IMP

Process View

Mus musculus

9 genes annotated in mouse

metaphase anaphase transition of mitotic cell cycle

The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "metaphase anaphase transition of mitotic cell cycle"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "metaphase anaphase transition of mitotic cell cycle" (in gray)

Name	Description	Probability	Func Analog Organism
Trp53	transformation related protein 53	0.966
Pten	phosphatase and tensin homolog	0.888
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.879	Yeast Worm Fly
Ctnnb1	catenin (cadherin associated protein), beta 1	0.817
Ccnb1	cyclin B1	0.597
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.531
Prc1	protein regulator of cytokinesis 1	0.490
Ccnb2	cyclin B2	0.450
Brca1	breast cancer 1	0.441
Cdk1	cyclin-dependent kinase 1	0.371
Spag5	sperm associated antigen 5	0.335
Cenpe	centromere protein E	0.327
Ccna2	cyclin A2	0.314
Ccnf	cyclin F	0.292
Mdm2	transformed mouse 3T3 cell double minute 2	0.263
Ooep	oocyte expressed protein homolog (dog)	0.241
Brca2	breast cancer 2	0.240
Kif22	kinesin family member 22	0.211
Cdk2	cyclin-dependent kinase 2	0.202
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.186
Kif20a	kinesin family member 20A	0.183
4632434I11Rik	RIKEN cDNA 4632434I11 gene	0.163
Cdca8	cell division cycle associated 8	0.161
Ube2c	ubiquitin-conjugating enzyme E2C	0.160	Fly
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.133
Cenpa	centromere protein A	0.130
Cul4a	cullin 4A	0.113
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.109
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.107
Apc	adenomatosis polyposis coli	0.107
Plk1	polo-like kinase 1 (Drosophila)	0.103	Human
Kif4	kinesin family member 4	0.101
Cdc25c	cell division cycle 25 homolog C (S. pombe)	0.100
Birc5	baculoviral IAP repeat-containing 5	0.097
Kif2c	kinesin family member 2C	0.097
Sgol2	shugoshin-like 2 (S. pombe)	0.097
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.097
Sgol1	shugoshin-like 1 (S. pombe)	0.096
6720463M24Rik	RIKEN cDNA 6720463M24 gene	0.095
Cep55	centrosomal protein 55	0.095
Kit	kit oncogene	0.094
Nbn	nibrin	0.088
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.086
Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	0.084	Yeast
Ush1g	Usher syndrome 1G homolog (human)	0.081
Axin1	axin 1	0.078
Melk	maternal embryonic leucine zipper kinase	0.075
Ptprq	protein tyrosine phosphatase, receptor type, Q	0.073
Aurkb	aurora kinase B	0.072
Ccne1	cyclin E1	0.071	Fly
Cdkn3	cyclin-dependent kinase inhibitor 3	0.070
Mki67	antigen identified by monoclonal antibody Ki 67	0.061
Nf2	neurofibromatosis 2	0.055
C330027C09Rik	RIKEN cDNA C330027C09 gene	0.055
Aurka	aurora kinase A	0.053
E2f8	E2F transcription factor 8	0.052
Hist1h2bm	histone cluster 1, H2bm	0.050
Psen1	presenilin 1	0.050
Dna2	DNA replication helicase 2 homolog (yeast)	0.048
Mybl2	myeloblastosis oncogene-like 2	0.045
Mis18bp1	MIS18 binding protein 1	0.045
Incenp	inner centromere protein	0.043
Cdca5	cell division cycle associated 5	0.042
E2f1	E2F transcription factor 1	0.042
Ckap2	cytoskeleton associated protein 2	0.041
Stil	Scl/Tal1 interrupting locus	0.040
Nf1	neurofibromatosis 1	0.040
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.037	Fly
Creb1	cAMP responsive element binding protein 1	0.037
Lig4	ligase IV, DNA, ATP-dependent	0.037
Gtse1	G two S phase expressed protein 1	0.036
Ncapd2	non-SMC condensin I complex, subunit D2	0.036
Foxm1	forkhead box M1	0.035
Kntc1	kinetochore associated 1	0.035
Nuf2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.034
Kif11	kinesin family member 11	0.032
Ckap2l	cytoskeleton associated protein 2-like	0.031
Mns1	meiosis-specific nuclear structural protein 1	0.030
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.030
Myo6	myosin VI	0.030
Braf	Braf transforming gene	0.029
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.029
Notch1	Notch gene homolog 1 (Drosophila)	0.029
Acd	adrenocortical dysplasia	0.029
Stag1	stromal antigen 1	0.029
Dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.029
H2afx	H2A histone family, member X	0.029
Gsg2	germ cell-specific gene 2	0.028
Wdhd1	WD repeat and HMG-box DNA binding protein 1	0.028
Msh2	mutS homolog 2 (E. coli)	0.028
Fignl1	fidgetin-like 1	0.027
Nlrp5	NLR family, pyrin domain containing 5	0.027
Cenpf	centromere protein F	0.026
Dbf4	DBF4 homolog (S. cerevisiae)	0.025
Ccnd1	cyclin D1	0.025
Pkn2	protein kinase N2	0.025
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.025
Stk11	serine/threonine kinase 11	0.025
Espl1	extra spindle poles-like 1 (S. cerevisiae)	0.024
Kif23	kinesin family member 23	0.024
Depdc1a	DEP domain containing 1a	0.024
Diap3	diaphanous homolog 3 (Drosophila)	0.024
Qk	quaking	0.023
Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	0.022
Lin9	lin-9 homolog (C. elegans)	0.022
Mxd3	Max dimerization protein 3	0.022
Cenpk	centromere protein K	0.021
Mdm4	transformed mouse 3T3 cell double minute 4	0.021
Myh9	myosin, heavy polypeptide 9, non-muscle	0.020
Cbx1	chromobox homolog 1 (Drosophila HP1 beta)	0.020
Gsk3b	glycogen synthase kinase 3 beta	0.020	Fly
Whrn	whirlin	0.020
Chtf18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0.020
Rad51ap1	RAD51 associated protein 1	0.020
Fbxo5	F-box protein 5	0.020	Human Fly
Usp9x	ubiquitin specific peptidase 9, X chromosome	0.020
Stat6	signal transducer and activator of transcription 6	0.019
Suv39h2	suppressor of variegation 3-9 homolog 2 (Drosophila)	0.019
Ndc80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.019
Xpa	xeroderma pigmentosum, complementation group A	0.019
Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)	0.019
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.019
Ncapd3	non-SMC condensin II complex, subunit D3	0.019
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.019
Kitl	kit ligand	0.019
Chek1	checkpoint kinase 1 homolog (S. pombe)	0.018
Rb1	retinoblastoma 1	0.018	Human
E2f7	E2F transcription factor 7	0.018
Wdr26	WD repeat domain 26	0.018
Slmap	sarcolemma associated protein	0.018
Rrm2	ribonucleotide reductase M2	0.018
Ppp1ca	protein phosphatase 1, catalytic subunit, alpha isoform	0.017
D2Ertd750e	DNA segment, Chr 2, ERATO Doi 750, expressed	0.017
Racgap1	Rac GTPase-activating protein 1	0.017
Wrn	Werner syndrome homolog (human)	0.016
Tsc1	tuberous sclerosis 1	0.016
Gins2	GINS complex subunit 2 (Psf2 homolog)	0.016
Ube2t	ubiquitin-conjugating enzyme E2T (putative)	0.016
Cenpn	centromere protein N	0.016
Atf2	activating transcription factor 2	0.016
Ezh2	enhancer of zeste homolog 2 (Drosophila)	0.015
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.015
Tcf19	transcription factor 19	0.015
Smad3	MAD homolog 3 (Drosophila)	0.015
Haus4	HAUS augmin-like complex, subunit 4	0.015
Vasp	vasodilator-stimulated phosphoprotein	0.015
Arl6ip6	ADP-ribosylation factor-like 6 interacting protein 6	0.015
Lrrk2	leucine-rich repeat kinase 2	0.015
Pot1a	protection of telomeres 1A	0.015
Bmi1	Bmi1 polycomb ring finger oncogene	0.015
Cdkn2d	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.014
Wdr1	WD repeat domain 1	0.014
Fam64a	family with sequence similarity 64, member A	0.014
Ncapg	non-SMC condensin I complex, subunit G	0.014
Neurod1	neurogenic differentiation 1	0.014
Iqgap3	IQ motif containing GTPase activating protein 3	0.014
Cdca2	cell division cycle associated 2	0.014
Cops7b	COP9 (constitutive photomorphogenic) homolog, subunit 7b (Arabidopsis thaliana)	0.013
Rad51	RAD51 homolog (S. cerevisiae)	0.013
Pik3c3	phosphoinositide-3-kinase, class 3	0.013
E130303B06Rik	RIKEN cDNA E130303B06 gene	0.013
Kiss1	KiSS-1 metastasis-suppressor	0.013
Cdca4	cell division cycle associated 4	0.013
Cpsf3l	cleavage and polyadenylation specific factor 3-like	0.013
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.013
Aimp1	aminoacyl tRNA synthetase complex-interacting multifunctional protein 1	0.013
Blm	Bloom syndrome, RecQ helicase-like	0.013
Hist2h4	histone cluster 2, H4	0.012
Cdc45	cell division cycle 45 homolog (S. cerevisiae)	0.012
Rnf8	ring finger protein 8	0.012
2810417H13Rik	RIKEN cDNA 2810417H13 gene	0.012
Ttk	Ttk protein kinase	0.012	Yeast Fly
Spc24	SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.012
Fbxo15	F-box protein 15	0.012
Shcbp1	Shc SH2-domain binding protein 1	0.012
Sass6	spindle assembly 6 homolog (C. elegans)	0.012
Thbs1	thrombospondin 1	0.012
Rbl2	retinoblastoma-like 2	0.012
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.012
Ccdc99	coiled-coil domain containing 99	0.012
Nsf	N-ethylmaleimide sensitive fusion protein	0.012
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.012	Yeast Fly
Psmd4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.012
Chek2	CHK2 checkpoint homolog (S. pombe)	0.012
Trp73	transformation related protein 73	0.012
Orc1	origin recognition complex, subunit 1	0.012
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.011
Grxcr1	glutaredoxin, cysteine rich 1	0.011
2500003M10Rik	RIKEN cDNA 2500003M10 gene	0.011
Rad54l	RAD54 like (S. cerevisiae)	0.011
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.011
Ncoa3	nuclear receptor coactivator 3	0.011
Depdc1b	DEP domain containing 1B	0.011
Rac1	RAS-related C3 botulinum substrate 1	0.011
Cdc25b	cell division cycle 25 homolog B (S. pombe)	0.011
Hist2h3c2-ps	histone cluster 2, H3c2, pseudogene	0.011
Cd44	CD44 antigen	0.011
Esco2	establishment of cohesion 1 homolog 2 (S. cerevisiae)	0.011
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.011
Ect2	ect2 oncogene	0.011
Lrp6	low density lipoprotein receptor-related protein 6	0.010
Spnb2	spectrin beta 2	0.010
Iqgap1	IQ motif containing GTPase activating protein 1	0.010
Gm13290	predicted gene 13290	0.010
Mybl1	myeloblastosis oncogene-like 1	0.010
Myo7a	myosin VIIA	0.010
Ube3a	ubiquitin protein ligase E3A	0.010
Chaf1b	chromatin assembly factor 1, subunit B (p60)	0.010
Smad4	MAD homolog 4 (Drosophila)	0.010
Dsg1a	desmoglein 1 alpha	0.010
Exo1	exonuclease 1	0.010