IMP

Process View

Homo sapiens

19 genes annotated in human

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains" (in gray)

Name	Description	Probability	Func Analog Organism
HLA-A	major histocompatibility complex, class I, A	0.968
HLA-G	major histocompatibility complex, class I, G	0.963	Human
HLA-C	major histocompatibility complex, class I, C	0.961	Human
B2M	beta-2-microglobulin	0.945	Mouse
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.893
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.862
HLA-E	major histocompatibility complex, class I, E	0.838	Human
IL4R	interleukin 4 receptor	0.803
HLA-B	major histocompatibility complex, class I, B	0.763
TRAF2	TNF receptor-associated factor 2	0.712
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.634
BIRC3	baculoviral IAP repeat containing 3	0.607
TAPBP	TAP binding protein (tapasin)	0.568
CD40	CD40 molecule, TNF receptor superfamily member 5	0.496	Mouse Rat
HLA-F	major histocompatibility complex, class I, F	0.472	Human
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.350
TRAF6	TNF receptor-associated factor 6	0.345
SYK	spleen tyrosine kinase	0.260
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.233
CCR5	chemokine (C-C motif) receptor 5	0.204
CCL5	chemokine (C-C motif) ligand 5	0.181	Human
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.174
CCL4	chemokine (C-C motif) ligand 4	0.141	Human
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	0.141
GRAP2	GRB2-related adaptor protein 2	0.126
TRAF1	TNF receptor-associated factor 1	0.109	Human
TRAF3	TNF receptor-associated factor 3	0.108	Human
BIRC2	baculoviral IAP repeat containing 2	0.080
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.076
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.075
CXCL9	chemokine (C-X-C motif) ligand 9	0.075
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.074
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.074
CXCL11	chemokine (C-X-C motif) ligand 11	0.073
IL2RG	interleukin 2 receptor, gamma	0.065
ZMYND11	zinc finger, MYND-type containing 11	0.063
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.058
PVRL4	poliovirus receptor-related 4	0.056
TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.055	Mouse Rat
IL23A	interleukin 23, alpha subunit p19	0.053
ICAM1	intercellular adhesion molecule 1	0.052
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.048
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.046
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.045
VAMP4	vesicle-associated membrane protein 4	0.041
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.041
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.039
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.034
CCR7	chemokine (C-C motif) receptor 7	0.033
HLA-DMB	major histocompatibility complex, class II, DM beta	0.031
CCL22	chemokine (C-C motif) ligand 22	0.030	Human
PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	0.029
CCL8	chemokine (C-C motif) ligand 8	0.029	Human
TPP1	tripeptidyl peptidase I	0.028
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.027
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.026	Human
TRADD	TNFRSF1A-associated via death domain	0.025
NUMBL	numb homolog (Drosophila)-like	0.024
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.023
CXCL10	chemokine (C-X-C motif) ligand 10	0.022
CCL19	chemokine (C-C motif) ligand 19	0.022	Human Mouse
CCL3	chemokine (C-C motif) ligand 3	0.021	Human
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.021
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.021
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.020
GLRX3	glutaredoxin 3	0.020
CFH	complement factor H	0.020
LCK	lymphocyte-specific protein tyrosine kinase	0.019
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.019
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.019
TRAF5	TNF receptor-associated factor 5	0.018	Human
CD48	CD48 molecule	0.017
IL2RB	interleukin 2 receptor, beta	0.017
DPP4	dipeptidyl-peptidase 4	0.017
LMO2	LIM domain only 2 (rhombotin-like 1)	0.017
IDE	insulin-degrading enzyme	0.016
CCR1	chemokine (C-C motif) receptor 1	0.016
IL4	interleukin 4	0.016	Mouse
PVRL3	poliovirus receptor-related 3	0.016	Human
CCL13	chemokine (C-C motif) ligand 13	0.016	Human
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.016
CXCL13	chemokine (C-X-C motif) ligand 13	0.015
TNF	tumor necrosis factor	0.015
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.014
CD22	CD22 molecule	0.014
IRF4	interferon regulatory factor 4	0.014
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.014
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.014
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.014
TNFRSF17	tumor necrosis factor receptor superfamily, member 17	0.014
DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.013
ENG	endoglin	0.013
IL10RA	interleukin 10 receptor, alpha	0.013
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.013
CCL2	chemokine (C-C motif) ligand 2	0.013	Human
CCR4	chemokine (C-C motif) receptor 4	0.013
IL8	interleukin 8	0.012
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.012	Mouse
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.012
PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	0.012
TGFB3	transforming growth factor, beta 3	0.012
CCL7	chemokine (C-C motif) ligand 7	0.011	Human
NSF	N-ethylmaleimide-sensitive factor	0.011
BCL10	B-cell CLL/lymphoma 10	0.011
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.011
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.011
CARD11	caspase recruitment domain family, member 11	0.011
EBI3	Epstein-Barr virus induced 3	0.010
IL6	interleukin 6 (interferon, beta 2)	0.010