IMP

Process View

Homo sapiens

26 genes annotated in human

antimicrobial humoral response

GO:0019730

An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "antimicrobial humoral response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "antimicrobial humoral response" (in gray)

Name	Description	Probability	Func Analog Organism
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.999
JUN	jun proto-oncogene	0.988	Fly
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.988	Fly
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.986	Fly
HIST1H2BD	histone cluster 1, H2bd	0.986	Human
BCL3	B-cell CLL/lymphoma 3	0.975	Mouse Fly
HIST1H2BE	histone cluster 1, H2be	0.952
HIST1H2AC	histone cluster 1, H2ac	0.924
HIST1H2BF	histone cluster 1, H2bf	0.901
JUNB	jun B proto-oncogene	0.896	Fly
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.891	Fly
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.885	Fly
HIST1H1C	histone cluster 1, H1c	0.834
HIST1H2BH	histone cluster 1, H2bh	0.759	Human
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.727
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.665
LAT	linker for activation of T cells	0.651
HIST1H2BG	histone cluster 1, H2bg	0.626
EP300	E1A binding protein p300	0.592
HIST1H2BI	histone cluster 1, H2bi	0.590
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.560	Fly
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.555	Fly
INSR	insulin receptor	0.520
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.472	Fly
CDK2	cyclin-dependent kinase 2	0.471
ATF3	activating transcription factor 3	0.455	Fly
ZFYVE9	zinc finger, FYVE domain containing 9	0.427
SOS1	son of sevenless homolog 1 (Drosophila)	0.390
HIST1H3D	histone cluster 1, H3d	0.340
ATF2	activating transcription factor 2	0.332
MAPK14	mitogen-activated protein kinase 14	0.321	Fly
JUND	jun D proto-oncogene	0.316	Fly
CHUK	conserved helix-loop-helix ubiquitous kinase	0.287	Fly
SOX10	SRY (sex determining region Y)-box 10	0.274
NCOA3	nuclear receptor coactivator 3	0.272
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.257
GAB1	GRB2-associated binding protein 1	0.247	Fly
NCOA1	nuclear receptor coactivator 1	0.241
NRP1	neuropilin 1	0.226
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.220	Fly
DUSP1	dual specificity phosphatase 1	0.213
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.190	Fly
PPP1R15A	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.179
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.159
SOCS3	suppressor of cytokine signaling 3	0.155
RARA	retinoic acid receptor, alpha	0.154
HIST1H2AE	histone cluster 1, H2ae	0.143
HIST1H2AJ	histone cluster 1, H2aj	0.116
RXRA	retinoid X receptor, alpha	0.109
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.109
HIST1H2BC	histone cluster 1, H2bc	0.105
IL4R	interleukin 4 receptor	0.104
JAK2	Janus kinase 2	0.103
ANG	angiogenin, ribonuclease, RNase A family, 5	0.101	Human Mouse
HIST2H2AA4	histone cluster 2, H2aa4	0.100
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.095
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.095
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.093
RAB11FIP2	RAB11 family interacting protein 2 (class I)	0.089
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.088
IRF2BP1	interferon regulatory factor 2 binding protein 1	0.087
RNASE4	ribonuclease, RNase A family, 4	0.083	Human
PGF	placental growth factor	0.082
IGF1R	insulin-like growth factor 1 receptor	0.077
MAP2K4	mitogen-activated protein kinase kinase 4	0.076
NLRC4	NLR family, CARD domain containing 4	0.076
KDM6B	lysine (K)-specific demethylase 6B	0.070
STAP2	signal transducing adaptor family member 2	0.070
MAPK8	mitogen-activated protein kinase 8	0.067	Fly
EGFR	epidermal growth factor receptor	0.064
IER2	immediate early response 2	0.061
HIST1H2BK	histone cluster 1, H2bk	0.060
TPT1	tumor protein, translationally-controlled 1	0.060
HDAC4	histone deacetylase 4	0.055
CPNE6	copine VI (neuronal)	0.055
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.053	Fly
IRAK2	interleukin-1 receptor-associated kinase 2	0.053
GSK3B	glycogen synthase kinase 3 beta	0.052
VEGFA	vascular endothelial growth factor A	0.052
IL1R1	interleukin 1 receptor, type I	0.051
IRAK1	interleukin-1 receptor-associated kinase 1	0.051
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.051
RYBP	RING1 and YY1 binding protein	0.049
CD28	CD28 molecule	0.049
TNIP2	TNFAIP3 interacting protein 2	0.048
BCAR1	breast cancer anti-estrogen resistance 1	0.046
GAB2	GRB2-associated binding protein 2	0.046	Fly
MED16	mediator complex subunit 16	0.045
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.043
ASF1A	ASF1 anti-silencing function 1 homolog A (S. cerevisiae)	0.042
ZC3H12A	zinc finger CCCH-type containing 12A	0.042
ARID1A	AT rich interactive domain 1A (SWI-like)	0.041
FOSL1	FOS-like antigen 1	0.040	Fly
YY1	YY1 transcription factor	0.039
MEF2C	myocyte enhancer factor 2C	0.039	Fly
HDAC9	histone deacetylase 9	0.038
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.037
SOS2	son of sevenless homolog 2 (Drosophila)	0.036
TCF4	transcription factor 4	0.036
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.035
NMI	N-myc (and STAT) interactor	0.034
IGL@	immunoglobulin lambda locus	0.034
AXL	AXL receptor tyrosine kinase	0.034
HIST1H3H	histone cluster 1, H3h	0.033
XPO7	exportin 7	0.033
TDG	thymine-DNA glycosylase	0.033
GHR	growth hormone receptor	0.033
JDP2	Jun dimerization protein 2	0.033	Fly
ORC1	origin recognition complex, subunit 1	0.032
TFDP2	transcription factor Dp-2 (E2F dimerization partner 2)	0.032
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.032
PGR	progesterone receptor	0.032
SOCS1	suppressor of cytokine signaling 1	0.031
SMAD3	SMAD family member 3	0.031
IRS1	insulin receptor substrate 1	0.031
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.031
MEN1	multiple endocrine neoplasia I	0.031
RAB11FIP1	RAB11 family interacting protein 1 (class I)	0.030
EGR1	early growth response 1	0.030
DDIT3	DNA-damage-inducible transcript 3	0.029
OGT	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	0.029
PKN1	protein kinase N1	0.029
IL1R2	interleukin 1 receptor, type II	0.028
NCOA6	nuclear receptor coactivator 6	0.028
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.027	Fly
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.027
E2F4	E2F transcription factor 4, p107/p130-binding	0.027
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.027
CHMP4B	chromatin modifying protein 4B	0.026
HIST1H2AG	histone cluster 1, H2ag	0.026
MLL3	myeloid/lymphoid or mixed-lineage leukemia 3	0.026
RPS27	ribosomal protein S27	0.025
PPARA	peroxisome proliferator-activated receptor alpha	0.025
TCF12	transcription factor 12	0.025
MPO	myeloperoxidase	0.025
FOSL2	FOS-like antigen 2	0.025	Fly
NCOR2	nuclear receptor corepressor 2	0.024
ARRB1	arrestin, beta 1	0.024
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.024
CCR2	chemokine (C-C motif) receptor 2	0.023
IL2RB	interleukin 2 receptor, beta	0.023
IL1B	interleukin 1, beta	0.022
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.022
CMIP	c-Maf-inducing protein	0.022
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.022
MZB1	marginal zone B and B1 cell-specific protein	0.022
KCNQ1	potassium voltage-gated channel, KQT-like subfamily, member 1	0.021
BPTF	bromodomain PHD finger transcription factor	0.021
ELF4	E74-like factor 4 (ets domain transcription factor)	0.021
HIST2H2BE	histone cluster 2, H2be	0.021
RPL41	ribosomal protein L41	0.020
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.020
MAPK15	mitogen-activated protein kinase 15	0.019
E2F2	E2F transcription factor 2	0.019
BTBD10	BTB (POZ) domain containing 10	0.019
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.019
IGF2	insulin-like growth factor 2 (somatomedin A)	0.018
AKAP2	A kinase (PRKA) anchor protein 2	0.018
HIST1H4H	histone cluster 1, H4h	0.018
S100A9	S100 calcium binding protein A9	0.017
RPL34	ribosomal protein L34	0.017
IGK@	immunoglobulin kappa locus	0.017
HIST1H2AI	histone cluster 1, H2ai	0.016
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.016
DEFA1B	defensin, alpha 1B	0.016
CTSG	cathepsin G	0.016
TMEM173	transmembrane protein 173	0.016
RUNX1	runt-related transcription factor 1	0.016
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.016
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.016
LCN2	lipocalin 2	0.016
PLAUR	plasminogen activator, urokinase receptor	0.016
TSG101	tumor susceptibility gene 101	0.015
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.015
HIST1H2BO	histone cluster 1, H2bo	0.015	Human
PDGFA	platelet-derived growth factor alpha polypeptide	0.015
LRDD	leucine-rich repeats and death domain containing	0.015
NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive	0.015
TICAM2	toll-like receptor adaptor molecule 2	0.015
TBX5	T-box 5	0.015
PTPRB	protein tyrosine phosphatase, receptor type, B	0.015
EPB49	erythrocyte membrane protein band 4.9 (dematin)	0.015
PELI2	pellino homolog 2 (Drosophila)	0.015
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.015	Fly
TLR2	toll-like receptor 2	0.015
RBM4	RNA binding motif protein 4	0.015
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.014
STAT5A	signal transducer and activator of transcription 5A	0.014	Fly
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.014
ELANE	elastase, neutrophil expressed	0.014
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.014	Fly
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.014
HIST1H3G	histone cluster 1, H3g	0.014
KITLG	KIT ligand	0.014
GADD45B	growth arrest and DNA-damage-inducible, beta	0.014
FGL2	fibrinogen-like 2	0.014
MLL2	myeloid/lymphoid or mixed-lineage leukemia 2	0.013
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.013
HIST1H2AM	histone cluster 1, H2am	0.013
MED12	mediator complex subunit 12	0.013
IRF4	interferon regulatory factor 4	0.013
TLK2	tousled-like kinase 2	0.013	Fly
PDCD6	programmed cell death 6	0.013
HIST1H2BM	histone cluster 1, H2bm	0.013	Human
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.013
ICAM1	intercellular adhesion molecule 1	0.013
ZBTB20	zinc finger and BTB domain containing 20	0.013
TNFRSF17	tumor necrosis factor receptor superfamily, member 17	0.013
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.013
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.013
RAI1	retinoic acid induced 1	0.013
ARG1	arginase, liver	0.013
FGFR1	fibroblast growth factor receptor 1	0.013
NCOA2	nuclear receptor coactivator 2	0.013
TLR4	toll-like receptor 4	0.013
CNOT4	CCR4-NOT transcription complex, subunit 4	0.012
CSRNP1	cysteine-serine-rich nuclear protein 1	0.012
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.012
SH3GL2	SH3-domain GRB2-like 2	0.012
ESR1	estrogen receptor 1	0.012
SPTBN1	spectrin, beta, non-erythrocytic 1	0.012
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.012
RBBP5	retinoblastoma binding protein 5	0.012
MYL12B	myosin, light chain 12B, regulatory	0.012
IRAK3	interleukin-1 receptor-associated kinase 3	0.012
ATM	ataxia telangiectasia mutated	0.012
VAMP2	vesicle-associated membrane protein 2 (synaptobrevin 2)	0.012
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.012
CYBB	cytochrome b-245, beta polypeptide	0.011
ITGB1BP1	integrin beta 1 binding protein 1	0.011
ARHGAP32	Rho GTPase activating protein 32	0.011
POU3F3	POU class 3 homeobox 3	0.011	Fly
IL2RG	interleukin 2 receptor, gamma	0.011
RNASE3	ribonuclease, RNase A family, 3	0.011
MYD88	myeloid differentiation primary response gene (88)	0.011	Fly
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.011
RNH1	ribonuclease/angiogenin inhibitor 1	0.011
HIST1H2AL	histone cluster 1, H2al	0.011
MDC1	mediator of DNA-damage checkpoint 1	0.011
BPI	bactericidal/permeability-increasing protein	0.011
CD19	CD19 molecule	0.011
TGM3	transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.011
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.010
SOX21	SRY (sex determining region Y)-box 21	0.010
PRUNE	prune homolog (Drosophila)	0.010
DUSP8	dual specificity phosphatase 8	0.010
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.010
PRKD2	protein kinase D2	0.010