The network for 'cytokine biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cytokine biosynthetic process

The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.

Homo sapiens
Name Description Probability Func Analog Organism
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.994
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.980
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.974
CD80 CD80 molecule 0.947
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.939
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.929
IL1R1 interleukin 1 receptor, type I 0.887
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.877
BIRC3 baculoviral IAP repeat containing 3 0.868
TICAM2 toll-like receptor adaptor molecule 2 0.829
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.821
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.818
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.807
SYK spleen tyrosine kinase 0.773
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.759
BTN3A1 butyrophilin, subfamily 3, member A1 0.759
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.748
IL1B interleukin 1, beta 0.721
CD86 CD86 molecule 0.693
LCK lymphocyte-specific protein tyrosine kinase 0.666
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.632
BTN3A3 butyrophilin, subfamily 3, member A3 0.631
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.629
TNIP2 TNFAIP3 interacting protein 2 0.547
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.533
BTN3A2 butyrophilin, subfamily 3, member A2 0.526
TRAF1 TNF receptor-associated factor 1 0.512
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.507
MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) 0.474
BCL10 B-cell CLL/lymphoma 10 0.471
IL2RB interleukin 2 receptor, beta 0.424
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.393
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.387
STAT2 signal transducer and activator of transcription 2, 113kDa 0.380
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.366
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.361
TLR4 toll-like receptor 4 0.361
DDIT3 DNA-damage-inducible transcript 3 0.355
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.353
CARD11 caspase recruitment domain family, member 11 0.351
LAT linker for activation of T cells 0.346
IRAK1 interleukin-1 receptor-associated kinase 1 0.342
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.328
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.306
BCL3 B-cell CLL/lymphoma 3 0.279
IL8 interleukin 8 0.278
MYD88 myeloid differentiation primary response gene (88) 0.260
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.247
CD2 CD2 molecule 0.245
TRAF2 TNF receptor-associated factor 2 0.240
TRAF5 TNF receptor-associated factor 5 0.214
CREBBP CREB binding protein 0.207
CD247 CD247 molecule 0.202
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.197
GNLY granulysin 0.192
IL10RA interleukin 10 receptor, alpha 0.166
JUN jun proto-oncogene 0.161
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.160
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.156
BLNK B-cell linker 0.148
IRF7 interferon regulatory factor 7 0.148
INSR insulin receptor 0.147
SIGLEC7 sialic acid binding Ig-like lectin 7 0.139
CD28 CD28 molecule 0.138
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.137
DUSP1 dual specificity phosphatase 1 0.136
JUNB jun B proto-oncogene 0.134
PILRA paired immunoglobin-like type 2 receptor alpha 0.134
EPOR erythropoietin receptor 0.133
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.131
IL1R2 interleukin 1 receptor, type II 0.130
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.128
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.121
TRADD TNFRSF1A-associated via death domain 0.121
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.120
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.115
GADD45B growth arrest and DNA-damage-inducible, beta 0.111
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.109
CD48 CD48 molecule 0.109
BTK Bruton agammaglobulinemia tyrosine kinase 0.108
TNIP1 TNFAIP3 interacting protein 1 0.105
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.104
GRAP2 GRB2-related adaptor protein 2 0.103
SLAMF7 SLAM family member 7 0.102
KAT2B K(lysine) acetyltransferase 2B 0.101
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.097
CRYAB crystallin, alpha B 0.097
IL4R interleukin 4 receptor 0.094
IRF4 interferon regulatory factor 4 0.092
IRAK2 interleukin-1 receptor-associated kinase 2 0.089
CD1C CD1c molecule 0.088
SH2D1A SH2 domain containing 1A 0.088
JAK2 Janus kinase 2 0.087
PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.083
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.080
UBASH3B ubiquitin associated and SH3 domain containing B 0.077
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) 0.077
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.077
APOA1 apolipoprotein A-I 0.077
SQSTM1 sequestosome 1 0.077
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
epor erythropoietin receptor 0.012
stat1b signal transducer and activator of transcription 1b 0.010
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Tlr4 toll-like receptor 4 0.998
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.998
Myd88 myeloid differentiation primary response gene 88 0.997
Cd40 CD40 antigen 0.997
Tnf tumor necrosis factor 0.995
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.993
Ikzf1 IKAROS family zinc finger 1 0.986
Il4 interleukin 4 0.985
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.980
Sfpi1 SFFV proviral integration 1 0.972
Lyz2 lysozyme 2 0.972
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.966
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.960
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.952
Cd28 CD28 antigen 0.947
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.947
Stat6 signal transducer and activator of transcription 6 0.940
Ccr1 chemokine (C-C motif) receptor 1 0.938
Birc3 baculoviral IAP repeat-containing 3 0.916
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.911
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.898
Cd19 CD19 antigen 0.894
Il27ra interleukin 27 receptor, alpha 0.883
Irf9 interferon regulatory factor 9 0.880
Irf4 interferon regulatory factor 4 0.860
Ikbkb inhibitor of kappaB kinase beta 0.848
Ticam1 toll-like receptor adaptor molecule 1 0.834
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.824
Btk Bruton agammaglobulinemia tyrosine kinase 0.823
Casp1 caspase 1 0.813
Runx1 runt related transcription factor 1 0.805
Pdcd1 programmed cell death 1 0.771
Lta lymphotoxin A 0.722
Fasl Fas ligand (TNF superfamily, member 6) 0.710
Il4ra interleukin 4 receptor, alpha 0.693
Il10 interleukin 10 0.684
Ifng interferon gamma 0.666
Ikbkg inhibitor of kappaB kinase gamma 0.661
Clec4d C-type lectin domain family 4, member d 0.649
Cxcr5 chemokine (C-X-C motif) receptor 5 0.648
Stat3 signal transducer and activator of transcription 3 0.643
Fas Fas (TNF receptor superfamily member 6) 0.637
Vav1 vav 1 oncogene 0.632
Il1r1 interleukin 1 receptor, type I 0.616
Nckap1l NCK associated protein 1 like 0.592
Inpp5d inositol polyphosphate-5-phosphatase D 0.592
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.582
Socs1 suppressor of cytokine signaling 1 0.570
Cd80 CD80 antigen 0.570
Stat5a signal transducer and activator of transcription 5A 0.549
Prf1 perforin 1 (pore forming protein) 0.543
Cd86 CD86 antigen 0.535
Igh immunoglobulin heavy chain complex 0.524
Ccr6 chemokine (C-C motif) receptor 6 0.524
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.524
Stat1 signal transducer and activator of transcription 1 0.514
Ccl2 chemokine (C-C motif) ligand 2 0.514
Il6 interleukin 6 0.514
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.509
Cd5 CD5 antigen 0.506
Ccr7 chemokine (C-C motif) receptor 7 0.493
Il10ra interleukin 10 receptor, alpha 0.487
Stat5b signal transducer and activator of transcription 5B 0.484
Blk B lymphoid kinase 0.480
Mmp8 matrix metallopeptidase 8 0.472
Ifnar2 interferon (alpha and beta) receptor 2 0.449
Clec4n C-type lectin domain family 4, member n 0.443
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.435
Cd6 CD6 antigen 0.426
Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide 0.416
Selp selectin, platelet 0.407
Clec4e C-type lectin domain family 4, member e 0.404
Flt3 FMS-like tyrosine kinase 3 0.402
Il2rb interleukin 2 receptor, beta chain 0.389
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.388
Inhba inhibin beta-A 0.380
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.368
Foxp3 forkhead box P3 0.359
Tbx21 T-box 21 0.353
Cd7 CD7 antigen 0.350
Traf6 TNF receptor-associated factor 6 0.348
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.348
Itgal integrin alpha L 0.346
C3ar1 complement component 3a receptor 1 0.341
Ccr5 chemokine (C-C motif) receptor 5 0.339
Rhoh ras homolog gene family, member H 0.338
Fcgr2b Fc receptor, IgG, low affinity IIb 0.332
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.327
Pax5 paired box gene 5 0.325
Tlr7 toll-like receptor 7 0.313
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.309
Cd4 CD4 antigen 0.306
Bcl3 B-cell leukemia/lymphoma 3 0.304
Pou2af1 POU domain, class 2, associating factor 1 0.304
Card11 caspase recruitment domain family, member 11 0.285
Ifngr1 interferon gamma receptor 1 0.284
Il1rl1 interleukin 1 receptor-like 1 0.280
Ptgs2 prostaglandin-endoperoxide synthase 2 0.273
Map3k1 mitogen-activated protein kinase kinase kinase 1 0.272
Ccr2 chemokine (C-C motif) receptor 2 0.270
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Ccl3 chemokine (C-C motif) ligand 3 0.605
Ccl4 chemokine (C-C motif) ligand 4 0.345
Il1b interleukin 1 beta 0.290
Tlr2 toll-like receptor 2 0.223
Errfi1 ERBB receptor feedback inhibitor 1 0.167
Igsf6 immunoglobulin superfamily, member 6 0.165
Il1r2 interleukin 1 receptor, type II 0.152
Hpgds hematopoietic prostaglandin D synthase 0.130
Folr2 folate receptor 2 (fetal) 0.128
Cfp complement factor properdin 0.102
Cxcl2 chemokine (C-X-C motif) ligand 2 0.087
Xdh xanthine dehydrogenase 0.087
Il1a interleukin 1 alpha 0.086
Thbd thrombomodulin 0.083
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.082
Il6 interleukin 6 0.080
C5ar1 complement component 5a receptor 1 0.077
Fcn1 ficolin (collagen/fibrinogen domain containing) 1 0.071
Mmp12 matrix metallopeptidase 12 0.070
Arl11 ADP-ribosylation factor-like 11 0.069
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.068
Prf1 perforin 1 (pore forming protein) 0.064
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.062
Dnase1l3 deoxyribonuclease 1-like 3 0.062
Cxcl3 chemokine (C-X-C motif) ligand 3 0.062
Reg3b regenerating islet-derived 3 beta 0.060
Arl5c ADP-ribosylation factor-like 5C 0.060
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.059
Ccl2 chemokine (C-C motif) ligand 2 0.055
Stat3 signal transducer and activator of transcription 3 0.052
C3ar1 complement component 3a receptor 1 0.051
Nradd neurotrophin receptor associated death domain 0.050
Itgam integrin, alpha M 0.050
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.049
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.049
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.049
Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 0.049
Nkg7 natural killer cell group 7 sequence 0.049
Cst7 cystatin F (leukocystatin) 0.048
Ncf4 neutrophil cytosolic factor 4 0.048
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.048
Duox2 dual oxidase 2 0.045
Cybb cytochrome b-245, beta polypeptide 0.045
Cd247 Cd247 molecule 0.045
Cd200r1 CD200 receptor 1 0.044
Cfd complement factor D (adipsin) 0.043
Slc9a2 solute carrier family 9 (sodium/hydrogen exchanger), member 2 0.043
Myd88 myeloid differentiation primary response gene 88 0.043
Xcl1 chemokine (C motif) ligand 1 0.043
Sla src-like adaptor 0.042
Clec9a C-type lectin domain family 9, member a 0.040
Arhgap4 Rho GTPase activating protein 4 0.039
Csf1r colony stimulating factor 1 receptor 0.039
Hspa1a heat shock 70kD protein 1A 0.039
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.038
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.038
Adarb2 adenosine deaminase, RNA-specific, B2 0.038
Rgs1 regulator of G-protein signaling 1 0.037
Mmp3 matrix metallopeptidase 3 0.036
Il6r interleukin 6 receptor 0.036
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.034
Musk muscle, skeletal, receptor tyrosine kinase 0.034
Tlr4 toll-like receptor 4 0.033
Il13ra2 interleukin 13 receptor, alpha 2 0.033
Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 0.033
Il2rg interleukin 2 receptor, gamma 0.033
Prdm1 PR domain containing 1, with ZNF domain 0.033
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.032
Il2rb interleukin 2 receptor, beta 0.032
Jun Jun oncogene 0.032
Stx11 syntaxin 11 0.032
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.032
LOC685020 similar to paired immunoglobin-like type 2 receptor alpha 0.032
Ccl20 chemokine (C-C motif) ligand 20 0.031
Gzmk granzyme K 0.031
Fcnb ficolin B 0.031
Mmp13 matrix metallopeptidase 13 0.031
Sp140 SP140 nuclear body protein 0.031
Casp12 caspase 12 0.030
Olah oleoyl-ACP hydrolase 0.030
Ido1 indoleamine 2,3-dioxygenase 1 0.030
Apol3 apolipoprotein L, 3 0.030
Ch25h cholesterol 25-hydroxylase 0.030
Dpp4 dipeptidylpeptidase 4 0.030
Ell elongation factor RNA polymerase II 0.029
LOC100363783 rCG53773-like 0.029
Lilrb3l leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like 0.029
Svs3a seminal vesicle secretory protein 3A 0.029
Junb jun B proto-oncogene 0.028
Cd2 Cd2 molecule 0.028
Cnr2 cannabinoid receptor 2 (macrophage) 0.028
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.028
Ncr1 natural cytotoxicity triggering receptor 1 0.027
Cd8b CD8b molecule 0.027
Ltbr lymphotoxin beta receptor (TNFR superfamily, member 3) 0.027
Arnt aryl hydrocarbon receptor nuclear translocator 0.027
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.026
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.026
Plscr1 phospholipid scramblase 1 0.026
Itgad integrin, alpha D 0.026
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism