The network for 'chemokine production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

chemokine production

The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

Homo sapiens
Name Description Probability Func Analog Organism
C1QA complement component 1, q subcomponent, A chain 0.995
IL1R1 interleukin 1 receptor, type I 0.983
MYD88 myeloid differentiation primary response gene (88) 0.970
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.969
HDAC2 histone deacetylase 2 0.894
TLR4 toll-like receptor 4 0.744
ABI2 abl-interactor 2 0.692
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.652
APOE apolipoprotein E 0.624
CCR2 chemokine (C-C motif) receptor 2 0.492
VEGFA vascular endothelial growth factor A 0.486
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.480
TICAM2 toll-like receptor adaptor molecule 2 0.456
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.444
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.440
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.381
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.373
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.327
IL1R2 interleukin 1 receptor, type II 0.306
C1QC complement component 1, q subcomponent, C chain 0.290
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.288
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.288
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.287
LAT linker for activation of T cells 0.281
CCL5 chemokine (C-C motif) ligand 5 0.281
TLR2 toll-like receptor 2 0.281
IL1B interleukin 1, beta 0.278
IL1RAP interleukin 1 receptor accessory protein 0.252
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.246
NRP1 neuropilin 1 0.216
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.203
NLRC4 NLR family, CARD domain containing 4 0.196
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.193
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.172
IRF4 interferon regulatory factor 4 0.171
KLF4 Kruppel-like factor 4 (gut) 0.171
KLF6 Kruppel-like factor 6 0.162
C1QB complement component 1, q subcomponent, B chain 0.160
SETD8 SET domain containing (lysine methyltransferase) 8 0.157
CAV1 caveolin 1, caveolae protein, 22kDa 0.152
CD14 CD14 molecule 0.146
IL6R interleukin 6 receptor 0.145
PYCARD PYD and CARD domain containing 0.144
CCR5 chemokine (C-C motif) receptor 5 0.139
FZD1 frizzled homolog 1 (Drosophila) 0.138
CDH5 cadherin 5, type 2 (vascular endothelium) 0.134
CXCL9 chemokine (C-X-C motif) ligand 9 0.133
CCL22 chemokine (C-C motif) ligand 22 0.131
CCR4 chemokine (C-C motif) receptor 4 0.130
TXN thioredoxin 0.127
CLEC7A C-type lectin domain family 7, member A 0.126
IRAK2 interleukin-1 receptor-associated kinase 2 0.123
CXCR4 chemokine (C-X-C motif) receptor 4 0.121
MAP2K4 mitogen-activated protein kinase kinase 4 0.118
IFNG interferon, gamma 0.114
TRAF6 TNF receptor-associated factor 6 0.113
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.112
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.110
CCL19 chemokine (C-C motif) ligand 19 0.105
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.103
IL10 interleukin 10 0.102
GAB1 GRB2-associated binding protein 1 0.100
CFH complement factor H 0.099
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.096
MEFV Mediterranean fever 0.091
LY96 lymphocyte antigen 96 0.085
DLG1 discs, large homolog 1 (Drosophila) 0.084
CCR7 chemokine (C-C motif) receptor 7 0.082
MPO myeloperoxidase 0.081
GATA2 GATA binding protein 2 0.079
ASRGL1 asparaginase like 1 0.077
IL8 interleukin 8 0.077
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.076
PGF placental growth factor 0.074
SNX9 sorting nexin 9 0.074
CYBB cytochrome b-245, beta polypeptide 0.073
TRAF1 TNF receptor-associated factor 1 0.072
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.071
SNX33 sorting nexin 33 0.067
CFI complement factor I 0.066
NOD1 nucleotide-binding oligomerization domain containing 1 0.065
CXCR6 chemokine (C-X-C motif) receptor 6 0.065
IL6 interleukin 6 (interferon, beta 2) 0.064
PTPRB protein tyrosine phosphatase, receptor type, B 0.064
FTH1 ferritin, heavy polypeptide 1 0.062
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.062
SH3D19 SH3 domain containing 19 0.061
STAB1 stabilin 1 0.060
CCL7 chemokine (C-C motif) ligand 7 0.059
SLA Src-like-adaptor 0.059
LRP6 low density lipoprotein receptor-related protein 6 0.058
INSR insulin receptor 0.056
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.053
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.052
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.051
JAK1 Janus kinase 1 0.050
CCR1 chemokine (C-C motif) receptor 1 0.050
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.050
IRF8 interferon regulatory factor 8 0.049
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.049
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Tlr4 toll-like receptor 4 0.998
Myd88 myeloid differentiation primary response gene 88 0.997
Tnf tumor necrosis factor 0.992
Cd44 CD44 antigen 0.989
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.986
Ccl2 chemokine (C-C motif) ligand 2 0.938
Il1r1 interleukin 1 receptor, type I 0.915
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.839
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.800
Ccr2 chemokine (C-C motif) receptor 2 0.682
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.680
Il1rl1 interleukin 1 receptor-like 1 0.628
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.593
Il6 interleukin 6 0.587
Il1b interleukin 1 beta 0.569
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.569
Mmp9 matrix metallopeptidase 9 0.535
Il6st interleukin 6 signal transducer 0.480
Lyz2 lysozyme 2 0.469
Cd86 CD86 antigen 0.360
Il1rn interleukin 1 receptor antagonist 0.354
Tlr2 toll-like receptor 2 0.342
Mmp8 matrix metallopeptidase 8 0.320
Gata1 GATA binding protein 1 0.309
Casp1 caspase 1 0.276
Stat3 signal transducer and activator of transcription 3 0.271
Unc93b1 unc-93 homolog B1 (C. elegans) 0.245
Il18rap interleukin 18 receptor accessory protein 0.184
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.181
Ccl4 chemokine (C-C motif) ligand 4 0.181
Csf1 colony stimulating factor 1 (macrophage) 0.176
Selp selectin, platelet 0.176
Cxcl2 chemokine (C-X-C motif) ligand 2 0.171
Mefv Mediterranean fever 0.168
Casp8 caspase 8 0.167
Ccr1 chemokine (C-C motif) receptor 1 0.163
Il10 interleukin 10 0.163
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.149
Hif1a hypoxia inducible factor 1, alpha subunit 0.149
Nos2 nitric oxide synthase 2, inducible 0.143
Stat6 signal transducer and activator of transcription 6 0.138
Ptgs2 prostaglandin-endoperoxide synthase 2 0.128
Cd33 CD33 antigen 0.123
Rel reticuloendotheliosis oncogene 0.121
Cxcr2 chemokine (C-X-C motif) receptor 2 0.121
H2-Aa histocompatibility 2, class II antigen A, alpha 0.117
Traf3 TNF receptor-associated factor 3 0.114
Irak4 interleukin-1 receptor-associated kinase 4 0.113
Spp1 secreted phosphoprotein 1 0.105
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.103
Irg1 immunoresponsive gene 1 0.098
Cxcl1 chemokine (C-X-C motif) ligand 1 0.097
Slpi secretory leukocyte peptidase inhibitor 0.094
Cd14 CD14 antigen 0.092
Havcr2 hepatitis A virus cellular receptor 2 0.091
Gja1 gap junction protein, alpha 1 0.091
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.090
Ccr5 chemokine (C-C motif) receptor 5 0.089
Batf basic leucine zipper transcription factor, ATF-like 0.085
Fpr2 formyl peptide receptor 2 0.084
Klra2 killer cell lectin-like receptor, subfamily A, member 2 0.083
Cx3cr1 chemokine (C-X3-C) receptor 1 0.082
Nlrp3 NLR family, pyrin domain containing 3 0.079
Ifnar1 interferon (alpha and beta) receptor 1 0.077
Ccl3 chemokine (C-C motif) ligand 3 0.074
Sftpd surfactant associated protein D 0.074
Cd80 CD80 antigen 0.072
Phldb2 pleckstrin homology-like domain, family B, member 2 0.071
Il10ra interleukin 10 receptor, alpha 0.069
Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.069
Icam1 intercellular adhesion molecule 1 0.066
Lif leukemia inhibitory factor 0.065
Ccl7 chemokine (C-C motif) ligand 7 0.064
Ccl22 chemokine (C-C motif) ligand 22 0.063
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.063
Ooep oocyte expressed protein homolog (dog) 0.062
Adam8 a disintegrin and metallopeptidase domain 8 0.061
Clec4e C-type lectin domain family 4, member e 0.061
Igsf6 immunoglobulin superfamily, member 6 0.058
Socs3 suppressor of cytokine signaling 3 0.056
Ifng interferon gamma 0.054
Osmr oncostatin M receptor 0.052
Clec4d C-type lectin domain family 4, member d 0.052
Il21r interleukin 21 receptor 0.050
Vim vimentin 0.050
Mapk14 mitogen-activated protein kinase 14 0.049
Egr2 early growth response 2 0.049
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.048
Ggt5 gamma-glutamyltransferase 5 0.046
C3ar1 complement component 3a receptor 1 0.046
Niacr1 niacin receptor 1 0.046
Slamf8 SLAM family member 8 0.045
Tgfbi transforming growth factor, beta induced 0.045
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.044
Cxcl5 chemokine (C-X-C motif) ligand 5 0.044
Elk4 ELK4, member of ETS oncogene family 0.042
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.042
Ptgs1 prostaglandin-endoperoxide synthase 1 0.041
Rgs1 regulator of G-protein signaling 1 0.041
Slfn4 schlafen 4 0.040
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism