The network for 'regulation of steroid metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of steroid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.

Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 0.998
FGF1 fibroblast growth factor 1 (acidic) 0.882
FGFR1 fibroblast growth factor receptor 1 0.858
HNF4A hepatocyte nuclear factor 4, alpha 0.826
IL1R1 interleukin 1 receptor, type I 0.815
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.713
AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) 0.705
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.680
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.676
AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 0.642
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.592
INSR insulin receptor 0.468
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.430
CREBBP CREB binding protein 0.415
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.387
ZFYVE9 zinc finger, FYVE domain containing 9 0.341
FGF10 fibroblast growth factor 10 0.314
BMPR1A bone morphogenetic protein receptor, type IA 0.313
GH1 growth hormone 1 0.295
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.292
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.291
BCL3 B-cell CLL/lymphoma 3 0.252
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.251
NCOR2 nuclear receptor corepressor 2 0.242
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.223
NCOA1 nuclear receptor coactivator 1 0.205
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.200
AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) 0.197
ALB albumin 0.192
SREBF2 sterol regulatory element binding transcription factor 2 0.186
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.156
CSHL1 chorionic somatomammotropin hormone-like 1 0.151
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.149
TNIP1 TNFAIP3 interacting protein 1 0.145
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.143
EP300 E1A binding protein p300 0.136
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.133
FGF8 fibroblast growth factor 8 (androgen-induced) 0.125
GH2 growth hormone 2 0.110
APOC2 apolipoprotein C-II 0.095
ESR1 estrogen receptor 1 0.094
BMPR1B bone morphogenetic protein receptor, type IB 0.084
CSH2 chorionic somatomammotropin hormone 2 0.084
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.082
KLB klotho beta 0.073
PGRMC1 progesterone receptor membrane component 1 0.069
FGF7 fibroblast growth factor 7 0.068
MED15 mediator complex subunit 15 0.067
FGF2 fibroblast growth factor 2 (basic) 0.064
APOC1 apolipoprotein C-I 0.062
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.060
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.059
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.055
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.050
IRS1 insulin receptor substrate 1 0.048
RRAGC Ras-related GTP binding C 0.046
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.046
RXRA retinoid X receptor, alpha 0.045
SKIL SKI-like oncogene 0.044
MYO6 myosin VI 0.044
RUNX1 runt-related transcription factor 1 0.043
SMAD3 SMAD family member 3 0.042
IL2RB interleukin 2 receptor, beta 0.041
HDAC3 histone deacetylase 3 0.040
SF3B4 splicing factor 3b, subunit 4, 49kDa 0.040
HP haptoglobin 0.040
HR hairless homolog (mouse) 0.040
RLN3 relaxin 3 0.039
TIMP3 TIMP metallopeptidase inhibitor 3 0.039
ITGB1BP3 integrin beta 1 binding protein 3 0.038
WNT1 wingless-type MMTV integration site family, member 1 0.038
APOC3 apolipoprotein C-III 0.037
LDLR low density lipoprotein receptor 0.035
ZMYND11 zinc finger, MYND-type containing 11 0.034
SMAD6 SMAD family member 6 0.034
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.034
GRB10 growth factor receptor-bound protein 10 0.034
FRS2 fibroblast growth factor receptor substrate 2 0.033
FGF4 fibroblast growth factor 4 0.033
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.032
ACAA1 acetyl-CoA acyltransferase 1 0.031
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 0.031
RRAGA Ras-related GTP binding A 0.031
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.030
FBXL15 F-box and leucine-rich repeat protein 15 0.030
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.029
SP1 Sp1 transcription factor 0.029
FGF18 fibroblast growth factor 18 0.028
PPARA peroxisome proliferator-activated receptor alpha 0.028
C7orf59 chromosome 7 open reading frame 59 0.027
PGR progesterone receptor 0.027
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.027
FSTL1 follistatin-like 1 0.027
CAV1 caveolin 1, caveolae protein, 22kDa 0.026
TG thyroglobulin 0.026
IRS2 insulin receptor substrate 2 0.026
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.025
CXXC5 CXXC finger protein 5 0.025
SNW1 SNW domain containing 1 0.025
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.025
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
stumps CG31317 gene product from transcript CG31317-RC 0.202
dib disembodied 0.124
pex16 peroxin 16 0.119
mi minus 0.109
tim timeless 0.094
myoglianin CG1838 gene product from transcript CG1838-RD 0.078
tll tailless 0.077
CG5362 CG5362 gene product from transcript CG5362-RA 0.077
CG31122 CG31122 gene product from transcript CG31122-RA 0.074
tsg twisted gastrulation 0.073
ci cubitus interruptus 0.070
dsx doublesex 0.066
ptc patched 0.066
PP2A-B' CG7913 gene product from transcript CG7913-RK 0.066
CG1907 CG1907 gene product from transcript CG1907-RA 0.065
Aldh-III Aldehyde dehydrogenase type III 0.062
CG9510 CG9510 gene product from transcript CG9510-RC 0.061
shn schnurri 0.060
elB elbow B 0.056
Nlp Nucleoplasmin 0.055
bnl branchless 0.054
cnc cap-n-collar 0.054
path pathetic 0.050
CG2107 CG2107 gene product from transcript CG2107-RA 0.049
Plc21C Phospholipase C at 21C 0.049
brk brinker 0.048
Mpk2 CG5475 gene product from transcript CG5475-RB 0.048
eve even skipped 0.047
Phm Peptidylglycine-alpha-hydroxylating monooxygenase 0.047
Lasp CG3849 gene product from transcript CG3849-RB 0.047
Clk Clock 0.046
foxo forkhead box, sub-group O 0.046
G-salpha60A G protein salpha 60A 0.043
Cat Catalase 0.042
p38b CG7393 gene product from transcript CG7393-RA 0.042
scw screw 0.041
Gip GIP-like 0.040
Myo31DF Myosin 31DF 0.038
sr stripe 0.038
sro shroud 0.038
comt comatose 0.038
hkb huckebein 0.038
CG7461 CG7461 gene product from transcript CG7461-RB 0.037
rtv retroactive 0.037
Egfr Epidermal growth factor receptor 0.036
CG12264 CG12264 gene product from transcript CG12264-RA 0.036
Kr Kruppel 0.036
ScpX Sterol carrier protein X-related thiolase 0.035
CG4389 CG4389 gene product from transcript CG4389-RA 0.035
gcm glial cells missing 0.034
Atg18 Autophagy-specific gene 18 0.034
CG7970 CG7970 gene product from transcript CG7970-RA 0.033
dpp decapentaplegic 0.032
CG17838 CG17838 gene product from transcript CG17838-RA 0.032
byn brachyenteron 0.031
CG3415 CG3415 gene product from transcript CG3415-RA 0.031
UGP CG4347 gene product from transcript CG4347-RE 0.030
CG1703 CG1703 gene product from transcript CG1703-RA 0.030
Med Medea 0.030
vvl ventral veins lacking 0.030
sna snail 0.030
CG12140 CG12140 gene product from transcript CG12140-RA 0.029
CG1640 CG1640 gene product from transcript CG1640-RB 0.029
slo slowpoke 0.029
kl-5 male fertility factor kl5 0.029
PHGPx CG12013 gene product from transcript CG12013-RC 0.029
rib ribbon 0.029
sll slalom 0.029
Vha26 Vacuolar H[+]-ATPase 26kD E subunit 0.029
pnr pannier 0.028
CG6178 CG6178 gene product from transcript CG6178-RA 0.028
Cyt-b5 CG2140 gene product from transcript CG2140-RB 0.028
NTPase CG3059 gene product from transcript CG3059-RD 0.027
ifc infertile crescent 0.027
CG17597 CG17597 gene product from transcript CG17597-RA 0.027
Fer2LCH Ferritin 2 light chain homologue 0.027
Csp Cysteine string protein 0.027
shd shade 0.026
Smg1 CG32743 gene product from transcript CG32743-RA 0.025
cora coracle 0.025
msl-1 male-specific lethal 1 0.025
sfl sulfateless 0.025
CG4598 CG4598 gene product from transcript CG4598-RA 0.025
Hcf Host cell factor 0.025
wg wingless 0.025
pst pastrel 0.025
ftz fushi tarazu 0.025
Trf2 TATA box binding protein-related factor 2 0.024
pyr pyramus 0.024
Pka-C1 cAMP-dependent protein kinase 1 0.024
CG3662 CG3662 gene product from transcript CG3662-RB 0.024
spo spook 0.024
ATPsyn-beta ATP synthase-beta 0.024
wor worniu 0.024
regucalcin CG1803 gene product from transcript CG1803-RA 0.024
cln3 CG5582 gene product from transcript CG5582-RA 0.024
tin tinman 0.024
CG11151 CG11151 gene product from transcript CG11151-RA 0.023
lab labial 0.023
Eaf ELL-associated factor 0.023
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Mus musculus
Name Description Probability Func Analog Organism
Pax8 paired box gene 8 0.987
Ghr growth hormone receptor 0.981
Lepr leptin receptor 0.879
Foxc1 forkhead box C1 0.855
Pax2 paired box gene 2 0.848
Thrb thyroid hormone receptor beta 0.847
Prlr prolactin receptor 0.786
Shh sonic hedgehog 0.750
Fgfr2 fibroblast growth factor receptor 2 0.655
Apoa1 apolipoprotein A-I 0.618
Gli3 GLI-Kruppel family member GLI3 0.504
Insr insulin receptor 0.501
Ar androgen receptor 0.488
Kl klotho 0.479
Fgf8 fibroblast growth factor 8 0.424
Bmp7 bone morphogenetic protein 7 0.400
Tgfb1 transforming growth factor, beta 1 0.386
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.385
Grb10 growth factor receptor bound protein 10 0.380
Fgfr1 fibroblast growth factor receptor 1 0.379
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.368
Hnf4a hepatic nuclear factor 4, alpha 0.361
Dmgdh dimethylglycine dehydrogenase precursor 0.336
Sox9 SRY-box containing gene 9 0.321
Rxra retinoid X receptor alpha 0.319
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.294
Rarg retinoic acid receptor, gamma 0.270
Rarb retinoic acid receptor, beta 0.259
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.256
Onecut1 one cut domain, family member 1 0.240
Ctnnb1 catenin (cadherin associated protein), beta 1 0.212
Fgf10 fibroblast growth factor 10 0.189
Duox2 dual oxidase 2 0.189
Hpd 4-hydroxyphenylpyruvic acid dioxygenase 0.165
Agtr1a angiotensin II receptor, type 1a 0.164
Drd2 dopamine receptor D2 0.160
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.160
Irf9 interferon regulatory factor 9 0.159
Wnt7a wingless-related MMTV integration site 7A 0.156
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.155
Tbx1 T-box 1 0.152
Gdnf glial cell line derived neurotrophic factor 0.148
Fgfr3 fibroblast growth factor receptor 3 0.147
Otx1 orthodenticle homolog 1 (Drosophila) 0.145
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.144
Egfr epidermal growth factor receptor 0.143
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.143
Gcgr glucagon receptor 0.142
Amhr2 anti-Mullerian hormone type 2 receptor 0.136
Tlr4 toll-like receptor 4 0.134
Pten phosphatase and tensin homolog 0.133
Bmp4 bone morphogenetic protein 4 0.131
Lhx1 LIM homeobox protein 1 0.131
Ren1 renin 1 structural 0.129
En1 engrailed 1 0.123
Il6st interleukin 6 signal transducer 0.118
Foxa2 forkhead box A2 0.113
Socs1 suppressor of cytokine signaling 1 0.108
Ldlr low density lipoprotein receptor 0.108
Tgfb2 transforming growth factor, beta 2 0.107
Lep leptin 0.107
Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 0.107
Lyz2 lysozyme 2 0.107
Foxn1 forkhead box N1 0.107
Nkx2-1 NK2 homeobox 1 0.105
Apoe apolipoprotein E 0.105
Pou4f3 POU domain, class 4, transcription factor 3 0.104
Hamp hepcidin antimicrobial peptide 0.103
Gpr50 G-protein-coupled receptor 50 0.102
Lmx1b LIM homeobox transcription factor 1 beta 0.102
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.102
Tgfbr2 transforming growth factor, beta receptor II 0.101
Esr2 estrogen receptor 2 (beta) 0.100
Igfals insulin-like growth factor binding protein, acid labile subunit 0.099
Stat5a signal transducer and activator of transcription 5A 0.099
Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 0.097
Slc12a1 solute carrier family 12, member 1 0.095
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.094
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.094
Esr1 estrogen receptor 1 (alpha) 0.094
Pnpla2 patatin-like phospholipase domain containing 2 0.093
Stat5b signal transducer and activator of transcription 5B 0.092
Lhx3 LIM homeobox protein 3 0.092
Nr1i3 nuclear receptor subfamily 1, group I, member 3 0.091
Ppara peroxisome proliferator activated receptor alpha 0.091
Htt huntingtin 0.091
Fshr follicle stimulating hormone receptor 0.089
Inhbc inhibin beta-C 0.088
Pparg peroxisome proliferator activated receptor gamma 0.087
Acvr1 activin A receptor, type 1 0.086
Il1a interleukin 1 alpha 0.084
Apob apolipoprotein B 0.083
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.082
Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 0.081
Lmx1a LIM homeobox transcription factor 1 alpha 0.081
Rara retinoic acid receptor, alpha 0.080
Nr0b1 nuclear receptor subfamily 0, group B, member 1 0.080
F2 coagulation factor II 0.079
Csf1 colony stimulating factor 1 (macrophage) 0.077
Nr0b2 nuclear receptor subfamily 0, group B, member 2 0.076
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Rattus norvegicus
Name Description Probability Func Analog Organism
Dbp D site of albumin promoter (albumin D-box) binding protein 0.028
Decr1 2,4-dienoyl CoA reductase 1, mitochondrial 0.023
Pip prolactin induced protein 0.019
Fasn fatty acid synthase 0.019
Bdkrb1 bradykinin receptor B1 0.019
Acaa2 acetyl-Coenzyme A acyltransferase 2 0.016
Etfdh electron-transferring-flavoprotein dehydrogenase 0.015
Ugt2b UDP glycosyltransferase 2 family, polypeptide B 0.015
Acadm acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain 0.015
LOC293989 cytochrome P450-like 0.015
Cyp51 cytochrome P450, family 51 0.015
Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 0.014
Cpt2 carnitine palmitoyltransferase 2 0.013
Chrng cholinergic receptor, nicotinic, gamma 0.013
Ech1 enoyl coenzyme A hydratase 1, peroxisomal 0.013
Ednra endothelin receptor type A 0.013
Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 0.013
Mcpt3 mast cell peptidase 3 0.012
Stc1 stanniocalcin 1 0.012
Sval1 seminal vesicle antigen-like 1 0.012
Lss lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.012
Scn9a sodium channel, voltage-gated, type IX, alpha 0.012
Pth parathyroid hormone 0.011
Foxj1 forkhead box J1 0.011
Eci2 enoyl-Coenzyme A delta isomerase 2 0.011
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.011
Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 0.011
Acmsd aminocarboxymuconate semialdehyde decarboxylase 0.011
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.011
Gja5 gap junction protein, alpha 5 0.011
Atp6v1g3 ATPase, H+ transporting, lysosomal V1 subunit G3 0.011
Sult1c3 sulfotransferase family, cytosolic, 1C, member 3 0.011
Nat1 N-acetyltransferase 1 0.011
Etfa electron-transfer-flavoprotein, alpha polypeptide 0.011
Ddr1 discoidin domain receptor tyrosine kinase 1 0.011
Slc25a20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.011
Lepr leptin receptor 0.010
Fgb fibrinogen beta chain 0.010
Aqp4 aquaporin 4 0.010
Fam108b1 family with sequence similarity 108, member B1 0.010
Vom1r93 vomeronasal 1 receptor 93 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism