The network for 'regulation of phospholipase c activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of phospholipase c activity

Any process that modulates the frequency, rate or extent of phospholipase C activity.

Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 1.000
FGF1 fibroblast growth factor 1 (acidic) 1.000
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.986
PLCG1 phospholipase C, gamma 1 0.861
MPDZ multiple PDZ domain protein 0.860
SPRR2A small proline-rich protein 2A 0.843
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.808
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.806
ANG angiogenin, ribonuclease, RNase A family, 5 0.726
RNASE4 ribonuclease, RNase A family, 4 0.654
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.620
FGF10 fibroblast growth factor 10 0.583
SOS1 son of sevenless homolog 1 (Drosophila) 0.550
FGFR1 fibroblast growth factor receptor 1 0.497
VEGFA vascular endothelial growth factor A 0.448
FRS2 fibroblast growth factor receptor substrate 2 0.411
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.370
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.349
BCAR1 breast cancer anti-estrogen resistance 1 0.340
FYB FYN binding protein 0.259
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.229
LAT linker for activation of T cells 0.197
FGF7 fibroblast growth factor 7 0.189
ARRB1 arrestin, beta 1 0.189
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.186
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.185
EGFR epidermal growth factor receptor 0.173
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.134
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.123
ARRDC3 arrestin domain containing 3 0.104
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.103
MAPT microtubule-associated protein tau 0.090
KITLG KIT ligand 0.087
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.087
CDH5 cadherin 5, type 2 (vascular endothelium) 0.064
SOS2 son of sevenless homolog 2 (Drosophila) 0.061
PTPRJ protein tyrosine phosphatase, receptor type, J 0.057
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.056
PGF placental growth factor 0.055
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.051
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.050
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.050
KRT8 keratin 8 0.046
FYN FYN oncogene related to SRC, FGR, YES 0.046
NIN ninein (GSK3B interacting protein) 0.044
GSK3B glycogen synthase kinase 3 beta 0.042
FGFR3 fibroblast growth factor receptor 3 0.041
GAB1 GRB2-associated binding protein 1 0.040
FLT4 fms-related tyrosine kinase 4 0.040
HPGDS hematopoietic prostaglandin D synthase 0.039
HSPG2 heparan sulfate proteoglycan 2 0.037
CPA3 carboxypeptidase A3 (mast cell) 0.035
SLA Src-like-adaptor 0.035
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.033
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.031
CTGF connective tissue growth factor 0.031
AGTR1 angiotensin II receptor, type 1 0.031
SHANK3 SH3 and multiple ankyrin repeat domains 3 0.030
HDC histidine decarboxylase 0.030
RNH1 ribonuclease/angiogenin inhibitor 1 0.030
SHB Src homology 2 domain containing adaptor protein B 0.028
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.028
SELE selectin E 0.028
GRAP2 GRB2-related adaptor protein 2 0.027
PTEN phosphatase and tensin homolog 0.026
LDLR low density lipoprotein receptor 0.025
CCR2 chemokine (C-C motif) receptor 2 0.021
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 0.021
MAP2 microtubule-associated protein 2 0.019
PDGFA platelet-derived growth factor alpha polypeptide 0.019
RIN1 Ras and Rab interactor 1 0.019
RET ret proto-oncogene 0.019
RNASE3 ribonuclease, RNase A family, 3 0.019
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.019
PRKCQ protein kinase C, theta 0.019
FGF8 fibroblast growth factor 8 (androgen-induced) 0.018
MPO myeloperoxidase 0.018
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.018
GPR171 G protein-coupled receptor 171 0.017
CTSG cathepsin G 0.017
VAV1 vav 1 guanine nucleotide exchange factor 0.017
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.016
PTK2B PTK2B protein tyrosine kinase 2 beta 0.015
MAPK8 mitogen-activated protein kinase 8 0.014
ADRB3 adrenergic, beta-3-, receptor 0.014
FASLG Fas ligand (TNF superfamily, member 6) 0.013
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.013
MAPK10 mitogen-activated protein kinase 10 0.013
NOSTRIN nitric oxide synthase trafficker 0.013
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B 0.012
CCR3 chemokine (C-C motif) receptor 3 0.012
GHRHR growth hormone releasing hormone receptor 0.012
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.012
DARC Duffy blood group, chemokine receptor 0.011
PDGFC platelet derived growth factor C 0.011
GPR6 G protein-coupled receptor 6 0.011
EFS embryonal Fyn-associated substrate 0.011
ADORA3 adenosine A3 receptor 0.011
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.011
PGR progesterone receptor 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.707
si:ch73-60e21.1 si:ch73-60e21.1 0.365
esr2b estrogen receptor 2b 0.263
fgf4 fibroblast growth factor 4 0.210
sulf1 sulfatase 1 0.165
rhoub ras homolog gene family, member Ub 0.134
tie2 endothelium-specific receptor tyrosine kinase 2 0.125
meis2.2 myeloid ecotropic viral integration site 2.2 0.118
fstl1b follistatin-like 1b 0.081
esama endothelial cell adhesion molecule a 0.080
tbpl2 TATA box binding protein like 2 0.055
bmpr1ba bone morphogenetic protein receptor, type 1ba 0.055
fgf8b fibroblast growth factor 8 b 0.048
plxnd1 plexin D1 0.048
bmp15 bone morphogenetic protein 15 0.047
tjp1 tight junction protein 1 (zona occludens 1) 0.043
zgc:64042 zgc:64042 0.041
st14a suppression of tumorigenicity 14 (colon carcinoma) a 0.040
dnmt4 DNA (cytosine-5-)-methyltransferase 4 0.039
notch3 notch homolog 3 0.037
LOC100006361 galanin-like 0.036
prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.036
efnb2a ephrin B2a 0.034
phf21a PHD finger protein 21A 0.032
fmnl2a formin-like 2a 0.032
phex phosphate regulating gene with homologues to endopeptidases on the X chromosome 0.031
elmo1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) 0.029
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.028
lrrtm1 leucine rich repeat transmembrane neuronal 1 0.025
pea3 ETS-domain transcription factor pea3 0.025
slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.024
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.024
sinup siaz-interacting nuclear protein 0.023
arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.023
cnga5 cyclic nucleotide gated channel alpha 5 0.023
stab2 stabilin 2 0.023
cald1 caldesmon 1 0.022
msi1 musashi homolog 1 (Drosophila) 0.022
bsk146 brain specific kinase 146 0.022
abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.021
nxn nucleoredoxin 0.021
nppa natriuretic peptide precursor A 0.021
ryk receptor-like tyrosine kinase 0.021
fgf22 fibroblast growth factor 22 0.020
csrnp1b cysteine-serine-rich nuclear protein 1b 0.020
igf1rb insulin-like growth factor 1b receptor 0.020
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.019
cnn2 calponin 2 0.019
ptpra protein tyrosine phosphatase, receptor type, A 0.019
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.019
mtmr8 myotubularin related protein 8 0.019
arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.019
pdlim3b PDZ and LIM domain 3b 0.018
vtg4 vitellogenin 4 0.018
alp alkaline phosphatase 0.018
wu:fv91b12 wu:fv91b12 0.018
akt2 v-akt murine thymoma viral oncogene homolog 2 0.018
ddc dopa decarboxylase 0.017
six4.3 sine oculis homeobox homolog 4.3 0.017
lhx2b LIM homeobox 2b 0.017
usp49 ubiquitin specific peptidase 49 0.017
pdgfb platelet derived growth factor, B polypeptide 0.017
spry1 sprouty homolog 1 (Drosophila) 0.017
chrm2a cholinergic receptor, muscarinic 2a 0.017
mmp17a matrix metallopeptidase 17a 0.017
ifnphi1 interferon phi 1 0.017
eda ectodysplasin A 0.017
fyna FYN oncogene related to SRC, FGR, YES a 0.016
fzd7b frizzled homolog 7b 0.016
pth2r parathyroid hormone 2 receptor 0.016
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.016
adrbk2 adrenergic, beta, receptor kinase 2 0.015
vegfaa vascular endothelial growth factor Aa 0.015
rhbdl2 rhomboid, veinlet-like 2 (Drosophila) 0.015
prickle2 prickle-like 2 (Drosophila) 0.015
nr1h3 nuclear receptor subfamily 1, group H, member 3 0.015
sema3aa semaphorin 3aa 0.015
opn1lw1 opsin 1 (cone pigments), long-wave-sensitive, 1 0.014
oc90 otoconin 90 0.014
sfrp5 secreted frizzled-related protein 5 0.014
dazl daz-like gene 0.014
acp5b acid phosphatase 5b, tartrate resistant 0.014
kirrela kin of IRRE like a 0.014
wnt3a wingless-type MMTV integration site family, member 3A 0.014
lgi1b leucine-rich, glioma inactivated 1b 0.013
zgc:101847 zgc:101847 0.013
siah2l seven in absentia homolog 2 (Drosophila)-like 0.013
gro1 groucho 1 0.013
sc:d411 sc:d411 0.012
tas2r202 taste receptor, type 2, member 202 0.012
jazf1b JAZF zinc finger 1b 0.012
ppap2c phosphatidic acid phosphatase type 2C 0.012
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.012
hcrt hypocretin (orexin) neuropeptide precursor 0.012
lass2 LAG1 homolog, ceramide synthase 2 (S. cerevisiae) 0.012
tjp2a tight junction protein 2a (zona occludens 2) 0.012
rbm24b RNA binding motif protein 24b 0.011
six1b sine oculis homeobox homolog 1b 0.011
vtg2 vitellogenin 2 0.011
per3 period homolog 3 (Drosophila) 0.011
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Cbl Casitas B-lineage lymphoma 0.993
Ptk2 PTK2 protein tyrosine kinase 2 0.973
Lepr leptin receptor 0.824
Dok1 docking protein 1 0.820
Was Wiskott-Aldrich syndrome homolog (human) 0.819
Inpp5d inositol polyphosphate-5-phosphatase D 0.798
Rab6 RAB6, member RAS oncogene family 0.755
Trp53 transformation related protein 53 0.630
Dok2 docking protein 2 0.622
Tcra T-cell receptor alpha chain 0.619
Thra thyroid hormone receptor alpha 0.593
Pten phosphatase and tensin homolog 0.523
Plcg1 phospholipase C, gamma 1 0.509
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.493
Cd247 CD247 antigen 0.486
Fyn Fyn proto-oncogene 0.477
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.466
Nos2 nitric oxide synthase 2, inducible 0.461
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.450
Csf1 colony stimulating factor 1 (macrophage) 0.438
Acvr1 activin A receptor, type 1 0.432
Sell selectin, lymphocyte 0.430
Notch2 Notch gene homolog 2 (Drosophila) 0.425
Ric8 resistance to inhibitors of cholinesterase 8 homolog (C. elegans) 0.416
Fgfr2 fibroblast growth factor receptor 2 0.382
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.373
Cd19 CD19 antigen 0.369
Selp selectin, platelet 0.342
Plcg2 phospholipase C, gamma 2 0.330
Agtr1a angiotensin II receptor, type 1a 0.319
Prrx1 paired related homeobox 1 0.307
Il2rb interleukin 2 receptor, beta chain 0.293
Ptpre protein tyrosine phosphatase, receptor type, E 0.291
Fgfr1 fibroblast growth factor receptor 1 0.287
Prkce protein kinase C, epsilon 0.286
Hcls1 hematopoietic cell specific Lyn substrate 1 0.264
Bcar1 breast cancer anti-estrogen resistance 1 0.258
Ptprc protein tyrosine phosphatase, receptor type, C 0.251
Bmp2 bone morphogenetic protein 2 0.249
Tgfbr2 transforming growth factor, beta receptor II 0.243
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.235
Runx2 runt related transcription factor 2 0.224
Cd22 CD22 antigen 0.219
Apoe apolipoprotein E 0.213
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.209
Vegfa vascular endothelial growth factor A 0.200
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.195
Duox2 dual oxidase 2 0.194
Itgb3 integrin beta 3 0.191
Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) 0.191
Ldlr low density lipoprotein receptor 0.191
Sykb spleen tyrosine kinase 0.188
Cd40 CD40 antigen 0.185
Fshr follicle stimulating hormone receptor 0.180
Hck hemopoietic cell kinase 0.178
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.176
Lyl1 lymphoblastomic leukemia 1 0.174
Ms4a1 membrane-spanning 4-domains, subfamily A, member 1 0.174
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.172
Ednra endothelin receptor type A 0.170
Itgb2 integrin beta 2 0.167
Fyb FYN binding protein 0.166
Nos3 nitric oxide synthase 3, endothelial cell 0.165
Fcgr1 Fc receptor, IgG, high affinity I 0.155
Blnk B-cell linker 0.155
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.149
Wt1 Wilms tumor 1 homolog 0.143
Igf1r insulin-like growth factor I receptor 0.142
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.141
Pxn paxillin 0.138
Cybb cytochrome b-245, beta polypeptide 0.136
Lck lymphocyte protein tyrosine kinase 0.134
Cd28 CD28 antigen 0.132
Pgr progesterone receptor 0.131
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 0.131
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.128
Ncr1 natural cytotoxicity triggering receptor 1 0.128
C5ar1 complement component 5a receptor 1 0.123
Gna15 guanine nucleotide binding protein, alpha 15 0.120
Ren1 renin 1 structural 0.119
Kit kit oncogene 0.115
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.114
Gpr97 G protein-coupled receptor 97 0.114
Cnr2 cannabinoid receptor 2 (macrophage) 0.114
Psen1 presenilin 1 0.112
Ghr growth hormone receptor 0.109
Lat linker for activation of T cells 0.109
Zap70 zeta-chain (TCR) associated protein kinase 0.108
Itgax integrin alpha X 0.107
Ccr6 chemokine (C-C motif) receptor 6 0.104
Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.104
Fgfr4 fibroblast growth factor receptor 4 0.100
Aoah acyloxyacyl hydrolase 0.099
Umod uromodulin 0.098
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.097
S1pr4 sphingosine-1-phosphate receptor 4 0.097
Clnk cytokine-dependent hematopoietic cell linker 0.097
Fgf7 fibroblast growth factor 7 0.095
Pdgfb platelet derived growth factor, B polypeptide 0.094
Src Rous sarcoma oncogene 0.092
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Rattus norvegicus
Name Description Probability Func Analog Organism
Akt2 v-akt murine thymoma viral oncogene homolog 2 0.045
Rup2 urinary protein 2 0.039
Alb albumin 0.033
Lims1 LIM and senescent cell antigen-like domains 1 0.025
Ccr5 chemokine (C-C motif) receptor 5 0.022
Epas1 endothelial PAS domain protein 1 0.017
Serpina1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.016
Spp2 secreted phosphoprotein 2 0.016
Igf2 insulin-like growth factor 2 0.015
Ahsg alpha-2-HS-glycoprotein 0.015
Csf1 colony stimulating factor 1 (macrophage) 0.015
Map3k3 mitogen activated protein kinase kinase kinase 3 0.014
Foxa1 forkhead box A1 0.014
Mpeg1 macrophage expressed 1 0.014
Folh1 folate hydrolase 1 0.012
Cfp complement factor properdin 0.012
Ntsr2 neurotensin receptor 2 0.012
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.011
Apoh apolipoprotein H (beta-2-glycoprotein I) 0.011
Sh2b3 SH2B adaptor protein 3 0.011
Gc group specific component 0.011
Lim2 lens intrinsic membrane protein 2 0.011
Sdc3 syndecan 3 0.010
Il1rl1 interleukin 1 receptor-like 1 0.010
Gucy1b3 guanylate cyclase 1, soluble, beta 3 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism