The network for 'placenta development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

placenta development

The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.

Mus musculus
Name Description Probability Func Analog Organism
Ptgs2 prostaglandin-endoperoxide synthase 2 0.998
Pax2 paired box gene 2 0.994
Egfr epidermal growth factor receptor 0.993
Fgf8 fibroblast growth factor 8 0.990
Shh sonic hedgehog 0.987
Otx2 orthodenticle homolog 2 (Drosophila) 0.981
Pitx2 paired-like homeodomain transcription factor 2 0.975
Tbx3 T-box 3 0.973
Fgfr2 fibroblast growth factor receptor 2 0.972
Gdnf glial cell line derived neurotrophic factor 0.971
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.965
Esr1 estrogen receptor 1 (alpha) 0.962
Hand1 heart and neural crest derivatives expressed transcript 1 0.962
Rxra retinoid X receptor alpha 0.956
Hand2 heart and neural crest derivatives expressed transcript 2 0.946
Gli3 GLI-Kruppel family member GLI3 0.945
Bmp4 bone morphogenetic protein 4 0.933
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.930
Gata4 GATA binding protein 4 0.922
Etv4 ets variant gene 4 (E1A enhancer binding protein, E1AF) 0.916
Ctnnb1 catenin (cadherin associated protein), beta 1 0.909
Egr1 early growth response 1 0.903
Nos3 nitric oxide synthase 3, endothelial cell 0.902
Csf1 colony stimulating factor 1 (macrophage) 0.902
Gata6 GATA binding protein 6 0.901
Notch2 Notch gene homolog 2 (Drosophila) 0.901
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.893
Fos FBJ osteosarcoma oncogene 0.880
Foxa2 forkhead box A2 0.879
Hoxd13 homeobox D13 0.872
Foxc1 forkhead box C1 0.869
Neurog2 neurogenin 2 0.867
Smad3 MAD homolog 3 (Drosophila) 0.854
Pax8 paired box gene 8 0.851
Pitx1 paired-like homeodomain transcription factor 1 0.835
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.833
Fgf15 fibroblast growth factor 15 0.826
Evx2 even skipped homeotic gene 2 homolog 0.824
Tbx1 T-box 1 0.824
Wnt11 wingless-related MMTV integration site 11 0.819
Emx1 empty spiracles homolog 1 (Drosophila) 0.805
Tgfb2 transforming growth factor, beta 2 0.800
Jag1 jagged 1 0.789
Smad4 MAD homolog 4 (Drosophila) 0.788
Nos2 nitric oxide synthase 2, inducible 0.786
Adra2b adrenergic receptor, alpha 2b 0.777
Tbx2 T-box 2 0.772
Atoh7 atonal homolog 7 (Drosophila) 0.766
Gpc3 glypican 3 0.755
Efnb2 ephrin B2 0.749
Axl AXL receptor tyrosine kinase 0.745
Lhx5 LIM homeobox protein 5 0.741
Padi3 peptidyl arginine deiminase, type III 0.738
Cdx2 caudal type homeobox 2 0.736
Gdf5 growth differentiation factor 5 0.720
Hmx3 H6 homeobox 3 0.716
Cyr61 cysteine rich protein 61 0.716
Tcfap2c transcription factor AP-2, gamma 0.715
Nkx2-1 NK2 homeobox 1 0.704
Hes1 hairy and enhancer of split 1 (Drosophila) 0.698
Tead4 TEA domain family member 4 0.695
Fgf10 fibroblast growth factor 10 0.694
Vegfa vascular endothelial growth factor A 0.685
Lef1 lymphoid enhancer binding factor 1 0.683
Sox2 SRY-box containing gene 2 0.678
Hes5 hairy and enhancer of split 5 (Drosophila) 0.674
Smad6 MAD homolog 6 (Drosophila) 0.672
Sox9 SRY-box containing gene 9 0.659
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.658
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.654
Trp63 transformation related protein 63 0.654
Pten phosphatase and tensin homolog 0.649
Dlx3 distal-less homeobox 3 0.645
Wt1 Wilms tumor 1 homolog 0.639
Tlx3 T-cell leukemia, homeobox 3 0.639
Vhl von Hippel-Lindau tumor suppressor 0.634
Wnt3a wingless-related MMTV integration site 3A 0.634
Tbx5 T-box 5 0.630
Prrx1 paired related homeobox 1 0.627
Amhr2 anti-Mullerian hormone type 2 receptor 0.617
Foxd3 forkhead box D3 0.615
Nodal nodal 0.607
Hoxa13 homeobox A13 0.606
Jun Jun oncogene 0.601
Krt27 keratin 27 0.594
Nog noggin 0.592
Gli1 GLI-Kruppel family member GLI1 0.591
Hoxa1 homeobox A1 0.589
Wnt6 wingless-related MMTV integration site 6 0.584
Evx1 even skipped homeotic gene 1 homolog 0.582
Stat3 signal transducer and activator of transcription 3 0.581
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.577
Foxc2 forkhead box C2 0.572
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.570
Cldn3 claudin 3 0.568
Aldh1a3 aldehyde dehydrogenase family 1, subfamily A3 0.566
Tgfbr1 transforming growth factor, beta receptor I 0.553
Itgb3 integrin beta 3 0.550
Snai1 snail homolog 1 (Drosophila) 0.546
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.543
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SP1 Sp1 transcription factor 0.894
NCOA1 nuclear receptor coactivator 1 0.692
EP300 E1A binding protein p300 0.643
MAPK1 mitogen-activated protein kinase 1 0.409
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.318
E2F7 E2F transcription factor 7 0.291
ESR1 estrogen receptor 1 0.270
HNF4A hepatocyte nuclear factor 4, alpha 0.248
CAV1 caveolin 1, caveolae protein, 22kDa 0.246
NCOR2 nuclear receptor corepressor 2 0.201
EPAS1 endothelial PAS domain protein 1 0.187
EGR1 early growth response 1 0.182
MAPK14 mitogen-activated protein kinase 14 0.181
E2F8 E2F transcription factor 8 0.167
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.156
RARA retinoic acid receptor, alpha 0.154
CREBBP CREB binding protein 0.129
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.118
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.085
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.082
JUN jun proto-oncogene 0.078
TP53 tumor protein p53 0.076
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.074
ATF2 activating transcription factor 2 0.066
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.062
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.059
KRT15 keratin 15 0.053
DUSP1 dual specificity phosphatase 1 0.052
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.050
MAPK3 mitogen-activated protein kinase 3 0.046
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.045
FBXL12 F-box and leucine-rich repeat protein 12 0.044
NCOA3 nuclear receptor coactivator 3 0.044
KAT2B K(lysine) acetyltransferase 2B 0.043
SKIL SKI-like oncogene 0.041
NCOA2 nuclear receptor coactivator 2 0.041
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.040
GADD45B growth arrest and DNA-damage-inducible, beta 0.035
NCOR1 nuclear receptor corepressor 1 0.034
FAM46A family with sequence similarity 46, member A 0.033
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.033
POU5F1 POU class 5 homeobox 1 0.033
EGLN3 egl nine homolog 3 (C. elegans) 0.031
SPOP speckle-type POZ protein 0.031
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.030
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.030
NOTCH1 notch 1 0.029
ARID1B AT rich interactive domain 1B (SWI1-like) 0.028
PLAU plasminogen activator, urokinase 0.028
KRT6B keratin 6B 0.027
VEGFA vascular endothelial growth factor A 0.027
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.026
YY1 YY1 transcription factor 0.025
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.024
PRKG1 protein kinase, cGMP-dependent, type I 0.024
FGF10 fibroblast growth factor 10 0.023
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.022
CYR61 cysteine-rich, angiogenic inducer, 61 0.021
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.021
BMPR1B bone morphogenetic protein receptor, type IB 0.020
RANBP3 RAN binding protein 3 0.020
SMAD2 SMAD family member 2 0.019
SOCS3 suppressor of cytokine signaling 3 0.018
SAV1 salvador homolog 1 (Drosophila) 0.018
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.018
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.016
FOS FBJ murine osteosarcoma viral oncogene homolog 0.016
RGS2 regulator of G-protein signaling 2, 24kDa 0.016
SH3KBP1 SH3-domain kinase binding protein 1 0.015
BCL2 B-cell CLL/lymphoma 2 0.015
NIPBL Nipped-B homolog (Drosophila) 0.015
TRRAP transformation/transcription domain-associated protein 0.014
MAPK8 mitogen-activated protein kinase 8 0.013
CREB1 cAMP responsive element binding protein 1 0.013
PLAT plasminogen activator, tissue 0.013
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.013
BAG1 BCL2-associated athanogene 0.013
JAK2 Janus kinase 2 0.012
TCF4 transcription factor 4 0.012
AHR aryl hydrocarbon receptor 0.012
FGF1 fibroblast growth factor 1 (acidic) 0.012
PGK1 phosphoglycerate kinase 1 0.012
AR androgen receptor 0.012
MAP1S microtubule-associated protein 1S 0.012
ARNT aryl hydrocarbon receptor nuclear translocator 0.012
HEYL hairy/enhancer-of-split related with YRPW motif-like 0.012
PTPRJ protein tyrosine phosphatase, receptor type, J 0.011
PIAS1 protein inhibitor of activated STAT, 1 0.011
OSMR oncostatin M receptor 0.011
BHLHE40 basic helix-loop-helix family, member e40 0.011
RXRA retinoid X receptor, alpha 0.011
KRT18 keratin 18 0.011
SQSTM1 sequestosome 1 0.011
ARID1A AT rich interactive domain 1A (SWI-like) 0.011
MAX MYC associated factor X 0.011
BAG2 BCL2-associated athanogene 2 0.011
HSPB1 heat shock 27kDa protein 1 0.010
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.010
VHL von Hippel-Lindau tumor suppressor 0.010
FGF7 fibroblast growth factor 7 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Krt18 keratin 18 0.266
Nefl neurofilament, light polypeptide 0.262
Ptgs2 prostaglandin-endoperoxide synthase 2 0.144
Cd48 Cd48 molecule 0.142
Tgfbr2 transforming growth factor, beta receptor II 0.132
Cald1 caldesmon 1 0.126
Gja1 gap junction protein, alpha 1 0.119
Eef2 eukaryotic translation elongation factor 2 0.108
Dcn decorin 0.106
Lox lysyl oxidase 0.098
Lum lumican 0.095
Col5a2 collagen, type V, alpha 2 0.094
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.088
Fn1 fibronectin 1 0.074
Nefh neurofilament, heavy polypeptide 0.071
Mgp matrix Gla protein 0.063
Cd63 Cd63 molecule 0.061
Bmp6 bone morphogenetic protein 6 0.061
Ogn osteoglycin 0.060
Nefm neurofilament, medium polypeptide 0.059
Foxa3 forkhead box A3 0.058
Fkbp4 FK506 binding protein 4 0.054
Col4a5 collagen, type IV, alpha 5 0.053
Rara retinoic acid receptor, alpha 0.052
Col1a2 collagen, type I, alpha 2 0.050
Ddr2 discoidin domain receptor tyrosine kinase 2 0.050
Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.048
Hand2 heart and neural crest derivatives expressed 2 0.048
Abcb4 ATP-binding cassette, subfamily B (MDR/TAP), member 4 0.047
Aebp1 AE binding protein 1 0.047
Acox3 acyl-Coenzyme A oxidase 3, pristanoyl 0.045
Foxe3 forkhead box E3 0.044
Bok BCL2-related ovarian killer 0.043
Dab2 disabled homolog 2 (Drosophila) 0.042
Col3a1 collagen, type III, alpha 1 0.040
G6pc glucose-6-phosphatase, catalytic subunit 0.039
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.039
Il6 interleukin 6 0.038
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.038
Dhdpsl dihydrodipicolinate synthase-like, mitochondrial 0.038
Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 0.038
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.036
Fth1 ferritin, heavy polypeptide 1 0.036
Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 0.036
Gal galanin prepropeptide 0.035
Egfr epidermal growth factor receptor 0.034
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.033
Trib1 tribbles homolog 1 (Drosophila) 0.033
Col1a1 collagen, type I, alpha 1 0.032
Smad7 SMAD family member 7 0.031
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.030
Junb jun B proto-oncogene 0.030
Bmp7 bone morphogenetic protein 7 0.030
Pck1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.030
Vom1r101 vomeronasal 1 receptor 101 0.030
Abcb11 ATP-binding cassette, subfamily B (MDR/TAP), member 11 0.029
Btg2 BTG family, member 2 0.029
Aqp9 aquaporin 9 0.029
Igfals insulin-like growth factor binding protein, acid labile subunit 0.029
Jak2 Janus kinase 2 0.029
Bat3 HLA-B-associated transcript 3 0.029
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.029
Ptch1 patched homolog 1 (Drosophila) 0.029
Calcb calcitonin-related polypeptide, beta 0.029
Cyb5r1 cytochrome b5 reductase 1 0.028
Acot12 acyl-CoA thioesterase 12 0.028
Fosl2 fos-like antigen 2 0.028
Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 0.028
Ccl2 chemokine (C-C motif) ligand 2 0.028
Hnf4a hepatocyte nuclear factor 4, alpha 0.027
Efemp1 EGF-containing fibulin-like extracellular matrix protein 1 0.027
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.027
Zfp36 zinc finger protein 36 0.027
Actg2 actin, gamma 2, smooth muscle, enteric 0.026
Cbl Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.026
Plaur plasminogen activator, urokinase receptor 0.026
Slc22a6 solute carrier family 22 (organic anion transporter), member 6 0.026
Prkca protein kinase C, alpha 0.025
Mmp3 matrix metallopeptidase 3 0.025
Oprd1 opioid receptor, delta 1 0.025
Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 0.025
Errfi1 ERBB receptor feedback inhibitor 1 0.024
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.024
Cyth1 cytohesin 1 0.023
Myo1a myosin IA 0.023
Hmox1 heme oxygenase (decycling) 1 0.023
Igfbp2 insulin-like growth factor binding protein 2 0.022
Mmp9 matrix metallopeptidase 9 0.022
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.022
Ldlr low density lipoprotein receptor 0.022
Ndfip1 Nedd4 family interacting protein 1 0.022
Ppy pancreatic polypeptide 0.022
Acads acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain 0.022
Gabrp gamma-aminobutyric acid (GABA-A) receptor, pi 0.021
Epcam epithelial cell adhesion molecule 0.021
Ppara peroxisome proliferator activated receptor alpha 0.021
Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C 0.021
Il1rl2 interleukin 1 receptor-like 2 0.021
Cryba4 crystallin, beta A4 0.020
Homer3 homer homolog 3 (Drosophila) 0.020
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism