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Process View

Homo sapiens

16 genes annotated in human

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eye morphogenesis

GO:0048592

The process in which the anatomical structures of the eye are generated and organized.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "eye morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "eye morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.638
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.605
COL1A1	collagen, type I, alpha 1	0.581	Human
SP1	Sp1 transcription factor	0.500	Mouse
CREBBP	CREB binding protein	0.447
BCOR	BCL6 corepressor	0.412
BMI1	BMI1 polycomb ring finger oncogene	0.312
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.304
EGFR	epidermal growth factor receptor	0.274	Fly
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.197	Fly
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.185
NCOR1	nuclear receptor corepressor 1	0.167
INADL	InaD-like (Drosophila)	0.161
SMAD3	SMAD family member 3	0.155
NRP1	neuropilin 1	0.153
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.148
RUNX1	runt-related transcription factor 1	0.147	Fly
COL3A1	collagen, type III, alpha 1	0.145	Human
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.136	Fly
BCL2L1	BCL2-like 1	0.124
PBX1	pre-B-cell leukemia homeobox 1	0.121
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.113
HDAC2	histone deacetylase 2	0.112
PCGF2	polycomb group ring finger 2	0.111
PIAS1	protein inhibitor of activated STAT, 1	0.111
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.108
MCM7	minichromosome maintenance complex component 7	0.105
YAP1	Yes-associated protein 1	0.102
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.097
NOTCH3	notch 3	0.097	Fly
TP53	tumor protein p53	0.092
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.090
BBS2	Bardet-Biedl syndrome 2	0.089
DDR2	discoidin domain receptor tyrosine kinase 2	0.088
EP300	E1A binding protein p300	0.087
SMAD4	SMAD family member 4	0.083
COL6A1	collagen, type VI, alpha 1	0.083
HCFC1	host cell factor C1 (VP16-accessory protein)	0.080
COL1A2	collagen, type I, alpha 2	0.079	Human
APC	adenomatous polyposis coli	0.078	Fly
MDFI	MyoD family inhibitor	0.078
TP53BP2	tumor protein p53 binding protein, 2	0.077
SMO	smoothened homolog (Drosophila)	0.075	Fly
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.075
CSNK1E	casein kinase 1, epsilon	0.072	Fly
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.072
SUFU	suppressor of fused homolog (Drosophila)	0.068
PXN	paxillin	0.066
HTT	huntingtin	0.064
UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	0.063
NOTCH1	notch 1	0.060	Fly
PTCH1	patched 1	0.060	Fly
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.059
ENG	endoglin	0.058
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.056	Fly
CDK19	cyclin-dependent kinase 19	0.056
RBBP4	retinoblastoma binding protein 4	0.055
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.055
PML	promyelocytic leukemia	0.054
PVRL4	poliovirus receptor-related 4	0.053
HIPK2	homeodomain interacting protein kinase 2	0.053	Mouse
C2orf65	chromosome 2 open reading frame 65	0.052
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.052	Fly
STK3	serine/threonine kinase 3	0.052
SOX11	SRY (sex determining region Y)-box 11	0.052	Mouse
ESR1	estrogen receptor 1	0.049
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.049
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.049	Fly
TAL1	T-cell acute lymphocytic leukemia 1	0.047	Human
CADM4	cell adhesion molecule 4	0.044
FGFR1	fibroblast growth factor receptor 1	0.043
COL11A1	collagen, type XI, alpha 1	0.042	Human
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.040
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.039
COL2A1	collagen, type II, alpha 1	0.039	Human
PAX2	paired box 2	0.038	Mouse Fly
BBS7	Bardet-Biedl syndrome 7	0.038
SETD8	SET domain containing (lysine methyltransferase) 8	0.037
BBS9	Bardet-Biedl syndrome 9	0.036
GRB7	growth factor receptor-bound protein 7	0.035
COL5A1	collagen, type V, alpha 1	0.035
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.035
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.034	Mouse Fly
BAD	BCL2-associated agonist of cell death	0.034
BBS4	Bardet-Biedl syndrome 4	0.032	Mouse
EFNA1	ephrin-A1	0.031
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.031
NKX2-1	NK2 homeobox 1	0.029
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.029
PVRL3	poliovirus receptor-related 3	0.029	Mouse
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.028
SKIL	SKI-like oncogene	0.028
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.028
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.028
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.028
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.027
MXRA5	matrix-remodelling associated 5	0.027
RB1	retinoblastoma 1	0.026
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.026
FGF1	fibroblast growth factor 1 (acidic)	0.026
DYNLT3	dynein, light chain, Tctex-type 3	0.026
HNF4A	hepatocyte nuclear factor 4, alpha	0.025
EYA2	eyes absent homolog 2 (Drosophila)	0.025	Fly
PCGF1	polycomb group ring finger 1	0.025
COL5A2	collagen, type V, alpha 2	0.025
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.025	Zebrafish
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.024
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.024	Zebrafish
BBS1	Bardet-Biedl syndrome 1	0.024
CAV1	caveolin 1, caveolae protein, 22kDa	0.023
GRB10	growth factor receptor-bound protein 10	0.023
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.022
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.022
JAK2	Janus kinase 2	0.022	Fly
GAB1	GRB2-associated binding protein 1	0.022
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.021
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.021
TCF12	transcription factor 12	0.021
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.021
ELN	elastin	0.021
MYOD1	myogenic differentiation 1	0.020
MED12	mediator complex subunit 12	0.020
POU5F1	POU class 5 homeobox 1	0.020
ZFYVE9	zinc finger, FYVE domain containing 9	0.020
PGF	placental growth factor	0.020
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.020
HOXA9	homeobox A9	0.020
WNT3A	wingless-type MMTV integration site family, member 3A	0.020
CTGF	connective tissue growth factor	0.020
PAX6	paired box 6	0.020
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.019	Mouse
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.019
PDX1	pancreatic and duodenal homeobox 1	0.019
PAX7	paired box 7	0.019
PDCD6IP	programmed cell death 6 interacting protein	0.019
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.019
GATA4	GATA binding protein 4	0.019
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.018
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.018
TP73	tumor protein p73	0.018
FBLN1	fibulin 1	0.018
POU3F2	POU class 3 homeobox 2	0.018
NCOR2	nuclear receptor corepressor 2	0.018
CBX4	chromobox homolog 4	0.018
MCC	mutated in colorectal cancers	0.017
FOXD3	forkhead box D3	0.017
MAP1S	microtubule-associated protein 1S	0.017
LMO2	LIM domain only 2 (rhombotin-like 1)	0.017
ERBB2IP	erbb2 interacting protein	0.017
LOX	lysyl oxidase	0.017
CDK4	cyclin-dependent kinase 4	0.017
CTBP1	C-terminal binding protein 1	0.017
SOX1	SRY (sex determining region Y)-box 1	0.017
SOX2	SRY (sex determining region Y)-box 2	0.017	Zebrafish Mouse
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.017
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.017
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.017
SEC31A	SEC31 homolog A (S. cerevisiae)	0.017
SIX3	SIX homeobox 3	0.016	Fly
GLI3	GLI family zinc finger 3	0.016	Mouse Fly
LHX2	LIM homeobox 2	0.016
GADD45G	growth arrest and DNA-damage-inducible, gamma	0.016
TRIM33	tripartite motif containing 33	0.015
TRPV5	transient receptor potential cation channel, subfamily V, member 5	0.015
PCDH9	protocadherin 9	0.015
EPHB3	EPH receptor B3	0.015
PTK2	PTK2 protein tyrosine kinase 2	0.015	Zebrafish
SIX6	SIX homeobox 6	0.015	Zebrafish Fly
SOCS1	suppressor of cytokine signaling 1	0.015	Zebrafish
CDH5	cadherin 5, type 2 (vascular endothelium)	0.014
GSK3B	glycogen synthase kinase 3 beta	0.014
TRRAP	transformation/transcription domain-associated protein	0.014
TACC1	transforming, acidic coiled-coil containing protein 1	0.014
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.013
PCM1	pericentriolar material 1	0.013
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.013
TWIST1	twist homolog 1 (Drosophila)	0.013
CCT7	chaperonin containing TCP1, subunit 7 (eta)	0.013
LHX1	LIM homeobox 1	0.013	Mouse
SFN	stratifin	0.013
POSTN	periostin, osteoblast specific factor	0.013
CBX8	chromobox homolog 8	0.013
DAXX	death-domain associated protein	0.013
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.013
DNM2	dynamin 2	0.013	Fly
ACAN	aggrecan	0.013
SIX1	SIX homeobox 1	0.013	Fly
JAG1	jagged 1	0.013	Mouse Fly
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.013
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.013
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.013	Zebrafish
FOXC1	forkhead box C1	0.013
MEIS2	Meis homeobox 2	0.013
MED20	mediator complex subunit 20	0.013
NOTCH2	notch 2	0.013	Mouse Fly
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.013
GLI1	GLI family zinc finger 1	0.012	Fly
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.012	Mouse
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.012
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.012
POU4F1	POU class 4 homeobox 1	0.012
RAX	retina and anterior neural fold homeobox	0.012
FN1	fibronectin 1	0.012	Zebrafish
CDK5	cyclin-dependent kinase 5	0.012	Zebrafish
PCGF5	polycomb group ring finger 5	0.012
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.012	Zebrafish
CFLAR	CASP8 and FADD-like apoptosis regulator	0.012
PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)	0.012
ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b	0.012
POU4F2	POU class 4 homeobox 2	0.011
SMAD1	SMAD family member 1	0.011	Fly
BMP7	bone morphogenetic protein 7	0.011	Mouse
SALL2	sal-like 2 (Drosophila)	0.011
MCM2	minichromosome maintenance complex component 2	0.011
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.011	Zebrafish
MSX1	msh homeobox 1	0.011
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.011
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.011
FOXA2	forkhead box A2	0.011
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.011
FBLN2	fibulin 2	0.011
AATF	apoptosis antagonizing transcription factor	0.011
NTM	neurotrimin	0.011
COMP	cartilage oligomeric matrix protein	0.011
EPHB2	EPH receptor B2	0.011	Mouse
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.010
HIC1	hypermethylated in cancer 1	0.010
IRX4	iroquois homeobox 4	0.010
ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	0.010
FOXG1	forkhead box G1	0.010	Zebrafish
DLL1	delta-like 1 (Drosophila)	0.010	Fly
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.010
NEUROD1	neurogenic differentiation 1	0.010	Human
THY1	Thy-1 cell surface antigen	0.010	Mouse
RNF144B	ring finger protein 144B	0.010
SMAD2	SMAD family member 2	0.010