IMP

Process View

Homo sapiens

4 genes annotated in human

Multi-species View

regulation of endothelial cell differentiation

GO:0045601

Any process that modulates the frequency, rate or extent of endothelial cell differentiation.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of endothelial cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of endothelial cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
NRP1	neuropilin 1	1.000
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.990	Mouse
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.958
JAG1	jagged 1	0.944
CDH5	cadherin 5, type 2 (vascular endothelium)	0.936
VEGFA	vascular endothelial growth factor A	0.820	Mouse
CNOT8	CCR4-NOT transcription complex, subunit 8	0.738
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.687
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.650
NOTCH3	notch 3	0.640
FBXW11	F-box and WD repeat domain containing 11	0.537
SMAD2	SMAD family member 2	0.520
TCF4	transcription factor 4	0.479
PGF	placental growth factor	0.468
ERBB2IP	erbb2 interacting protein	0.434
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.402
GATA2	GATA binding protein 2	0.386
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.380
SMAD4	SMAD family member 4	0.357
RUNX1	runt-related transcription factor 1	0.353
APC	adenomatous polyposis coli	0.291
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.257
PTPRB	protein tyrosine phosphatase, receptor type, B	0.241
KRT5	keratin 5	0.232
ENG	endoglin	0.210
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.201
MAML1	mastermind-like 1 (Drosophila)	0.184
PNRC1	proline-rich nuclear receptor coactivator 1	0.165
SMAD7	SMAD family member 7	0.150
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.138
DDIT4	DNA-damage-inducible transcript 4	0.137
ZFYVE9	zinc finger, FYVE domain containing 9	0.133
XIAP	X-linked inhibitor of apoptosis	0.125
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.122
FKBP1A	FK506 binding protein 1A, 12kDa	0.110
NFIL3	nuclear factor, interleukin 3 regulated	0.104
JAG2	jagged 2	0.096
DLL1	delta-like 1 (Drosophila)	0.094
JUP	junction plakoglobin	0.091
PEX1	peroxisomal biogenesis factor 1	0.088
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.081
BTRC	beta-transducin repeat containing	0.080
TP63	tumor protein p63	0.079
E2F1	E2F transcription factor 1	0.078
FLT4	fms-related tyrosine kinase 4	0.077
CTNND1	catenin (cadherin-associated protein), delta 1	0.072
GLIS2	GLIS family zinc finger 2	0.066
CNOT6L	CCR4-NOT transcription complex, subunit 6-like	0.064
FERMT2	fermitin family member 2	0.063
PSEN1	presenilin 1	0.060
AR	androgen receptor	0.058
YAP1	Yes-associated protein 1	0.055
LYL1	lymphoblastic leukemia derived sequence 1	0.055
NOTCH2	notch 2	0.052
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.051
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.051
CREBBP	CREB binding protein	0.050
FOXO1	forkhead box O1	0.047
SHB	Src homology 2 domain containing adaptor protein B	0.047
TCF12	transcription factor 12	0.046
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.046
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.045
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.045
GATAD1	GATA zinc finger domain containing 1	0.043
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.043
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.042
SMAD1	SMAD family member 1	0.041
BTG2	BTG family, member 2	0.041	Human
CNOT1	CCR4-NOT transcription complex, subunit 1	0.041
NCOA2	nuclear receptor coactivator 2	0.040
AXIN1	axin 1	0.039
STC1	stanniocalcin 1	0.038
EMD	emerin	0.038
CDK6	cyclin-dependent kinase 6	0.037
SMAD3	SMAD family member 3	0.036
BMPR1A	bone morphogenetic protein receptor, type IA	0.035
MCPH1	microcephalin 1	0.035
GFI1B	growth factor independent 1B transcription repressor	0.033
PKP4	plakophilin 4	0.033
EGFL7	EGF-like-domain, multiple 7	0.033
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.032
BTG1	B-cell translocation gene 1, anti-proliferative	0.032
NDRG1	N-myc downstream regulated 1	0.030
FZD4	frizzled homolog 4 (Drosophila)	0.030
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.029
LEF1	lymphoid enhancer-binding factor 1	0.028
CD34	CD34 molecule	0.028
EP300	E1A binding protein p300	0.028
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.028
NCOR2	nuclear receptor corepressor 2	0.027
GP1BA	glycoprotein Ib (platelet), alpha polypeptide	0.026
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.026
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.026
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.025
ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2	0.025
LDLR	low density lipoprotein receptor	0.025
DOCK8	dedicator of cytokinesis 8	0.025
SPECC1L	sperm antigen with calponin homology and coiled-coil domains 1-like	0.025
GSK3B	glycogen synthase kinase 3 beta	0.024
HIPK2	homeodomain interacting protein kinase 2	0.024
KIAA0528	KIAA0528	0.024
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.024
ETAA1	Ewing tumor-associated antigen 1	0.024
APP	amyloid beta (A4) precursor protein	0.023
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.023
HES1	hairy and enhancer of split 1, (Drosophila)	0.023
NOTCH1	notch 1	0.023	Rat
TUBA1A	tubulin, alpha 1a	0.023
NCOA6	nuclear receptor coactivator 6	0.022
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.022
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.022	Mouse
HOXB7	homeobox B7	0.022
VWF	von Willebrand factor	0.022
GJA4	gap junction protein, alpha 4, 37kDa	0.021
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.021
ANTXR2	anthrax toxin receptor 2	0.021
BMP6	bone morphogenetic protein 6	0.021	Mouse
TCF7	transcription factor 7 (T-cell specific, HMG-box)	0.020
PRKCE	protein kinase C, epsilon	0.020
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.020
HOXB9	homeobox B9	0.020
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.019
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.019
TOB1	transducer of ERBB2, 1	0.019
EFNB2	ephrin-B2	0.019
GFRA4	GDNF family receptor alpha 4	0.019
RGS16	regulator of G-protein signaling 16	0.018
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.018
CTDSP2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	0.018
BHLHE40	basic helix-loop-helix family, member e40	0.018
FOXF1	forkhead box F1	0.018
RAMP3	receptor (G protein-coupled) activity modifying protein 3	0.017
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.017
PPAP2B	phosphatidic acid phosphatase type 2B	0.017
SLC28A3	solute carrier family 28 (sodium-coupled nucleoside transporter), member 3	0.017
EMCN	endomucin	0.017
TXNIP	thioredoxin interacting protein	0.017
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.016
STARD8	StAR-related lipid transfer (START) domain containing 8	0.016
EZR	ezrin	0.016
KAT2B	K(lysine) acetyltransferase 2B	0.016
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.016
GATA3	GATA binding protein 3	0.016
ZFPM1	zinc finger protein, multitype 1	0.016
KLF2	Kruppel-like factor 2 (lung)	0.016
CHIA	chitinase, acidic	0.016
CALCRL	calcitonin receptor-like	0.016
ICAM2	intercellular adhesion molecule 2	0.016
FGFR1	fibroblast growth factor receptor 1	0.016
ACVR1B	activin A receptor, type IB	0.016
PTK7	PTK7 protein tyrosine kinase 7	0.015
PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	0.015
CTNNBIP1	catenin, beta interacting protein 1	0.015
SLC5A1	solute carrier family 5 (sodium/glucose cotransporter), member 1	0.015
SDPR	serum deprivation response	0.015
HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.015
FOXA1	forkhead box A1	0.015
POPDC2	popeye domain containing 2	0.015
TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	0.015
ANGPT2	angiopoietin 2	0.015
CRHR2	corticotropin releasing hormone receptor 2	0.015
HS3ST2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	0.015
SOX17	SRY (sex determining region Y)-box 17	0.015
GATAD2B	GATA zinc finger domain containing 2B	0.014
LMO2	LIM domain only 2 (rhombotin-like 1)	0.014
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.014
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.014
KRT1	keratin 1	0.014
SERTAD2	SERTA domain containing 2	0.014
PRKCI	protein kinase C, iota	0.014
ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	0.014
HSD17B3	hydroxysteroid (17-beta) dehydrogenase 3	0.014
CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	0.014
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.014
SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	0.014
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.014
SLCO2A1	solute carrier organic anion transporter family, member 2A1	0.014
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.014
VEGFC	vascular endothelial growth factor C	0.014
CD5	CD5 molecule	0.014
PF4	platelet factor 4	0.014
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.014
POU2F2	POU class 2 homeobox 2	0.014
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.013
GPR12	G protein-coupled receptor 12	0.013	Human
GAB2	GRB2-associated binding protein 2	0.013
FUT1	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)	0.013
WNT10B	wingless-type MMTV integration site family, member 10B	0.013
BMP2	bone morphogenetic protein 2	0.013
ZNF623	zinc finger protein 623	0.013
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.013
FOXO3	forkhead box O3	0.013
LMNA	lamin A/C	0.013
SCUBE2	signal peptide, CUB domain, EGF-like 2	0.013
EFNA1	ephrin-A1	0.013
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.013
GFRA3	GDNF family receptor alpha 3	0.013
IER5	immediate early response 5	0.013
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.013
MYL4	myosin, light chain 4, alkali; atrial, embryonic	0.013
TNIP1	TNFAIP3 interacting protein 1	0.013
TEK	TEK tyrosine kinase, endothelial	0.013
IER2	immediate early response 2	0.013
FOXI1	forkhead box I1	0.013
COLEC12	collectin sub-family member 12	0.013
IL1R1	interleukin 1 receptor, type I	0.013
KRT13	keratin 13	0.013
FSTL1	follistatin-like 1	0.013
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.013
PTPRG	protein tyrosine phosphatase, receptor type, G	0.013
ICAM4	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	0.012
BMP4	bone morphogenetic protein 4	0.012	Mouse
JAM2	junctional adhesion molecule 2	0.012
ATXN1L	ataxin 1-like	0.012
GREM1	gremlin 1	0.012
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.012
TERT	telomerase reverse transcriptase	0.012
MAL	mal, T-cell differentiation protein	0.012
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.012
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.012
NIN	ninein (GSK3B interacting protein)	0.012
LRP6	low density lipoprotein receptor-related protein 6	0.012
PDE4B	phosphodiesterase 4B, cAMP-specific	0.012
FGF4	fibroblast growth factor 4	0.012
CTSE	cathepsin E	0.012
DLL4	delta-like 4 (Drosophila)	0.012
HYAL1	hyaluronoglucosaminidase 1	0.012
MMRN2	multimerin 2	0.012
MFNG	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.012
GNAI1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	0.012
NRP2	neuropilin 2	0.012
CCNL1	cyclin L1	0.012
LYVE1	lymphatic vessel endothelial hyaluronan receptor 1	0.012
PRRG4	proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)	0.012
ZNF835	zinc finger protein 835	0.012
ANKIB1	ankyrin repeat and IBR domain containing 1	0.012
BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)	0.012
LMO1	LIM domain only 1 (rhombotin 1)	0.012
CNOT7	CCR4-NOT transcription complex, subunit 7	0.012
RYK	RYK receptor-like tyrosine kinase	0.012
TRIB1	tribbles homolog 1 (Drosophila)	0.012
ZNF302	zinc finger protein 302	0.012
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.012
ZFP36L2	zinc finger protein 36, C3H type-like 2	0.012
KIAA1191	KIAA1191	0.012
KLC4	kinesin light chain 4	0.012
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.012
TRIM33	tripartite motif containing 33	0.012
RASGRP2	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	0.012
VCL	vinculin	0.012
PIPOX	pipecolic acid oxidase	0.011
DIABLO	diablo, IAP-binding mitochondrial protein	0.011
MAGED1	melanoma antigen family D, 1	0.011
ADORA2A	adenosine A2a receptor	0.011
TSC22D3	TSC22 domain family, member 3	0.011
PRKG1	protein kinase, cGMP-dependent, type I	0.011
VLDLR	very low density lipoprotein receptor	0.011
S1PR2	sphingosine-1-phosphate receptor 2	0.011
SLC6A8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	0.011
FAM116A	family with sequence similarity 116, member A	0.011
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.011
MKNK2	MAP kinase interacting serine/threonine kinase 2	0.011
NOS3	nitric oxide synthase 3 (endothelial cell)	0.011
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.011
PRDM12	PR domain containing 12	0.011
YY1	YY1 transcription factor	0.011
CXCR7	chemokine (C-X-C motif) receptor 7	0.011
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.011
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.011
GABRA4	gamma-aminobutyric acid (GABA) A receptor, alpha 4	0.011
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.011
SNAI1	snail homolog 1 (Drosophila)	0.011
DRD2	dopamine receptor D2	0.011
PITPNM3	PITPNM family member 3	0.011
VPREB3	pre-B lymphocyte 3	0.011
RHOB	ras homolog gene family, member B	0.011
PDK4	pyruvate dehydrogenase kinase, isozyme 4	0.011
STC2	stanniocalcin 2	0.011
PIK3IP1	phosphoinositide-3-kinase interacting protein 1	0.011
ASCL1	achaete-scute complex homolog 1 (Drosophila)	0.011
GPR182	G protein-coupled receptor 182	0.011
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.011
SUMF2	sulfatase modifying factor 2	0.011
HOXB13	homeobox B13	0.011
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.011
PDZK1IP1	PDZK1 interacting protein 1	0.011
KRT14	keratin 14	0.011
PNOC	prepronociceptin	0.011
KIAA0174	KIAA0174	0.011
ROR1	receptor tyrosine kinase-like orphan receptor 1	0.011
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.011
GPR124	G protein-coupled receptor 124	0.011
FAT4	FAT tumor suppressor homolog 4 (Drosophila)	0.011
DPY19L4	dpy-19-like 4 (C. elegans)	0.011
FCHO1	FCH domain only 1	0.011
RAB11FIP4	RAB11 family interacting protein 4 (class II)	0.011
GPR27	G protein-coupled receptor 27	0.011
SPTB	spectrin, beta, erythrocytic	0.011
PAPSS2	3'-phosphoadenosine 5'-phosphosulfate synthase 2	0.011
ERRFI1	ERBB receptor feedback inhibitor 1	0.011
CTRL	chymotrypsin-like	0.011
FOLR3	folate receptor 3 (gamma)	0.011
FAM107A	family with sequence similarity 107, member A	0.011
SESN2	sestrin 2	0.011
CEP170	centrosomal protein 170kDa	0.011
HBD	hemoglobin, delta	0.011
CRHBP	corticotropin releasing hormone binding protein	0.010
GTPBP2	GTP binding protein 2	0.010
SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	0.010
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.010
MSH3	mutS homolog 3 (E. coli)	0.010
AOC2	amine oxidase, copper containing 2 (retina-specific)	0.010
BNC1	basonuclin 1	0.010
EPHA4	EPH receptor A4	0.010
SIK1	salt-inducible kinase 1	0.010
GPX2	glutathione peroxidase 2 (gastrointestinal)	0.010
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	0.010
CA4	carbonic anhydrase IV	0.010
IL3RA	interleukin 3 receptor, alpha (low affinity)	0.010
TNFSF9	tumor necrosis factor (ligand) superfamily, member 9	0.010
CETP	cholesteryl ester transfer protein, plasma	0.010
CLC	Charcot-Leyden crystal protein	0.010
PF4V1	platelet factor 4 variant 1	0.010
FIGF	c-fos induced growth factor (vascular endothelial growth factor D)	0.010
CIR1	corepressor interacting with RBPJ, 1	0.010
GIMAP7	GTPase, IMAP family member 7	0.010
SOX7	SRY (sex determining region Y)-box 7	0.010
JAM3	junctional adhesion molecule 3	0.010
KANK3	KN motif and ankyrin repeat domains 3	0.010
EDNRB	endothelin receptor type B	0.010
CSHL1	chorionic somatomammotropin hormone-like 1	0.010
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.010
TCL1A	T-cell leukemia/lymphoma 1A	0.010
TBXA2R	thromboxane A2 receptor	0.010
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.010
APAF1	apoptotic peptidase activating factor 1	0.010
ACSS3	acyl-CoA synthetase short-chain family member 3	0.010
MTMR4	myotubularin related protein 4	0.010
BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	0.010
THBD	thrombomodulin	0.010
PGC	progastricsin (pepsinogen C)	0.010
FOXN1	forkhead box N1	0.010
CCIN	calicin	0.010
NCSTN	nicastrin	0.010
MYLIP	myosin regulatory light chain interacting protein	0.010
NFE2	nuclear factor (erythroid-derived 2), 45kDa	0.010
TRIM9	tripartite motif containing 9	0.010
F10	coagulation factor X	0.010
LPAR3	lysophosphatidic acid receptor 3	0.010	Human
RALGPS2	Ral GEF with PH domain and SH3 binding motif 2	0.010
KL	klotho	0.010
ABCA6	ATP-binding cassette, sub-family A (ABC1), member 6	0.010
RHCE	Rh blood group, CcEe antigens	0.010
GSTT1	glutathione S-transferase theta 1	0.010
CD248	CD248 molecule, endosialin	0.010