IMP

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Danio rerio

1 genes annotated in zebrafish

p38mapk cascade

An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "p38mapk cascade"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "p38mapk cascade" (in gray)

Name	Description	Probability	Func Analog Organism
bmp4	bone morphogenetic protein 4	0.902
gadd45bb	growth arrest and DNA-damage-inducible, beta b	0.749	Human
gadd45ba	growth arrest and DNA-damage-inducible, beta a	0.527	Human
zgc:55813	zgc:55813	0.464
gadd45aa	growth arrest and DNA-damage-inducible, alpha, a	0.445	Human
zgc:110340	zgc:110340	0.444
mvp	major vault protein	0.335
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.314
atf3	activating transcription factor 3	0.228
sgk1	serum/glucocorticoid regulated kinase 1	0.204
fos	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.204
bbc3	BCL2 binding component 3	0.153
cd63	Cd63 antigen	0.140
junb	jun B proto-oncogene	0.132
jag2	jagged 2	0.127
zgc:114199	zgc:114199	0.122
sat1a	spermidine/spermine N1-acetyltransferase 1a	0.118
gadd45g	growth arrest and DNA-damage-inducible, gamma	0.108	Human
bmp2a	bone morphogenetic protein 2a	0.097	Human
socs3a	suppressor of cytokine signaling 3a	0.093
mdm2	transformed 3T3 cell double minute 2 homolog (mouse)	0.087
baxa	bcl2-associated X protein, a	0.087
npc1	Niemann-Pick disease, type C1	0.087
igf1rb	insulin-like growth factor 1b receptor	0.084
acsl4a	acyl-CoA synthetase long-chain family member 4a	0.084
tmem38a	transmembrane protein 38A	0.079
slc3a2	solute carrier family 3, member 2	0.077
dlx3b	distal-less homeobox gene 3b	0.073
arl5c	ADP-ribosylation factor-like 5C	0.070
inhbaa	inhibin, beta Aa	0.069
cebpd	CCAAT/enhancer binding protein (C/EBP), delta	0.066
zgc:101724	zgc:101724	0.065
dlat	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	0.065
zgc:92851	zgc:92851	0.061
myl10	myosin, light chain 10, regulatory	0.060
wt1b	wilms tumor 1b	0.059
foxa3	forkhead box A3	0.058
LOC100000332	e3 ubiquitin-protein ligase RNF182-like	0.057
nphs2	nephrosis 2, idiopathic, steroid-resistant (podocin)	0.056
pias4a	protein inhibitor of activated STAT, 4a	0.053
hspb1	heat shock protein, alpha-crystallin-related, 1	0.053
smox	spermine oxidase	0.052
her1	hairy-related 1	0.052
jun	jun proto-oncogene	0.047
gadd45ab	growth arrest and DNA-damage-inducible, alpha, b	0.047	Human
atp1b1a	ATPase, Na+/K+ transporting, beta 1a polypeptide	0.046
junbl	jun B proto-oncogene, like	0.046
zgc:56005	zgc:56005	0.046
smc1al	structural maintenance of chromosomes 1A, like	0.044
LOC100331484	hypothetical protein LOC100331484	0.042
tpm3	tropomyosin 3	0.041
zgc:136817	zgc:136817	0.041
hig1	hypoxia induced gene 1	0.039
zgc:112180	zgc:112180	0.039
zgc:85727	zgc:85727	0.039
zgc:162126	zgc:162126	0.039
mpp1	membrane protein, palmitoylated 1	0.038
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.037
atp2b1a	ATPase, Ca++ transporting, plasma membrane 1a	0.036
pgam2	phosphoglycerate mutase 2 (muscle)	0.036
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.036
fbln4	fibulin 4	0.036
bcl2l1	bcl2-like 1	0.036
rtf1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.035
fxr2	fragile X mental retardation, autosomal homolog 2	0.035
bmp2b	bone morphogenetic protein 2b	0.034	Human
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.033
papolb	poly(A) polymerase beta (testis specific)	0.033
per2	period homolog 2 (Drosophila)	0.033
pim1	pim-1 oncogene	0.032
copeb	core promoter element binding protein	0.031
keap1a	kelch-like ECH-associated protein 1a	0.031
fas	Fas (TNF receptor superfamily, member 6)	0.030
hbegfa	heparin-binding EGF-like growth factor a	0.030
ctage5	CTAGE family, member 5	0.029
otud7b	OTU domain containing 7B	0.029
msxd	muscle segment homeobox D	0.029
ved	ventrally expressed dharma/bozozok antagonist	0.028
csnk1g2a	casein kinase 1, gamma 2a	0.028
appl2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	0.028
slc30a1	solute carrier family 30 (zinc transporter), member 1	0.028
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.027
LOC567131	calcitonin gene-related peptide type 1 receptor-like	0.027
hsp70l	heat shock cognate 70-kd protein, like	0.027
casp8	caspase 8, apoptosis-related cysteine peptidase	0.026
hoxc8a	homeo box C8a	0.026
twist1a	twist1a	0.026
nphs1l	nephrosis 1, congenital, Finnish type (nephrin)-like	0.026
spag1	sperm associated antigen 1	0.026
ube4b	ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)	0.025
acta1b	actin, alpha 1b, skeletal muscle	0.025
ppm1ba	protein phosphatase, Mg2+/Mn2+ dependent, 1Ba	0.024
zgc:112257	zgc:112257	0.024
si:ch211-14a17.3	si:ch211-14a17.3	0.024
si:dkey-97i18.2	si:dkey-97i18.2	0.024
vasp	vasodilator-stimulated phosphoprotein	0.024
dhrs3b	dehydrogenase/reductase (SDR family) member 3b	0.023
si:ch211-57k11.10	si:ch211-57k11.10	0.023
cadps2	Ca2+-dependent activator protein for secretion 2	0.023
gngt2b	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2b	0.023
si:ch211-89f7.4	si:ch211-89f7.4	0.022
csnk1db	casein kinase 1, delta b	0.022
kirrelb	kin of IRRE like b	0.022
rbbp6	retinoblastoma binding protein 6	0.022
eif2ak3	eukaryotic translation initiation factor 2-alpha kinase 3	0.022
zgc:153997	zgc:153997	0.022
xbp1	X-box binding protein 1	0.022
bmper	BMP binding endothelial regulator	0.021
kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.021
pcmtd1	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	0.021
mll4b	myeloid/lymphoid or mixed-lineage leukemia 4b	0.021
mcl1a	myeloid cell leukemia sequence 1a	0.021
myog	myogenin	0.020
aplp2	amyloid beta (A4) precursor-like protein 2	0.020
cry1a	cryptochrome 1a	0.020
st3gal2l	ST3 beta-galactoside alpha-2,3-sialyltransferase 2, like	0.020
clcn7	chloride channel 7	0.020
cyp3c1	cytochrome P450, family 3, subfamily c, polypeptide 1	0.020
zmynd11	zinc finger, MYND domain containing 11	0.020
hoxa13b	homeo box A13b	0.020
akt2	v-akt murine thymoma viral oncogene homolog 2	0.020
ctsl1a	cathepsin L, 1 a	0.020
myom1a	myomesin 1a (skelemin)	0.019
rab22a	RAB22A, member RAS oncogene family	0.019
atp6v1e1b	ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b	0.019
col7a1l	collagen type VII alpha 1-like	0.019
col5a3b	collagen type V alpha-3b	0.019
eif4ebp3l	eukaryotic translation initiation factor 4E binding protein 3, like	0.019
agpat4	1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)	0.019
fadd	Fas (tnfrsf6)-associated via death domain	0.019
wtip	Wilms tumor 1 interacting protein	0.019
bida	BH3 interacting domain death agonist	0.018
socs1	suppressor of cytokine signaling 1	0.018
capn2a	calpain 2, (m/II) large subunit a	0.018
colec11	collectin sub-family member 11	0.018
si:dkey-177e13.4	si:dkey-177e13.4	0.018
rhoab	ras homolog gene family, member Ab	0.018
irf7	interferon regulatory factor 7	0.018
socs3b	suppressor of cytokine signaling 3b	0.018
npepps	aminopeptidase puromycin sensitive	0.018
mtmr8	myotubularin related protein 8	0.018
clptm1	cleft lip and palate associated transmembrane protein 1	0.018
igfbp1a	insulin-like growth factor binding protein 1a	0.018
zgc:66286	zgc:66286	0.018
rrm2b	ribonucleotide reductase M2 b	0.017
zgc:66385	zgc:66385	0.017
si:dkey-177p2.6	si:dkey-177p2.6	0.017
stau2	staufen, RNA binding protein, homolog 2 (Drosophila)	0.017
adam23a	a disintegrin and metallopeptidase domain 23a	0.017
irgq1	immunity-related GTPase family, q1	0.017
rbl1	retinoblastoma-like 1 (p107)	0.017
kbtbd10b	kelch repeat and BTB (POZ) domain containing 10b	0.017
myl1	myosin, light chain 1, alkali; skeletal, fast	0.017
myf5	myogenic factor 5	0.017
cndp2	CNDP dipeptidase 2 (metallopeptidase M20 family)	0.017
ell2	elongation factor, RNA polymerase II, 2	0.017
abhd16a	abhydrolase domain containing 16A	0.017
fosl2	fos-like antigen 2	0.016
stk25b	serine/threonine kinase 25b	0.016
si:ch211-272f3.4	si:ch211-272f3.4	0.016
mical1	microtubule associated monoxygenase, calponin and LIM domain containing 1	0.016
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.016
LOC100001530	isotocin receptor-like 2	0.016
ubiad1	UbiA prenyltransferase domain containing 1	0.016
zbtb22b	zinc finger and BTB domain containing 22b	0.016
spry4	sprouty (Drosophila) homolog 4	0.016
trim3a	tripartite motif-containing 3a	0.016
gtdc1	glycosyltransferase-like domain containing 1	0.016
tp53inp1	tumor protein p53 inducible nuclear protein 1	0.016
dock5	dedicator of cytokinesis 5	0.016
dlst	dihydrolipoamide S-succinyltransferase	0.016
slc31a1	solute carrier family 31 (copper transporters), member 1	0.016
frmd6	FERM domain containing 6	0.016
agr2	anterior gradient homolog 2 (Xenopus laevis)	0.016
cflar	CASP8 and FADD-like apoptosis regulator	0.015
aftpha	aftiphilin a	0.015
efnb2a	ephrin B2a	0.015
nrg2b	neuregulin 2b	0.015
zgc:136894	zgc:136894	0.015
gab1	GRB2-associated binding protein 1	0.015
sb:cb134	sb:cb134	0.015
zgc:112052	zgc:112052	0.015
apaf1	apoptotic protease activating factor 1	0.015
acin1a	apoptotic chromatin condensation inducer 1a	0.015
csrnp1a	cysteine-serine-rich nuclear protein 1a	0.015
LOC798872	deiodinase 3	0.015
frzb	frizzled-related protein	0.015
vcana	versican a	0.015
cd40	CD40 antigen	0.014
tceb2	transcription elongation factor B (SIII), polypeptide 2 (18kD, elongin B)	0.014
wnt5a	wingless-type MMTV integration site family, member 5a	0.014
ccng1	cyclin G1	0.014
ppm1aa	protein phosphatase, Mg2+/Mn2+ dependent, 1Aa	0.014	Fly
fgf24	fibroblast growth factor 24	0.014
mxa	myxovirus (influenza) resistance A	0.014
nf1b	neurofibromin 1b	0.014
mylz2	myosin, light polypeptide 2, skeletal muscle	0.014
LOC100150090	sphingosine kinase 2-like	0.014
wwp2	WW domain containing E3 ubiquitin protein ligase 2	0.014
zgc:56376	zgc:56376	0.014
itga7	integrin, alpha 7	0.014
odf3l2	outer dense fiber of sperm tails 3-like 2	0.014
selt1a	selenoprotein T, 1a	0.014
ogt.1	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 1	0.014
sccpdhb	saccharopine dehydrogenase b	0.014
mapk6	mitogen-activated protein kinase 6	0.014
atp1b3a	ATPase, Na+/K+ transporting, beta 3a polypeptide	0.014
usp36	ubiquitin specific peptidase 36	0.014
tlk1b	tousled-like kinase 1b	0.014
irak4	interleukin-1 receptor-associated kinase 4	0.014
adipor2	adiponectin receptor 2	0.014
capzb	capping protein (actin filament) muscle Z-line, beta	0.014
pdpk1a	3-phosphoinositide dependent protein kinase-1a	0.013
sat1b	spermidine/spermine N1-acetyl transferase 1b	0.013
LOC100537975	thyroid receptor-interacting protein 11-like	0.013
wnt9b	wingless-type MMTV integration site family, member 9B	0.013
optn	optineurin	0.013
ampd3	adenosine monophosphate deaminase 3	0.013
stat1b	signal transducer and activator of transcription 1b	0.013
pttg1ipb	pituitary tumor-transforming 1 interacting protein b	0.013
tnfsf10l4	tumor necrosis factor (ligand) superfamily, member 10 like 4	0.013
hdc	histidine decarboxylase	0.013
furinb	furin (paired basic amino acid cleaving enzyme) b	0.013
eve1	even-skipped-like1	0.013
dusp7	dual specificity phosphatase 7	0.013
tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.013
vps33b	vacuolar protein sorting 33B	0.013
ythdf1	YTH domain family, member 1	0.013
tsc22d3	TSC22 domain family, member 3	0.013
cldn1	claudin 1	0.013
gna12	guanine nucleotide binding protein (G protein) alpha 12	0.013
pvalb4	parvalbumin 4	0.012
lyrm1	LYR motif containing 1	0.012
mt2	metallothionein 2	0.012
hs3st1l1	heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like1	0.012
map2k4a	mitogen-activated protein kinase kinase 4a	0.012
ifi30	interferon gamma inducible protein 30	0.012
ptprk	protein tyrosine phosphatase, receptor type, K	0.012
bik	BCL2-interacting killer (apoptosis-inducing)	0.012
hoxc5a	homeo box C5a	0.012
xirp1	xin actin-binding repeat containing 1	0.012
si:dkey-21e7.2	si:dkey-21e7.2	0.012
nitr5	novel immune-type receptor 5 and immune-type receptor 5-like	0.012
ncoa2	nuclear receptor coactivator 2	0.012
jak1	Janus kinase 1	0.012
insig1	insulin induced gene 1	0.012
fgf6a	fibroblast growth factor 6a	0.012
cldna	claudin a	0.012
pank1b	pantothenate kinase 1b	0.012
wu:fa04h02	wu:fa04h02	0.012
hsf4	heat shock transcription factor 4	0.012
si:ch211-241e15.2	si:ch211-241e15.2	0.012
alas1	aminolevulinate, delta-, synthetase 1	0.012
dusp4	dual specificity phosphatase 4	0.012
ccr6a	chemokine (C-C motif) receptor 6a	0.012
tsc1a	tuberous sclerosis 1a	0.012
zgc:64114	zgc:64114	0.012
cdc42ep2	CDC42 effector protein (Rho GTPase binding) 2	0.012
ppp6r2	protein phosphatase 6, regulatory subunit 2	0.012
pacsin1a	protein kinase C and casein kinase substrate in neurons 1a	0.012
cyb5r4	cytochrome b5 reductase 4	0.012
abcc4	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	0.012
pdap1	pdgfa associated protein 1	0.012
tnnt1	troponin T1, skeletal, slow	0.012
wisp1b	WNT1 inducible signaling pathway protein 1b	0.012
parp3	poly (ADP-ribose) polymerase family, member 3	0.012
huwe1	HECT, UBA and WWE domain containing 1	0.012
nrg2a	neuregulin 2a	0.012
slc16a9b	solute carrier family 16 (monocarboxylic acid transporters), member 9b	0.012
kop	askopos	0.012
pygma	phosphorylase, glycogen (muscle) A	0.011
btg2	B-cell translocation gene 2	0.011
zgc:86757	zgc:86757	0.011
bscv	bscv (C20orf3) homolog	0.011
furina	furin (paired basic amino acid cleaving enzyme) a	0.011
vipr1	vasoactive intestinal peptide receptor 1	0.011
crtc3	CREB regulated transcription coactivator 3	0.011
zdhhc8b	zinc finger, DHHC-type containing 8b	0.011
ugt5b4	UDP glucuronosyltransferase 5 family, polypeptide B4	0.011
tgfbr2	transforming growth factor, beta receptor II	0.011
hspb8	heat shock protein, alpha-crystallin-related, b8	0.011
il13ra1	interleukin 13 receptor, alpha 1	0.011
itgb3a	integrin beta 3a	0.011
ppp1cbl	protein phosphatase 1, catalytic subunit, beta isoform, like	0.011
ugt5a5	UDP glucuronosyltransferase 5 family, polypeptide A5	0.011
wu:fi25h02	wu:fi25h02	0.011
tirap	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.011
kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.011
hkdc1	hexokinase domain containing 1	0.011
ugt2a1	UDP glucuronosyltransferase 2 family, polypeptide A1	0.011
slc39a10	solute carrier family 39 (zinc transporter), member 10	0.011
myf6	myogenic factor 6	0.011
pcdh1a6	protocadherin 1 alpha 6	0.011
trim55a	tripartite motif-containing 55a	0.011
stat1a	signal transduction and activation of transcription 1a	0.011
slc16a9a	solute carrier family 16 (monocarboxylic acid transporters), member 9a	0.011
zgc:64115	zgc:64115	0.011
atg12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.011
ntn2	netrin 2	0.011
ufm1	ubiquitin-fold modifier 1	0.011
si:dkeyp-69b9.5	si:dkeyp-69b9.5	0.011
tnni1al	troponin I, skeletal, slow like	0.011
prkaa1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.011
im:7138239	im:7138239	0.011
tp53bp2	tumor protein p53 binding protein, 2	0.011
sfswap	splicing factor, suppressor of white-apricot homolog (Drosophila)	0.011
illr4	immune-related, lectin-like receptor 4	0.011
etv5a	ets variant 5a	0.011
zgc:154110	zgc:154110	0.011
abca1a	ATP-binding cassette, sub-family A (ABC1), member 1A	0.011
letm2	leucine zipper-EF-hand containing transmembrane protein 2	0.011
wu:fb78c02	wu:fb78c02	0.011
zc3h14	zinc finger CCCH-type containing 14	0.011
dhdhl	dihydrodiol dehydrogenase (dimeric), like	0.011
copa	coatomer protein complex, subunit alpha	0.011
stx3a	syntaxin 3A	0.011
LOC100005454	Gig2-like protein DreK	0.011
saga	S-antigen; retina and pineal gland (arrestin) a	0.011
irf2bp1	interferon regulatory factor 2 binding protein 1	0.011
zgc:112084	zgc:112084	0.011
zgc:92683	zgc:92683	0.011
eya3	eyes absent homolog 3	0.011
ncaldb	neurocalcin delta b	0.011
mospd2	motile sperm domain containing 2	0.011
pcsk7	proprotein convertase subtilisin/kexin type 7	0.011
hoxc6b	homeo box C6b	0.010
brap	BRCA1 associated protein	0.010
kbtbd8	kelch repeat and BTB (POZ) domain containing 8	0.010
pcdh1a9	protocadherin 1 alpha 9	0.010
pcdh1a8	protocadherin 1 alpha 8	0.010
pcdh1a5	protocadherin 1 alpha 5	0.010
flrt1a	fibronectin leucine rich transmembrane 1a	0.010
nos2a	nitric oxide synthase 2a, inducible	0.010
gabarapa	GABA(A) receptor-associated protein a	0.010
irak3	interleukin-1 receptor-associated kinase 3	0.010
il10	interleukin 10	0.010
ghrhra	growth hormone releasing hormone receptor a	0.010
ivns1abpa	influenza virus NS1A binding protein a	0.010
tie2	endothelium-specific receptor tyrosine kinase 2	0.010
cyp1c2	cytochrome P450, family 1, subfamily C, polypeptide 2	0.010
acp5b	acid phosphatase 5b, tartrate resistant	0.010
hbs1l	HBS1-like (S. cerevisiae)	0.010
pls3	plastin 3 (T isoform)	0.010
lrata	lecithin retinol acyltransferase a (phosphatidylcholine--retinol O-acyltransferase a)	0.010
rhoh	ras homolog gene family, member H	0.010
macf1	microtubule-actin crosslinking factor 1	0.010
insra	insulin receptor a	0.010
ptrfb	polymerase I and transcript release factor b	0.010
tbce	tubulin folding cofactor E	0.010
ugt2a3	UDP glucuronosyltransferase 2 family, polypeptide A3	0.010
etv5b	ets variant 5b	0.010
zswim5	zinc finger, SWIM-type containing 5	0.010
il1rapl1a	interleukin 1 receptor accessory protein-like 1a	0.010
dhrs7b	dehydrogenase/reductase (SDR family) member 7B	0.010
baxb	bcl2-associated X protein, b	0.010
keap1b	kelch-like ECH-associated protein 1b	0.010
gnb3b	guanine nucleotide binding protein (G protein), beta polypeptide 3b	0.010
sarm1	sterile alpha and TIR motif containing 1	0.010
crfb7	cytokine receptor family member b7	0.010
katnb1	katanin p80 (WD repeat containing) subunit B 1	0.010
ndst2a	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2a	0.010
zgc:101598	zgc:101598	0.010
zgc:113409	zgc:113409	0.010
wu:fj98a08	wu:fj98a08	0.010
itln1	intelectin 1	0.010
ugt5f1	UDP glucuronosyltransferase 5 family, polypeptide F1	0.010
por	P450 (cytochrome) oxidoreductase	0.010
zgc:123120	zgc:123120	0.010
mid1ip1b	MID1 interacting protein 1b	0.010
aqp9b	aquaporin 9b	0.010
zgc:123296	zgc:123296	0.010
rbpjb	recombination signal binding protein for immunoglobulin kappa J region b	0.010
tlr20f	toll-like receptor 20f	0.010
LOC100005504	Gig2-like protein DreL	0.010