IMP

Process View

Mus musculus

1 genes annotated in mouse

granzyme mediated apoptotic signaling pathway

A series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "granzyme mediated apoptotic signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "granzyme mediated apoptotic signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Xcl1	chemokine (C motif) ligand 1	0.896
Fasl	Fas ligand (TNF superfamily, member 6)	0.847
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.845
Gzmb	granzyme B	0.825
Ctsw	cathepsin W	0.765
Ncr1	natural cytotoxicity triggering receptor 1	0.755
Cpa3	carboxypeptidase A3, mast cell	0.716
Gzma	granzyme A	0.691	Mouse
Gzmc	granzyme C	0.689	Mouse
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.670
Mcpt4	mast cell protease 4	0.609	Mouse
Cst7	cystatin F (leukocystatin)	0.589
Cma1	chymase 1, mast cell	0.562	Mouse
Ctsg	cathepsin G	0.557	Mouse
Cd96	CD96 antigen	0.536
Gzmf	granzyme F	0.478	Mouse
Gzmd	granzyme D	0.466	Mouse
Il2rb	interleukin 2 receptor, beta chain	0.452
Fcer1a	Fc receptor, IgE, high affinity I, alpha polypeptide	0.443
Plbd2	phospholipase B domain containing 2	0.428
Klrc1	killer cell lectin-like receptor subfamily C, member 1	0.426
Cd3e	CD3 antigen, epsilon polypeptide	0.424
Sh2d2a	SH2 domain protein 2A	0.415
Mmp10	matrix metallopeptidase 10	0.409
Ctsb	cathepsin B	0.359
Prl7a1	prolactin family 7, subfamily a, member 1	0.359
Klra9	killer cell lectin-like receptor subfamily A, member 9	0.350
Il18rap	interleukin 18 receptor accessory protein	0.327
Sh2d1a	SH2 domain protein 1A	0.313
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.303
Gzmg	granzyme G	0.301	Mouse
Vcp	valosin containing protein	0.285
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.264
Cd7	CD7 antigen	0.250
Itk	IL2-inducible T-cell kinase	0.218
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.217
Prl2b1	prolactin family 2, subfamily b, member 1	0.217
Cd8a	CD8 antigen, alpha chain	0.215
Mpo	myeloperoxidase	0.192
Ngp	neutrophilic granule protein	0.190
Sva	seminal vesicle antigen	0.188
Cidec	cell death-inducing DFFA-like effector c	0.188
Ctsd	cathepsin D	0.185
Lamp2	lysosomal-associated membrane protein 2	0.178
Retn	resistin	0.164
Nkg7	natural killer cell group 7 sequence	0.160
Ear2	eosinophil-associated, ribonuclease A family, member 2	0.149
Adipoq	adiponectin, C1Q and collagen domain containing	0.145
Aqp7	aquaporin 7	0.140
Gcet2	germinal center expressed transcript 2	0.138
Aoah	acyloxyacyl hydrolase	0.134
Gzme	granzyme E	0.125	Mouse
Icos	inducible T-cell co-stimulator	0.115
Ido1	indoleamine 2,3-dioxygenase 1	0.107
Il1rl1	interleukin 1 receptor-like 1	0.104
Ccl22	chemokine (C-C motif) ligand 22	0.100
Klk1b26	kallikrein 1-related petidase b26	0.099
Mcpt1	mast cell protease 1	0.096	Mouse
Gp1ba	glycoprotein 1b, alpha polypeptide	0.095
Il12rb2	interleukin 12 receptor, beta 2	0.094
Myf6	myogenic factor 6	0.089
Ccl5	chemokine (C-C motif) ligand 5	0.088
Elane	elastase, neutrophil expressed	0.088
Mcpt2	mast cell protease 2	0.087	Mouse
Prss2	protease, serine, 2	0.085
Cma2	chymase 2, mast cell	0.085
Cd3d	CD3 antigen, delta polypeptide	0.082
Sprr2h	small proline-rich protein 2H	0.082
Cd2	CD2 antigen	0.080
Mcpt8	mast cell protease 8	0.080	Mouse
Pgk2	phosphoglycerate kinase 2	0.080
Ccl1	chemokine (C-C motif) ligand 1	0.079
Gzmk	granzyme K	0.078	Mouse
Cxcl9	chemokine (C-X-C motif) ligand 9	0.075
Enam	enamelin	0.070
S100a9	S100 calcium binding protein A9 (calgranulin B)	0.070
Mup4	major urinary protein 4	0.068
Prg2	proteoglycan 2, bone marrow	0.064
Prol1	proline rich, lacrimal 1	0.064
Gbp1	guanylate binding protein 1	0.064
Klra7	killer cell lectin-like receptor, subfamily A, member 7	0.062
Ccl8	chemokine (C-C motif) ligand 8	0.056
Cd3g	CD3 antigen, gamma polypeptide	0.056
Tg	thyroglobulin	0.056
Ccl24	chemokine (C-C motif) ligand 24	0.056
Akap4	A kinase (PRKA) anchor protein 4	0.055
Mmp8	matrix metallopeptidase 8	0.055
Klrb1a	killer cell lectin-like receptor subfamily B member 1A	0.052
Fabp4	fatty acid binding protein 4, adipocyte	0.052
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2	0.052
Rhag	Rhesus blood group-associated A glycoprotein	0.051
Cxcr3	chemokine (C-X-C motif) receptor 3	0.050
Rfpl4	ret finger protein-like 4	0.049
Prl3d1	prolactin family 3, subfamily d, member 1	0.049
Try5	trypsin 5	0.048
Tnfsf8	tumor necrosis factor (ligand) superfamily, member 8	0.048
Lcn4	lipocalin 4	0.048
Rragc	Ras-related GTP binding C	0.047
Tssk2	testis-specific serine kinase 2	0.046
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.046
Tnfrsf18	tumor necrosis factor receptor superfamily, member 18	0.044
Ubd	ubiquitin D	0.043
Gimap7	GTPase, IMAP family member 7	0.041
Slco6c1	solute carrier organic anion transporter family, member 6c1	0.041
Obox2	oocyte specific homeobox 2	0.040
Il2ra	interleukin 2 receptor, alpha chain	0.040
Ccbp2	chemokine binding protein 2	0.039
Cd160	CD160 antigen	0.039
Glrp1	glutamine repeat protein 1	0.038
Akr1a4	aldo-keto reductase family 1, member A4 (aldehyde reductase)	0.037
Ear5	eosinophil-associated, ribonuclease A family, member 5	0.037
Il1r2	interleukin 1 receptor, type II	0.037
Chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)	0.037
Ly6a	lymphocyte antigen 6 complex, locus A	0.035
Cd27	CD27 antigen	0.035
Art2a-ps	ADP-ribosyltransferase 2a, pseudogene	0.034
Ccr3	chemokine (C-C motif) receptor 3	0.034
Atp6v0c	ATPase, H+ transporting, lysosomal V0 subunit C	0.034
Ostm1	osteopetrosis associated transmembrane protein 1	0.034
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.034
Slamf7	SLAM family member 7	0.034
Irs3	insulin receptor substrate 3	0.033
Ighg	Immunoglobulin heavy chain (gamma polypeptide)	0.033
Thrsp	thyroid hormone responsive SPOT14 homolog (Rattus)	0.031
Pla2g2a	phospholipase A2, group IIA (platelets, synovial fluid)	0.031
Cxcr2	chemokine (C-X-C motif) receptor 2	0.031
Smr3a	submaxillary gland androgen regulated protein 3A	0.031
Mc2r	melanocortin 2 receptor	0.031
Prss58	protease, serine 58	0.031
Fcrla	Fc receptor-like A	0.031
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.030
Hemgn	hemogen	0.030
Ear11	eosinophil-associated, ribonuclease A family, member 11	0.030
Ccl11	chemokine (C-C motif) ligand 11	0.030
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.030
S100a8	S100 calcium binding protein A8 (calgranulin A)	0.030
Krtap3-3	keratin associated protein 3-3	0.030
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.030
Gabarapl1	gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1	0.030
Txk	TXK tyrosine kinase	0.029
Cryga	crystallin, gamma A	0.029
Klra5	killer cell lectin-like receptor, subfamily A, member 5	0.029
Ftl1	ferritin light chain 1	0.029
Mucl1	mucin-like 1	0.028
Gfi1	growth factor independent 1	0.028
Sepp1	selenoprotein P, plasma, 1	0.028
Myl10	myosin, light chain 10, regulatory	0.027
Fam3b	family with sequence similarity 3, member B	0.027
Klk1b11	kallikrein 1-related peptidase b11	0.027
Ceacam11	carcinoembryonic antigen-related cell adhesion molecule 11	0.027
Eomes	eomesodermin homolog (Xenopus laevis)	0.027
Slc7a11	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	0.026
Sdcbp	syndecan binding protein	0.026
Pth	parathyroid hormone	0.026
Ceacam12	carcinoembryonic antigen-related cell adhesion molecule 12	0.026
Serpina3c	serine (or cysteine) peptidase inhibitor, clade A, member 3C	0.026
Tmbim6	transmembrane BAX inhibitor motif containing 6	0.026
Clnk	cytokine-dependent hematopoietic cell linker	0.025
Prl7d1	prolactin family 7, subfamily d, member 1	0.025
Art2b	ADP-ribosyltransferase 2b	0.025
Hbb-y	hemoglobin Y, beta-like embryonic chain	0.025
Pbsn	probasin	0.025
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.025
Adam7	a disintegrin and metallopeptidase domain 7	0.024
Klrb1c	killer cell lectin-like receptor subfamily B member 1C	0.024
Sell	selectin, lymphocyte	0.024
Ang2	angiogenin, ribonuclease A family, member 2	0.024
C2	complement component 2 (within H-2S)	0.023
Pgk1	phosphoglycerate kinase 1	0.023
Prl7a2	prolactin family 7, subfamily a, member 2	0.022
Zpbp	zona pellucida binding protein	0.022
H2-M9	histocompatibility 2, M region locus 9	0.022
Kdelr1	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1	0.022
4930579C15Rik	RIKEN cDNA 4930579C15 gene	0.022
Bex6	brain expressed gene 6	0.022
Rpl39l	ribosomal protein L39-like	0.022
Nampt	nicotinamide phosphoribosyltransferase	0.022
Adrb3	adrenergic receptor, beta 3	0.021
Cnga1	cyclic nucleotide gated channel alpha 1	0.021
Camp	cathelicidin antimicrobial peptide	0.021
Il13ra2	interleukin 13 receptor, alpha 2	0.021
Scgb1a1	secretoglobin, family 1A, member 1 (uteroglobin)	0.021
Reg3g	regenerating islet-derived 3 gamma	0.021
Lgals2	lectin, galactose-binding, soluble 2	0.021
Tbx21	T-box 21	0.021
Il12rb1	interleukin 12 receptor, beta 1	0.021
LOC100504404	h-2 class II histocompatibility antigen, E-K alpha chain-like	0.021
Krtap8-2	keratin associated protein 8-2	0.020
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.020
Tnfrsf17	tumor necrosis factor receptor superfamily, member 17	0.020
F2rl3	coagulation factor II (thrombin) receptor-like 3	0.020
Itm2b	integral membrane protein 2B	0.020
Svs6	seminal vesicle secretory protein 6	0.020
Vpreb3	pre-B lymphocyte gene 3	0.020
Pdcd1lg2	programmed cell death 1 ligand 2	0.020
Sgca	sarcoglycan, alpha (dystrophin-associated glycoprotein)	0.019
Prl8a2	prolactin family 8, subfamily a, member 2	0.019
Ly6i	lymphocyte antigen 6 complex, locus I	0.019
Cyp3a16	cytochrome P450, family 3, subfamily a, polypeptide 16	0.019
Kif4	kinesin family member 4	0.019
Klk1b8	kallikrein 1-related peptidase b8	0.018
Ear1	eosinophil-associated, ribonuclease A family, member 1	0.018
Sult1c1	sulfotransferase family, cytosolic, 1C, member 1	0.018
Ccr8	chemokine (C-C motif) receptor 8	0.018
Omt2b	oocyte maturation, beta	0.018
Chi3l3	chitinase 3-like 3	0.018
Areg	amphiregulin	0.018
Klrc2	killer cell lectin-like receptor subfamily C, member 2	0.018
Tktl1	transketolase-like 1	0.018
Cxcr6	chemokine (C-X-C motif) receptor 6	0.018
Grap2	GRB2-related adaptor protein 2	0.018
Cd8b1	CD8 antigen, beta chain 1	0.018
Acsm3	acyl-CoA synthetase medium-chain family member 3	0.018
Klk1b5	kallikrein 1-related peptidase b5	0.017
Myh4	myosin, heavy polypeptide 4, skeletal muscle	0.017
Myl1	myosin, light polypeptide 1	0.017
Cryba1	crystallin, beta A1	0.017
Itln1	intelectin 1 (galactofuranose binding)	0.017
Cdh17	cadherin 17	0.017
Mmp12	matrix metallopeptidase 12	0.017
Crtam	cytotoxic and regulatory T cell molecule	0.017
Gabarap	gamma-aminobutyric acid receptor associated protein	0.017
Cysltr2	cysteinyl leukotriene receptor 2	0.017
Pttg1ip	pituitary tumor-transforming 1 interacting protein	0.017
Spam1	sperm adhesion molecule 1	0.016
Cts7	cathepsin 7	0.016
Epyc	epiphycan	0.016
Omd	osteomodulin	0.016
Il3	interleukin 3	0.016
Krt20	keratin 20	0.016
Tlr7	toll-like receptor 7	0.016
Tshr	thyroid stimulating hormone receptor	0.016
Tpsb2	tryptase beta 2	0.016
Snx3	sorting nexin 3	0.016
Naip1	NLR family, apoptosis inhibitory protein 1	0.016
Klra8	killer cell lectin-like receptor, subfamily A, member 8	0.015
Dpt	dermatopontin	0.015
Tcstv3	2-cell-stage, variable group, member 3	0.015
Sfrp4	secreted frizzled-related protein 4	0.015
Fshb	follicle stimulating hormone beta	0.015
Fpr1	formyl peptide receptor 1	0.015
Clec4e	C-type lectin domain family 4, member e	0.015
Bnip3l	BCL2/adenovirus E1B interacting protein 3-like	0.015
Uts2r	urotensin 2 receptor	0.015
Ugp2	UDP-glucose pyrophosphorylase 2	0.015
Krt27	keratin 27	0.015
Epb4.2	erythrocyte protein band 4.2	0.015
Il2	interleukin 2	0.015
Hesx1	homeobox gene expressed in ES cells	0.014
Soat2	sterol O-acyltransferase 2	0.014
Stat4	signal transducer and activator of transcription 4	0.014
Ifng	interferon gamma	0.014
Prl8a6	prolactin family 8, subfamily a, member 6	0.014
Klra3	killer cell lectin-like receptor, subfamily A, member 3	0.014
Alox15	arachidonate 15-lipoxygenase	0.014
Ptk6	PTK6 protein tyrosine kinase 6	0.014
Ccr9	chemokine (C-C motif) receptor 9	0.014
Ctse	cathepsin E	0.014
Prtn3	proteinase 3	0.014
Ccl3	chemokine (C-C motif) ligand 3	0.014
Rnase1	ribonuclease, RNase A family, 1 (pancreatic)	0.014
Cd209b	CD209b antigen	0.014
Il18r1	interleukin 18 receptor 1	0.014
Col10a1	collagen, type X, alpha 1	0.014
LOC677008	natural killer cell receptor 2B4-like	0.014
Irg1	immunoresponsive gene 1	0.014
Gm10228	predicted gene 10228	0.013
Phyh	phytanoyl-CoA hydroxylase	0.013
Slfn3	schlafen 3	0.013
Slfn1	schlafen 1	0.013
Cd80	CD80 antigen	0.013
Batf	basic leucine zipper transcription factor, ATF-like	0.013
Klre1	killer cell lectin-like receptor family E member 1	0.013
Fth1	ferritin heavy chain 1	0.013
Csn3	casein kappa	0.013
Sat1	spermidine/spermine N1-acetyl transferase 1	0.013
Myh2	myosin, heavy polypeptide 2, skeletal muscle, adult	0.013
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.013
Afp	alpha fetoprotein	0.013
Car1	carbonic anhydrase 1	0.013
Npy6r	neuropeptide Y receptor Y6	0.013
Klra17	killer cell lectin-like receptor, subfamily A, member 17	0.013
Pdk1	pyruvate dehydrogenase kinase, isoenzyme 1	0.013
Muc13	mucin 13, epithelial transmembrane	0.013
Crisp1	cysteine-rich secretory protein 1	0.013
Tmprss15	transmembrane protease, serine 15	0.013
Ltf	lactotransferrin	0.012
Cst9	cystatin 9	0.012
Lck	lymphocyte protein tyrosine kinase	0.012
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.012
Scin	scinderin	0.012
Psg19	pregnancy specific glycoprotein 19	0.012
Spna1	spectrin alpha 1	0.012
Gbe1	glucan (1,4-alpha-), branching enzyme 1	0.012
Lag3	lymphocyte-activation gene 3	0.012
Kera	keratocan	0.012
Slc36a1	solute carrier family 36 (proton/amino acid symporter), member 1	0.012
Clec3b	C-type lectin domain family 3, member b	0.012
Rpl3l	ribosomal protein L3-like	0.012
Grn	granulin	0.012
Glycam1	glycosylation dependent cell adhesion molecule 1	0.012
Gimap6	GTPase, IMAP family member 6	0.012
Macf1	microtubule-actin crosslinking factor 1	0.012
Cd244	CD244 natural killer cell receptor 2B4	0.012
Trim10	tripartite motif-containing 10	0.012
Hsd17b3	hydroxysteroid (17-beta) dehydrogenase 3	0.012
Rgs1	regulator of G-protein signaling 1	0.012
Atp6ap1	ATPase, H+ transporting, lysosomal accessory protein 1	0.012
Defb2	defensin beta 2	0.012
Ang3	angiogenin, ribonuclease A family, member 3	0.011
Ccrl2	chemokine (C-C motif) receptor-like 2	0.011
Ccl4	chemokine (C-C motif) ligand 4	0.011
Ska1	spindle and kinetochore associated complex subunit 1	0.011
Havcr2	hepatitis A virus cellular receptor 2	0.011
Csn1s2b	casein alpha s2-like B	0.011
Slamf6	SLAM family member 6	0.011
Rhoh	ras homolog gene family, member H	0.011
Ctsl	cathepsin L	0.011
Dntt	deoxynucleotidyltransferase, terminal	0.011
Gns	glucosamine (N-acetyl)-6-sulfatase	0.011
Zap70	zeta-chain (TCR) associated protein kinase	0.011
Atp6v0e	ATPase, H+ transporting, lysosomal V0 subunit E	0.011
Pfkfb1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.011
Cd209f	CD209f antigen	0.010
Theg	testicular haploid expressed gene	0.010
Rapsn	receptor-associated protein of the synapse	0.010
Gpr171	G protein-coupled receptor 171	0.010
Bard1	BRCA1 associated RING domain 1	0.010
Ggt5	gamma-glutamyltransferase 5	0.010