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Danio rerio

14 genes annotated in zebrafish

dorsal ventral axis specification

The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dorsal ventral axis specification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "dorsal ventral axis specification" (in gray)

Name	Description	Probability	Func Analog Organism
ndr2	nodal-related 2	0.913	Zebrafish
wnt4a	wingless-type MMTV integration site family, member 4a	0.717	Zebrafish
tbx1	T-box 1	0.711
lef1	lymphocyte enhancer binding factor 1	0.709
dharma	dharma	0.640	Zebrafish
fgf3	fibroblast growth factor 3	0.578
ntn1b	netrin 1b	0.509
dkk1b	dickkopf 1b	0.462
bmp4	bone morphogenetic protein 4	0.460	Zebrafish Fly
sox3	SRY-box containing gene 3	0.435	Zebrafish
oep	one-eyed pinhead	0.413
pth2r	parathyroid hormone 2 receptor	0.381
her5	hairy-related 5	0.359
ntla	no tail a	0.349
wnt8b	wingless-type MMTV integration site family, member 8b	0.289	Zebrafish
ephb4b	eph receptor B4b	0.282
gli1	GLI-Kruppel family member 1	0.266
spry4	sprouty (Drosophila) homolog 4	0.264
wnt11r	wingless-type MMTV integration site family, member 11, related	0.200	Zebrafish
sox1a	SRY-box containing gene 1a	0.199	Zebrafish
sox17	SRY-box containing gene 17	0.193	Zebrafish
vent	ventral expressed homeobox	0.182
sox9a	SRY-box containing gene 9a	0.179	Zebrafish
igf1rb	insulin-like growth factor 1b receptor	0.178
sfrp1a	secreted frizzled-related protein 1a	0.177	Human
sox4b	SRY-box containing gene 4b	0.170
flh	floating head	0.169
msxc	muscle segment homeobox C	0.164
wnt10a	wingless-type MMTV integration site family, member 10a	0.160	Zebrafish
map2k4a	mitogen-activated protein kinase kinase 4a	0.154
nkx6.2	NK6 transcription factor related, locus 2	0.149
zic3	zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)	0.143
znf711	zinc finger protein 711	0.131
zic2a	zic family member 2 (odd-paired homolog, Drosophila), a	0.119
nanos3	nanos homolog 3	0.119
snai1b	snail homolog 1b (Drosophila)	0.118
fgf8a	fibroblast growth factor 8 a	0.112
jag2	jagged 2	0.110
si:ch211-235f6.2	si:ch211-235f6.2	0.106
bmp2b	bone morphogenetic protein 2b	0.102
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.100
hoxd4a	homeo box D4a	0.099
wnt2	wingless-type MMTV integration site family member 2	0.099	Zebrafish
sox19b	SRY-box containing gene 19b	0.099
lhx2b	LIM homeobox 2b	0.096
mos	v-mos Moloney murine sarcoma viral oncogene homolog	0.095
dusp6	dual specificity phosphatase 6	0.094
buc	bucky ball	0.092
bmp2a	bone morphogenetic protein 2a	0.090	Zebrafish Fly
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.089
wnt7ba	wingless-type MMTV integration site family, member 7Ba	0.087	Zebrafish
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.086	Zebrafish
gli3	GLI-Kruppel family member GLI3	0.086
ca15b	carbonic anhydrase XV b	0.080
rel	v-rel reticuloendotheliosis viral oncogene homolog	0.078
pou5f1	POU domain, class 5, transcription factor 1	0.077
foxh1	forkhead box H1	0.077
cdx4	caudal type homeo box transcription factor 4	0.076
shhb	sonic hedgehog b	0.074
hgfa	hepatocyte growth factor a	0.073
gbx2	gastrulation brain homeo box 2	0.073
otx1b	orthodenticle homolog 1b	0.067
hmx1	H6 homeo box 1	0.067
col2a1a	collagen type II, alpha-1a	0.066
wnt9b	wingless-type MMTV integration site family, member 9B	0.065	Zebrafish
si:ch211-173o4.2	si:ch211-173o4.2	0.064
wnt7bb	wingless-type MMTV integration site family, member 7Bb	0.063
wnt3	wingless-type MMTV integration site family, member 3	0.063	Zebrafish Mouse
sema3aa	semaphorin 3aa	0.062
ptch2	patched 2	0.061
efnb2a	ephrin B2a	0.060
tbx16	T-box gene 16	0.056
extl3	exostoses (multiple)-like 3	0.056
sfrp5	secreted frizzled-related protein 5	0.055
wnt11	wingless-type MMTV integration site family, member 11	0.054	Zebrafish
shha	sonic hedgehog a	0.052
nkx2.5	NK2 transcription factor related 5	0.051
nkx6.1	NK6 transcription factor related, locus 1 (Drosophila)	0.051
foxg1a	forkhead box G1a	0.051
lfng	lunatic fringe homolog	0.051
tmpoa	thymopoietin a	0.049
hhip	hedgehog interacting protein	0.048
cdh2	cadherin 2, neuronal	0.047
sp5l	Sp5 transcription factor-like	0.046
wnt7aa	wingless-type MMTV integration site family, member 7Aa	0.045	Zebrafish
dazl	daz-like gene	0.045
dbx1a	developing brain homeobox 1a	0.043
vasa	vasa homolog	0.043
otx2	orthodenticle homolog 2	0.040
her6	hairy-related 6	0.040
lft1	lefty1	0.040
sox2	SRY-box containing gene 2	0.040	Zebrafish
fgfr1a	fibroblast growth factor receptor 1a	0.039
eng2a	engrailed 2a	0.038
ippk	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	0.038
spry2	sprouty homolog 2	0.036
hand2	heart and neural crest derivatives expressed transcript 2	0.035
ndr1	nodal-related 1	0.035
rbpja	recombination signal binding protein for immunoglobulin kappa J region a	0.034
gro2	groucho 2	0.033
csnk1da	casein kinase 1, delta a	0.033
msxe	muscle segment homeobox E	0.033
pbx4	pre-B-cell leukemia transcription factor 4	0.032
kita	kit receptor a	0.032
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.031
mcm7	MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)	0.031
ism1	isthmin 1	0.031
gata4	GATA-binding protein 4	0.031
zgc:111944	zgc:111944	0.031
wnt16	wingless-type MMTV integration site family, member 16	0.030
atoh1a	atonal homolog 1a	0.030
frem3	Fras1 related extracellular matrix 3	0.030
eya1	eyes absent homolog 1	0.029
csnk1g2a	casein kinase 1, gamma 2a	0.028
uxs1	UDP-glucuronic acid decarboxylase 1	0.028
ext2	exostoses (multiple) 2	0.028
smo	smoothened homolog (Drosophila)	0.028
ppp1r12a	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.028
ptch1	patched 1	0.027
zic1	zic family member 1 (odd-paired homolog, Drosophila)	0.027
sinup	siaz-interacting nuclear protein	0.027
chd7	chromodomain helicase DNA binding protein 7	0.027
frem2a	Fras1 related extracellular matrix protein 2a	0.027
evx1	even-skipped homeobox 1	0.026
zgc:77155	zgc:77155	0.026
nrg2a	neuregulin 2a	0.026
kop	askopos	0.025
twist3	twist3	0.025
fgfr1b	fibroblast growth factor receptor 1b	0.025
vax1	ventral anterior homeobox 1	0.025
emx3	empty spiracles homeobox 3	0.025
pdlim7	PDZ and LIM domain 7	0.025
rltpr	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	0.025
igf1ra	insulin-like growth factor 1a receptor	0.024
org	oogenesis-related gene	0.024
fbn2b	fibrillin 2b	0.024
her8a	hairy-related 8a	0.024
sox32	SRY-box containing gene 32	0.024	Zebrafish
gata5	GATA-binding protein 5	0.024
wnt5b	wingless-type MMTV integration site family, member 5b	0.024	Zebrafish
fzd8b	frizzled homolog 8b	0.024
epb4.1l4	erythrocyte protein band 4.1-like 4	0.024
angpt1	angiopoietin 1	0.024
fgf24	fibroblast growth factor 24	0.024
rarab	retinoic acid receptor, alpha b	0.023
cct8	chaperonin containing TCP1, subunit 8 (theta)	0.022
wnt9a	wingless-type MMTV integration site family, member 9A	0.022	Zebrafish
zbtb4	zinc finger and BTB domain containing 4	0.022
zgc:158603	zgc:158603	0.022
wnt10b	wingless-type MMTV integration site family, member 10b	0.022	Zebrafish
lft2	lefty2	0.022
sall4	sal-like 4 (Drosophila)	0.022
emx1	empty spiracles homeobox 1	0.021
znf503	zinc finger protein 503	0.021
polb	polymerase (DNA directed), beta	0.021
wnt3a	wingless-type MMTV integration site family, member 3A	0.021	Zebrafish
cdkn1c	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.021
zorba	Orb/CPEB-related RNA-binding protein	0.021	Fly
zfyve26	zinc finger, FYVE domain containing 26	0.021
sufu	suppressor of fused homolog (Drosophila)	0.021
fzd5	frizzled homolog 5	0.021	Human
h1m	linker histone H1M	0.021
boc	brother of CDO	0.020
szl	sizzled	0.020
pax8	paired box gene 8	0.020
nkx2.2a	NK2 transcription factor related 2a	0.020
edn1	endothelin 1	0.020
cnot8	CCR4-NOT transcription complex, subunit 8	0.020
arx	aristaless related homeobox	0.020
ewsr1a	Ewing sarcoma breakpoint region 1a	0.019
tia1	cytotoxic granule-associated RNA binding protein 1	0.019
raraa	retinoic acid receptor, alpha a	0.019
ihha	Indian hedgehog homolog a	0.019
max	myc-associated factor X	0.018
smad3b	MAD, mothers against decapentaplegic homolog 3b (Drosophila)	0.018
hmx4	H6 family homeobox 4	0.018
sox21a	SRY-box containing gene 21a	0.018
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.018	Fly
plekhh1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.018
osr1	odd-skipped related 1 (Drosophila)	0.017
efnb1	ephrin B1	0.017
smu1	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	0.017
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.017
olig4	oligodendrocyte transcription factor 4	0.017
htra1a	HtrA serine peptidase 1a	0.017
itga3b	integrin, alpha 3b	0.017
zgc:114095	zgc:114095	0.017
zeb1	zinc finger E-box binding homeobox 1	0.016
otul	OTU like protein	0.016
zgc:73265	zgc:73265	0.016
map2k6	mitogen-activated protein kinase kinase 6	0.016
hnrnpa0	heterogeneous nuclear ribonucleoprotein A0	0.016
wu:fb80a07	wu:fb80a07	0.016
sox11b	SRY-box containing gene 11b	0.016
rbpms2	RNA binding protein with multiple splicing 2	0.016
numbl	numb homolog (Drosophila)-like	0.016
dmrt3a	doublesex and mab-3 related transcription factor 3a	0.016
grem2	gremlin 2, cysteine knot superfamily	0.016
frem1a	Fras1 related extracellular matrix 1a	0.016
unc5c	unc-5 homolog C (C. elegans)	0.016
rnd3a	Rho family GTPase 3a	0.015
tbx5b	T-box 5b	0.015
chd	chordin	0.015	Fly
jag1b	jagged 1b	0.015
LOC100000687	signal peptide, CUB and EGF-like domain-containing protein 3-like	0.015
si:dkeyp-7c9.1	si:dkeyp-7c9.1	0.015
hmgb1a	high-mobility group box 1a	0.015
lama5	laminin, alpha 5	0.015
eif4e1b	eukaryotic translation initiation factor 4e 1b	0.015
mab21l2	mab-21-like 2	0.015
fn1	fibronectin 1	0.015
mga	MAX gene associated	0.015
glcea	glucuronyl C5-epimerase a	0.015
foxo3b	forkhead box O3b	0.015
nrarpa	notch-regulated ankyrin repeat protein a	0.015
bty	bloodthirsty	0.015
tbpl2	TATA box binding protein like 2	0.015
pom121	POM121 membrane glycoprotein (rat)	0.015
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.014
ved	ventrally expressed dharma/bozozok antagonist	0.014
rhoab	ras homolog gene family, member Ab	0.014
zgc:103697	zgc:103697	0.014
ncor1	nuclear receptor co-repressor 1	0.014
gata6	GATA-binding protein 6	0.014
tfeb	transcription factor EB	0.014
map2k4b	mitogen-activated protein kinase kinase 4b	0.014
admp	anti-dorsalizing morphogenic protein	0.014
si:ch1073-351m12.1	si:ch1073-351m12.1	0.014
piwil1	piwi-like 1 (Drosophila)	0.014
runx2b	runt-related transcription factor 2b	0.014
acvr1b	activin A receptor, type IB	0.013
celf1	cugbp, Elav-like family member 1	0.013
hs6st3	heparan sulfate 6-O-sulfotransferase 3	0.013
bon	bonnie and clyde	0.013
pld1a	phospholipase D1a	0.013
pcbp2	poly(rC) binding protein 2	0.013
tcf7l1b	transcription factor 7-like 1b (T-cell specific, HMG-box)	0.013
sass6	spindle assembly 6 homolog (C. elegans)	0.013
crygm4	crystallin, gamma M4	0.013
zgc:56304	zgc:56304	0.013
akirin2	akirin 2	0.013
fgfr4	fibroblast growth factor receptor 4	0.013
epha4b	eph receptor A4b	0.013
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.013
gsc	goosecoid	0.012
rpl37	ribosomal protein L37	0.012
efna5a	ephrin A5a	0.012
faf1	Fas associated factor 1	0.012
fbxl14b	F-box and leucine-rich repeat protein 14b	0.012
mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.012
foxa1	forkhead box A1	0.012
tnfsf10l3	tumor necrosis factor (ligand) superfamily, member 10 like 3	0.012
lhx3	LIM homeobox 3	0.012
fras1	Fraser syndrome 1	0.012
ppp2cb	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	0.012
cldnd	claudin d	0.012
sp2	sp2 transcription factor	0.012
pop7	processing of precursor 7, ribonuclease P family	0.012
otpb	orthopedia homolog b	0.012
vsx1	visual system homeobox 1 homolog, chx10-like	0.012
wnt8a	wingless-type MMTV integration site family, member 8a	0.012
si:ch211-255l12.1	si:ch211-255l12.1	0.012
smek1	SMEK homolog 1, suppressor of mek1 (Dictyostelium)	0.012
spsb1	splA/ryanodine receptor domain and SOCS box containing 1	0.012
nkx2.1a	NK2 homeobox 1a	0.012
axin1	axin 1	0.012
nav3	neuron navigator 3	0.012
hlxb9la	homeo box HB9 like a	0.012
asz1	ankyrin repeat, SAM and basic leucine zipper domain containing 1	0.012
pitx2	paired-like homeodomain transcription factor 2	0.012
pax4	paired box 4	0.012
fgf17	fibroblast growth factor 17	0.011
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.011
aplnra	apelin receptor a	0.011
morf4l1	mortality factor 4 like 1	0.011
mapk6	mitogen-activated protein kinase 6	0.011
brd3a	bromodomain containing 3a	0.011
bcl2	B-cell leukemia/lymphoma 2	0.011
atoh7	atonal homolog 7	0.011
atp6v1b2	ATPase, H+ transporting, lysosomal V1 subunit B2	0.011
abcc5	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	0.011
u2af2b	U2 small nuclear RNA auxiliary factor 2b	0.011
LOC559454	glypican-5-like	0.011
zgc:171802	zgc:171802	0.011
dnmt7	DNA (cytosine-5-)-methyltransferase 7	0.011
sept7b	septin 7b	0.011
eif1b	eukaryotic translation initiation factor 1B	0.011
gdf6a	growth differentiation factor 6a	0.011
trim3a	tripartite motif-containing 3a	0.011
syncripl	synaptotagmin binding, cytoplasmic RNA interacting protein, like	0.011	Fly
pcdh8	protocadherin 8	0.011
ildr1b	immunoglobulin-like domain containing receptor 1b	0.011
plk3	polo-like kinase 3 (Drosophila)	0.011
rnd1l	Rho family GTPase 1 like	0.011
mecp2	methyl CpG binding protein 2	0.011
aplnrb	apelin receptor b	0.010
foxi3b	forkhead box I3b	0.010
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.010
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.010	Fly
hoxa13a	homeo box A13a	0.010
meis3	myeloid ecotropic viral integration site 3	0.010
onecutl	one cut domain, family member, like	0.010
apoeb	apolipoprotein Eb	0.010
vgll4l	vestigial like 4 like	0.010
ncaph	non-SMC condensin I complex, subunit H	0.010
arl4ab	ADP-ribosylation factor-like 4ab	0.010
wnt5a	wingless-type MMTV integration site family, member 5a	0.010	Zebrafish
foxa2	forkhead box A2	0.010
mcl1a	myeloid cell leukemia sequence 1a	0.010
cables1	Cdk5 and Abl enzyme substrate 1	0.010
six3b	sine oculis homeobox homolog 3b	0.010