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Mus musculus

0 genes annotated in mouse

lysosomal storage disease

DOID:3211

An inherited metabolic disorder that involve an abnormal accumulation of substances inside the lysosome resulting from defects in lysosomal function.

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "lysosomal storage disease" (in gray)

Name	Description	Probability	Func Analog Organism
Ctsb	cathepsin B	0.993
Lamp1	lysosomal-associated membrane protein 1	0.984
Hexa	hexosaminidase A	0.983	Human
Gns	glucosamine (N-acetyl)-6-sulfatase	0.969	Human
Hexb	hexosaminidase B	0.966	Human
0610031J06Rik	RIKEN cDNA 0610031J06 gene	0.958
Npc2	Niemann Pick type C2	0.878	Human
Dpp7	dipeptidylpeptidase 7	0.849
Idua	iduronidase, alpha-L-	0.839
Grn	granulin	0.837	Human
Psap	prosaposin	0.832	Human
Lgmn	legumain	0.827
Ctsd	cathepsin D	0.820	Human
Ctsa	cathepsin A	0.786
Gba	glucosidase, beta, acid	0.777	Human
Tpp1	tripeptidyl peptidase I	0.700	Human
Asah1	N-acylsphingosine amidohydrolase 1	0.666	Human
Itm2b	integral membrane protein 2B	0.613
Coro1b	coronin, actin binding protein 1B	0.502
Atp6ap1	ATPase, H+ transporting, lysosomal accessory protein 1	0.480
Ctsz	cathepsin Z	0.457
Pld3	phospholipase D family, member 3	0.442
Lepr	leptin receptor	0.401
Mfsd1	major facilitator superfamily domain containing 1	0.352
Man2b1	mannosidase 2, alpha B1	0.345	Human
Tcn2	transcobalamin 2	0.324
Itm2c	integral membrane protein 2C	0.281
Lamp2	lysosomal-associated membrane protein 2	0.266	Human
Rragc	Ras-related GTP binding C	0.237
Naga	N-acetyl galactosaminidase, alpha	0.225
Atp6v0d1	ATPase, H+ transporting, lysosomal V0 subunit D1	0.208
Gusb	glucuronidase, beta	0.195
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.170
Lrp1	low density lipoprotein receptor-related protein 1	0.159
Naglu	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	0.146
Atp6ap2	ATPase, H+ transporting, lysosomal accessory protein 2	0.145
Pold4	polymerase (DNA-directed), delta 4	0.145
Manba	mannosidase, beta A, lysosomal	0.144
Dscr3	Down syndrome critical region gene 3	0.133
Scarb2	scavenger receptor class B, member 2	0.131
Ghr	growth hormone receptor	0.121
Atp6v0b	ATPase, H+ transporting, lysosomal V0 subunit B	0.121
Prnp	prion protein	0.118
Sumf1	sulfatase modifying factor 1	0.116	Human
Lyz2	lysozyme 2	0.111
Shisa5	shisa homolog 5 (Xenopus laevis)	0.110
Soat1	sterol O-acyltransferase 1	0.100
Ctsh	cathepsin H	0.099
Scpep1	serine carboxypeptidase 1	0.090
Apoe	apolipoprotein E	0.083	Human
Kiss1	KiSS-1 metastasis-suppressor	0.077
Fuca1	fucosidase, alpha-L- 1, tissue	0.073	Human
Itgb5	integrin beta 5	0.073
Abcg1	ATP-binding cassette, sub-family G (WHITE), member 1	0.070
Myo7a	myosin VIIA	0.065
Gaa	glucosidase, alpha, acid	0.061
Lipa	lysosomal acid lipase A	0.061
Hgsnat	heparan-alpha-glucosaminide N-acetyltransferase	0.061
2010106G01Rik	RIKEN cDNA 2010106G01 gene	0.060
Rnh1	ribonuclease/angiogenin inhibitor 1	0.060
Cst3	cystatin C	0.059
Leprot	leptin receptor overlapping transcript	0.057
Kif3b	kinesin family member 3B	0.054
Hsd3b7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.050
Clcn5	chloride channel 5	0.049
Npc1	Niemann Pick type C1	0.047	Human
Glb1	galactosidase, beta 1	0.047	Human
Pttg1ip	pituitary tumor-transforming 1 interacting protein	0.047
Nucb1	nucleobindin 1	0.047
Gpr116	G protein-coupled receptor 116	0.046
Gm2a	GM2 ganglioside activator protein	0.043	Human
Creg1	cellular repressor of E1A-stimulated genes 1	0.040
Ctsl	cathepsin L	0.038
Vkorc1	vitamin K epoxide reductase complex, subunit 1	0.038
Kdelr1	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1	0.036
Pten	phosphatase and tensin homolog	0.034
C1qa	complement component 1, q subcomponent, alpha polypeptide	0.034
Uap1l1	UDP-N-acteylglucosamine pyrophosphorylase 1-like 1	0.034
Aga	aspartylglucosaminidase	0.034
Cstb	cystatin B	0.033
Cdipt	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)	0.033
Rnase4	ribonuclease, RNase A family 4	0.031
Scd1	stearoyl-Coenzyme A desaturase 1	0.031
Adam9	a disintegrin and metallopeptidase domain 9 (meltrin gamma)	0.031
Anxa5	annexin A5	0.030
Lrpap1	low density lipoprotein receptor-related protein associated protein 1	0.029
Tyrobp	TYRO protein tyrosine kinase binding protein	0.029
Ppt1	palmitoyl-protein thioesterase 1	0.029
Tmem176b	transmembrane protein 176B	0.028
Vamp8	vesicle-associated membrane protein 8	0.027
Sat1	spermidine/spermine N1-acetyl transferase 1	0.027
App	amyloid beta (A4) precursor protein	0.026
Cndp2	CNDP dipeptidase 2 (metallopeptidase M20 family)	0.026
Ldlr	low density lipoprotein receptor	0.026
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.026
Rab7l1	RAB7, member RAS oncogene family-like 1	0.026
Klraq1	KLRAQ motif containing 1	0.025
Glg1	golgi apparatus protein 1	0.025
Arsa	arylsulfatase A	0.024
Cyba	cytochrome b-245, alpha polypeptide	0.024
Txndc16	thioredoxin domain containing 16	0.024
Mecp2	methyl CpG binding protein 2	0.024
Anxa4	annexin A4	0.023
Iah1	isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)	0.023
Renbp	renin binding protein	0.023
Sepp1	selenoprotein P, plasma, 1	0.022
Pltp	phospholipid transfer protein	0.022
Degs1	degenerative spermatocyte homolog 1 (Drosophila)	0.022
C1qc	complement component 1, q subcomponent, C chain	0.022
Csf1r	colony stimulating factor 1 receptor	0.022
Abhd12	abhydrolase domain containing 12	0.022
Gpr137b	G protein-coupled receptor 137B	0.022
Atp6v0e	ATPase, H+ transporting, lysosomal V0 subunit E	0.022
Man2a1	mannosidase 2, alpha 1	0.022
Hsd17b11	hydroxysteroid (17-beta) dehydrogenase 11	0.022
Btd	biotinidase	0.022
Tmub2	transmembrane and ubiquitin-like domain containing 2	0.021
Tmem176a	transmembrane protein 176A	0.021
Irs2	insulin receptor substrate 2	0.021
Sgpl1	sphingosine phosphate lyase 1	0.021
1110003E01Rik	RIKEN cDNA 1110003E01 gene	0.020
Cd68	CD68 antigen	0.020
Pla2g15	phospholipase A2, group XV	0.020
Plin2	perilipin 2	0.020
P2rx4	purinergic receptor P2X, ligand-gated ion channel 4	0.019
Dscaml1	Down syndrome cell adhesion molecule-like 1	0.019
Cyp4v3	cytochrome P450, family 4, subfamily v, polypeptide 3	0.019
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.019
Foxo3	forkhead box O3	0.019
Ifngr1	interferon gamma receptor 1	0.019
Pros1	protein S (alpha)	0.019
Tmbim6	transmembrane BAX inhibitor motif containing 6	0.018
Tmem19	transmembrane protein 19	0.018
Stx7	syntaxin 7	0.018
Dap	death-associated protein	0.018
Tmed10	transmembrane emp24-like trafficking protein 10 (yeast)	0.018
Mertk	c-mer proto-oncogene tyrosine kinase	0.018
Itfg3	integrin alpha FG-GAP repeat containing 3	0.018
Elovl1	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1	0.017
Vhl	von Hippel-Lindau tumor suppressor	0.017
Sh3bgrl3	SH3 domain binding glutamic acid-rich protein-like 3	0.017
Tm7sf3	transmembrane 7 superfamily member 3	0.017
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.017
Cpt1a	carnitine palmitoyltransferase 1a, liver	0.017
Nhlrc3	NHL repeat containing 3	0.017
Usp12	ubiquitin specific peptidase 12	0.017
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.016
Ndfip1	Nedd4 family interacting protein 1	0.016
Braf	Braf transforming gene	0.016
Daglb	diacylglycerol lipase, beta	0.016
Acp2	acid phosphatase 2, lysosomal	0.016
Ostm1	osteopetrosis associated transmembrane protein 1	0.016
Stx4a	syntaxin 4A (placental)	0.016
Arf3	ADP-ribosylation factor 3	0.015
Capns1	calpain, small subunit 1	0.015
Tmem9b	TMEM9 domain family, member B	0.015
Abcd1	ATP-binding cassette, sub-family D (ALD), member 1	0.015
Apc	adenomatosis polyposis coli	0.015
Aplp2	amyloid beta (A4) precursor-like protein 2	0.015
Tmem50a	transmembrane protein 50A	0.015
Pcyox1	prenylcysteine oxidase 1	0.015
Siae	sialic acid acetylesterase	0.015
Tmem111	transmembrane protein 111	0.015
Akr1a4	aldo-keto reductase family 1, member A4 (aldehyde reductase)	0.015
Mfge8	milk fat globule-EGF factor 8 protein	0.014
C1qb	complement component 1, q subcomponent, beta polypeptide	0.014
Ern1	endoplasmic reticulum (ER) to nucleus signalling 1	0.014
Abhd4	abhydrolase domain containing 4	0.014
4930471M23Rik	RIKEN cDNA 4930471M23 gene	0.014
Scamp2	secretory carrier membrane protein 2	0.013
2310044H10Rik	RIKEN cDNA 2310044H10 gene	0.013
Tk2	thymidine kinase 2, mitochondrial	0.013
Tsc1	tuberous sclerosis 1	0.013
Lass2	LAG1 homolog, ceramide synthase 2	0.013
Serpinb6a	serine (or cysteine) peptidase inhibitor, clade B, member 6a	0.013
Prkar2a	protein kinase, cAMP dependent regulatory, type II alpha	0.013
Fkbp15	FK506 binding protein 15	0.013
Clta	clathrin, light polypeptide (Lca)	0.013
Cmtm6	CKLF-like MARVEL transmembrane domain containing 6	0.013
Cln5	ceroid-lipofuscinosis, neuronal 5	0.013
0610007C21Rik	RIKEN cDNA 0610007C21 gene	0.013
Atp6v0c	ATPase, H+ transporting, lysosomal V0 subunit C	0.013
D6Wsu116e	DNA segment, Chr 6, Wayne State University 116, expressed	0.013
Vps41	vacuolar protein sorting 41 (yeast)	0.013
Ftl1	ferritin light chain 1	0.013
Ergic3	ERGIC and golgi 3	0.013
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.012
Man2b2	mannosidase 2, alpha B2	0.012
Galc	galactosylceramidase	0.012
Ccpg1	cell cycle progression 1	0.012
C3	complement component 3	0.012
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.012
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.012
Ctss	cathepsin S	0.012
Rnaset2a	ribonuclease T2A	0.012
Mid1	midline 1	0.012
Gabarap	gamma-aminobutyric acid receptor associated protein	0.012
Ncoa2	nuclear receptor coactivator 2	0.012
Grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.012
Pqlc3	PQ loop repeat containing	0.012
Cyfip1	cytoplasmic FMR1 interacting protein 1	0.012
Zfp398	zinc finger protein 398	0.012
Eps8	epidermal growth factor receptor pathway substrate 8	0.012
Sdf2	stromal cell derived factor 2	0.011
Dnase1l1	deoxyribonuclease 1-like 1	0.011
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.011
Yipf3	Yip1 domain family, member 3	0.011
Slc9a3r1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.011
Tex264	testis expressed gene 264	0.011
Fcgrt	Fc receptor, IgG, alpha chain transporter	0.011
Slc38a6	solute carrier family 38, member 6	0.011
Wdr81	WD repeat domain 81	0.011
Adam17	a disintegrin and metallopeptidase domain 17	0.011
Tspyl1	testis-specific protein, Y-encoded-like 1	0.011
Fam63a	family with sequence similarity 63, member A	0.011
Slc30a7	solute carrier family 30 (zinc transporter), member 7	0.011
Angptl4	angiopoietin-like 4	0.011
Sgpp1	sphingosine-1-phosphate phosphatase 1	0.011
Mcfd2	multiple coagulation factor deficiency 2	0.011
Scarb1	scavenger receptor class B, member 1	0.010
Sdcbp	syndecan binding protein	0.010
Nagk	N-acetylglucosamine kinase	0.010
Smpdl3a	sphingomyelin phosphodiesterase, acid-like 3A	0.010
Slc24a6	solute carrier family 24 (sodium/potassium/calcium exchanger), member 6	0.010
Ctns	cystinosis, nephropathic	0.010
Ssfa2	sperm specific antigen 2	0.010
Gnptab	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	0.010
Syap1	synapse associated protein 1	0.010
Snx27	sorting nexin family member 27	0.010
Man1a	mannosidase 1, alpha	0.010
Plbd2	phospholipase B domain containing 2	0.010
Hebp1	heme binding protein 1	0.010
Rasgrp1	RAS guanyl releasing protein 1	0.010
Nucb2	nucleobindin 2	0.010
Rnf103	ring finger protein 103	0.010
Tep1	telomerase associated protein 1	0.010