The network for 'peptide secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

peptide secretion

The controlled release of a peptide from a cell or a tissue.

Mus musculus
Name Description Probability Func Analog Organism
Ctnnb1 catenin (cadherin associated protein), beta 1 0.987
Drd2 dopamine receptor D2 0.951
Nos3 nitric oxide synthase 3, endothelial cell 0.927
Lepr leptin receptor 0.909
Thrb thyroid hormone receptor beta 0.907
Gata4 GATA binding protein 4 0.865
Pten phosphatase and tensin homolog 0.859
Esr1 estrogen receptor 1 (alpha) 0.855
Insm1 insulinoma-associated 1 0.834
Pax8 paired box gene 8 0.834
Smad3 MAD homolog 3 (Drosophila) 0.812
Lep leptin 0.799
Fshr follicle stimulating hormone receptor 0.794
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.790
Ephb2 Eph receptor B2 0.789
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.788
Nf1 neurofibromatosis 1 0.778
Lhx3 LIM homeobox protein 3 0.772
Gli3 GLI-Kruppel family member GLI3 0.731
Prlr prolactin receptor 0.719
Bmp4 bone morphogenetic protein 4 0.717
Nos2 nitric oxide synthase 2, inducible 0.708
Kl klotho 0.707
Per2 period homolog 2 (Drosophila) 0.700
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.695
Eda ectodysplasin-A 0.666
Pdx1 pancreatic and duodenal homeobox 1 0.654
Lef1 lymphoid enhancer binding factor 1 0.648
Pthlh parathyroid hormone-like peptide 0.638
Prox1 prospero-related homeobox 1 0.605
Tgfbr3 transforming growth factor, beta receptor III 0.586
Fgfr3 fibroblast growth factor receptor 3 0.578
Efnb2 ephrin B2 0.546
Adra2b adrenergic receptor, alpha 2b 0.517
Clock circadian locomotor output cycles kaput 0.505
Gata6 GATA binding protein 6 0.499
Sstr3 somatostatin receptor 3 0.464
Pnpla2 patatin-like phospholipase domain containing 2 0.460
Onecut1 one cut domain, family member 1 0.460
Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.427
Kiss1 KiSS-1 metastasis-suppressor 0.414
Pomc pro-opiomelanocortin-alpha 0.410
Axin1 axin 1 0.408
Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) 0.406
Insr insulin receptor 0.402
Sfrp2 secreted frizzled-related protein 2 0.384
S100a9 S100 calcium binding protein A9 (calgranulin B) 0.383
Cry2 cryptochrome 2 (photolyase-like) 0.378
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.378
Vdr vitamin D receptor 0.377
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.373
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.373
Fgfr2 fibroblast growth factor receptor 2 0.370
Acvr2a activin receptor IIA 0.368
Prop1 paired like homeodomain factor 1 0.366
Pim3 proviral integration site 3 0.354
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.353
Tgfbr2 transforming growth factor, beta receptor II 0.348
Adra2a adrenergic receptor, alpha 2a 0.347
Apoe apolipoprotein E 0.346
Fgf8 fibroblast growth factor 8 0.342
S100a8 S100 calcium binding protein A8 (calgranulin A) 0.342
Otp orthopedia homolog (Drosophila) 0.336
Eya1 eyes absent 1 homolog (Drosophila) 0.332
Sstr4 somatostatin receptor 4 0.329
Nrxn3 neurexin III 0.328
Pparg peroxisome proliferator activated receptor gamma 0.326
Bdkrb2 bradykinin receptor, beta 2 0.326
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.320
Tgfbr1 transforming growth factor, beta receptor I 0.319
Hoxd13 homeobox D13 0.319
Ar androgen receptor 0.319
Ghr growth hormone receptor 0.315
Hand1 heart and neural crest derivatives expressed transcript 1 0.313
Gck glucokinase 0.301
Foxh1 forkhead box H1 0.299
Pitx3 paired-like homeodomain transcription factor 3 0.297
Smad4 MAD homolog 4 (Drosophila) 0.294
Ihh Indian hedgehog 0.293
Rxra retinoid X receptor alpha 0.292
Rapgef4 Rap guanine nucleotide exchange factor (GEF) 4 0.292
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.289
Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 0.287
Il1b interleukin 1 beta 0.287
Irs1 insulin receptor substrate 1 0.279
Irs3 insulin receptor substrate 3 0.276
Cry1 cryptochrome 1 (photolyase-like) 0.275
Wnt7b wingless-related MMTV integration site 7B 0.274
Egfr epidermal growth factor receptor 0.274
Cckbr cholecystokinin B receptor 0.273
Pitx2 paired-like homeodomain transcription factor 2 0.271
Efnb1 ephrin B1 0.268
Oprd1 opioid receptor, delta 1 0.267
Gata5 GATA binding protein 5 0.265
Foxc1 forkhead box C1 0.265
Gabrb2 gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 0.264
Gast gastrin 0.264
Inhba inhibin beta-A 0.260
Syt7 synaptotagmin VII 0.259
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.257
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Actbeta Activin-beta 0.069
Ric Ras which interacts with Calmodulin 0.054
Shaw Shaker cognate w 0.038
CaMKII Calcium/calmodulin-dependent protein kinase II 0.029
CycJ Cyclin J 0.025
Sema-1a CG18405 gene product from transcript CG18405-RD 0.024
trio CG18214 gene product from transcript CG18214-RA 0.022
NetB Netrin-B 0.019
myoglianin CG1838 gene product from transcript CG1838-RD 0.019
tim timeless 0.019
Eip63F-1 Ecdysone-induced protein 63F 1 0.018
shn schnurri 0.017
Atg9 Autophagy-specific gene 9 0.016
CadN Cadherin-N 0.016
MTF-1 Metal response element-binding Transcription Factor-1 0.015
Mekk1 CG7717 gene product from transcript CG7717-RB 0.015
Irk3 Inwardly rectifying potassium channel 3 0.014
kibra kibra ortholog 0.014
Mmp2 Matrix metalloproteinase 2 0.014
Pka-C1 cAMP-dependent protein kinase 1 0.012
CG34139 CG34139 gene product from transcript CG34139-RD 0.012
S6k RPS6-p70-protein kinase 0.012
rtGEF rho-type guanine exchange factor 0.012
raw CG12437 gene product from transcript CG12437-RB 0.011
Plc21C Phospholipase C at 21C 0.011
usp ultraspiracle 0.010
RhoGAP100F CG1976 gene product from transcript CG1976-RB 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
HNF4A hepatocyte nuclear factor 4, alpha 0.988
PDX1 pancreatic and duodenal homeobox 1 0.987
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.972
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.954
GRB2 growth factor receptor-bound protein 2 0.952
HLA-DRA major histocompatibility complex, class II, DR alpha 0.945
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.924
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.901
TEK TEK tyrosine kinase, endothelial 0.886
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.854
HLA-DMA major histocompatibility complex, class II, DM alpha 0.853
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.842
S100A8 S100 calcium binding protein A8 0.842
SNAP23 synaptosomal-associated protein, 23kDa 0.831
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.817
IL1R1 interleukin 1 receptor, type I 0.759
HLA-DMB major histocompatibility complex, class II, DM beta 0.755
MT1A metallothionein 1A 0.755
ZFYVE9 zinc finger, FYVE domain containing 9 0.748
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.743
CRHR1 corticotropin releasing hormone receptor 1 0.718
S100A9 S100 calcium binding protein A9 0.717
KCNE1 potassium voltage-gated channel, Isk-related family, member 1 0.711
CCR5 chemokine (C-C motif) receptor 5 0.708
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.707
HCK hemopoietic cell kinase 0.700
CCL4 chemokine (C-C motif) ligand 4 0.685
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.658
FGB fibrinogen beta chain 0.630
INSR insulin receptor 0.616
CCNY cyclin Y 0.601
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.563
CHD8 chromodomain helicase DNA binding protein 8 0.554
IGF1R insulin-like growth factor 1 receptor 0.552
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.547
ADORA2A adenosine A2a receptor 0.544
CXCL9 chemokine (C-X-C motif) ligand 9 0.534
NEUROD1 neurogenic differentiation 1 0.484
SOCS1 suppressor of cytokine signaling 1 0.449
FGA fibrinogen alpha chain 0.444
EP300 E1A binding protein p300 0.427
CCL2 chemokine (C-C motif) ligand 2 0.401
LIN7B lin-7 homolog B (C. elegans) 0.399
CRH corticotropin releasing hormone 0.395
PPARA peroxisome proliferator-activated receptor alpha 0.375
NOSTRIN nitric oxide synthase trafficker 0.365
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.365
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.364
MEOX1 mesenchyme homeobox 1 0.362
CLASP1 cytoplasmic linker associated protein 1 0.347
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.343
CREBBP CREB binding protein 0.339
PSEN2 presenilin 2 (Alzheimer disease 4) 0.331
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.326
ONECUT1 one cut homeobox 1 0.314
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.314
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.312
VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 0.310
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.309
TP53 tumor protein p53 0.295
CDX2 caudal type homeobox 2 0.279
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.278
IL1B interleukin 1, beta 0.271
ESRRG estrogen-related receptor gamma 0.270
DRD2 dopamine receptor D2 0.259
SH2B1 SH2B adaptor protein 1 0.252
CCR1 chemokine (C-C motif) receptor 1 0.251
HOXD12 homeobox D12 0.245
BLNK B-cell linker 0.240
CRP C-reactive protein, pentraxin-related 0.234
NKX2-1 NK2 homeobox 1 0.233
HNF1B HNF1 homeobox B 0.221
CXCL10 chemokine (C-X-C motif) ligand 10 0.221
SNAP25 synaptosomal-associated protein, 25kDa 0.214
SETD8 SET domain containing (lysine methyltransferase) 8 0.213
SREBF2 sterol regulatory element binding transcription factor 2 0.206
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.205
GJD2 gap junction protein, delta 2, 36kDa 0.191
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.190
CCL5 chemokine (C-C motif) ligand 5 0.183
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.178
CLOCK clock homolog (mouse) 0.173
CHD7 chromodomain helicase DNA binding protein 7 0.172
AHR aryl hydrocarbon receptor 0.171
IL1RN interleukin 1 receptor antagonist 0.170
IRS1 insulin receptor substrate 1 0.169
KAT2B K(lysine) acetyltransferase 2B 0.166
GRB10 growth factor receptor-bound protein 10 0.162
FGG fibrinogen gamma chain 0.161
FGF3 fibroblast growth factor 3 0.161
FOXA2 forkhead box A2 0.158
HNF1A HNF1 homeobox A 0.153
SMAD3 SMAD family member 3 0.144
IL6R interleukin 6 receptor 0.141
PYY peptide YY 0.140
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.140
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.135
IL1R2 interleukin 1 receptor, type II 0.135
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.134
STX5 syntaxin 5 0.133
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Rattus norvegicus
Name Description Probability Func Analog Organism
Glp1r glucagon-like peptide 1 receptor 0.409
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.363
Gast gastrin 0.258
Arpc1b actin related protein 2/3 complex, subunit 1B 0.240
Mef2d myocyte enhancer factor 2D 0.228
Nfasc neurofascin 0.207
Neurod2 neurogenic differentiation 2 0.198
Ptgfr prostaglandin F receptor 0.197
Lifr leukemia inhibitory factor receptor alpha 0.179
Notch4 Notch homolog 4 (Drosophila) 0.174
Ppara peroxisome proliferator activated receptor alpha 0.164
Cxcr5 chemokine (C-X-C motif) receptor 5 0.162
Accn2 amiloride-sensitive cation channel 2, neuronal 0.162
Pnliprp2 pancreatic lipase-related protein 2 0.161
G6pc glucose-6-phosphatase, catalytic subunit 0.157
Mamdc4 MAM domain containing 4 0.157
Bsn bassoon 0.157
Acsl4 acyl-CoA synthetase long-chain family member 4 0.156
Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 0.151
Scn10a sodium channel, voltage-gated, type X, alpha subunit 0.150
Htr3a 5-hydroxytryptamine (serotonin) receptor 3a 0.149
Mapk10 mitogen activated protein kinase 10 0.149
Ins2 insulin 2 0.145
Syt4 synaptotagmin IV 0.145
Scn3a sodium channel, voltage-gated, type III, alpha 0.143
Necab2 N-terminal EF-hand calcium binding protein 2 0.141
Ptprz1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.139
Lgals3 lectin, galactoside-binding, soluble, 3 0.138
Apoa4 apolipoprotein A-IV 0.136
Adora2a adenosine A2a receptor 0.133
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.130
Th tyrosine hydroxylase 0.129
Igf2 insulin-like growth factor 2 0.129
S100a6 S100 calcium binding protein A6 0.129
Grm7 glutamate receptor, metabotropic 7 0.128
Elavl4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) 0.128
Crhbp corticotropin releasing hormone binding protein 0.128
Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 0.127
Expi extracellular proteinase inhibitor 0.123
Prlhr prolactin releasing hormone receptor 0.122
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.122
Mtmr7 myotubularin related protein 7 0.120
Iapp islet amyloid polypeptide 0.117
Aqp2 aquaporin 2 (collecting duct) 0.115
Adrb1 adrenergic, beta-1-, receptor 0.112
Epas1 endothelial PAS domain protein 1 0.112
Pax6 paired box 6 0.111
Casp3 caspase 3 0.108
Unc5a unc-5 homolog A (C. elegans) 0.107
Lim2 lens intrinsic membrane protein 2 0.107
Phkg1 phosphorylase kinase, gamma 1 0.107
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.106
Sox17 SRY (sex determining region Y)-box 17 0.105
Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 0.103
Gabra3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 0.102
Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.102
Hist1h2aa histone cluster 1, H2aa 0.102
Ush1c Usher syndrome 1C homolog (human) 0.101
Cntn5 contactin 5 0.099
Gad2 glutamate decarboxylase 2 0.099
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.099
Nrsn1 neurensin 1 0.099
RT1-Ba RT1 class II, locus Ba 0.098
Sstr2 somatostatin receptor 2 0.098
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.096
Acaa1b acetyl-Coenzyme A acyltransferase 1B 0.095
Kcnq1 potassium voltage-gated channel, KQT-like subfamily, member 1 0.094
Fbp1 fructose-1,6-bisphosphatase 1 0.093
St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 0.092
Necab1 N-terminal EF-hand calcium binding protein 1 0.092
Clstn3 calsyntenin 3 0.091
Grm1 glutamate receptor, metabotropic 1 0.088
Adora1 adenosine A1 receptor 0.088
Rxrg retinoid X receptor gamma 0.087
Pnoc prepronociceptin 0.087
Dio1 deiodinase, iodothyronine, type I 0.085
Insrr insulin receptor-related receptor 0.085
Avp arginine vasopressin 0.085
Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 0.085
Sftpd surfactant protein D 0.085
Rims1 regulating synaptic membrane exocytosis 1 0.085
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.084
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.084
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.083
Vip vasoactive intestinal peptide 0.083
S100a10 S100 calcium binding protein A10 0.082
Ucn urocortin 0.082
Reg3g regenerating islet-derived 3 gamma 0.082
Dbp D site of albumin promoter (albumin D-box) binding protein 0.082
Sebox SEBOX homeobox 0.081
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.081
Lep leptin 0.081
Socs7 suppressor of cytokine signaling 7 0.081
Tle4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 0.080
Cdh22 cadherin 22 0.080
Pcsk1 proprotein convertase subtilisin/kexin type 1 0.079
Cartpt CART prepropeptide 0.079
Ghr growth hormone receptor 0.078
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.077
Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 0.076
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism