The network for 'negative regulation of immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of immune response

Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

Homo sapiens
Name Description Probability Func Analog Organism
C1S complement component 1, s subcomponent 0.884
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.879
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.854
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.827
CD86 CD86 molecule 0.827
HLA-A major histocompatibility complex, class I, A 0.821
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.813
HLA-C major histocompatibility complex, class I, C 0.799
HLA-G major histocompatibility complex, class I, G 0.789
IL4R interleukin 4 receptor 0.786
GHR growth hormone receptor 0.726
B2M beta-2-microglobulin 0.725
ALB albumin 0.680
HLA-E major histocompatibility complex, class I, E 0.677
CD80 CD80 molecule 0.664
CCL4 chemokine (C-C motif) ligand 4 0.649
CD14 CD14 molecule 0.645
SMAD4 SMAD family member 4 0.641
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.613
CCR1 chemokine (C-C motif) receptor 1 0.591
C1R complement component 1, r subcomponent 0.578
CCR5 chemokine (C-C motif) receptor 5 0.562
NCOR2 nuclear receptor corepressor 2 0.522
COL1A2 collagen, type I, alpha 2 0.504
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.500
CXCL9 chemokine (C-X-C motif) ligand 9 0.491
IL2RG interleukin 2 receptor, gamma 0.489
COL1A1 collagen, type I, alpha 1 0.487
IL2RB interleukin 2 receptor, beta 0.453
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.449
HLA-B major histocompatibility complex, class I, B 0.440
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.425
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.411
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.399
COL3A1 collagen, type III, alpha 1 0.384
THOC4 THO complex 4 0.376
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.303
TFF1 trefoil factor 1 0.283
PILRA paired immunoglobin-like type 2 receptor alpha 0.279
CFH complement factor H 0.276
SOCS3 suppressor of cytokine signaling 3 0.271
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.270
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.266
THOC5 THO complex 5 0.260
CCR7 chemokine (C-C motif) receptor 7 0.247
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.237
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.236
TAPBP TAP binding protein (tapasin) 0.233
PML promyelocytic leukemia 0.232
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.232
CCL22 chemokine (C-C motif) ligand 22 0.231
C2 complement component 2 0.228
SIGLEC7 sialic acid binding Ig-like lectin 7 0.225
JAK2 Janus kinase 2 0.224
HLA-F major histocompatibility complex, class I, F 0.220
MED15 mediator complex subunit 15 0.217
TRAF1 TNF receptor-associated factor 1 0.209
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.205
ARRB1 arrestin, beta 1 0.204
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.204
CCL8 chemokine (C-C motif) ligand 8 0.193
HP haptoglobin 0.186
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.185
IL10RA interleukin 10 receptor, alpha 0.179
SP100 SP100 nuclear antigen 0.178
CCL5 chemokine (C-C motif) ligand 5 0.176
IFNG interferon, gamma 0.173
ATF2 activating transcription factor 2 0.164
MED10 mediator complex subunit 10 0.164
CXCL10 chemokine (C-X-C motif) ligand 10 0.162
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.161
SLAMF1 signaling lymphocytic activation molecule family member 1 0.160
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.159
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.159
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.154
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.151
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.151
APOC1 apolipoprotein C-I 0.144
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) 0.143
IL10 interleukin 10 0.142
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.141
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.140
ENG endoglin 0.138
HLA-DMB major histocompatibility complex, class II, DM beta 0.136
HK3 hexokinase 3 (white cell) 0.125
CCL2 chemokine (C-C motif) ligand 2 0.125
HLA-DRA major histocompatibility complex, class II, DR alpha 0.123
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.123
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.123
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.123
TGFB1 transforming growth factor, beta 1 0.120
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.119
TGFB3 transforming growth factor, beta 3 0.117
DDR2 discoidin domain receptor tyrosine kinase 2 0.116
IL22RA1 interleukin 22 receptor, alpha 1 0.113
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 0.113
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.112
BTN3A3 butyrophilin, subfamily 3, member A3 0.111
CCL19 chemokine (C-C motif) ligand 19 0.110
COL5A2 collagen, type V, alpha 2 0.109
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
atf3 activating transcription factor 3 0.199
junb jun B proto-oncogene 0.190
lrrc33 leucine rich repeat containing 33 0.107
adra2da adrenergic, alpha-2D-, receptor a 0.097
mmp9 matrix metalloproteinase 9 0.096
adra2b adrenergic, alpha-2B-, receptor 0.078
socs1 suppressor of cytokine signaling 1 0.072
pglyrp5 peptidoglycan recognition protein 5 0.059
vipr2 vasoactive intestinal peptide receptor 2 0.056
zgc:64051 zgc:64051 0.052
cxcr3.2 chemokine (C-X-C motif) receptor 3.2 0.051
skia nuclear oncoprotein skia 0.049
sb:cb429 sb:cb429 0.048
si:ch211-235f6.2 si:ch211-235f6.2 0.046
jak1 Janus kinase 1 0.046
fn1b fibronectin 1b 0.039
yrk Yes-related kinase 0.039
si:dkeyp-50f5.1 si:dkeyp-50f5.1 0.037
psmb2 proteasome (prosome, macropain) subunit, beta type, 2 0.036
jhdm1da jumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae) 0.034
ldb2a LIM-domain binding factor 2a 0.033
pglyrp6 peptidoglycan recognition protein 6 0.033
eya2 eyes absent homolog 2 (Drosophila) 0.033
ptpn21 protein tyrosine phosphatase, non-receptor type 21 0.031
ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.030
lsr lipolysis stimulated lipoprotein receptor 0.030
ca15a carbonic anhydrase XV a 0.030
ptprc protein tyrosine phosphatase, receptor type, C 0.029
npy8br neuropeptide Y receptor Y8b 0.029
npnt nephronectin 0.029
csnk1a1 casein kinase 1, alpha 1 0.029
fli1b friend leukemia integration 1b 0.028
tlr21 toll-like receptor 21 0.028
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.028
sgk1 serum/glucocorticoid regulated kinase 1 0.028
psmd4b proteasome (prosome, macropain) 26S subunit, non-ATPase, 4b 0.028
llgl2 lethal giant larvae homolog 2 (Drosophila) 0.028
sox5 SRY-box containing gene 5 0.028
tbx5b T-box 5b 0.027
ccm2 cerebral cavernous malformation 2 0.027
waca WW domain containing adaptor with coiled-coil a 0.027
gmfg glia maturation factor, gamma 0.026
poldip2 polymerase (DNA-directed), delta interacting protein 2 0.026
il7r interleukin 7 receptor 0.026
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.026
psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.026
krit1 KRIT1, ankyrin repeat containing 0.026
ncf1 neutrophil cytosolic factor 1 0.025
rhogb ras homolog gene family, member Gb 0.025
elk4 ELK4, ETS-domain protein 0.025
slc2a1a solute carrier family 2 (facilitated glucose transporter), member 1a 0.025
wnt10a wingless-type MMTV integration site family, member 10a 0.025
si:rp71-39b20.7 si:rp71-39b20.7 0.025
atp1b1a ATPase, Na+/K+ transporting, beta 1a polypeptide 0.024
abcb3l1 ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 1 0.023
bmpr2b bone morphogenetic protein receptor, type II b (serine/threonine kinase) 0.023
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.023
wu:fi25h02 wu:fi25h02 0.023
myh11a myosin, heavy polypeptide 11, smooth muscle a 0.022
si:dkeyp-81f3.1 si:dkeyp-81f3.1 0.022
si:dkeyp-55c8.3 si:dkeyp-55c8.3 0.022
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.022
zgc:103710 zgc:103710 0.022
si:dkey-27i16.2 si:dkey-27i16.2 0.022
lpp LIM domain containing preferred translocation partner in lipoma 0.022
igf2b insulin-like growth factor 2b 0.022
npy7r neuropeptide Y receptor Y7 0.022
dkk3l dickkopf homolog 3 like (Xenopus laevis) 0.022
rap1b RAS related protein 1b 0.022
spint1a serine peptidase inhibitor, Kunitz type 1 a 0.022
mst1rb macrophage stimulating 1 receptor (c-met-related tyrosine kinase), b 0.022
ednra endothelin receptor type A 0.022
znf148 zinc finger protein 148 0.021
gdf11 growth differentiation factor 11 0.021
pknox1.2 pbx/knotted 1 homeobox 1.2 0.021
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.021
vdra vitamin D receptor a 0.021
cd8a CD8 antigen, alpha polypeptide 0.021
dnm2 dynamin 2 0.021
cebpd CCAAT/enhancer binding protein (C/EBP), delta 0.021
taf3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto 0.021
lhx6 LIM homeobox 6 0.020
mmrn2a multimerin 2a 0.020
zgc:64042 zgc:64042 0.020
lipc lipase, hepatic 0.020
tgfb2 transforming growth factor, beta 2 0.020
vdrb vitamin D receptor b 0.020
pyya peptide YYa 0.020
bmp10 bone morphogenetic protein 10 0.020
timp2b tissue inhibitor of metalloproteinase 2b 0.020
aida axin interaction partner and dorsalization antagonist 0.020
tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.020
tagln2 transgelin 2 0.020
adra2db adrenergic, alpha-2D-, receptor b 0.019
junbl jun B proto-oncogene, like 0.019
wnt5a wingless-type MMTV integration site family, member 5a 0.019
rhcgb Rhesus blood group, C glycoprotein b 0.019
phex phosphate regulating gene with homologues to endopeptidases on the X chromosome 0.019
zgc:73111 zgc:73111 0.019
nr5a5 nuclear receptor subfamily 5, group A, member 5 0.019
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Stat92E Signal-transducer and activator of transcription protein at 92E 0.285
rl rolled 0.267
Mad Mothers against dpp 0.227
foxo forkhead box, sub-group O 0.156
fon fondue 0.140
p38b CG7393 gene product from transcript CG7393-RA 0.114
Rel Relish 0.113
Ras85D Ras oncogene at 85D 0.109
PGRP-LC Peptidoglycan recognition protein LC 0.108
CG9014 CG9014 gene product from transcript CG9014-RA 0.099
Spn27A Serpin 27A 0.095
grass Gram-positive Specific Serine protease 0.076
PGRP-LB Peptidoglycan recognition protein LB 0.075
Sp7 Serine protease 7 0.073
tkv thickveins 0.072
PGRP-SC1b CG8577 gene product from transcript CG8577-RA 0.072
AttA Attacin-A 0.058
ird1 immune response deficient 1 0.054
chico CG5686 gene product from transcript CG5686-RB 0.053
PGRP-SC1a CG14746 gene product from transcript CG14746-RA 0.052
RagA CG11968 gene product from transcript CG11968-RA 0.052
Socs36E Suppressor of cytokine signaling at 36E 0.052
CG42863 CG42863 gene product from transcript CG42863-RB 0.051
LysC Lysozyme C 0.049
babo baboon 0.048
Nrx-IV Neurexin IV 0.047
Ntf-2 Nuclear transport factor-2 0.043
CG18594 CG18594 gene product from transcript CG18594-RA 0.042
upd3 unpaired 3 0.041
Mtk Metchnikowin 0.041
modSP modular serine protease 0.040
Mekk1 CG7717 gene product from transcript CG7717-RB 0.040
Sod2 Superoxide dismutase 2 (Mn) 0.040
CG8709 CG8709 gene product from transcript CG8709-RK 0.040
fh frataxin homolog 0.039
scb scab 0.037
daw dawdle 0.037
Lmpt Limpet 0.037
wts warts 0.035
pnt pointed 0.034
poly CG9829 gene product from transcript CG9829-RB 0.033
drk downstream of receptor kinase 0.032
Pten CG5671 gene product from transcript CG5671-RB 0.031
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.029
dco discs overgrown 0.029
oys oysgedart 0.028
Unr Upstream of N-ras 0.027
pirk poor Imd response upon knock-in 0.027
CG15917 CG15917 gene product from transcript CG15917-RA 0.026
unk unkempt 0.026
Pvf1 PDGF- and VEGF-related factor 1 0.026
CG13060 CG13060 gene product from transcript CG13060-RA 0.025
Krn Keren 0.025
CaMKII Calcium/calmodulin-dependent protein kinase II 0.025
unc-104 CG8566 gene product from transcript CG8566-RB 0.025
eater CG6124 gene product from transcript CG6124-RB 0.024
coro CG9446 gene product from transcript CG9446-RC 0.024
CG5325 CG5325 gene product from transcript CG5325-RB 0.024
Cdc42 CG12530 gene product from transcript CG12530-RA 0.023
krz kurtz 0.023
Patr-1 Protein associated with topo II related - 1 0.023
ird5 immune response deficient 5 0.022
CG9238 CG9238 gene product from transcript CG9238-RA 0.022
PGRP-LF Peptidoglycan recognition protein LF 0.022
Pk61C Protein kinase 61C 0.021
PGRP-SC2 CG14745 gene product from transcript CG14745-RA 0.021
imd immune deficiency 0.021
upd2 unpaired 2 0.020
psh persephone 0.020
Myo31DF Myosin 31DF 0.020
rut rutabaga 0.020
cad caudal 0.020
tai taiman 0.020
SPE Spatzle-Processing Enzyme 0.019
Lasp CG3849 gene product from transcript CG3849-RB 0.019
Cyp12c1 CG4120 gene product from transcript CG4120-RA 0.019
gcl germ cell-less 0.019
psidin phagocyte signaling impaired 0.019
CG17633 CG17633 gene product from transcript CG17633-RA 0.019
PGRP-SA Peptidoglycan recognition protein SA 0.019
puc puckered 0.018
lic licorne 0.018
l(3)mbn lethal (3) malignant blood neoplasm 0.018
Actbeta Activin-beta 0.018
Drs Drosomycin 0.018
CG7607 CG7607 gene product from transcript CG7607-RA 0.018
Mmp1 Matrix metalloproteinase 1 0.018
CG34424 CG34424 gene product from transcript CG34424-RA 0.018
CG18135 CG18135 gene product from transcript CG18135-RC 0.018
spheroide CG9675 gene product from transcript CG9675-RA 0.018
CG11286 CG11286 gene product from transcript CG11286-RA 0.018
Spn1 Serine protease inhibitor 1 0.017
CG13641 CG13641 gene product from transcript CG13641-RA 0.017
CG9139 CG9139 gene product from transcript CG9139-RA 0.017
spi spitz 0.017
fs(1)N female sterile (1) Nasrat 0.017
CG33138 CG33138 gene product from transcript CG33138-RA 0.017
CG30031 CG30031 gene product from transcript CG30031-RA 0.017
GNBP1 Gram-negative bacteria binding protein 1 0.017
CG7017 CG7017 gene product from transcript CG7017-RA 0.017
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Gzmk granzyme K 0.080
Bgn biglycan 0.073
Ccr2 chemokine (C-C motif) receptor 2 0.067
Mmp12 matrix metallopeptidase 12 0.067
RT1-EC2 RT1 class Ib, locus EC2 0.059
Aebp1 AE binding protein 1 0.046
Arhgap4 Rho GTPase activating protein 4 0.039
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.038
Icam1 intercellular adhesion molecule 1 0.034
Cd247 Cd247 molecule 0.033
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.033
Aif1 allograft inflammatory factor 1 0.031
Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.029
Igsf6 immunoglobulin superfamily, member 6 0.026
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.024
C1r complement component 1, r subcomponent 0.024
C3 complement component 3 0.023
Fgg fibrinogen gamma chain 0.023
Cd2 Cd2 molecule 0.022
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.021
Timp2 TIMP metallopeptidase inhibitor 2 0.021
Cd37 CD37 molecule 0.020
Ccl5 chemokine (C-C motif) ligand 5 0.020
Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 0.019
Il1b interleukin 1 beta 0.019
Ctsl1 cathepsin L1 0.019
Col1a1 collagen, type I, alpha 1 0.018
Gzmb granzyme B 0.018
Ppp3r2 protein phosphatase 3, regulatory subunit B, beta isoform 0.017
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.017
Il2rb interleukin 2 receptor, beta 0.017
Ifng interferon gamma 0.017
Ptp4a2 protein tyrosine phosphatase 4a2 0.016
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.016
Lyz2 lysozyme 2 0.016
Xcl1 chemokine (C motif) ligand 1 0.016
Smcp sperm mitochondria-associated cysteine-rich protein 0.016
Arhgap25 Rho GTPase activating protein 25 0.015
Grpel1 GrpE-like 1, mitochondrial 0.015
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.015
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.015
Il7r interleukin 7 receptor 0.015
Sell selectin L 0.015
Nop58 nucleolar protein NOP58 0.015
Csn1s1 casein alpha s1 0.015
Gzmm granzyme M (lymphocyte met-ase 1) 0.015
Irf2 interferon regulatory factor 2 0.014
Uba7 ubiquitin-like modifier activating enzyme 7 0.014
Ceacam11 carcinoembryonic antigen-related cell adhesion molecule 11 0.014
C1s complement component 1, s subcomponent 0.014
Map4k1 mitogen activated protein kinase kinase kinase kinase 1 0.013
RT1-A3 RT1 class I, locus A3 0.013
Hes2 hairy and enhancer of split 2 (Drosophila) 0.013
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.013
Il17ra interleukin 17 receptor A 0.013
Oas1a 2'-5' oligoadenylate synthetase 1A 0.013
Cfb complement factor B 0.013
Rt1.aa MHC class I RT1.Aa alpha-chain 0.013
Klra5 killer cell lectin-like receptor, subfamily A, member 5 0.013
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.013
Gucy2e guanylate cyclase 2E 0.013
Fgf16 fibroblast growth factor 16 0.013
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.012
Lcn5 lipocalin 5 0.012
Tcp11 t-complex protein 11 0.012
Klrb1a killer cell lectin-like receptor subfamily B, member 1A 0.012
Olr1697 olfactory receptor 1697 0.012
Pcolce procollagen C-endopeptidase enhancer 0.012
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.012
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.012
Tfec transcription factor EC 0.012
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.011
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.011
Vom1r93 vomeronasal 1 receptor 93 0.011
Acpp acid phosphatase, prostate 0.011
Abcc6 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 0.011
Fcnb ficolin B 0.011
Mmp8 matrix metallopeptidase 8 0.011
Il1rn interleukin 1 receptor antagonist 0.010
Col3a1 collagen, type III, alpha 1 0.010
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.010
Gcgr glucagon receptor 0.010
Pdx1 pancreatic and duodenal homeobox 1 0.010
Pim1 pim-1 oncogene 0.010
Prf1 perforin 1 (pore forming protein) 0.010
Cxcl10 chemokine (C-X-C motif) ligand 10 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism