A12	0.011
CPA3	carboxypeptidase A3 (mast cell)	0.011
BIN2	bridging integrator 2	0.011
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.011
FPR2	formyl peptide receptor 2	0.011
S100P	S100 calcium binding protein P	0.011
CMIP	c-Maf-inducing protein	0.011
HP	haptoglobin	0.011
CD68	CD68 molecule	0.011
PNMAL1	PNMA-like 1	0.011
LOC728026	hypothetical protein LOC728026	0.011
CXCR1	chemokine (C-X-C motif) receptor 1	0.011	Rat
ZNF830	zinc finger protein 830	0.011
NOTCH2	notch 2	0.011	Mouse
ADAP1	ArfGAP with dual PH domains 1	0.011
ICOS	inducible T-cell co-stimulator	0.011
ADAM28	ADAM metallopeptidase domain 28	0.011
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.011
ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	0.010
CXorf56	chromosome X open reading frame 56	0.010
SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	0.010
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.010
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.010
CCL7	chemokine (C-C motif) ligand 7	0.010
LCN2	lipocalin 2	0.010
HAL	histidine ammonia-lyase	0.010
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.010
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.010
IL6R	interleukin 6 receptor	0.010
TRMT112	tRNA methyltransferase 11-2 homolog (S. cerevisiae)	0.010
LMNB1	lamin B1	0.010
CLEC4D	C-type lectin domain family 4, member D	0.010
GGH	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	0.010
GPR84	G protein-coupled receptor 84	0.010
CYTIP	cytohesin 1 interacting protein	0.010
C3AR1	complement component 3a receptor 1	0.010