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Danio rerio

1 genes annotated in zebrafish

negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway

GO:0022002

The series of molecular signals that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
wnt4a	wingless-type MMTV integration site family, member 4a	1.000	Zebrafish
wnt1	wingless-type MMTV integration site family, member 1	0.999	Zebrafish
tbx1	T-box 1	0.995
wnt8b	wingless-type MMTV integration site family, member 8b	0.983
wnt3a	wingless-type MMTV integration site family, member 3A	0.966	Zebrafish
wnt10a	wingless-type MMTV integration site family, member 10a	0.937	Zebrafish
col11a2	collagen type XI alpha-2	0.915
fgf17	fibroblast growth factor 17	0.881
wnt2	wingless-type MMTV integration site family member 2	0.857	Zebrafish
hoxd4a	homeo box D4a	0.852
hnf1ba	HNF1 homeobox Ba	0.841
fgf3	fibroblast growth factor 3	0.840
bmp2a	bone morphogenetic protein 2a	0.802
gli1	GLI-Kruppel family member 1	0.771
zfyve26	zinc finger, FYVE domain containing 26	0.761
wnt10b	wingless-type MMTV integration site family, member 10b	0.755	Zebrafish
wnt7ba	wingless-type MMTV integration site family, member 7Ba	0.751	Zebrafish
wnt9b	wingless-type MMTV integration site family, member 9B	0.741	Zebrafish
bmp4	bone morphogenetic protein 4	0.694
dbx1a	developing brain homeobox 1a	0.681
sfrp1a	secreted frizzled-related protein 1a	0.673
wnt9a	wingless-type MMTV integration site family, member 9A	0.597	Zebrafish
dkk1b	dickkopf 1b	0.581
twist1a	twist1a	0.573
wnt3	wingless-type MMTV integration site family, member 3	0.544	Zebrafish
lft1	lefty1	0.542
twist3	twist3	0.520
wnt11r	wingless-type MMTV integration site family, member 11, related	0.507	Zebrafish
wls	wntless homolog (Drosophila)	0.478
dharma	dharma	0.476
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.475
sox2	SRY-box containing gene 2	0.397
grem1a	gremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis)	0.395
mll	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.356
ndr2	nodal-related 2	0.355
zic3	zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)	0.348
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.339	Zebrafish
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.311
foxj1a	forkhead box J1a	0.306
wnt16	wingless-type MMTV integration site family, member 16	0.289
brd4	bromodomain containing 4	0.271
fbn2b	fibrillin 2b	0.267
hmx4	H6 family homeobox 4	0.232
foxb1.2	forkhead box B1.2	0.229
lft2	lefty2	0.223
wnt4b	wingless-type MMTV integration site family, member 4b	0.218	Zebrafish
wnt11	wingless-type MMTV integration site family, member 11	0.212	Zebrafish
fgf4	fibroblast growth factor 4	0.205
wnt5b	wingless-type MMTV integration site family, member 5b	0.203	Zebrafish
gli2b	GLI-Kruppel family member GLI2b	0.202
vent	ventral expressed homeobox	0.198
wnt7aa	wingless-type MMTV integration site family, member 7Aa	0.190	Zebrafish
pdlim7	PDZ and LIM domain 7	0.181
lef1	lymphocyte enhancer binding factor 1	0.177
zic2a	zic family member 2 (odd-paired homolog, Drosophila), a	0.167
ptch2	patched 2	0.166
sfrp5	secreted frizzled-related protein 5	0.162
eve1	even-skipped-like1	0.162
cdkn1c	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.160
znf711	zinc finger protein 711	0.160
rest	RE1-silencing transcription factor	0.159
rbpja	recombination signal binding protein for immunoglobulin kappa J region a	0.145
ntla	no tail a	0.141
ved	ventrally expressed dharma/bozozok antagonist	0.138
sox4b	SRY-box containing gene 4b	0.131
msxc	muscle segment homeobox C	0.130
tbx16	T-box gene 16	0.125
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.122
smad9	MAD homolog 9 (Drosophila)	0.122
pth2	parathyroid hormone 2	0.116
runx2b	runt-related transcription factor 2b	0.114
glra1	glycine receptor, alpha 1	0.114
her5	hairy-related 5	0.111
fgf8a	fibroblast growth factor 8 a	0.111
map2k4b	mitogen-activated protein kinase kinase 4b	0.110
dusp6	dual specificity phosphatase 6	0.109
frzb	frizzled-related protein	0.106
ntn1b	netrin 1b	0.105
ptch1	patched 1	0.104
kop	askopos	0.103
cdx4	caudal type homeo box transcription factor 4	0.101
shha	sonic hedgehog a	0.099
bmp2b	bone morphogenetic protein 2b	0.099
flh	floating head	0.099
gbx2	gastrulation brain homeo box 2	0.098
tnfsf10l3	tumor necrosis factor (ligand) superfamily, member 10 like 3	0.097
zbtb4	zinc finger and BTB domain containing 4	0.097
shhb	sonic hedgehog b	0.094
wnt5a	wingless-type MMTV integration site family, member 5a	0.094	Zebrafish
sox3	SRY-box containing gene 3	0.093
fgf10a	fibroblast growth factor 10a	0.091
chd	chordin	0.091
map2k7	mitogen-activated protein kinase kinase 7	0.089
sp5l	Sp5 transcription factor-like	0.087
ephb4b	eph receptor B4b	0.087
epha4a	eph receptor A4a	0.087
snai1b	snail homolog 1b (Drosophila)	0.084
admp	anti-dorsalizing morphogenic protein	0.084
sox17	SRY-box containing gene 17	0.083
bmp1a	bone morphogenetic protein 1a	0.083
glceb	glucuronyl C5-epimerase b	0.082
hoxa2b	homeo box A2b	0.082
pdlim3b	PDZ and LIM domain 3b	0.079
wif1	wnt inhibitory factor 1	0.079
nkx3.2	NK3 homeobox 2	0.077
si:dkey-273o13.1	si:dkey-273o13.1	0.077
eng2a	engrailed 2a	0.076
hoxa13b	homeo box A13b	0.076
spry4	sprouty (Drosophila) homolog 4	0.074
foxd5	forkhead box D5	0.074
hoxc6a	homeo box C6a	0.074
mapk8b	mitogen-activated protein kinase 8b	0.073
ippk	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	0.072
fzd10	frizzled homolog 10	0.069
onecutl	one cut domain, family member, like	0.069
amotl2a	angiomotin like 2a	0.067
sfrp1b	secreted frizzled-related protein 1b	0.065
bon	bonnie and clyde	0.065
rspo3	R-spondin 3 homolog (Xenopus laevis)	0.063
esrra	estrogen-related receptor alpha	0.060
sult1st4	sulfotransferase family 1, cytosolic sulfotransferase 4	0.059
frem3	Fras1 related extracellular matrix 3	0.058
igf1ra	insulin-like growth factor 1a receptor	0.057
pwp2h	PWP2 periodic tryptophan protein homolog (yeast)	0.057
oxtl	oxytocin-like	0.057
tfpi2	tissue factor pathway inhibitor 2	0.055
pcdh8	protocadherin 8	0.055
tbx2a	T-box gene 2a	0.055
map2k4a	mitogen-activated protein kinase kinase 4a	0.054
si:ch1073-351m12.1	si:ch1073-351m12.1	0.053
has3	hyaluronan synthase 3	0.053
spry2	sprouty homolog 2	0.052
LOC566708	FL cytokine receptor-like	0.052
mapk14a	mitogen-activated protein kinase 14a	0.052
dab1a	disabled homolog 1a (Drosophila)	0.050
nog1	noggin 1	0.049
ntrk1	neurotrophic tyrosine kinase, receptor, type 1	0.048
dag1	dystroglycan 1	0.048
hmx1	H6 homeo box 1	0.048
tp73	tumor protein p73	0.047
scube2	signal peptide, CUB domain, EGF-like 2	0.047
foxd3	forkhead box D3	0.046
epb4.1l4	erythrocyte protein band 4.1-like 4	0.046
twist1b	twist1b	0.046
ptenb	phosphatase and tensin homolog B (mutated in multiple advanced cancers 1)	0.046
tbx18	T-box 18	0.045
dkk3	dickkopf homolog 3 (Xenopus laevis)	0.044
angpt2	angiopoietin 2	0.043
spaw	southpaw	0.043
mmp2	matrix metalloproteinase 2	0.041
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.041
myf6	myogenic factor 6	0.041
vox	ventral homeobox	0.040
dld	deltaD	0.040
zgc:171802	zgc:171802	0.039
pcdh18b	protocadherin 18b	0.038
tll1	tolloid-like 1	0.037
ihha	Indian hedgehog homolog a	0.037
lhx2b	LIM homeobox 2b	0.037
wnt2ba	wingless-type MMTV integration site family, member 2Ba	0.036	Zebrafish
efnb2a	ephrin B2a	0.036
vax2	ventral anterior homeobox 2	0.036
oep	one-eyed pinhead	0.035
hspb1	heat shock protein, alpha-crystallin-related, 1	0.035
tob1a	transducer of ERBB2, 1a	0.035
fbln1	fibulin 1	0.035
foxa2	forkhead box A2	0.034
elk4	ELK4, ETS-domain protein	0.034
lhx1b	LIM homeobox 1b	0.033
foxn4	forkhead box N4	0.032
wnt8a	wingless-type MMTV integration site family, member 8a	0.032	Zebrafish
hoxb1b	homeo box B1b	0.032
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.032
im:7162646	im:7162646	0.031
wnt7bb	wingless-type MMTV integration site family, member 7Bb	0.031
cx27.5	connexin 27.5	0.031
gbx1	gastrulation brain homeobox 1	0.030
hoxa9a	homeo box A9a	0.030
pax8	paired box gene 8	0.030
sb:cb81	sb:cb81	0.030
myod1	myogenic differentiation 1	0.029
grem2	gremlin 2, cysteine knot superfamily	0.029
limk1	LIM domain kinase 1	0.029
znf503	zinc finger protein 503	0.028
fgf6a	fibroblast growth factor 6a	0.028
dlx3b	distal-less homeobox gene 3b	0.028
pax7a	paired box gene 7a	0.028
lmo4a	LIM domain only 4a	0.027
cfl2l	cofilin 2, like	0.027
hoxb5b	homeo box B5b	0.027
ndr1	nodal-related 1	0.027
atoh1a	atonal homolog 1a	0.026
neurod4	neurogenic differentiation 4	0.026
bhlhe41	basic helix-loop-helix family, member e41	0.026
nkx1.2la	NK1 transcription factor related 2-like,a	0.026
LOC100000687	signal peptide, CUB and EGF-like domain-containing protein 3-like	0.026
csnk1da	casein kinase 1, delta a	0.026
nkd1	naked cuticle homolog 1 (Drosophila)	0.026
otx2	orthodenticle homolog 2	0.025
gyltl1b	glycosyltransferase-like 1b	0.025
cryaba	crystallin, alpha B, a	0.025
sulf1	sulfatase 1	0.025
msxe	muscle segment homeobox E	0.024
oprm1	opioid receptor, mu 1	0.024
og9x	OG9 homeobox gene	0.024
runx2a	runt-related transcription factor 2a	0.024
satb2	SATB homeobox 2	0.023
pax2a	paired box gene 2a	0.023
klf4a	Kruppel-like transcription factor 4a	0.023
fbp1b	fructose-1,6-bisphosphatase 1b	0.023
chrna4	cholinergic receptor, nicotinic, alpha 4	0.023
lfng	lunatic fringe homolog	0.022
exorh	extra-ocular rhodopsin	0.022
cryaa	crystallin, alpha A	0.022
tbx24	T-box 24	0.021
prdm1a	PR domain containing 1a, with ZNF domain	0.021
sim1a	single-minded homolog 1a (Drosophila)	0.021
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.021
tbx5a	T-box 5a	0.021
her1	hairy-related 1	0.021
olig3	oligodendrocyte transcription factor 3	0.020
hoxc4a	homeo box C4a	0.020
sass6	spindle assembly 6 homolog (C. elegans)	0.020
bactin2	bactin2	0.020
htra1a	HtrA serine peptidase 1a	0.019
pggt1b	protein geranylgeranyltransferase type I, beta subunit	0.019
tbx6	T-box gene 6	0.019
csad	cysteine sulfinic acid decarboxylase	0.019
notum3	notum 3	0.019
gpr173	G-protein coupled receptor 173	0.019
sp2	sp2 transcription factor	0.019
alcamb	activated leukocyte cell adhesion molecule b	0.019
hoxb2a	homeo box B2a	0.019
robo3	roundabout homolog 3	0.019
sox11b	SRY-box containing gene 11b	0.019
bmp7a	bone morphogenetic protein 7a	0.019
si:ch211-173o4.2	si:ch211-173o4.2	0.019
veph	ventricular zone expressed PH domain protein	0.018
lhx3	LIM homeobox 3	0.018
raraa	retinoic acid receptor, alpha a	0.018
vax1	ventral anterior homeobox 1	0.018
hoxa3a	homeo box A3a	0.017
mxtx2	mix-type homeobox gene 2	0.017
edn1	endothelin 1	0.017
smad3b	MAD, mothers against decapentaplegic homolog 3b (Drosophila)	0.017
LOC100359374	BCL-WAV	0.017
hoxa1a	homeo box A1a	0.017
egr1	early growth response 1	0.016
msxb	muscle segment homeobox B	0.016
vcana	versican a	0.016
trim3a	tripartite motif-containing 3a	0.016
hoxd10a	homeo box D10a	0.016
rargb	retinoic acid receptor, gamma b	0.016
pdlim4	PDZ and LIM domain 4	0.016
sox1a	SRY-box containing gene 1a	0.016
fn1	fibronectin 1	0.016
dnase1	deoxyribonuclease I	0.015
bty	bloodthirsty	0.015
osr1	odd-skipped related 1 (Drosophila)	0.015
rnd1l	Rho family GTPase 1 like	0.015
pigu	phosphatidylinositol glycan anchor biosynthesis, class U	0.015
hapln1a	hyaluronan and proteoglycan link protein 1a	0.015
fzd7a	frizzled homolog 7a	0.015
gngt2b	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2b	0.015
boc	brother of CDO	0.015
or111-6	odorant receptor, family D, subfamily 111, member 6	0.015
mapk1	mitogen-activated protein kinase 1	0.015
cdkl1	cyclin-dependent kinase-like 1 (CDC2-related kinase)	0.015
tgfbi	transforming growth factor, beta-induced	0.014
vsx1	visual system homeobox 1 homolog, chx10-like	0.014
hmgb1a	high-mobility group box 1a	0.014
her3	hairy-related 3	0.014
igfbp3	insulin-like growth factor binding protein 3	0.014
emx1	empty spiracles homeobox 1	0.014
zgc:153674	zgc:153674	0.014
foxp1b	forkhead box P1b	0.014
met	met proto-oncogene (hepatocyte growth factor receptor)	0.014
LOC798514	regulator of G-protein signaling protein-like	0.014
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.014
dab1b	disabled homolog 1b (Drosophila)	0.013
sim2	single-minded homolog 2 (Drosophila)	0.013
araf	v-raf murine sarcoma 3611 viral oncogene homolog	0.013
ism1	isthmin 1	0.013
myf5	myogenic factor 5	0.013
cxcr4b	chemokine (C-X-C motif), receptor 4b	0.013
tpbgl	trophoblast glycoprotein-like	0.013
igf1	insulin-like growth factor 1	0.013
oprd1a	opioid receptor, delta 1a	0.013
nog2	noggin 2	0.013
smo	smoothened homolog (Drosophila)	0.013
limk2	LIM domain kinase 2	0.013
wu:fi26e04	wu:fi26e04	0.013
sox32	SRY-box containing gene 32	0.012
lzts2a	leucine zipper, putative tumor suppressor 2a	0.012
fgf24	fibroblast growth factor 24	0.012
glcea	glucuronyl C5-epimerase a	0.012
chrm2a	cholinergic receptor, muscarinic 2a	0.012
gle1	GLE1 RNA export mediator homolog (yeast)	0.012
pkd2	polycystic kidney disease 2	0.012
pou5f1	POU domain, class 5, transcription factor 1	0.012
fzd7b	frizzled homolog 7b	0.012
plagl2	pleiomorphic adenoma gene-like 2	0.012
rxrab	retinoid x receptor, alpha b	0.012
cpa2	carboxypeptidase A2 (pancreatic)	0.012
hspb7	heat shock protein family, alpha-crystallin-related, b7	0.012
LOC100001530	isotocin receptor-like 2	0.012
mc3r	melanocortin 3 receptor	0.012
dlx2a	distal-less homeobox gene 2a	0.012
esr2a	estrogen receptor 2a	0.012
hoxb1a	homeo box B1a	0.012
gdf6b	growth differentiation factor 6b	0.012
fes	feline sarcoma oncogene	0.011
eya1	eyes absent homolog 1	0.011
hoxb6b	homeo box B6b	0.011
chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.011
spry1	sprouty homolog 1 (Drosophila)	0.011
mesp2	mesoderm posterior 2 homolog (mouse)	0.011
etv2	ets variant gene 2	0.011
cx44.1	connexin 44.1	0.011
hoxc8a	homeo box C8a	0.011
robo2	roundabout homolog 2	0.011
csnk1db	casein kinase 1, delta b	0.011
stat1b	signal transducer and activator of transcription 1b	0.010
rln3a	relaxin 3a	0.010
cobl	cordon-bleu homolog (mouse)	0.010
tnnt2a	troponin T2a, cardiac	0.010
dlc	deltaC	0.010
pomca	proopiomelanocortin a	0.010
ca15b	carbonic anhydrase XV b	0.010
comta	catechol-O-methyltransferase a	0.010
ppp1r3ca	protein phosphatase 1, regulatory (inhibitor) subunit 3Ca	0.010