IMP
Process View
The network for 'positive regulation of leukocyte activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
positive regulation of leukocyte activation
Any process that activates or increases the frequency, rate, or extent of leukocyte activation.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| LCK | lymphocyte-specific protein tyrosine kinase | 1.000 | |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 1.000 | |
| ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.997 | |
| SYK | spleen tyrosine kinase | 0.996 | |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 0.990 | |
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.990 | |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.979 | |
| INSR | insulin receptor | 0.973 | |
| GRB2 | growth factor receptor-bound protein 2 | 0.967 | |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.943 | |
| BCL2 | B-cell CLL/lymphoma 2 | 0.920 | |
| HLA-F | major histocompatibility complex, class I, F | 0.908 | |
| CD80 | CD80 molecule | 0.871 | |
| HLA-G | major histocompatibility complex, class I, G | 0.847 | |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.842 | |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 0.842 | |
| HLA-B | major histocompatibility complex, class I, B | 0.802 | |
| MLLT4 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 0.788 | |
| B2M | beta-2-microglobulin | 0.780 | |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 0.775 | |
| HLA-DMB | major histocompatibility complex, class II, DM beta | 0.774 | |
| LAT | linker for activation of T cells | 0.752 | |
| IL1R1 | interleukin 1 receptor, type I | 0.748 | |
| HLA-C | major histocompatibility complex, class I, C | 0.704 | |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 | 0.697 | |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.697 | |
| HLA-A | major histocompatibility complex, class I, A | 0.678 | |
| HLA-E | major histocompatibility complex, class I, E | 0.657 | |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.653 | |
| CREBBP | CREB binding protein | 0.652 | |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 0.647 | |
| LILRA6 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 | 0.640 | |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.635 | |
| IL2RB | interleukin 2 receptor, beta | 0.607 | |
| ICAM1 | intercellular adhesion molecule 1 | 0.595 | |
| PTPRC | protein tyrosine phosphatase, receptor type, C | 0.591 | |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.577 | |
| FAS | Fas (TNF receptor superfamily, member 6) | 0.573 | |
| LILRB1 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | 0.565 | |
| MALT1 | mucosa associated lymphoid tissue lymphoma translocation gene 1 | 0.563 | |
| SH3BP2 | SH3-domain binding protein 2 | 0.552 | |
| PML | promyelocytic leukemia | 0.539 | |
| LILRB3 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 | 0.527 | |
| CD86 | CD86 molecule | 0.526 | |
| HLA-DRB5 | major histocompatibility complex, class II, DR beta 5 | 0.526 | |
| STAT4 | signal transducer and activator of transcription 4 | 0.520 | |
| CCR7 | chemokine (C-C motif) receptor 7 | 0.517 | |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.501 | |
| CDK2 | cyclin-dependent kinase 2 | 0.494 | |
| BCL2L1 | BCL2-like 1 | 0.492 | |
| IL4R | interleukin 4 receptor | 0.468 | |
| CTLA4 | cytotoxic T-lymphocyte-associated protein 4 | 0.466 | |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.459 | |
| BTN3A1 | butyrophilin, subfamily 3, member A1 | 0.455 | |
| MMP2 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 0.452 | |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.413 | |
| TICAM2 | toll-like receptor adaptor molecule 2 | 0.409 | |
| CCL22 | chemokine (C-C motif) ligand 22 | 0.395 | |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.386 | |
| SIGLEC7 | sialic acid binding Ig-like lectin 7 | 0.384 | |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.377 | |
| CD247 | CD247 molecule | 0.376 | |
| CCR5 | chemokine (C-C motif) receptor 5 | 0.376 | |
| HCK | hemopoietic cell kinase | 0.373 | |
| BLNK | B-cell linker | 0.370 | |
| NCOR2 | nuclear receptor corepressor 2 | 0.366 | |
| RUNX1 | runt-related transcription factor 1 | 0.365 | |
| CCL4 | chemokine (C-C motif) ligand 4 | 0.359 | |
| IL2RG | interleukin 2 receptor, gamma | 0.359 | |
| ABI1 | abl-interactor 1 | 0.357 | |
| ESR1 | estrogen receptor 1 | 0.352 | |
| IL1B | interleukin 1, beta | 0.351 | |
| LIN9 | lin-9 homolog (C. elegans) | 0.341 | |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.338 | |
| LILRB2 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 | 0.331 | |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 0.327 | |
| FGFR2 | fibroblast growth factor receptor 2 | 0.326 | |
| TNFRSF9 | tumor necrosis factor receptor superfamily, member 9 | 0.310 | |
| TGIF1 | TGFB-induced factor homeobox 1 | 0.310 | |
| RXRA | retinoid X receptor, alpha | 0.307 | |
| NLRC4 | NLR family, CARD domain containing 4 | 0.307 | |
| GBA | glucosidase, beta, acid | 0.305 | |
| PLCG1 | phospholipase C, gamma 1 | 0.297 | |
| TLR2 | toll-like receptor 2 | 0.291 | |
| BTN3A2 | butyrophilin, subfamily 3, member A2 | 0.286 | |
| IFNG | interferon, gamma | 0.283 | |
| IRF4 | interferon regulatory factor 4 | 0.276 | |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.274 | |
| HDAC9 | histone deacetylase 9 | 0.274 | |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.272 | |
| GAS7 | growth arrest-specific 7 | 0.271 | |
| IL10 | interleukin 10 | 0.265 | |
| ZAP70 | zeta-chain (TCR) associated protein kinase 70kDa | 0.262 | |
| LST1 | leukocyte specific transcript 1 | 0.257 | |
| HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | 0.250 | |
| CD28 | CD28 molecule | 0.242 | |
| PTEN | phosphatase and tensin homolog | 0.239 | |
| CD1C | CD1c molecule | 0.238 | |
| CARD11 | caspase recruitment domain family, member 11 | 0.238 | |
| CCL13 | chemokine (C-C motif) ligand 13 | 0.231 |
Loading network...
Rattus norvegicus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| RT1-Ba | RT1 class II, locus Ba | 0.787 | |
| RT1-Da | RT1 class II, locus Da | 0.374 | |
| Cd5 | Cd5 molecule | 0.336 | |
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.307 | |
| Cd37 | CD37 molecule | 0.288 | |
| Cd3g | CD3 molecule, gamma | 0.272 | |
| RT1-Db1 | RT1 class II, locus Db1 | 0.256 | |
| Rassf5 | Ras association (RalGDS/AF-6) domain family member 5 | 0.193 | |
| Casp1 | caspase 1 | 0.191 | |
| Cd247 | Cd247 molecule | 0.190 | |
| Il9r | interleukin 9 receptor | 0.184 | |
| Il2rb | interleukin 2 receptor, beta | 0.176 | |
| Lyn | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.157 | |
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.143 | |
| Itgb7 | integrin, beta 7 | 0.121 | |
| St8sia4 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | 0.121 | |
| LOC100364854 | similar to RIKEN cDNA A430107P09 gene-like | 0.105 | |
| Cxcr3 | chemokine (C-X-C motif) receptor 3 | 0.104 | |
| P2rx2 | purinergic receptor P2X, ligand-gated ion channel, 2 | 0.104 | |
| Csf1 | colony stimulating factor 1 (macrophage) | 0.097 | |
| Cybb | cytochrome b-245, beta polypeptide | 0.094 | |
| Gzmk | granzyme K | 0.092 | |
| Ndst1 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 | 0.092 | |
| Cd53 | Cd53 molecule | 0.091 | |
| Dnase1l3 | deoxyribonuclease 1-like 3 | 0.087 | |
| Cd48 | Cd48 molecule | 0.086 | |
| Socs3 | suppressor of cytokine signaling 3 | 0.082 | |
| Map3k3 | mitogen activated protein kinase kinase kinase 3 | 0.082 | |
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.081 | |
| Cd4 | Cd4 molecule | 0.080 | |
| Cd40lg | CD40 ligand | 0.075 | |
| Itpkb | inositol 1,4,5-trisphosphate 3-kinase B | 0.075 | |
| Il13 | interleukin 13 | 0.074 | |
| Syt8 | synaptotagmin VIII | 0.074 | |
| Ptger4 | prostaglandin E receptor 4 (subtype EP4) | 0.072 | |
| Tcrb | T-cell receptor beta chain | 0.070 | |
| Cd38 | CD38 molecule | 0.069 | |
| Tgfbr3 | transforming growth factor, beta receptor III | 0.068 | |
| Ripk1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.068 | |
| Zic1 | Zic family member 1 (odd-paired homolog, Drosophila) | 0.068 | |
| Lim2 | lens intrinsic membrane protein 2 | 0.066 | |
| Il1b | interleukin 1 beta | 0.064 | |
| Sirpa | signal-regulatory protein alpha | 0.064 | |
| Slc6a3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 0.064 | |
| Il2rg | interleukin 2 receptor, gamma | 0.063 | |
| Igh-6 | immunoglobulin heavy chain 6 | 0.063 | |
| Icos | inducible T-cell co-stimulator | 0.062 | |
| Fgb | fibrinogen beta chain | 0.060 | |
| Kcnh7 | potassium voltage-gated channel, subfamily H (eag-related), member 7 | 0.060 | |
| Nkg7 | natural killer cell group 7 sequence | 0.057 | |
| Arhgap4 | Rho GTPase activating protein 4 | 0.057 | |
| Tgfbr2 | transforming growth factor, beta receptor II | 0.055 | |
| Rab3il1 | RAB3A interacting protein (rabin3)-like 1 | 0.055 | |
| Ptafr | platelet-activating factor receptor | 0.054 | |
| Itgad | integrin, alpha D | 0.054 | |
| Cyp11a1 | cytochrome P450, family 11, subfamily a, polypeptide 1 | 0.053 | |
| RT1-Bb | RT1 class II, locus Bb | 0.053 | |
| Cpa3 | carboxypeptidase A3, mast cell | 0.053 | |
| Psd4 | pleckstrin and Sec7 domain containing 4 | 0.051 | |
| Ucn | urocortin | 0.051 | |
| Il1r1 | interleukin 1 receptor, type I | 0.051 | |
| Scn11a | sodium channel, voltage-gated, type XI, alpha | 0.051 | |
| Tnfrsf4 | tumor necrosis factor receptor superfamily, member 4 | 0.050 | |
| Vip | vasoactive intestinal peptide | 0.049 | |
| Cd86 | CD86 molecule | 0.049 | |
| Cd2 | Cd2 molecule | 0.049 | |
| Ciita | class II, major histocompatibility complex, transactivator | 0.048 | |
| Cxcl6 | chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | 0.048 | |
| Lat | linker for activation of T cells | 0.047 | |
| Ncan | neurocan | 0.046 | |
| Cfp | complement factor properdin | 0.043 | |
| Olr1078 | olfactory receptor 1078 | 0.043 | |
| Cmklr1 | chemokine-like receptor 1 | 0.043 | |
| Fam26f | family with sequence similarity 26, member F | 0.041 | |
| Plin | perilipin | 0.040 | |
| Alox5 | arachidonate 5-lipoxygenase | 0.040 | |
| Olr1500 | olfactory receptor 1500 | 0.040 | |
| Faslg | Fas ligand (TNF superfamily, member 6) | 0.038 | |
| Pecam1 | platelet/endothelial cell adhesion molecule 1 | 0.038 | |
| Spn | sialophorin | 0.038 | |
| Tnfrsf8 | tumor necrosis factor receptor superfamily, member 8 | 0.037 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.036 | |
| Hdac7 | histone deacetylase 7 | 0.036 | |
| Slc7a9 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 | 0.035 | |
| Ccl5 | chemokine (C-C motif) ligand 5 | 0.035 | |
| Il10 | interleukin 10 | 0.035 | |
| Hsp90aa1 | heat shock protein 90, alpha (cytosolic), class A member 1 | 0.034 | |
| Il13ra2 | interleukin 13 receptor, alpha 2 | 0.034 | |
| Pou2af1 | POU class 2 associating factor 1 | 0.034 | |
| Psp | parotid secretory protein | 0.033 | |
| RT1-DMb | RT1 class II, locus DMb | 0.033 | |
| Batf3 | basic leucine zipper transcription factor, ATF-like 3 | 0.033 | |
| Hck | hemopoietic cell kinase | 0.033 | |
| Csf2rb | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.033 | |
| Cd79b | Cd79b molecule, immunoglobulin-associated beta | 0.032 | |
| LOC100361706 | lambda-chain C1-region-like | 0.032 | |
| Il1rl1 | interleukin 1 receptor-like 1 | 0.032 | |
| Cxcr5 | chemokine (C-X-C motif) receptor 5 | 0.032 | |
| Kynu | kynureninase (L-kynurenine hydrolase) | 0.032 | |
| Tnfsf4 | tumor necrosis factor (ligand) superfamily, member 4 | 0.031 |