The network for 'extrinsic apoptotic signaling pathway via death domain receptors' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

extrinsic apoptotic signaling pathway via death domain receptors

A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.

Homo sapiens
Name Description Probability Func Analog Organism
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.000
SQSTM1 sequestosome 1 0.980
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.977
CFLAR CASP8 and FADD-like apoptosis regulator 0.977
FAS Fas (TNF receptor superfamily, member 6) 0.949
FADD Fas (TNFRSF6)-associated via death domain 0.922
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.891
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.778
BCL2 B-cell CLL/lymphoma 2 0.750
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.740
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.717
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.653
BIRC3 baculoviral IAP repeat containing 3 0.637
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.542
XIAP X-linked inhibitor of apoptosis 0.433
BCL2L1 BCL2-like 1 0.416
FGA fibrinogen alpha chain 0.404
FGB fibrinogen beta chain 0.403
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.376
SNAP23 synaptosomal-associated protein, 23kDa 0.328
TEK TEK tyrosine kinase, endothelial 0.319
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.307
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.284
SP100 SP100 nuclear antigen 0.273
APAF1 apoptotic peptidase activating factor 1 0.268
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.247
TRAF1 TNF receptor-associated factor 1 0.219
TRADD TNFRSF1A-associated via death domain 0.208
TGIF1 TGFB-induced factor homeobox 1 0.177
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.167
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.161
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.156
TRAF6 TNF receptor-associated factor 6 0.155
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.154
MAPK1 mitogen-activated protein kinase 1 0.146
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.141
CASP8AP2 caspase 8 associated protein 2 0.132
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.131
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.116
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.114
VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 0.109
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 0.101
IGF2R insulin-like growth factor 2 receptor 0.100
FGG fibrinogen gamma chain 0.095
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.095
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.093
GABARAPL1 GABA(A) receptor-associated protein like 1 0.089
CALCOCO2 calcium binding and coiled-coil domain 2 0.089
PLAT plasminogen activator, tissue 0.085
PDPK1 3-phosphoinositide dependent protein kinase-1 0.082
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.078
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.076
NLRC4 NLR family, CARD domain containing 4 0.076
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 0.074
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.073
FAM101B family with sequence similarity 101, member B 0.069
SMAD3 SMAD family member 3 0.068
MICA MHC class I polypeptide-related sequence A 0.067
C1orf93 chromosome 1 open reading frame 93 0.067
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.063
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.063
BID BH3 interacting domain death agonist 0.061
FTL ferritin, light polypeptide 0.052
SORT1 sortilin 1 0.052
FTH1 ferritin, heavy polypeptide 1 0.050
VIM vimentin 0.050
MAP2K1 mitogen-activated protein kinase kinase 1 0.049
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.049
MET met proto-oncogene (hepatocyte growth factor receptor) 0.047
BAD BCL2-associated agonist of cell death 0.046
ITGB1BP1 integrin beta 1 binding protein 1 0.043
IFI16 interferon, gamma-inducible protein 16 0.042
LRDD leucine-rich repeats and death domain containing 0.042
BAK1 BCL2-antagonist/killer 1 0.042
MUTED muted homolog (mouse) 0.042
HSPB1 heat shock 27kDa protein 1 0.042
SYNRG synergin, gamma 0.042
CRP C-reactive protein, pentraxin-related 0.041
DTNBP1 dystrobrevin binding protein 1 0.040
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.039
APOA1 apolipoprotein A-I 0.039
TRAF2 TNF receptor-associated factor 2 0.038
TNF tumor necrosis factor 0.038
PLDN pallidin homolog (mouse) 0.038
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.037
BIRC2 baculoviral IAP repeat containing 2 0.037
ULK1 unc-51-like kinase 1 (C. elegans) 0.035
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.035
PLAU plasminogen activator, urokinase 0.035
CSNK1A1 casein kinase 1, alpha 1 0.034
PLEK pleckstrin 0.034
RRAS related RAS viral (r-ras) oncogene homolog 0.034
RNF144B ring finger protein 144B 0.033
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.033
NPC2 Niemann-Pick disease, type C2 0.033
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.032
GDF5 growth differentiation factor 5 0.032
PSEN1 presenilin 1 0.031
FASLG Fas ligand (TNF superfamily, member 6) 0.030
ORM1 orosomucoid 1 0.030
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
hmgb2a high-mobility group box 2a 0.544
met met proto-oncogene (hepatocyte growth factor receptor) 0.365
pitx3 paired-like homeodomain transcription factor 3 0.274
fgg fibrinogen, gamma polypeptide 0.252
wnt3a wingless-type MMTV integration site family, member 3A 0.236
sulf2l sulfatase 2, like 0.223
bcl2l1 bcl2-like 1 0.213
wnt9b wingless-type MMTV integration site family, member 9B 0.174
nkx6.1 NK6 transcription factor related, locus 1 (Drosophila) 0.137
hmx2 H6 family homeobox 2 0.126
wif1 wnt inhibitory factor 1 0.126
mdm2 transformed 3T3 cell double minute 2 homolog (mouse) 0.124
LOC554173 abnormal spindles 0.119
gadd45aa growth arrest and DNA-damage-inducible, alpha, a 0.115
nf1a neurofibromin 1a 0.104
hmga1a high mobility group AT-hook 1a 0.101
cdc42 cell division cycle 42 0.100
bty bloodthirsty 0.097
vcp valosin containing protein 0.092
fzd7b frizzled homolog 7b 0.089
vat1 vesicle amine transport protein 1 homolog (T californica) 0.079
nf1b neurofibromin 1b 0.078
hoxa4a homeo box A4a 0.077
notch3 notch homolog 3 0.076
mcoln1 mucolipin 1 0.076
hgfb hepatocyte growth factor b 0.073
irf6 interferon regulatory factor 6 0.071
notch2 notch homolog 2 0.070
hmgb2b high-mobility group box 2b 0.069
scrt1a scratch homolog 1, zinc finger protein a (Drosophila) 0.069
fadd Fas (tnfrsf6)-associated via death domain 0.068
drd1 dopamine receptor D1 0.067
ntn2 netrin 2 0.066
lass2 LAG1 homolog, ceramide synthase 2 (S. cerevisiae) 0.064
pcdh18b protocadherin 18b 0.064
tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.059
cflar CASP8 and FADD-like apoptosis regulator 0.058
ranbp1 RAN binding protein 1 0.057
rasl11b RAS-like, family 11, member B 0.056
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.055
si:dkeyp-7c9.1 si:dkeyp-7c9.1 0.055
LOC567131 calcitonin gene-related peptide type 1 receptor-like 0.054
rras related RAS viral (r-ras) oncogene homolog 0.053
il6r interleukin 6 receptor 0.053
hmgb3a high-mobility group box 3a 0.052
stc1l stanniocalcin 1, like 0.052
casp8 caspase 8, apoptosis-related cysteine peptidase 0.051
tfam transcription factor A, mitochondrial 0.051
gata6 GATA-binding protein 6 0.050
h2afvl H2A histone family, member V, like 0.048
postn periostin, osteoblast specific factor 0.047
tac1 tachykinin 1 0.046
hmgb1b high-mobility group box 1b 0.045
wu:fi25h02 wu:fi25h02 0.044
lmna lamin A 0.044
nkd1 naked cuticle homolog 1 (Drosophila) 0.044
bbc3 BCL2 binding component 3 0.043
igfbp1b insulin-like growth factor binding protein 1b 0.043
mapk15 mitogen-activated protein kinase 15 0.043
cdh11 cadherin 11, osteoblast 0.042
rhoab ras homolog gene family, member Ab 0.041
wnt10a wingless-type MMTV integration site family, member 10a 0.041
pmp22a peripheral myelin protein 22a 0.041
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.039
csnk1g2a casein kinase 1, gamma 2a 0.039
mcl1a myeloid cell leukemia sequence 1a 0.039
matn4 matrilin 4 0.039
irgq1 immunity-related GTPase family, q1 0.037
tm9sf2 transmembrane 9 superfamily member 2 0.037
sh3gl1b SH3-domain GRB2-like 1b 0.037
mapk6 mitogen-activated protein kinase 6 0.037
cyp2v2 cytochrome P450, family 2, subfamily V, polypeptide 2 0.036
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.036
prpf31 PRP31 pre-mRNA processing factor 31 homolog (yeast) 0.036
nkx6.2 NK6 transcription factor related, locus 2 0.035
comta catechol-O-methyltransferase a 0.035
sp2 sp2 transcription factor 0.035
col5a1 procollagen, type V, alpha 1 0.035
col7a1l collagen type VII alpha 1-like 0.035
col4a6 collagen, type IV, alpha 6 0.035
zgc:195154 zgc:195154 0.035
akt2 v-akt murine thymoma viral oncogene homolog 2 0.034
fgfr3 fibroblast growth factor receptor 3 0.034
pcsk5a proprotein convertase subtilisin/kexin type 5a 0.033
fgf3 fibroblast growth factor 3 0.033
pkz protein kinase containing Z-DNA binding domains 0.033
si:ch211-57k11.10 si:ch211-57k11.10 0.033
kal1b Kallmann syndrome 1b sequence 0.033
manf mesencephalic astrocyte-derived neurotrophic factor 0.033
mxa myxovirus (influenza) resistance A 0.032
ccz1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) 0.032
ptpn11a protein tyrosine phosphatase, non-receptor type 11, a 0.032
bnip3lb BCL2/adenovirus E1B interacting protein 3-like b 0.031
vtnb vitronectin b 0.031
cdh6 cadherin 6 0.031
ube4b ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) 0.031
tp53bp2 tumor protein p53 binding protein, 2 0.031
dcc deleted in colorectal carcinoma 0.030
a2ml alpha-2-macroglobulin-like 0.030
msi2b musashi homolog 2b (Drosophila) 0.030
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Fas Fas (TNF receptor superfamily member 6) 0.998
Trp53 transformation related protein 53 0.997
Pten phosphatase and tensin homolog 0.996
Apc adenomatosis polyposis coli 0.991
Ptgs2 prostaglandin-endoperoxide synthase 2 0.990
Tgfbr2 transforming growth factor, beta receptor II 0.981
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.979
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.975
Igh immunoglobulin heavy chain complex 0.968
Bcl2 B-cell leukemia/lymphoma 2 0.965
Ctnnb1 catenin (cadherin associated protein), beta 1 0.960
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.934
Bax BCL2-associated X protein 0.916
Ccl2 chemokine (C-C motif) ligand 2 0.897
Psen1 presenilin 1 0.893
Smad4 MAD homolog 4 (Drosophila) 0.881
Smad3 MAD homolog 3 (Drosophila) 0.852
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.843
Tlr4 toll-like receptor 4 0.822
Vhl von Hippel-Lindau tumor suppressor 0.818
Tnf tumor necrosis factor 0.817
Cd44 CD44 antigen 0.774
Rxra retinoid X receptor alpha 0.761
Mmp9 matrix metallopeptidase 9 0.740
Hif1a hypoxia inducible factor 1, alpha subunit 0.721
Casp8 caspase 8 0.702
Notch2 Notch gene homolog 2 (Drosophila) 0.657
Lyz2 lysozyme 2 0.622
Tgfbr1 transforming growth factor, beta receptor I 0.619
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.573
Vegfa vascular endothelial growth factor A 0.555
Fgfr2 fibroblast growth factor receptor 2 0.546
Lta lymphotoxin A 0.537
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.532
Csf1 colony stimulating factor 1 (macrophage) 0.501
Egfr epidermal growth factor receptor 0.490
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.488
Fadd Fas (TNFRSF6)-associated via death domain 0.485
Mcl1 myeloid cell leukemia sequence 1 0.482
Kit kit oncogene 0.454
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.442
Esr1 estrogen receptor 1 (alpha) 0.428
Nos3 nitric oxide synthase 3, endothelial cell 0.428
Notch1 Notch gene homolog 1 (Drosophila) 0.415
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.393
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.387
Ikbkb inhibitor of kappaB kinase beta 0.358
Nos2 nitric oxide synthase 2, inducible 0.358
Acvr1 activin A receptor, type 1 0.350
Sfrp1 secreted frizzled-related protein 1 0.301
Ncoa3 nuclear receptor coactivator 3 0.298
Sfrp2 secreted frizzled-related protein 2 0.295
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.292
Bmpr1a bone morphogenetic protein receptor, type 1A 0.277
Il10 interleukin 10 0.274
Cd40 CD40 antigen 0.270
Gbp5 guanylate binding protein 5 0.263
Pycard PYD and CARD domain containing 0.260
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.258
Ikzf1 IKAROS family zinc finger 1 0.243
Il6st interleukin 6 signal transducer 0.239
Mdm2 transformed mouse 3T3 cell double minute 2 0.239
Chuk conserved helix-loop-helix ubiquitous kinase 0.226
Casp1 caspase 1 0.225
Braf Braf transforming gene 0.221
Runx1 runt related transcription factor 1 0.218
Rb1 retinoblastoma 1 0.218
Adam17 a disintegrin and metallopeptidase domain 17 0.213
Eng endoglin 0.207
Ifng interferon gamma 0.204
Vcl vinculin 0.202
Ret ret proto-oncogene 0.198
Kitl kit ligand 0.194
Thbs1 thrombospondin 1 0.169
Sox9 SRY-box containing gene 9 0.169
Cyld cylindromatosis (turban tumor syndrome) 0.167
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.166
Lyst lysosomal trafficking regulator 0.156
Nf1 neurofibromatosis 1 0.154
Casp3 caspase 3 0.147
Rarg retinoic acid receptor, gamma 0.144
Ltb lymphotoxin B 0.144
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.141
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.139
Stk4 serine/threonine kinase 4 0.138
Sufu suppressor of fused homolog (Drosophila) 0.137
Fgg fibrinogen gamma chain 0.136
Hmgb1 high mobility group box 1 0.133
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.132
Stat3 signal transducer and activator of transcription 3 0.130
Ptch1 patched homolog 1 0.130
Bak1 BCL2-antagonist/killer 1 0.128
Ikbkg inhibitor of kappaB kinase gamma 0.125
Rara retinoic acid receptor, alpha 0.121
Stag1 stromal antigen 1 0.119
Pml promyelocytic leukemia 0.116
Il7 interleukin 7 0.112
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.107
Rad21 RAD21 homolog (S. pombe) 0.100
Ece1 endothelin converting enzyme 1 0.099
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Rattus norvegicus
Name Description Probability Func Analog Organism
Lepr leptin receptor 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism