The network for 'response to tumor necrosis factor' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to tumor necrosis factor

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.

Homo sapiens
Name Description Probability Func Analog Organism
TRAF2 TNF receptor-associated factor 2 0.997
BIRC3 baculoviral IAP repeat containing 3 0.995
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.989
TRAF1 TNF receptor-associated factor 1 0.986
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.975
ZNF43 zinc finger protein 43 0.948
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.945
FAS Fas (TNF receptor superfamily, member 6) 0.942
TRADD TNFRSF1A-associated via death domain 0.864
C1QA complement component 1, q subcomponent, A chain 0.856
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.813
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.809
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.805
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.801
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.793
RIPK2 receptor-interacting serine-threonine kinase 2 0.780
BCAR1 breast cancer anti-estrogen resistance 1 0.766
TANK TRAF family member-associated NFKB activator 0.724
ZNF253 zinc finger protein 253 0.659
BIRC2 baculoviral IAP repeat containing 2 0.657
ZNF273 zinc finger protein 273 0.656
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.647
CXCL9 chemokine (C-X-C motif) ligand 9 0.642
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.636
CXCL10 chemokine (C-X-C motif) ligand 10 0.632
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.624
TRAF3 TNF receptor-associated factor 3 0.608
IFNGR1 interferon gamma receptor 1 0.606
CD40 CD40 molecule, TNF receptor superfamily member 5 0.562
CXCL3 chemokine (C-X-C motif) ligand 3 0.547
IL8 interleukin 8 0.541
XIAP X-linked inhibitor of apoptosis 0.522
INSR insulin receptor 0.498
ZNF675 zinc finger protein 675 0.496
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.488
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.469
IL4R interleukin 4 receptor 0.442
TRAF5 TNF receptor-associated factor 5 0.436
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.418
NMI N-myc (and STAT) interactor 0.417
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.406
EGFR epidermal growth factor receptor 0.393
ZNF260 zinc finger protein 260 0.391
CCL2 chemokine (C-C motif) ligand 2 0.386
CCR5 chemokine (C-C motif) receptor 5 0.381
MAP2K4 mitogen-activated protein kinase kinase 4 0.377
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.376
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.375
CXCL2 chemokine (C-X-C motif) ligand 2 0.371
CCL8 chemokine (C-C motif) ligand 8 0.369
JAK2 Janus kinase 2 0.368
ICAM1 intercellular adhesion molecule 1 0.368
SOCS3 suppressor of cytokine signaling 3 0.357
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.354
MAPK8 mitogen-activated protein kinase 8 0.349
CFLAR CASP8 and FADD-like apoptosis regulator 0.343
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.338
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.313
TNF tumor necrosis factor 0.310
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.278
ZNF91 zinc finger protein 91 0.275
NLRC4 NLR family, CARD domain containing 4 0.274
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.272
MAFG v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) 0.271
CXCL5 chemokine (C-X-C motif) ligand 5 0.267
CAV1 caveolin 1, caveolae protein, 22kDa 0.259
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.250
KEAP1 kelch-like ECH-associated protein 1 0.248
CCL4 chemokine (C-C motif) ligand 4 0.246
APAF1 apoptotic peptidase activating factor 1 0.244
ZNF85 zinc finger protein 85 0.239
SOD2 superoxide dismutase 2, mitochondrial 0.231
TAL1 T-cell acute lymphocytic leukemia 1 0.231
CCL5 chemokine (C-C motif) ligand 5 0.228
NOSTRIN nitric oxide synthase trafficker 0.227
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.222
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.221
IL2RB interleukin 2 receptor, beta 0.220
IL1B interleukin 1, beta 0.216
IRAK1 interleukin-1 receptor-associated kinase 1 0.216
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.207
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.207
ABI2 abl-interactor 2 0.207
APOC1 apolipoprotein C-I 0.205
INADL InaD-like (Drosophila) 0.203
CXCL11 chemokine (C-X-C motif) ligand 11 0.201
MAPK1 mitogen-activated protein kinase 1 0.198
C1QC complement component 1, q subcomponent, C chain 0.194
ZNF708 zinc finger protein 708 0.193
ZNF430 zinc finger protein 430 0.192
ZNF93 zinc finger protein 93 0.192
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.191
DPP4 dipeptidyl-peptidase 4 0.190
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.189
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.188
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.173
IRF1 interferon regulatory factor 1 0.172
SLAMF8 SLAM family member 8 0.170
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.169
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.166
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 1.000
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.998
Ccl2 chemokine (C-C motif) ligand 2 0.973
Lta lymphotoxin A 0.860
Ikbkg inhibitor of kappaB kinase gamma 0.819
Il1r1 interleukin 1 receptor, type I 0.775
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.716
Krt5 keratin 5 0.642
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.617
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.615
Cxcl13 chemokine (C-X-C motif) ligand 13 0.598
Apoe apolipoprotein E 0.592
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.570
Socs1 suppressor of cytokine signaling 1 0.553
Pparg peroxisome proliferator activated receptor gamma 0.527
Csf1 colony stimulating factor 1 (macrophage) 0.517
Stat3 signal transducer and activator of transcription 3 0.498
Tlr4 toll-like receptor 4 0.489
Nos1 nitric oxide synthase 1, neuronal 0.482
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.482
Mdm2 transformed mouse 3T3 cell double minute 2 0.476
Trp53 transformation related protein 53 0.467
Cd44 CD44 antigen 0.440
Myd88 myeloid differentiation primary response gene 88 0.421
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.413
Ar androgen receptor 0.399
Pten phosphatase and tensin homolog 0.397
Ccr1 chemokine (C-C motif) receptor 1 0.393
Krt17 keratin 17 0.372
Ccl7 chemokine (C-C motif) ligand 7 0.360
Lyz2 lysozyme 2 0.360
Il6 interleukin 6 0.358
Traf2 TNF receptor-associated factor 2 0.356
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.345
Lepr leptin receptor 0.334
Igh immunoglobulin heavy chain complex 0.315
Ifng interferon gamma 0.293
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.287
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.283
Ptgs2 prostaglandin-endoperoxide synthase 2 0.269
Tnfrsf18 tumor necrosis factor receptor superfamily, member 18 0.254
Krtap8-1 keratin associated protein 8-1 0.236
Ltb lymphotoxin B 0.233
Ccl4 chemokine (C-C motif) ligand 4 0.232
Rnf31 ring finger protein 31 0.221
Pkp1 plakophilin 1 0.212
Cd40 CD40 antigen 0.203
Traf6 TNF receptor-associated factor 6 0.200
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.187
Krt33b keratin 33B 0.187
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.186
Casp1 caspase 1 0.182
Icam1 intercellular adhesion molecule 1 0.176
Ch25h cholesterol 25-hydroxylase 0.165
Il1b interleukin 1 beta 0.162
Sprr1a small proline-rich protein 1A 0.159
Saa3 serum amyloid A 3 0.158
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.157
Krt6a keratin 6A 0.153
Il1rn interleukin 1 receptor antagonist 0.149
Irf1 interferon regulatory factor 1 0.147
C3 complement component 3 0.146
Thbs1 thrombospondin 1 0.146
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.144
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.140
Ccl8 chemokine (C-C motif) ligand 8 0.138
Ikbkb inhibitor of kappaB kinase beta 0.137
Ccr2 chemokine (C-C motif) receptor 2 0.135
Ccl12 chemokine (C-C motif) ligand 12 0.133
Socs3 suppressor of cytokine signaling 3 0.133
Selp selectin, platelet 0.133
Cxcl2 chemokine (C-X-C motif) ligand 2 0.128
Clec4d C-type lectin domain family 4, member d 0.119
Krt14 keratin 14 0.118
Nlrp3 NLR family, pyrin domain containing 3 0.114
Krt35 keratin 35 0.113
Has1 hyaluronan synthase1 0.110
Bcl3 B-cell leukemia/lymphoma 3 0.109
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.107
Mef2d myocyte enhancer factor 2D 0.107
Hr hairless 0.106
Ncoa3 nuclear receptor coactivator 3 0.103
Krtap3-1 keratin associated protein 3-1 0.102
Ccl3 chemokine (C-C motif) ligand 3 0.101
Sharpin SHANK-associated RH domain interacting protein 0.099
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.097
Irg1 immunoresponsive gene 1 0.096
Tlr2 toll-like receptor 2 0.094
Ccl17 chemokine (C-C motif) ligand 17 0.086
Birc3 baculoviral IAP repeat-containing 3 0.086
S100a8 S100 calcium binding protein A8 (calgranulin A) 0.085
Krt86 keratin 86 0.085
Tg thyroglobulin 0.085
Cxcr5 chemokine (C-X-C motif) receptor 5 0.081
Lep leptin 0.081
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.081
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.080
Hif1a hypoxia inducible factor 1, alpha subunit 0.078
Il10 interleukin 10 0.072
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.071
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 0.906
Cxcl10 chemokine (C-X-C motif) ligand 10 0.902
Ccl2 chemokine (C-C motif) ligand 2 0.882
Cxcl2 chemokine (C-X-C motif) ligand 2 0.868
Mmp12 matrix metallopeptidase 12 0.808
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.806
Il6 interleukin 6 0.621
Il1b interleukin 1 beta 0.619
Col3a1 collagen, type III, alpha 1 0.560
Mobp myelin-associated oligodendrocyte basic protein 0.529
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.522
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.462
Ccl4 chemokine (C-C motif) ligand 4 0.450
Tgm1 transglutaminase 1, K polypeptide 0.445
Col1a2 collagen, type I, alpha 2 0.444
Mmp3 matrix metallopeptidase 3 0.430
Ccl7 chemokine (C-C motif) ligand 7 0.381
Col5a1 collagen, type V, alpha 1 0.360
Cd14 CD14 molecule 0.354
Orm1 orosomucoid 1 0.338
Krt18 keratin 18 0.325
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.324
Col5a2 collagen, type V, alpha 2 0.317
Hck hemopoietic cell kinase 0.308
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.300
Calcb calcitonin-related polypeptide, beta 0.285
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.276
Postn periostin, osteoblast specific factor 0.255
Ggt1 gamma-glutamyltransferase 1 0.248
Il4ra interleukin 4 receptor, alpha 0.240
Neurl3 neuralized homolog 3 (Drosophila) 0.233
Ccl3 chemokine (C-C motif) ligand 3 0.214
Gpx2 glutathione peroxidase 2 0.214
Crhr1 corticotropin releasing hormone receptor 1 0.205
Clec9a C-type lectin domain family 9, member a 0.200
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.197
LOC100363783 rCG53773-like 0.196
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.182
Slc13a1 solute carrier family 13 (sodium/sulfate symporters), member 1 0.169
Cd86 CD86 molecule 0.169
Anxa1 annexin A1 0.167
Col14a1 collagen, type XIV, alpha 1 0.166
Stc1 stanniocalcin 1 0.152
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.149
Birc3 baculoviral IAP repeat-containing 3 0.149
Myd88 myeloid differentiation primary response gene 88 0.146
Rhoj ras homolog gene family, member J 0.145
Gja4 gap junction protein, alpha 4 0.143
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.143
Psp parotid secretory protein 0.140
Fosl1 fos-like antigen 1 0.140
Lum lumican 0.136
Stat3 signal transducer and activator of transcription 3 0.136
Ifng interferon gamma 0.135
Stat6 signal transducer and activator of transcription 6 0.128
Nkx6-1 NK6 homeobox 1 0.126
Ripk3 receptor-interacting serine-threonine kinase 3 0.125
P2ry2 purinergic receptor P2Y, G-protein coupled, 2 0.124
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.123
Reg3g regenerating islet-derived 3 gamma 0.118
Syt6 synaptotagmin VI 0.116
Litaf lipopolysaccharide-induced TNF factor 0.115
Bcl2 B-cell CLL/lymphoma 2 0.115
Ece1 endothelin converting enzyme 1 0.110
Il1rn interleukin 1 receptor antagonist 0.110
Nfkbie nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.107
Ppard peroxisome proliferator-activated receptor delta 0.105
Hmox1 heme oxygenase (decycling) 1 0.105
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.103
Gja3 gap junction protein, alpha 3 0.102
Selp selectin P 0.101
Ier3 immediate early response 3 0.101
Ltbr lymphotoxin beta receptor (TNFR superfamily, member 3) 0.100
Pdcl phosducin-like 0.099
Ctsk cathepsin K 0.096
Prss22 protease, serine, 22 0.096
Dab2 disabled homolog 2 (Drosophila) 0.094
Inhba inhibin beta-A 0.093
Arl5c ADP-ribosylation factor-like 5C 0.091
Mmp2 matrix metallopeptidase 2 0.089
Rhox5 reproductive homeobox 5 0.089
Col12a1 collagen, type XII, alpha 1 0.088
Chrnb3 cholinergic receptor, nicotinic, beta 3 0.088
Flt1 FMS-related tyrosine kinase 1 0.088
Mmp13 matrix metallopeptidase 13 0.088
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.087
Sbno2 strawberry notch homolog 2 (Drosophila) 0.087
Mos Moloney sarcoma oncogene 0.085
Col4a2 collagen, type IV, alpha 2 0.085
Gss glutathione synthetase 0.085
Des desmin 0.085
Cd8a CD8a molecule 0.083
Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase 0.083
Bdkrb2 bradykinin receptor B2 0.082
RT1-Ba RT1 class II, locus Ba 0.082
Nrg1 neuregulin 1 0.082
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.081
Steap1 six transmembrane epithelial antigen of the prostate 1 0.081
Mvp major vault protein 0.080
Runx1 runt-related transcription factor 1 0.080
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism