The network for 'cell substrate junction assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell substrate junction assembly

The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate.

Homo sapiens
Name Description Probability Func Analog Organism
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.997
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.983
PTK2 PTK2 protein tyrosine kinase 2 0.950
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.940
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.917
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.883
EGFR epidermal growth factor receptor 0.882
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.843
S100B S100 calcium binding protein B 0.832
VEGFA vascular endothelial growth factor A 0.808
FN1 fibronectin 1 0.788
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.773
NCK2 NCK adaptor protein 2 0.734
BCAR1 breast cancer anti-estrogen resistance 1 0.708
FYN FYN oncogene related to SRC, FGR, YES 0.642
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.610
FLNA filamin A, alpha 0.579
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.536
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.495
S100A8 S100 calcium binding protein A8 0.451
S100A6 S100 calcium binding protein A6 0.448
S100A9 S100 calcium binding protein A9 0.447
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.445
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.408
S100A1 S100 calcium binding protein A1 0.402
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.383
ENG endoglin 0.382
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.363
NRP1 neuropilin 1 0.353
CAV1 caveolin 1, caveolae protein, 22kDa 0.334
PDIA3 protein disulfide isomerase family A, member 3 0.314
PXN paxillin 0.295
EPHA2 EPH receptor A2 0.291
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.262
ZYX zyxin 0.245
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.242
PLEC plectin 0.225
PDCD6IP programmed cell death 6 interacting protein 0.224
S100A4 S100 calcium binding protein A4 0.224
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.221
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.216
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.212
TGFB1 transforming growth factor, beta 1 0.211
BMP2 bone morphogenetic protein 2 0.207
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.195
TJP1 tight junction protein 1 (zona occludens 1) 0.193
SFN stratifin 0.182
ANGPT2 angiopoietin 2 0.179
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.174
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.164
GRB7 growth factor receptor-bound protein 7 0.163
ITGB4 integrin, beta 4 0.150
CDH5 cadherin 5, type 2 (vascular endothelium) 0.148
SMAD2 SMAD family member 2 0.144
MEOX2 mesenchyme homeobox 2 0.131
EPHA7 EPH receptor A7 0.131
FKBP1A FK506 binding protein 1A, 12kDa 0.129
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.126
EFNA1 ephrin-A1 0.123
GHR growth hormone receptor 0.122
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.110
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.109
TRIP6 thyroid hormone receptor interactor 6 0.107
PLCG1 phospholipase C, gamma 1 0.104
CAPG capping protein (actin filament), gelsolin-like 0.100
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.099
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.096
PTPRB protein tyrosine phosphatase, receptor type, B 0.093
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.092
SMAD7 SMAD family member 7 0.092
GRB2 growth factor receptor-bound protein 2 0.090
SOX10 SRY (sex determining region Y)-box 10 0.084
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.083
TCF4 transcription factor 4 0.078
ZNF746 zinc finger protein 746 0.076
QKI quaking homolog, KH domain RNA binding (mouse) 0.076
PRKG1 protein kinase, cGMP-dependent, type I 0.074
TEK TEK tyrosine kinase, endothelial 0.071
MET met proto-oncogene (hepatocyte growth factor receptor) 0.071
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.068
ITGA6 integrin, alpha 6 0.068
PDGFA platelet-derived growth factor alpha polypeptide 0.067
GRB10 growth factor receptor-bound protein 10 0.064
S100A2 S100 calcium binding protein A2 0.064
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.063
PVRL3 poliovirus receptor-related 3 0.063
CALD1 caldesmon 1 0.061
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.058
BMP1 bone morphogenetic protein 1 0.058
PTRF polymerase I and transcript release factor 0.058
ATF7IP activating transcription factor 7 interacting protein 0.057
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.056
S100A11 S100 calcium binding protein A11 0.055
LDLR low density lipoprotein receptor 0.055
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.054
LMNA lamin A/C 0.054
KITLG KIT ligand 0.053
PDGFC platelet derived growth factor C 0.053
GDF5 growth differentiation factor 5 0.049
ACVR1 activin A receptor, type I 0.049
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
pat-2 Protein PAT-2 0.010
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Danio rerio
Name Description Probability Func Analog Organism
gpm6aa glycoprotein M6Aa 0.384
pdia3 protein disulfide isomerase family A, member 3 0.326
vegfaa vascular endothelial growth factor Aa 0.199
sh3gl1b SH3-domain GRB2-like 1b 0.167
bactin1 bactin1 0.156
krt8 keratin 8 0.135
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.131
egr1 early growth response 1 0.125
hsp90b1 heat shock protein 90, beta (grp94), member 1 0.122
myf5 myogenic factor 5 0.119
calrl calreticulin like 0.113
cnn2 calponin 2 0.108
fbn2b fibrillin 2b 0.099
tpm4 tropomyosin 4 0.097
lamb1a laminin, beta 1a 0.092
gro1 groucho 1 0.090
hyou1 hypoxia up-regulated 1 0.088
dnajc3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.086
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.084
si:dkey-76k16.7 si:dkey-76k16.7 0.082
sfrs3b splicing factor, arginine/serine-rich 3b 0.080
osr1 odd-skipped related 1 (Drosophila) 0.074
pfn1 profilin 1 0.072
sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.070
kdrl kinase insert domain receptor like 0.070
hs3st3b1a heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1a 0.067
calr calreticulin and calreticulin 0.065
hcfc1a host cell factor C1a 0.064
tagln2 transgelin 2 0.063
hspa5 heat shock protein 5 0.063
adam8a a disintegrin and metalloproteinase domain 8a 0.061
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.059
pdia4 protein disulfide isomerase associated 4 0.057
hnrnpm heterogeneous nuclear ribonucleoprotein M 0.057
ntn2 netrin 2 0.056
pdlim1 PDZ and LIM domain 1 (elfin) 0.056
lgi1b leucine-rich, glioma inactivated 1b 0.055
calcrla calcitonin receptor-like a 0.055
pdip5 protein disulfide isomerase-related protein (provisional) 0.054
ptch2 patched 2 0.054
fstl1b follistatin-like 1b 0.053
manf mesencephalic astrocyte-derived neurotrophic factor 0.052
pdia5 protein disulfide isomerase family A, member 5 0.052
itgav integrin, alpha V 0.051
mapk1 mitogen-activated protein kinase 1 0.051
crip2 cysteine-rich protein 2 0.050
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.049
rab11fip4a RAB11 family interacting protein 4 (class II) a 0.049
itgb1b integrin, beta 1b 0.049
emilin1a elastin microfibril interfacer 1a 0.049
sept6 septin 6 0.047
gatsl2 GATS protein-like 2 0.046
crb2b crumbs homolog 2b 0.046
hspg2 heparan sulfate proteoglycan 2 0.045
copb2 coatomer protein complex, subunit beta 2 0.045
calrl2 calreticulin, like 2 0.044
she Src homology 2 domain containing E 0.044
plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.044
chrna6 cholinergic receptor, nicotinic, alpha 6 0.043
elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.043
rbpms2 RNA binding protein with multiple splicing 2 0.043
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.042
mapk15 mitogen-activated protein kinase 15 0.042
efnb2a ephrin B2a 0.042
nphs2 nephrosis 2, idiopathic, steroid-resistant (podocin) 0.041
zgc:100829 zgc:100829 0.040
angpt1 angiopoietin 1 0.039
uba1 ubiquitin-like modifier activating enzyme 1 0.039
hnrnph1l heterogeneous nuclear ribonucleoprotein H1, like 0.039
mtmr8 myotubularin related protein 8 0.039
snai2 snail homolog 2 (Drosophila) 0.039
pdlim4 PDZ and LIM domain 4 0.039
mespa mesoderm posterior a 0.038
LOC100151531 zinc finger protein Gfi-1b-like 0.038
icn ictacalcin 0.038
podxl podocalyxin-like 0.038
si:ch211-51m24.3 si:ch211-51m24.3 0.038
crb2a crumbs homolog 2a 0.037
LOC100149834 cdc2-related kinase, arginine/serine-rich-like 0.037
gdf6a growth differentiation factor 6a 0.037
bcam basal cell adhesion molecule (Lutheran blood group) 0.037
limk1 LIM domain kinase 1 0.037
ptgs1 prostaglandin-endoperoxide synthase 1 0.037
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.036
dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.036
wnt3a wingless-type MMTV integration site family, member 3A 0.036
LOC100537975 thyroid receptor-interacting protein 11-like 0.036
dpysl5b dihydropyrimidinase-like 5b 0.036
pqbp1l polyglutamine binding protein 1-like 0.036
etv2 ets variant gene 2 0.036
hnrpl heterogeneous nuclear ribonucleoprotein L 0.035
hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 0.035
dag1 dystroglycan 1 0.035
ddx5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 0.035
zgc:77262 zgc:77262 0.035
top2b topoisomerase (DNA) II beta 0.035
slc4a2a solute carrier family 4, anion exchanger, member 2a 0.034
bmp1a bone morphogenetic protein 1a 0.034
msna moesin a 0.034
nrp1b neuropilin 1b 0.034
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Eng endoglin 0.847
Pxn paxillin 0.844
Trp53 transformation related protein 53 0.731
Bcl2 B-cell leukemia/lymphoma 2 0.715
Lama5 laminin, alpha 5 0.664
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.620
Col4a2 collagen, type IV, alpha 2 0.595
Apc adenomatosis polyposis coli 0.592
Ptk2 PTK2 protein tyrosine kinase 2 0.527
Lamc1 laminin, gamma 1 0.456
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.370
Ptprb protein tyrosine phosphatase, receptor type, B 0.301
Itga3 integrin alpha 3 0.288
Wt1 Wilms tumor 1 homolog 0.288
Fgfr2 fibroblast growth factor receptor 2 0.273
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.246
Col4a3 collagen, type IV, alpha 3 0.245
Cd151 CD151 antigen 0.213
Vcl vinculin 0.213
Flt4 FMS-like tyrosine kinase 4 0.198
Nid1 nidogen 1 0.173
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.167
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.148
Pax8 paired box gene 8 0.148
Rarg retinoic acid receptor, gamma 0.141
Tenc1 tensin like C1 domain-containing phosphatase 0.137
Itgb3 integrin beta 3 0.131
Gdnf glial cell line derived neurotrophic factor 0.126
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.125
Rbms1 RNA binding motif, single stranded interacting protein 1 0.106
Ctnnb1 catenin (cadherin associated protein), beta 1 0.105
Dlg1 discs, large homolog 1 (Drosophila) 0.103
Parva parvin, alpha 0.094
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.093
Plec plectin 0.092
Wwtr1 WW domain containing transcription regulator 1 0.091
Notch2 Notch gene homolog 2 (Drosophila) 0.090
Vegfa vascular endothelial growth factor A 0.090
App amyloid beta (A4) precursor protein 0.088
Mta2 metastasis-associated gene family, member 2 0.083
Ret ret proto-oncogene 0.081
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.081
Ptgs2 prostaglandin-endoperoxide synthase 2 0.078
Lhx1 LIM homeobox protein 1 0.075
Hnrpdl heterogeneous nuclear ribonucleoprotein D-like 0.070
Des desmin 0.069
Spnb2 spectrin beta 2 0.060
Flna filamin, alpha 0.056
Lepr leptin receptor 0.055
Rxra retinoid X receptor alpha 0.055
Fgfr1 fibroblast growth factor receptor 1 0.055
Tnks1bp1 tankyrase 1 binding protein 1 0.054
Itga5 integrin alpha 5 (fibronectin receptor alpha) 0.053
Rara retinoic acid receptor, alpha 0.052
Rac1 RAS-related C3 botulinum substrate 1 0.049
Bcar1 breast cancer anti-estrogen resistance 1 0.048
Fzd4 frizzled homolog 4 (Drosophila) 0.048
Lrp5 low density lipoprotein receptor-related protein 5 0.048
Amotl2 angiomotin-like 2 0.046
Lpp LIM domain containing preferred translocation partner in lipoma 0.046
Sorbs3 sorbin and SH3 domain containing 3 0.045
Porcn porcupine homolog (Drosophila) 0.045
Fuz fuzzy homolog (Drosophila) 0.044
Srsf6 serine/arginine-rich splicing factor 6 0.044
Tmod3 tropomodulin 3 0.044
Hnrnpd heterogeneous nuclear ribonucleoprotein D 0.042
Cd97 CD97 antigen 0.042
Emx2 empty spiracles homolog 2 (Drosophila) 0.041
Gab1 growth factor receptor bound protein 2-associated protein 1 0.041
Wasf2 WAS protein family, member 2 0.040
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.039
Tcfcp2l1 transcription factor CP2-like 1 0.039
Aebp1 AE binding protein 1 0.038
Lama4 laminin, alpha 4 0.037
Fermt2 fermitin family homolog 2 (Drosophila) 0.036
Ptp4a2 protein tyrosine phosphatase 4a2 0.036
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.035
Smad4 MAD homolog 4 (Drosophila) 0.035
Ptpn13 protein tyrosine phosphatase, non-receptor type 13 0.034
Lamb1 laminin B1 0.034
Cyr61 cysteine rich protein 61 0.034
Zyx zyxin 0.034
Nos3 nitric oxide synthase 3, endothelial cell 0.033
Tpm4 tropomyosin 4 0.033
Gpc3 glypican 3 0.033
Selp selectin, platelet 0.033
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.032
Mta1 metastasis associated 1 0.032
Capn2 calpain 2 0.032
Eltd1 EGF, latrophilin seven transmembrane domain containing 1 0.032
Pvrl2 poliovirus receptor-related 2 0.032
Rhbdf1 rhomboid family 1 (Drosophila) 0.032
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.032
Tgfbr3 transforming growth factor, beta receptor III 0.032
Nf1 neurofibromatosis 1 0.032
Trp63 transformation related protein 63 0.031
Fgf2 fibroblast growth factor 2 0.031
Emp2 epithelial membrane protein 2 0.031
Wnt4 wingless-related MMTV integration site 4 0.031
Ahnak AHNAK nucleoprotein (desmoyokin) 0.031
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Rattus norvegicus
Name Description Probability Func Analog Organism
Lamc1 laminin, gamma 1 0.021
Dchs1 dachsous 1 (Drosophila) 0.012
Myo1b myosin Ib 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism