The network for 'stem cell development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

stem cell development

The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate.

Mus musculus
Name Description Probability Func Analog Organism
Tgfb2 transforming growth factor, beta 2 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Bmp4 bone morphogenetic protein 4 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Shh sonic hedgehog 1.000
Foxc1 forkhead box C1 1.000
Pax6 paired box gene 6 1.000
Pax3 paired box gene 3 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Egfr epidermal growth factor receptor 1.000
Vangl2 vang-like 2 (van gogh, Drosophila) 1.000
Hand1 heart and neural crest derivatives expressed transcript 1 1.000
Msx2 homeobox, msh-like 2 1.000
Fgfr1 fibroblast growth factor receptor 1 1.000
Ctnnb1 catenin (cadherin associated protein), beta 1 1.000
Fgf8 fibroblast growth factor 8 0.999
Msx1 homeobox, msh-like 1 0.999
Prrx1 paired related homeobox 1 0.999
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.999
Nodal nodal 0.999
Pten phosphatase and tensin homolog 0.999
Notch1 Notch gene homolog 1 (Drosophila) 0.999
Hand2 heart and neural crest derivatives expressed transcript 2 0.999
Dlx5 distal-less homeobox 5 0.999
Alx4 aristaless-like homeobox 4 0.998
Tbx3 T-box 3 0.998
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.998
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.998
Runx2 runt related transcription factor 2 0.998
Sox2 SRY-box containing gene 2 0.998
Foxg1 forkhead box G1 0.996
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.995
Eya1 eyes absent 1 homolog (Drosophila) 0.995
Foxc2 forkhead box C2 0.994
Sox9 SRY-box containing gene 9 0.994
Tcfap2a transcription factor AP-2, alpha 0.994
Acvr1 activin A receptor, type 1 0.994
Lhx1 LIM homeobox protein 1 0.994
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.993
Meox2 mesenchyme homeobox 2 0.992
Gata4 GATA binding protein 4 0.992
Gli2 GLI-Kruppel family member GLI2 0.992
Apc adenomatosis polyposis coli 0.991
Zic3 zinc finger protein of the cerebellum 3 0.991
Bcl2 B-cell leukemia/lymphoma 2 0.989
Jag1 jagged 1 0.989
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.989
Ret ret proto-oncogene 0.989
Hes1 hairy and enhancer of split 1 (Drosophila) 0.988
Rarg retinoic acid receptor, gamma 0.988
Vegfa vascular endothelial growth factor A 0.987
Isl1 ISL1 transcription factor, LIM/homeodomain 0.986
Bmp7 bone morphogenetic protein 7 0.986
Hoxa1 homeobox A1 0.986
Gata6 GATA binding protein 6 0.983
Nog noggin 0.981
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.977
Foxh1 forkhead box H1 0.976
Tlx3 T-cell leukemia, homeobox 3 0.976
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.975
Hoxd13 homeobox D13 0.975
Lhx3 LIM homeobox protein 3 0.973
Smo smoothened homolog (Drosophila) 0.971
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.971
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.970
Fgf10 fibroblast growth factor 10 0.970
Pou3f3 POU domain, class 3, transcription factor 3 0.969
Smad6 MAD homolog 6 (Drosophila) 0.968
Pax2 paired box gene 2 0.966
Tcfap2c transcription factor AP-2, gamma 0.966
Foxn1 forkhead box N1 0.964
Mecp2 methyl CpG binding protein 2 0.961
Foxf1a forkhead box F1a 0.959
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.958
Zeb1 zinc finger E-box binding homeobox 1 0.957
Dll4 delta-like 4 (Drosophila) 0.955
Lmx1b LIM homeobox transcription factor 1 beta 0.953
Ptk7 PTK7 protein tyrosine kinase 7 0.952
Trp53 transformation related protein 53 0.952
Chd7 chromodomain helicase DNA binding protein 7 0.950
Smad3 MAD homolog 3 (Drosophila) 0.950
Pkd1 polycystic kidney disease 1 homolog 0.949
Neurod1 neurogenic differentiation 1 0.948
Lef1 lymphoid enhancer binding factor 1 0.948
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.947
Prrx2 paired related homeobox 2 0.946
Runx1 runt related transcription factor 1 0.943
Foxa2 forkhead box A2 0.943
Col2a1 collagen, type II, alpha 1 0.942
Etv4 ets variant gene 4 (E1A enhancer binding protein, E1AF) 0.940
Trp63 transformation related protein 63 0.938
Emx1 empty spiracles homolog 1 (Drosophila) 0.938
Gdnf glial cell line derived neurotrophic factor 0.937
Neurog2 neurogenin 2 0.937
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.936
Rara retinoic acid receptor, alpha 0.935
Nanog Nanog homeobox 0.934
Tbx15 T-box 15 0.931
Eda ectodysplasin-A 0.930
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tgfb3 transforming growth factor, beta 3 0.973
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.961
wnt5b wingless-type MMTV integration site family, member 5b 0.955
notch1a notch homolog 1a 0.954
sox2 SRY-box containing gene 2 0.949
spry4 sprouty (Drosophila) homolog 4 0.934
tp53 tumor protein p53 0.931
dlc deltaC 0.927
wu:fv91b12 wu:fv91b12 0.921
gli1 GLI-Kruppel family member 1 0.907
tll1 tolloid-like 1 0.883
bmp2b bone morphogenetic protein 2b 0.881
sox10 SRY-box containing gene 10 0.868
cdh2 cadherin 2, neuronal 0.862
jag1b jagged 1b 0.857
vcana versican a 0.836
flh floating head 0.820
crabp2a cellular retinoic acid binding protein 2, a 0.817
dld deltaD 0.810
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.793
col15a1b collagen, type XV, alpha 1b 0.771
dlx2a distal-less homeobox gene 2a 0.770
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.756
oep one-eyed pinhead 0.743
gdf6a growth differentiation factor 6a 0.743
mecom MDS1 and EVI1 complex locus 0.741
lef1 lymphocyte enhancer binding factor 1 0.741
tbx1 T-box 1 0.723
fn1 fibronectin 1 0.711
twist1a twist1a 0.707
pax6a paired box gene 6a 0.705
osr2 odd-skipped related 2 (Drosophila) 0.684
tbx16 T-box gene 16 0.683
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.683
myod1 myogenic differentiation 1 0.675
foxd3 forkhead box D3 0.668
boc brother of CDO 0.649
tmem2 transmembrane protein 2 0.634
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.633
pax6b paired box gene 6b 0.629
osr1 odd-skipped related 1 (Drosophila) 0.593
eya1 eyes absent homolog 1 0.557
ascl1a achaete-scute complex-like 1a (Drosophila) 0.551
chd chordin 0.551
nrp2b neuropilin 2b 0.546
fbn2b fibrillin 2b 0.545
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.527
foxi1 forkhead box I1 0.519
her1 hairy-related 1 0.510
supt6h suppressor of Ty 6 homolog 0.504
gli2a GLI-Kruppel family member GLI2a 0.503
cdh1 cadherin 1, epithelial 0.492
shha sonic hedgehog a 0.488
dla deltaA 0.482
twist1b twist1b 0.477
prdm5 PR domain containing 5 0.477
col8a1a collagen, type VIII, alpha 1a 0.471
s1pr2 sphingosine-1-phosphate receptor 2 0.441
fgf10a fibroblast growth factor 10a 0.438
wnt8b wingless-type MMTV integration site family, member 8b 0.433
sox32 SRY-box containing gene 32 0.412
gata3 GATA-binding protein 3 0.410
twist3 twist3 0.403
rarga retinoic acid receptor gamma a 0.400
tbx20 T-box 20 0.400
mib mind bomb 0.392
pdzrn3 PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3 0.388
kita kit receptor a 0.387
igf1rb insulin-like growth factor 1b receptor 0.387
dlx3b distal-less homeobox gene 3b 0.385
crb2a crumbs homolog 2a 0.383
snai1b snail homolog 1b (Drosophila) 0.379
crestin crestin 0.376
plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.370
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.368
pitx3 paired-like homeodomain transcription factor 3 0.365
sema3d semaphorin 3d 0.365
id3 inhibitor of DNA binding 3 0.358
notch3 notch homolog 3 0.353
acvr1l activin A receptor, type I like 0.351
her7 hairy and enhancer of split related-7 0.350
neurod neurogenic differentiation 0.350
pax9 paired box gene 9 0.350
sox19a SRY-box containing gene 19a 0.344
her6 hairy-related 6 0.342
notch1b notch homolog 1b 0.339
pax7a paired box gene 7a 0.333
dlb deltaB 0.332
sall4 sal-like 4 (Drosophila) 0.327
mespa mesoderm posterior a 0.325
irx3a iroquois homeobox protein 3a 0.325
sema3fa semaphorin 3fa 0.315
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.314
mef2ca myocyte enhancer factor 2ca 0.310
chsy1 chondroitin sulfate synthase 1 0.302
gria4a glutamate receptor, ionotropic, AMPA 4a 0.297
her15.1 hairy and enhancer of split-related 15.1 0.294
lhx2b LIM homeobox 2b 0.290
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.289
has2 hyaluronan synthase 2 0.287
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Drosophila melanogaster
Name Description Probability Func Analog Organism
tkv thickveins 0.999
Mad Mothers against dpp 0.997
N Notch 0.996
Ras85D Ras oncogene at 85D 0.995
dsh dishevelled 0.994
ci cubitus interruptus 0.991
brat brain tumor 0.990
Egfr Epidermal growth factor receptor 0.959
dpp decapentaplegic 0.915
Dl Delta 0.870
put punt 0.844
Pten CG5671 gene product from transcript CG5671-RB 0.842
HLHm7 E(spl) region transcript m7 0.831
klu klumpfuss 0.813
Hop Hsp70/Hsp90 organizing protein homolog 0.806
Stat92E Signal-transducer and activator of transcription protein at 92E 0.788
mam mastermind 0.783
ash2 absent, small, or homeotic discs 2 0.774
Su(H) Suppressor of Hairless 0.769
dm diminutive 0.761
eya eyes absent 0.750
hh hedgehog 0.745
zpg zero population growth 0.741
emc extra macrochaetae 0.736
dpn deadpan 0.710
InR Insulin-like receptor 0.694
ap apterous 0.687
hts hu li tai shao 0.669
ato atonal 0.660
Nrt Neurotactin 0.653
E(spl) Enhancer of split 0.646
ttv tout-velu 0.604
Sfmbt Scm-related gene containing four mbt domains 0.597
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.597
ush u-shaped 0.590
dally division abnormally delayed 0.582
babo baboon 0.563
sax saxophone 0.528
ptc patched 0.524
cnc cap-n-collar 0.523
Ote Otefin 0.511
bam bag of marbles 0.496
tsh teashirt 0.493
BicD Bicaudal D 0.479
nub nubbin 0.478
gcm glial cells missing 0.473
lz lozenge 0.467
Pabp2 CG2163 gene product from transcript CG2163-RA 0.466
HLHmgamma E(spl) region transcript mgamma 0.452
Wnt4 Wnt oncogene analog 4 0.447
wg wingless 0.424
bgcn benign gonial cell neoplasm 0.417
Dhc64C Dynein heavy chain 64C 0.414
robo roundabout 0.412
Su(var)3-3 Suppressor of variegation 3-3 0.407
grn grain 0.406
hth homothorax 0.404
sca scabrous 0.392
ara araucan 0.367
enok enoki mushroom 0.366
noc no ocelli 0.366
rictor rapamycin-insensitive companion of Tor 0.353
kn knot 0.352
Sin3A CG8815 gene product from transcript CG8815-RC 0.350
fu fused 0.350
CG11347 CG11347 gene product from transcript CG11347-RE 0.350
vvl ventral veins lacking 0.350
os outstretched 0.349
m2 E(spl) region transcript m2 0.340
brk brinker 0.334
chb chromosome bows 0.328
pnt pointed 0.326
ovo CG6824 gene product from transcript CG6824-RE 0.323
Sema-1a CG18405 gene product from transcript CG18405-RD 0.322
gsb gooseberry 0.317
Su(z)12 CG8013 gene product from transcript CG8013-RA 0.317
Lis-1 Lissencephaly-1 0.315
eyg eyegone 0.310
Top2 Topoisomerase 2 0.309
nkd naked cuticle 0.306
osa CG7467 gene product from transcript CG7467-RD 0.304
amos absent MD neurons and olfactory sensilla 0.299
Mef2 Myocyte enhancer factor 2 0.294
ecd ecdysoneless 0.290
brm brahma 0.289
eve even skipped 0.282
Adf1 Adh transcription factor 1 0.280
sog short gastrulation 0.280
ems empty spiracles 0.280
Atg1 Autophagy-specific gene 1 0.276
ro rough 0.276
Snoo Sno oncogene 0.275
par-6 CG5884 gene product from transcript CG5884-RA 0.273
Pc Polycomb 0.271
ph-p polyhomeotic proximal 0.268
piwi CG6122 gene product from transcript CG6122-RA 0.265
so sine oculis 0.263
pygo pygopus 0.263
CG6751 CG6751 gene product from transcript CG6751-RA 0.261
cos costa 0.261
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Homo sapiens
Name Description Probability Func Analog Organism
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.000
SMAD3 SMAD family member 3 0.999
SMAD7 SMAD family member 7 0.998
TGFB1 transforming growth factor, beta 1 0.998
CREBBP CREB binding protein 0.996
NOTCH1 notch 1 0.990
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.988
AR androgen receptor 0.984
SP1 Sp1 transcription factor 0.979
YAP1 Yes-associated protein 1 0.979
FGFR1 fibroblast growth factor receptor 1 0.975
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.974
SMAD4 SMAD family member 4 0.970
SMAD2 SMAD family member 2 0.966
JAG1 jagged 1 0.963
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.955
DICER1 dicer 1, ribonuclease type III 0.953
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.941
APC adenomatous polyposis coli 0.937
EP300 E1A binding protein p300 0.926
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.918
PAX3 paired box 3 0.911
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.907
STAG1 stromal antigen 1 0.900
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.897
BMP2 bone morphogenetic protein 2 0.884
COL1A1 collagen, type I, alpha 1 0.857
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.808
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.789
TP53 tumor protein p53 0.780
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.765
FOXD3 forkhead box D3 0.748
TAL1 T-cell acute lymphocytic leukemia 1 0.743
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.737
POU3F2 POU class 3 homeobox 2 0.719
EGFR epidermal growth factor receptor 0.716
CTR9 Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.716
WAPAL wings apart-like homolog (Drosophila) 0.701
COL6A1 collagen, type VI, alpha 1 0.693
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.662
DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 0.660
FGF1 fibroblast growth factor 1 (acidic) 0.647
WNT3A wingless-type MMTV integration site family, member 3A 0.636
BMPR1A bone morphogenetic protein receptor, type IA 0.622
NOTCH3 notch 3 0.620
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.611
ATF2 activating transcription factor 2 0.601
POU5F1 POU class 5 homeobox 1 0.595
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.582
TGFB3 transforming growth factor, beta 3 0.575
COL1A2 collagen, type I, alpha 2 0.573
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.570
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.567
PDX1 pancreatic and duodenal homeobox 1 0.564
FSTL1 follistatin-like 1 0.560
RAD21 RAD21 homolog (S. pombe) 0.560
SOX11 SRY (sex determining region Y)-box 11 0.546
CNOT8 CCR4-NOT transcription complex, subunit 8 0.540
PTBP1 polypyrimidine tract binding protein 1 0.531
AXIN1 axin 1 0.528
SMAD1 SMAD family member 1 0.524
CDC73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.517
EIF4A1 eukaryotic translation initiation factor 4A1 0.500
SOX1 SRY (sex determining region Y)-box 1 0.490
CDK2 cyclin-dependent kinase 2 0.483
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.481
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.481
SMAD6 SMAD family member 6 0.479
BBS10 Bardet-Biedl syndrome 10 0.478
GRB2 growth factor receptor-bound protein 2 0.478
COL3A1 collagen, type III, alpha 1 0.458
MSX1 msh homeobox 1 0.453
MBNL1 muscleblind-like (Drosophila) 0.452
CXXC5 CXXC finger protein 5 0.450
HIC1 hypermethylated in cancer 1 0.441
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.434
GATA4 GATA binding protein 4 0.430
CSNK1E casein kinase 1, epsilon 0.426
HMGA2 high mobility group AT-hook 2 0.426
COL5A1 collagen, type V, alpha 1 0.422
SOX2 SRY (sex determining region Y)-box 2 0.415
LRP6 low density lipoprotein receptor-related protein 6 0.399
PUM1 pumilio homolog 1 (Drosophila) 0.394
FKBP1A FK506 binding protein 1A, 12kDa 0.393
CNOT2 CCR4-NOT transcription complex, subunit 2 0.390
HNF4A hepatocyte nuclear factor 4, alpha 0.388
NCOR1 nuclear receptor corepressor 1 0.377
THBS1 thrombospondin 1 0.374
COL2A1 collagen, type II, alpha 1 0.369
FOXA2 forkhead box A2 0.368
HNF1A HNF1 homeobox A 0.367
SKIL SKI-like oncogene 0.364
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.357
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.357
PTK2 PTK2 protein tyrosine kinase 2 0.356
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.351
RBPMS RNA binding protein with multiple splicing 0.350
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.347
SFRP1 secreted frizzled-related protein 1 0.343
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.337
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Rattus norvegicus
Name Description Probability Func Analog Organism
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.047
Nfix nuclear factor I/X (CCAAT-binding transcription factor) 0.028
Pnrc2 proline-rich nuclear receptor coactivator 2 0.025
Nfia nuclear factor I/A 0.020
Igfbp5 insulin-like growth factor binding protein 5 0.018
Hnrnpk heterogeneous nuclear ribonucleoprotein K 0.017
Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.016
Ednra endothelin receptor type A 0.016
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.016
Nfib nuclear factor I/B 0.014
Tgfbr2 transforming growth factor, beta receptor II 0.014
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.014
Hmgb1 high mobility group box 1 0.014
Dchs1 dachsous 1 (Drosophila) 0.014
Col12a1 collagen, type XII, alpha 1 0.014
Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.012
Sox13 SRY (sex determining region Y)-box 13 0.012
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.012
Tor1aip1 torsin A interacting protein 1 0.011
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.011
Met met proto-oncogene 0.011
Gna15 guanine nucleotide binding protein, alpha 15 0.011
Tcf4 transcription factor 4 0.011
Hnrpd heterogeneous nuclear ribonucleoprotein D 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism