The network for 'regulation of cardioblast differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cardioblast differentiation

Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
Gata4 GATA binding protein 4 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Vangl2 vang-like 2 (van gogh, Drosophila) 1.000
Hand2 heart and neural crest derivatives expressed transcript 2 0.999
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.999
Hand1 heart and neural crest derivatives expressed transcript 1 0.998
Fgf8 fibroblast growth factor 8 0.998
Pitx2 paired-like homeodomain transcription factor 2 0.997
Pax3 paired box gene 3 0.994
Bmp4 bone morphogenetic protein 4 0.994
Tbx1 T-box 1 0.993
Psen1 presenilin 1 0.993
Sox9 SRY-box containing gene 9 0.992
Notch1 Notch gene homolog 1 (Drosophila) 0.985
Rxra retinoid X receptor alpha 0.985
Foxc2 forkhead box C2 0.984
Foxc1 forkhead box C1 0.980
Gli3 GLI-Kruppel family member GLI3 0.976
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.961
Ctnnb1 catenin (cadherin associated protein), beta 1 0.960
Jag1 jagged 1 0.959
Vangl1 vang-like 1 (van gogh, Drosophila) 0.956
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.949
Vegfa vascular endothelial growth factor A 0.945
Gsc goosecoid homeobox 0.937
Pitx1 paired-like homeodomain transcription factor 1 0.934
Fgfr1 fibroblast growth factor receptor 1 0.923
Gata6 GATA binding protein 6 0.923
Tgfb2 transforming growth factor, beta 2 0.884
Mesp1 mesoderm posterior 1 0.877
Efnb2 ephrin B2 0.875
Rara retinoic acid receptor, alpha 0.873
Scn5a sodium channel, voltage-gated, type V, alpha 0.861
Msx1 homeobox, msh-like 1 0.845
Gli2 GLI-Kruppel family member GLI2 0.839
Tbx3 T-box 3 0.836
Lmx1b LIM homeobox transcription factor 1 beta 0.811
Dll1 delta-like 1 (Drosophila) 0.805
Hoxa13 homeobox A13 0.789
Fgf3 fibroblast growth factor 3 0.773
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.754
Wnt3a wingless-related MMTV integration site 3A 0.713
Itga3 integrin alpha 3 0.706
Notch2 Notch gene homolog 2 (Drosophila) 0.699
Tcfap2a transcription factor AP-2, alpha 0.686
Meox2 mesenchyme homeobox 2 0.670
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.663
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.637
Alx4 aristaless-like homeobox 4 0.606
Smo smoothened homolog (Drosophila) 0.598
Nkx6-1 NK6 homeobox 1 0.566
Chd7 chromodomain helicase DNA binding protein 7 0.554
Sox4 SRY-box containing gene 4 0.550
Zfpm2 zinc finger protein, multitype 2 0.537
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.536
Rarg retinoic acid receptor, gamma 0.531
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.502
Pten phosphatase and tensin homolog 0.497
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.477
Prrx1 paired related homeobox 1 0.465
Acvr1 activin A receptor, type 1 0.411
Hoxa1 homeobox A1 0.401
Alx3 aristaless-like homeobox 3 0.392
Hoxd13 homeobox D13 0.387
Foxf1a forkhead box F1a 0.372
Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.365
Fgf10 fibroblast growth factor 10 0.364
Nkx2-6 NK2 transcription factor related, locus 6 (Drosophila) 0.358
Pbx1 pre B-cell leukemia transcription factor 1 0.350
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.349
Gja5 gap junction protein, alpha 5 0.337
Pax9 paired box gene 9 0.329
Fgfr3 fibroblast growth factor receptor 3 0.329
Zeb1 zinc finger E-box binding homeobox 1 0.328
Isl1 ISL1 transcription factor, LIM/homeodomain 0.328
Apc adenomatosis polyposis coli 0.317
Pax1 paired box gene 1 0.311
Msx2 homeobox, msh-like 2 0.309
Lama5 laminin, alpha 5 0.304
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.299
Ighmbp2 immunoglobulin mu binding protein 2 0.288
Bmp7 bone morphogenetic protein 7 0.270
Lrp6 low density lipoprotein receptor-related protein 6 0.264
Vax1 ventral anterior homeobox containing gene 1 0.256
Smad6 MAD homolog 6 (Drosophila) 0.254
Lmx1a LIM homeobox transcription factor 1 alpha 0.252
Hes2 hairy and enhancer of split 2 (Drosophila) 0.250
Lef1 lymphoid enhancer binding factor 1 0.244
Pkd1 polycystic kidney disease 1 homolog 0.241
Otp orthopedia homolog (Drosophila) 0.235
Gbx2 gastrulation brain homeobox 2 0.234
Pitx3 paired-like homeodomain transcription factor 3 0.233
Lrp5 low density lipoprotein receptor-related protein 5 0.226
Ntf3 neurotrophin 3 0.225
Nos3 nitric oxide synthase 3, endothelial cell 0.222
Ptch1 patched homolog 1 0.219
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.216
Dll4 delta-like 4 (Drosophila) 0.208
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
hh hedgehog 0.973
Egfr Epidermal growth factor receptor 0.874
spi spitz 0.671
dpp decapentaplegic 0.571
sli slit 0.452
arm armadillo 0.414
ci cubitus interruptus 0.391
Kr Kruppel 0.364
en engrailed 0.294
hth homothorax 0.239
fz frizzled 0.229
wg wingless 0.174
Ubx Ultrabithorax 0.156
zfh1 Zn finger homeodomain 1 0.156
tkv thickveins 0.153
gcm glial cells missing 0.146
NetB Netrin-B 0.139
Ser Serrate 0.124
RhoGAP100F CG1976 gene product from transcript CG1976-RB 0.118
mew multiple edematous wings 0.114
rho rhomboid 0.111
tld tolloid 0.080
in inturned 0.079
ptc patched 0.076
twi twist 0.068
slp2 sloppy paired 2 0.067
argos CG4531 gene product from transcript CG4531-RA 0.067
run runt 0.066
eya eyes absent 0.064
tin tinman 0.064
abd-A abdominal A 0.063
os outstretched 0.056
mam mastermind 0.054
brk brinker 0.052
eve even skipped 0.051
loqs loquacious 0.050
aop anterior open 0.049
robo3 CG5423 gene product from transcript CG5423-RA 0.044
ap apterous 0.043
rtv retroactive 0.041
kirre kin of irre 0.039
sano serrano 0.037
tll tailless 0.036
byn brachyenteron 0.036
ftz fushi tarazu 0.036
G-oalpha47A G protein oalpha 47A 0.035
mago mago nashi 0.034
Notum CG13076 gene product from transcript CG13076-RB 0.034
sog short gastrulation 0.033
pnt pointed 0.032
dally division abnormally delayed 0.031
bsk basket 0.030
fng fringe 0.029
wb wing blister 0.028
btl breathless 0.028
stumps CG31317 gene product from transcript CG31317-RC 0.028
sev sevenless 0.027
sim single-minded 0.027
so sine oculis 0.026
beat-Ia beaten path Ia 0.025
tsg twisted gastrulation 0.023
bin biniou 0.023
CadN Cadherin-N 0.023
scw screw 0.023
Cbl CG7037 gene product from transcript CG7037-RB 0.022
otk off-track 0.022
exex extra-extra 0.020
HLH54F CG5005 gene product from transcript CG5005-RA 0.020
Tsc1 CG6147 gene product from transcript CG6147-RA 0.020
Dl Delta 0.020
bun bunched 0.019
Lim3 CG10699 gene product from transcript CG10699-RB 0.018
ex expanded 0.018
frc fringe connection 0.017
kni knirps 0.016
ush u-shaped 0.016
myoglianin CG1838 gene product from transcript CG1838-RD 0.015
lbe ladybird early 0.015
crb crumbs 0.015
nkd naked cuticle 0.014
Cg25C Collagen type IV 0.014
sd scalloped 0.013
sna snail 0.013
klg klingon 0.012
slou slouch 0.012
mirr mirror 0.012
H Hairless 0.012
tj traffic jam 0.012
D Dichaete 0.012
ph-d polyhomeotic distal 0.012
beat-Ic beaten path Ic 0.011
pan pangolin 0.011
BicC Bicaudal C 0.011
nimC3 nimrod C3 0.011
shi shibire 0.011
cora coracle 0.011
CG11275 CG11275 gene product from transcript CG11275-RA 0.011
gsb gooseberry 0.010
zen zerknullt 0.010
Imp IGF-II mRNA-binding protein 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
JAG1 jagged 1 1.000
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
TBX5 T-box 5 0.999
CSNK1E casein kinase 1, epsilon 0.965
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.964
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.947
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.946
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.925
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.880
CTNNBIP1 catenin, beta interacting protein 1 0.784
APC adenomatous polyposis coli 0.779
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.715
AXIN1 axin 1 0.714
MAML1 mastermind-like 1 (Drosophila) 0.655
GATA4 GATA binding protein 4 0.637
ENG endoglin 0.630
PML promyelocytic leukemia 0.616
DLL1 delta-like 1 (Drosophila) 0.612
RFWD2 ring finger and WD repeat domain 2 0.571
FSTL1 follistatin-like 1 0.560
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.544
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.538
DAXX death-domain associated protein 0.537
CTNND1 catenin (cadherin-associated protein), delta 1 0.511
KLF13 Kruppel-like factor 13 0.472
FZD1 frizzled homolog 1 (Drosophila) 0.454
NOTCH1 notch 1 0.438
TWIST2 twist homolog 2 (Drosophila) 0.436
CSNK1D casein kinase 1, delta 0.366
CEP164 centrosomal protein 164kDa 0.353
REPS2 RALBP1 associated Eps domain containing 2 0.344
WT1 Wilms tumor 1 0.342
AR androgen receptor 0.337
LRRK2 leucine-rich repeat kinase 2 0.267
JAG2 jagged 2 0.264
TGFBR1 transforming growth factor, beta receptor 1 0.207
JUP junction plakoglobin 0.194
TGFB3 transforming growth factor, beta 3 0.191
THBS1 thrombospondin 1 0.190
NOTCH2 notch 2 0.177
ZNF512B zinc finger protein 512B 0.115
PSEN1 presenilin 1 0.108
NOTCH3 notch 3 0.108
DSP desmoplakin 0.105
MYST2 MYST histone acetyltransferase 2 0.098
NOTCH2NL notch 2 N-terminal like 0.096
FOXD3 forkhead box D3 0.093
SNIP1 Smad nuclear interacting protein 1 0.090
BAHD1 bromo adjacent homology domain containing 1 0.088
PITX1 paired-like homeodomain 1 0.088
FGF3 fibroblast growth factor 3 0.085
ZFYVE9 zinc finger, FYVE domain containing 9 0.084
LRP6 low density lipoprotein receptor-related protein 6 0.082
APP amyloid beta (A4) precursor protein 0.081
TBX1 T-box 1 0.081
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.081
XIAP X-linked inhibitor of apoptosis 0.080
GLIS2 GLIS family zinc finger 2 0.078
MCC mutated in colorectal cancers 0.078
LBX1 ladybird homeobox 1 0.077
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.074
JUN jun proto-oncogene 0.073
SMAD1 SMAD family member 1 0.073
GATA5 GATA binding protein 5 0.072
TRIM63 tripartite motif containing 63 0.071
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.068
CREBBP CREB binding protein 0.068
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.068
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.066
CDK10 cyclin-dependent kinase 10 0.064
PYY peptide YY 0.063
HIC1 hypermethylated in cancer 1 0.056
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.055
FBLN1 fibulin 1 0.054
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.052
NCOA2 nuclear receptor coactivator 2 0.052
NKD2 naked cuticle homolog 2 (Drosophila) 0.050
EGFL7 EGF-like-domain, multiple 7 0.048
HAND2 heart and neural crest derivatives expressed 2 0.048
NRP1 neuropilin 1 0.047
FZD8 frizzled homolog 8 (Drosophila) 0.045
ERG v-ets erythroblastosis virus E26 oncogene homolog (avian) 0.044
POU4F3 POU class 4 homeobox 3 0.044
PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide 0.043
HES1 hairy and enhancer of split 1, (Drosophila) 0.042
PKP4 plakophilin 4 0.042
DLL4 delta-like 4 (Drosophila) 0.042
C9orf100 chromosome 9 open reading frame 100 0.040
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.040
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.040
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.040
IQGAP1 IQ motif containing GTPase activating protein 1 0.040
PLEC plectin 0.039
WNT10A wingless-type MMTV integration site family, member 10A 0.039
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.038
CDX2 caudal type homeobox 2 0.038
OCLN occludin 0.037
TGFBR3 transforming growth factor, beta receptor III 0.036
FAM110C family with sequence similarity 110, member C 0.036
PDGFC platelet derived growth factor C 0.035
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism