The network for 'mast cell activation involved in immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mast cell activation involved in immune response

The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response.

Homo sapiens
Name Description Probability Func Analog Organism
SYK spleen tyrosine kinase 0.999
LCK lymphocyte-specific protein tyrosine kinase 0.999
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.980
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.943
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.900
BLNK B-cell linker 0.770
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.717
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.666
VEGFA vascular endothelial growth factor A 0.655
UBASH3B ubiquitin associated and SH3 domain containing B 0.638
EGFR epidermal growth factor receptor 0.629
GAB1 GRB2-associated binding protein 1 0.578
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.548
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.529
IL4R interleukin 4 receptor 0.458
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.415
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.404
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.396
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.352
SOS1 son of sevenless homolog 1 (Drosophila) 0.351
LAT linker for activation of T cells 0.348
NRP1 neuropilin 1 0.312
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.306
VAV1 vav 1 guanine nucleotide exchange factor 0.242
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.222
CRH corticotropin releasing hormone 0.202
TFF1 trefoil factor 1 0.190
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.189
GRB2 growth factor receptor-bound protein 2 0.182
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.180
BTK Bruton agammaglobulinemia tyrosine kinase 0.171
PLCG1 phospholipase C, gamma 1 0.151
SLA Src-like-adaptor 0.144
IL2RG interleukin 2 receptor, gamma 0.140
SPRR2A small proline-rich protein 2A 0.135
IL4 interleukin 4 0.130
PGF placental growth factor 0.124
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.104
HCK hemopoietic cell kinase 0.103
PDGFA platelet-derived growth factor alpha polypeptide 0.103
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.097
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.096
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.090
FYB FYN binding protein 0.090
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.088
ZNF746 zinc finger protein 746 0.086
AXL AXL receptor tyrosine kinase 0.081
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.078
BAI1 brain-specific angiogenesis inhibitor 1 0.076
SH3KBP1 SH3-domain kinase binding protein 1 0.065
CARD11 caspase recruitment domain family, member 11 0.062
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.055
FASLG Fas ligand (TNF superfamily, member 6) 0.053
PDGFC platelet derived growth factor C 0.050
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.047
CSF3R colony stimulating factor 3 receptor (granulocyte) 0.047
C1orf93 chromosome 1 open reading frame 93 0.045
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.043
HCLS1 hematopoietic cell-specific Lyn substrate 1 0.042
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.038
KITLG KIT ligand 0.036
FGFR1 fibroblast growth factor receptor 1 0.036
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.035
PRKCQ protein kinase C, theta 0.030
HK3 hexokinase 3 (white cell) 0.030
CD33 CD33 molecule 0.029
SOS2 son of sevenless homolog 2 (Drosophila) 0.028
LDLR low density lipoprotein receptor 0.027
FYN FYN oncogene related to SRC, FGR, YES 0.027
CDH5 cadherin 5, type 2 (vascular endothelium) 0.027
PTPRB protein tyrosine phosphatase, receptor type, B 0.027
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.027
GAS7 growth arrest-specific 7 0.026
TYROBP TYRO protein tyrosine kinase binding protein 0.026
EPHA8 EPH receptor A8 0.026
JAK2 Janus kinase 2 0.024
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 0.024
APOBR apolipoprotein B receptor 0.023
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.023
DOK3 docking protein 3 0.022
WIPF1 WAS/WASL interacting protein family, member 1 0.021
ARID3A AT rich interactive domain 3A (BRIGHT-like) 0.021
CD37 CD37 molecule 0.021
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.021
PTEN phosphatase and tensin homolog 0.020
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.020
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 0.020
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.019
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.019
SH2B2 SH2B adaptor protein 2 0.019
GHR growth hormone receptor 0.019
PRKCB protein kinase C, beta 0.019
MAPK8 mitogen-activated protein kinase 8 0.019
SBF1 SET binding factor 1 0.019
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.018
SASH3 SAM and SH3 domain containing 3 0.018
FLT4 fms-related tyrosine kinase 4 0.017
LRRC25 leucine rich repeat containing 25 0.017
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.017
PTAFR platelet-activating factor receptor 0.017
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Cd247 CD247 antigen 0.996
Mefv Mediterranean fever 0.964
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.901
Ikzf1 IKAROS family zinc finger 1 0.887
Lat linker for activation of T cells 0.872
Tcra T-cell receptor alpha chain 0.836
Inpp5d inositol polyphosphate-5-phosphatase D 0.829
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.811
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.805
Hcst hematopoietic cell signal transducer 0.801
Ptprc protein tyrosine phosphatase, receptor type, C 0.775
Il4 interleukin 4 0.723
Tyrobp TYRO protein tyrosine kinase binding protein 0.658
Il2rb interleukin 2 receptor, beta chain 0.572
Grb2 growth factor receptor bound protein 2 0.531
Rag1 recombination activating gene 1 0.527
Cd4 CD4 antigen 0.498
C5ar1 complement component 5a receptor 1 0.458
Nfam1 Nfat activating molecule with ITAM motif 1 0.423
Rgs14 regulator of G-protein signaling 14 0.413
Fyn Fyn proto-oncogene 0.394
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.373
Fes feline sarcoma oncogene 0.337
Msr1 macrophage scavenger receptor 1 0.326
Ptk2 PTK2 protein tyrosine kinase 2 0.306
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.297
AF251705 cDNA sequence AF251705 0.293
Il2 interleukin 2 0.267
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.259
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.245
Cd22 CD22 antigen 0.233
Pilra paired immunoglobin-like type 2 receptor alpha 0.210
Clec4n C-type lectin domain family 4, member n 0.206
Csf1r colony stimulating factor 1 receptor 0.202
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.194
Hck hemopoietic cell kinase 0.194
Itk IL2-inducible T-cell kinase 0.190
Tbxas1 thromboxane A synthase 1, platelet 0.188
Il2rg interleukin 2 receptor, gamma chain 0.183
Trem3 triggering receptor expressed on myeloid cells 3 0.179
Zap70 zeta-chain (TCR) associated protein kinase 0.177
Pilrb1 paired immunoglobin-like type 2 receptor beta 1 0.171
Cd180 CD180 antigen 0.165
Met met proto-oncogene 0.164
BC013712 cDNA sequence BC013712 0.162
Dok3 docking protein 3 0.162
Ifng interferon gamma 0.141
Cd40 CD40 antigen 0.136
Ebi3 Epstein-Barr virus induced gene 3 0.133
Fcrla Fc receptor-like A 0.132
Fcgr1 Fc receptor, IgG, high affinity I 0.131
Lyl1 lymphoblastomic leukemia 1 0.125
Lck lymphocyte protein tyrosine kinase 0.123
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.122
Siglece sialic acid binding Ig-like lectin E 0.121
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.114
Mmp8 matrix metallopeptidase 8 0.112
Was Wiskott-Aldrich syndrome homolog (human) 0.112
Il10ra interleukin 10 receptor, alpha 0.107
Fcgr4 Fc receptor, IgG, low affinity IV 0.105
Klra2 killer cell lectin-like receptor, subfamily A, member 2 0.096
Pou2f2 POU domain, class 2, transcription factor 2 0.096
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.094
Fyb FYN binding protein 0.089
Clec4d C-type lectin domain family 4, member d 0.087
Sfpi1 SFFV proviral integration 1 0.087
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.086
Foxf1a forkhead box F1a 0.078
Shc1 src homology 2 domain-containing transforming protein C1 0.076
Fpr1 formyl peptide receptor 1 0.075
C1qb complement component 1, q subcomponent, beta polypeptide 0.074
C3ar1 complement component 3a receptor 1 0.073
Myo1f myosin IF 0.073
Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.072
Vav1 vav 1 oncogene 0.071
F10 coagulation factor X 0.071
Irf5 interferon regulatory factor 5 0.070
Snai1 snail homolog 1 (Drosophila) 0.069
Cbl Casitas B-lineage lymphoma 0.068
Rac2 RAS-related C3 botulinum substrate 2 0.068
Cd28 CD28 antigen 0.067
Prkce protein kinase C, epsilon 0.066
Lair1 leukocyte-associated Ig-like receptor 1 0.066
Trem1 triggering receptor expressed on myeloid cells 1 0.064
Cd300lb CD300 antigen like family member B 0.063
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.062
Cd300ld CD300 molecule-like family member d 0.062
S1pr4 sphingosine-1-phosphate receptor 4 0.061
Cd5l CD5 antigen-like 0.061
Hmha1 histocompatibility (minor) HA-1 0.061
Ptpre protein tyrosine phosphatase, receptor type, E 0.058
Clec4a2 C-type lectin domain family 4, member a2 0.057
Dok1 docking protein 1 0.057
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.057
Fgd3 FYVE, RhoGEF and PH domain containing 3 0.056
Calcrl calcitonin receptor-like 0.056
Il1rn interleukin 1 receptor antagonist 0.056
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.056
Cd300a CD300A antigen 0.054
Stat6 signal transducer and activator of transcription 6 0.054
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cybb cytochrome b-245, beta polypeptide 0.253
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.162
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.061
Morf4l2 mortality factor 4 like 2 0.052
Arl11 ADP-ribosylation factor-like 11 0.044
Sdc3 syndecan 3 0.042
Il2rg interleukin 2 receptor, gamma 0.042
Cltc clathrin, heavy chain (Hc) 0.042
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.041
Sirpa signal-regulatory protein alpha 0.035
Ptafr platelet-activating factor receptor 0.034
RT1-Ba RT1 class II, locus Ba 0.031
Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.030
Ppp2cb protein phosphatase 2, catalytic subunit, beta isoform 0.028
Neurl3 neuralized homolog 3 (Drosophila) 0.026
Inpp5d inositol polyphosphate-5-phosphatase D 0.024
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.024
Klhl6 kelch-like 6 (Drosophila) 0.024
Rhob ras homolog gene family, member B 0.023
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.023
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.022
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.022
Ciita class II, major histocompatibility complex, transactivator 0.021
Dock8 dedicator of cytokinesis 8 0.021
Folr2 folate receptor 2 (fetal) 0.020
Arf4 ADP-ribosylation factor 4 0.020
Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.019
Eif4h eukaryotic translation initiation factor 4H 0.019
Clec4a3 C-type lectin domain family 4, member a3 0.018
Lcp2 lymphocyte cytosolic protein 2 0.018
Prf1 perforin 1 (pore forming protein) 0.017
Calm1 calmodulin 1 0.017
Ptprc protein tyrosine phosphatase, receptor type, C 0.016
Cd247 Cd247 molecule 0.016
C5ar1 complement component 5a receptor 1 0.016
Calm2 calmodulin 2 0.015
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.015
Slc14a1 solute carrier family 14 (urea transporter), member 1 0.014
Gzmk granzyme K 0.014
LOC363326 hypothetical LOC363326 0.014
Tgfbr2 transforming growth factor, beta receptor II 0.014
Atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1 0.013
Hnrnpk heterogeneous nuclear ribonucleoprotein K 0.013
Rac2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.013
Il17ra interleukin 17 receptor A 0.013
Cxcr3 chemokine (C-X-C motif) receptor 3 0.013
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.012
Dchs1 dachsous 1 (Drosophila) 0.012
Mutyh mutY homolog (E. coli) 0.012
Cfp complement factor properdin 0.012
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.012
Ccr5 chemokine (C-C motif) receptor 5 0.011
Ap2m1 adaptor-related protein complex 2, mu 1 subunit 0.011
Tlr4 toll-like receptor 4 0.011
Ncan neurocan 0.011
Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.011
Myo1g myosin IG 0.011
Adar adenosine deaminase, RNA-specific 0.011
Ugt1a6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.011
Gip gastric inhibitory polypeptide 0.010
Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.010
RGD1310262 hypothetical LOC304650 0.010
Tgfbr3 transforming growth factor, beta receptor III 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism