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Process View

Mus musculus

16 genes annotated in mouse

enteroendocrine cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "enteroendocrine cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "enteroendocrine cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	0.999
Otx2	orthodenticle homolog 2 (Drosophila)	0.996
Emx1	empty spiracles homolog 1 (Drosophila)	0.986
Neurod1	neurogenic differentiation 1	0.951
Fgf8	fibroblast growth factor 8	0.949
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.927	Mouse
Pax2	paired box gene 2	0.923
Foxc1	forkhead box C1	0.907
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.876
Hand1	heart and neural crest derivatives expressed transcript 1	0.866	Mouse
Gli3	GLI-Kruppel family member GLI3	0.860
Bmp4	bone morphogenetic protein 4	0.850	Human
Lhx3	LIM homeobox protein 3	0.842
Sox9	SRY-box containing gene 9	0.840
Isl1	ISL1 transcription factor, LIM/homeodomain	0.826	Zebrafish
Hand2	heart and neural crest derivatives expressed transcript 2	0.773	Mouse
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.770
Lhx1	LIM homeobox protein 1	0.741
Pax8	paired box gene 8	0.662
Pitx2	paired-like homeodomain transcription factor 2	0.659
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.627
Gata4	GATA binding protein 4	0.593	Mouse
Fgfr2	fibroblast growth factor receptor 2	0.592
Wnt3a	wingless-related MMTV integration site 3A	0.555	Mouse
Lhx5	LIM homeobox protein 5	0.539
Pax3	paired box gene 3	0.534
Gli2	GLI-Kruppel family member GLI2	0.525
Emx2	empty spiracles homolog 2 (Drosophila)	0.513
Clock	circadian locomotor output cycles kaput	0.503
Insm1	insulinoma-associated 1	0.483
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.483
Tbx1	T-box 1	0.473
Nog	noggin	0.472
Foxa2	forkhead box A2	0.454
Gata6	GATA binding protein 6	0.446
Pax6	paired box gene 6	0.422
Sox2	SRY-box containing gene 2	0.398
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.389
Kiss1	KiSS-1 metastasis-suppressor	0.359
Per2	period homolog 2 (Drosophila)	0.351
Foxc2	forkhead box C2	0.348
Tal1	T-cell acute lymphocytic leukemia 1	0.342	Mouse
Rarg	retinoic acid receptor, gamma	0.340
Hes1	hairy and enhancer of split 1 (Drosophila)	0.337
Nkx6-1	NK6 homeobox 1	0.328	Zebrafish Rat
En1	engrailed 1	0.326
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.314
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.309
Bmp7	bone morphogenetic protein 7	0.299
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.295
Cry1	cryptochrome 1 (photolyase-like)	0.282
Neurog1	neurogenin 1	0.281	Mouse
Onecut1	one cut domain, family member 1	0.267
T	brachyury	0.262
Hoxd13	homeobox D13	0.252
Neurog2	neurogenin 2	0.251	Mouse
Sox4	SRY-box containing gene 4	0.242
Rxra	retinoid X receptor alpha	0.222
Fgf15	fibroblast growth factor 15	0.222
Pou3f3	POU domain, class 3, transcription factor 3	0.218
Vax1	ventral anterior homeobox containing gene 1	0.207
Pitx1	paired-like homeodomain transcription factor 1	0.206
Ret	ret proto-oncogene	0.206
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.205
Ptf1a	pancreas specific transcription factor, 1a	0.204	Mouse
Hoxa13	homeobox A13	0.199
Msx1	homeobox, msh-like 1	0.196
Foxf1a	forkhead box F1a	0.192
Tbx3	T-box 3	0.190
Pten	phosphatase and tensin homolog	0.188
Tlx3	T-cell leukemia, homeobox 3	0.188
Rara	retinoic acid receptor, alpha	0.174
Mesp1	mesoderm posterior 1	0.171
Neurog3	neurogenin 3	0.167	Mouse
Gdnf	glial cell line derived neurotrophic factor	0.158
Fgf10	fibroblast growth factor 10	0.153
Sox11	SRY-box containing gene 11	0.146
Arx	aristaless related homeobox	0.142	Zebrafish
Sim1	single-minded homolog 1 (Drosophila)	0.140
Pdx1	pancreatic and duodenal homeobox 1	0.140	Human
Mecom	MDS1 and EVI1 complex locus	0.137
Alx3	aristaless-like homeobox 3	0.136
Sox1	SRY-box containing gene 1	0.133
Wnt4	wingless-related MMTV integration site 4	0.129	Mouse
Pou3f2	POU domain, class 3, transcription factor 2	0.127
Hes5	hairy and enhancer of split 5 (Drosophila)	0.123	Mouse
Gata1	GATA binding protein 1	0.122	Mouse
Uncx	UNC homeobox	0.119
Foxe1	forkhead box E1	0.109
Zfpm2	zinc finger protein, multitype 2	0.108
Ntf3	neurotrophin 3	0.107
Smad6	MAD homolog 6 (Drosophila)	0.106
Pcdh12	protocadherin 12	0.102
Tgfb2	transforming growth factor, beta 2	0.097
Foxd2	forkhead box D2	0.090
Dlx1	distal-less homeobox 1	0.089
Dlx2	distal-less homeobox 2	0.089
Gsc	goosecoid homeobox	0.086
Adra2b	adrenergic receptor, alpha 2b	0.084
Ptch1	patched homolog 1	0.083
Lmx1b	LIM homeobox transcription factor 1 beta	0.083
Hnf1a	HNF1 homeobox A	0.081
Hoxd11	homeobox D11	0.081
Rb1	retinoblastoma 1	0.080
Otp	orthopedia homolog (Drosophila)	0.079
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.078
Lepr	leptin receptor	0.076
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.076
Wnt6	wingless-related MMTV integration site 6	0.076	Mouse
Hoxa4	homeobox A4	0.074
Tbx5	T-box 5	0.074
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.073
Tcfap2a	transcription factor AP-2, alpha	0.073
Rarb	retinoic acid receptor, beta	0.072
Tcf21	transcription factor 21	0.071
Pou4f3	POU domain, class 4, transcription factor 3	0.070
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.068	Mouse
Efna2	ephrin A2	0.067
Ctnnb1	catenin (cadherin associated protein), beta 1	0.067
Hoxb4	homeobox B4	0.066
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.066
Vegfa	vascular endothelial growth factor A	0.065
Lef1	lymphoid enhancer binding factor 1	0.065
Foxf2	forkhead box F2	0.065
Hic1	hypermethylated in cancer 1	0.065
Hoxd12	homeobox D12	0.064
Lhx9	LIM homeobox protein 9	0.063
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.062
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.062
Sim2	single-minded homolog 2 (Drosophila)	0.062
Nkx2-1	NK2 homeobox 1	0.060	Mouse
Prrx2	paired related homeobox 2	0.057
Lmx1a	LIM homeobox transcription factor 1 alpha	0.057
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.055
Igfbpl1	insulin-like growth factor binding protein-like 1	0.055
Hes3	hairy and enhancer of split 3 (Drosophila)	0.054	Mouse
Zic1	zinc finger protein of the cerebellum 1	0.054
Wnt2b	wingless related MMTV integration site 2b	0.054	Mouse
Sall3	sal-like 3 (Drosophila)	0.053
Gja5	gap junction protein, alpha 5	0.053
Barx1	BarH-like homeobox 1	0.051
Hoxa1	homeobox A1	0.050
Amhr2	anti-Mullerian hormone type 2 receptor	0.049
Tbx2	T-box 2	0.049
Cry2	cryptochrome 2 (photolyase-like)	0.048
Cdx2	caudal type homeobox 2	0.047
Hoxd3	homeobox D3	0.047
Nodal	nodal	0.045
Col22a1	collagen, type XXII, alpha 1	0.044
Fgf18	fibroblast growth factor 18	0.043
Sox3	SRY-box containing gene 3	0.043
Gpr50	G-protein-coupled receptor 50	0.043
Npas2	neuronal PAS domain protein 2	0.043	Mouse
Ager	advanced glycosylation end product-specific receptor	0.042
Pitx3	paired-like homeodomain transcription factor 3	0.042
Axin2	axin2	0.042
Ccnd2	cyclin D2	0.041
Scn5a	sodium channel, voltage-gated, type V, alpha	0.041
Cdx1	caudal type homeobox 1	0.040
Nhlh1	nescient helix loop helix 1	0.040	Mouse
Pou3f4	POU domain, class 3, transcription factor 4	0.039
Dlx5	distal-less homeobox 5	0.039
Hmx1	H6 homeobox 1	0.039
Gnrh1	gonadotropin releasing hormone 1	0.038
Zic4	zinc finger protein of the cerebellum 4	0.037
Ahr	aryl-hydrocarbon receptor	0.037
Hes2	hairy and enhancer of split 2 (Drosophila)	0.037	Mouse
Chd7	chromodomain helicase DNA binding protein 7	0.037
Wnt1	wingless-related MMTV integration site 1	0.036	Mouse
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.035
Tbx15	T-box 15	0.034
Npas1	neuronal PAS domain protein 1	0.034
Hoxa11	homeobox A11	0.034
Rint1	RAD50 interactor 1	0.034
Foxg1	forkhead box G1	0.034
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.033
Ssbp3	single-stranded DNA binding protein 3	0.033
Meox2	mesenchyme homeobox 2	0.033
Padi3	peptidyl arginine deiminase, type III	0.033
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.032	Mouse
a	nonagouti	0.032
Dab1	disabled homolog 1 (Drosophila)	0.032
Zeb1	zinc finger E-box binding homeobox 1	0.032
Lhx6	LIM homeobox protein 6	0.031
Fzd8	frizzled homolog 8 (Drosophila)	0.031
Efna4	ephrin A4	0.031
Apc	adenomatosis polyposis coli	0.031
Sox7	SRY-box containing gene 7	0.030
Btbd17	BTB (POZ) domain containing 17	0.030
Sox14	SRY-box containing gene 14	0.030
Zic2	zinc finger protein of the cerebellum 2	0.030
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.030
Snai1	snail homolog 1 (Drosophila)	0.030
Pax9	paired box gene 9	0.030
Grid1	glutamate receptor, ionotropic, delta 1	0.030
Hoxc9	homeobox C9	0.029
Wnt7a	wingless-related MMTV integration site 7A	0.029	Mouse
Nf1	neurofibromatosis 1	0.028
Kl	klotho	0.028
Hs6st3	heparan sulfate 6-O-sulfotransferase 3	0.028
Gata5	GATA binding protein 5	0.028	Mouse
Pou4f2	POU domain, class 4, transcription factor 2	0.028
Foxb1	forkhead box B1	0.028
Neurod4	neurogenic differentiation 4	0.028	Mouse
Fzd4	frizzled homolog 4 (Drosophila)	0.028
Mnx1	motor neuron and pancreas homeobox 1	0.027	Zebrafish
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.027
Wnt9a	wingless-type MMTV integration site 9A	0.027	Mouse
1700065I17Rik	RIKEN cDNA 1700065I17 gene	0.027
Papln	papilin, proteoglycan-like sulfated glycoprotein	0.027
Foxd3	forkhead box D3	0.026
Fgf5	fibroblast growth factor 5	0.026
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.026
Hoxa10	homeobox A10	0.025
Fgfr1	fibroblast growth factor receptor 1	0.025
Barhl1	BarH-like 1 (Drosophila)	0.025
Myl7	myosin, light polypeptide 7, regulatory	0.025
Adra2a	adrenergic receptor, alpha 2a	0.025
Msi1	Musashi homolog 1(Drosophila)	0.024
Fgfr3	fibroblast growth factor receptor 3	0.024
Hoxa2	homeobox A2	0.024
Irx1	Iroquois related homeobox 1 (Drosophila)	0.024
Gdf11	growth differentiation factor 11	0.024
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.024
Cer1	cerberus 1 homolog (Xenopus laevis)	0.024
Gli1	GLI-Kruppel family member GLI1	0.023
Sox17	SRY-box containing gene 17	0.023
Myt1	myelin transcription factor 1	0.022
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.022
Cux2	cut-like homeobox 2	0.022
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.022
Epha1	Eph receptor A1	0.022
Gja1	gap junction protein, alpha 1	0.022
Eya4	eyes absent 4 homolog (Drosophila)	0.022
Tsc2	tuberous sclerosis 2	0.022
Evx2	even skipped homeotic gene 2 homolog	0.022
Alx4	aristaless-like homeobox 4	0.021
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.021
Hmx3	H6 homeobox 3	0.021
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.021
Nrk	Nik related kinase	0.021
H1fx	H1 histone family, member X	0.021
Otx1	orthodenticle homolog 1 (Drosophila)	0.021
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.021
Gipc3	GIPC PDZ domain containing family, member 3	0.021
She	src homology 2 domain-containing transforming protein E	0.021
Foxb2	forkhead box B2	0.021
Zscan2	zinc finger and SCAN domain containing 2	0.021
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.021
Col2a1	collagen, type II, alpha 1	0.021
Eya1	eyes absent 1 homolog (Drosophila)	0.020
Hapln1	hyaluronan and proteoglycan link protein 1	0.020
Fzd6	frizzled homolog 6 (Drosophila)	0.020
Ar	androgen receptor	0.020
Srrm4	serine/arginine repetitive matrix 4	0.020
Ighmbp2	immunoglobulin mu binding protein 2	0.020
Sfrp5	secreted frizzled-related sequence protein 5	0.019
Wnt10b	wingless related MMTV integration site 10b	0.019	Mouse
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.019
Prox1	prospero-related homeobox 1	0.019
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.019
Hoxa5	homeobox A5	0.019
Zfp771	zinc finger protein 771	0.019
Nos3	nitric oxide synthase 3, endothelial cell	0.019
Trp53	transformation related protein 53	0.019
Tbx20	T-box 20	0.019
Amh	anti-Mullerian hormone	0.019
Fgf3	fibroblast growth factor 3	0.019
Ccnd1	cyclin D1	0.019
Slc34a2	solute carrier family 34 (sodium phosphate), member 2	0.019
Evx1	even skipped homeotic gene 1 homolog	0.019
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.018
Wt1	Wilms tumor 1 homolog	0.018
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.018
Fgfrl1	fibroblast growth factor receptor-like 1	0.018
Fgf9	fibroblast growth factor 9	0.018
Trp73	transformation related protein 73	0.018
Atp7b	ATPase, Cu++ transporting, beta polypeptide	0.018
Chrd	chordin	0.017
Plac1	placental specific protein 1	0.017
Lhx4	LIM homeobox protein 4	0.017
Zic3	zinc finger protein of the cerebellum 3	0.017
Rspo1	R-spondin homolog (Xenopus laevis)	0.017
Slit1	slit homolog 1 (Drosophila)	0.016
Hmga2	high mobility group AT-hook 2	0.016
Cpa1	carboxypeptidase A1	0.016
Gbx2	gastrulation brain homeobox 2	0.016
Gip	gastric inhibitory polypeptide	0.016
Efs	embryonal Fyn-associated substrate	0.016
Ednra	endothelin receptor type A	0.016
Bnc1	basonuclin 1	0.016
Gpc3	glypican 3	0.016
Fgf17	fibroblast growth factor 17	0.016
Zfpm1	zinc finger protein, multitype 1	0.016
Akp3	alkaline phosphatase 3, intestine, not Mn requiring	0.016
Msx3	homeobox, msh-like 3	0.015
Rhpn1	rhophilin, Rho GTPase binding protein 1	0.015
Gjc2	gap junction protein, gamma 2	0.015
Odf3	outer dense fiber of sperm tails 3	0.015
Mpl	myeloproliferative leukemia virus oncogene	0.015
Hoxa7	homeobox A7	0.015
Gnrhr	gonadotropin releasing hormone receptor	0.015
Gdf5	growth differentiation factor 5	0.015
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.015
Rprm	reprimo, TP53 dependent G2 arrest mediator candidate	0.015
Pou3f1	POU domain, class 3, transcription factor 1	0.014
Pnoc	prepronociceptin	0.014
Bmp2	bone morphogenetic protein 2	0.014
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.014
Tlx2	T-cell leukemia, homeobox 2	0.014
Myog	myogenin	0.014
Sp5	trans-acting transcription factor 5	0.014
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.014
Shox2	short stature homeobox 2	0.014
Fzd10	frizzled homolog 10 (Drosophila)	0.014
Sost	sclerostin	0.014
Inhba	inhibin beta-A	0.013
Foxa1	forkhead box A1	0.013
Hif3a	hypoxia inducible factor 3, alpha subunit	0.013
Vipr1	vasoactive intestinal peptide receptor 1	0.013
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.013	Mouse
Glra1	glycine receptor, alpha 1 subunit	0.013
Nf2	neurofibromatosis 2	0.013
Mzf1	myeloid zinc finger 1	0.013
Mxd1	MAX dimerization protein 1	0.013
Hoxa3	homeobox A3	0.013
Dlx6	distal-less homeobox 6	0.013
Foxo1	forkhead box O1	0.013
Ccna1	cyclin A1	0.013
Ankrd36	ankyrin repeat domain 36	0.013
Ihh	Indian hedgehog	0.012
Tead3	TEA domain family member 3	0.012
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.012
Prph2	peripherin 2	0.012
Sh3pxd2a	SH3 and PX domains 2A	0.012
Ins2	insulin II	0.012
Pyy	peptide YY	0.012
Sox21	SRY-box containing gene 21	0.012
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.012
Irx4	Iroquois related homeobox 4 (Drosophila)	0.012
Rdh10	retinol dehydrogenase 10 (all-trans)	0.012
Foxe3	forkhead box E3	0.012
Foxp2	forkhead box P2	0.012
Ebf3	early B-cell factor 3	0.012
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.012
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.012
Hoxb7	homeobox B7	0.012
Fosl2	fos-like antigen 2	0.011
Adrb1	adrenergic receptor, beta 1	0.011
Trpc5	transient receptor potential cation channel, subfamily C, member 5	0.011
Sct	secretin	0.011
Etv2	ets variant gene 2	0.011
Atoh7	atonal homolog 7 (Drosophila)	0.011	Mouse
Hmga1	high mobility group AT-hook 1	0.011
Hoxc8	homeobox C8	0.011
Pax1	paired box gene 1	0.011
Foxn4	forkhead box N4	0.011
Gas1	growth arrest specific 1	0.011
Cabp7	calcium binding protein 7	0.011
Bmp8b	bone morphogenetic protein 8b	0.011
BC057022	cDNA sequence BC057022	0.011
Bicc1	bicaudal C homolog 1 (Drosophila)	0.011
Emid2	EMI domain containing 2	0.011
Rictor	RPTOR independent companion of MTOR, complex 2	0.011
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.011
Xpa	xeroderma pigmentosum, complementation group A	0.011
Tbx19	T-box 19	0.011
Stra6	stimulated by retinoic acid gene 6	0.010
Runx2	runt related transcription factor 2	0.010
Inhbb	inhibin beta-B	0.010
Cnr1	cannabinoid receptor 1 (brain)	0.010
Nat3	N-acetyltransferase 3	0.010
Edn3	endothelin 3	0.010
Wnt8b	wingless related MMTV integration site 8b	0.010	Mouse
Nobox	NOBOX oogenesis homeobox	0.010
Twist2	twist homolog 2 (Drosophila)	0.010	Mouse
Kiss1r	KISS1 receptor	0.010
Ephb2	Eph receptor B2	0.010
Fbln1	fibulin 1	0.010
Kcnk3	potassium channel, subfamily K, member 3	0.010