The network for 'ossification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ossification

The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.

Mus musculus
Name Description Probability Func Analog Organism
Fgfr3 fibroblast growth factor receptor 3 1.000
Fgfr1 fibroblast growth factor receptor 1 0.999
Tgfb2 transforming growth factor, beta 2 0.997
Pten phosphatase and tensin homolog 0.995
Fgfr2 fibroblast growth factor receptor 2 0.994
Bmp4 bone morphogenetic protein 4 0.993
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.993
Col1a1 collagen, type I, alpha 1 0.992
Bcl2 B-cell leukemia/lymphoma 2 0.990
Pax2 paired box gene 2 0.989
Ctnnb1 catenin (cadherin associated protein), beta 1 0.989
Gli3 GLI-Kruppel family member GLI3 0.989
Smad6 MAD homolog 6 (Drosophila) 0.988
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.985
Gli2 GLI-Kruppel family member GLI2 0.984
Trp53 transformation related protein 53 0.982
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.974
Prrx2 paired related homeobox 2 0.967
Notch1 Notch gene homolog 1 (Drosophila) 0.965
Smo smoothened homolog (Drosophila) 0.959
Notch2 Notch gene homolog 2 (Drosophila) 0.955
Bmpr1a bone morphogenetic protein receptor, type 1A 0.951
Pthlh parathyroid hormone-like peptide 0.949
Fgf10 fibroblast growth factor 10 0.944
Msx1 homeobox, msh-like 1 0.942
Gdnf glial cell line derived neurotrophic factor 0.942
Twist2 twist homolog 2 (Drosophila) 0.938
Prrx1 paired related homeobox 1 0.932
Runx2 runt related transcription factor 2 0.931
Vdr vitamin D receptor 0.930
Tgfb1i1 transforming growth factor beta 1 induced transcript 1 0.926
Rarg retinoic acid receptor, gamma 0.925
Gata4 GATA binding protein 4 0.921
Ret ret proto-oncogene 0.907
Grb10 growth factor receptor bound protein 10 0.903
Col2a1 collagen, type II, alpha 1 0.903
Smad3 MAD homolog 3 (Drosophila) 0.895
Lepr leptin receptor 0.894
Col1a2 collagen, type I, alpha 2 0.888
Pax9 paired box gene 9 0.886
Kl klotho 0.885
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.884
Npr2 natriuretic peptide receptor 2 0.874
Fzd2 frizzled homolog 2 (Drosophila) 0.871
Shh sonic hedgehog 0.871
Neurog3 neurogenin 3 0.865
Nf1 neurofibromatosis 1 0.847
Bmp7 bone morphogenetic protein 7 0.842
Pax3 paired box gene 3 0.842
Dlx5 distal-less homeobox 5 0.840
Vegfa vascular endothelial growth factor A 0.837
Col6a2 collagen, type VI, alpha 2 0.836
Sp1 trans-acting transcription factor 1 0.833
Bgn biglycan 0.833
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.823
Leprel2 leprecan-like 2 0.817
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.814
Sfrp2 secreted frizzled-related protein 2 0.809
Gata6 GATA binding protein 6 0.808
Notch3 Notch gene homolog 3 (Drosophila) 0.802
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.786
Eya1 eyes absent 1 homolog (Drosophila) 0.785
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.782
Mef2d myocyte enhancer factor 2D 0.782
Efnb2 ephrin B2 0.779
Gpc3 glypican 3 0.777
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.777
Ptgs2 prostaglandin-endoperoxide synthase 2 0.773
Nos3 nitric oxide synthase 3, endothelial cell 0.771
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.771
Mfap2 microfibrillar-associated protein 2 0.769
Ltbp2 latent transforming growth factor beta binding protein 2 0.765
Gas1 growth arrest specific 1 0.765
Efnb1 ephrin B1 0.759
Pbx1 pre B-cell leukemia transcription factor 1 0.751
Foxc1 forkhead box C1 0.750
Ednra endothelin receptor type A 0.743
Mrc2 mannose receptor, C type 2 0.741
Ltb lymphotoxin B 0.734
Pcolce procollagen C-endopeptidase enhancer protein 0.729
Plat plasminogen activator, tissue 0.727
Efs embryonal Fyn-associated substrate 0.726
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.725
Tbx2 T-box 2 0.721
Fzd1 frizzled homolog 1 (Drosophila) 0.721
Loxl1 lysyl oxidase-like 1 0.712
Fgf3 fibroblast growth factor 3 0.712
Bmp2 bone morphogenetic protein 2 0.704
Lep leptin 0.690
Myod1 myogenic differentiation 1 0.689
Col11a1 collagen, type XI, alpha 1 0.686
Col6a1 collagen, type VI, alpha 1 0.683
Tbx5 T-box 5 0.683
Tbx3 T-box 3 0.680
Wnt4 wingless-related MMTV integration site 4 0.677
Ar androgen receptor 0.677
Hic1 hypermethylated in cancer 1 0.674
Pitx3 paired-like homeodomain transcription factor 3 0.669
Tcf7l1 transcription factor 7-like 1 (T-cell specific, HMG box) 0.667
Hes1 hairy and enhancer of split 1 (Drosophila) 0.666
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
col1a2 collagen, type I, alpha 2 0.984
wnt5b wingless-type MMTV integration site family, member 5b 0.969
sox9b SRY-box containing gene 9b 0.969
bmp2b bone morphogenetic protein 2b 0.955
sox9a SRY-box containing gene 9a 0.741
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.678
pitx3 paired-like homeodomain transcription factor 3 0.648
myod1 myogenic differentiation 1 0.606
runx2b runt-related transcription factor 2b 0.515
ripply1 ripply1 0.493
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.450
col10a1 collagen, type X, alpha 1 0.445
nf1a neurofibromin 1a 0.416
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.414
runx2a runt-related transcription factor 2a 0.408
col1a1a collagen, type I, alpha 1a 0.388
tbx1 T-box 1 0.387
sparc secreted acidic cysteine rich glycoprotein 0.386
spry4 sprouty (Drosophila) homolog 4 0.382
boc brother of CDO 0.349
col5a1 procollagen, type V, alpha 1 0.347
wls wntless homolog (Drosophila) 0.320
twist1a twist1a 0.307
col5a2l collagen, type V, alpha 2-like 0.298
mmp15b matrix metallopeptidase 15b 0.297
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.297
osr1 odd-skipped related 1 (Drosophila) 0.294
fgf8a fibroblast growth factor 8 a 0.285
ihha Indian hedgehog homolog a 0.276
xylt1 xylosyltransferase 1 0.259
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.257
shha sonic hedgehog a 0.253
smo smoothened homolog (Drosophila) 0.251
mmp2 matrix metalloproteinase 2 0.248
fn1 fibronectin 1 0.227
hspa12b heat shock protein 12B 0.222
satb2 SATB homeobox 2 0.220
ctsl1b cathepsin L, 1 b 0.216
wif1 wnt inhibitory factor 1 0.207
zgc:111821 zgc:111821 0.206
dlx4a distal-less homeobox gene 4a 0.205
dacha dachshund a 0.191
wnt10a wingless-type MMTV integration site family, member 10a 0.185
tgfbi transforming growth factor, beta-induced 0.179
twist2 twist2 0.177
col2a1a collagen type II, alpha-1a 0.175
igf1rb insulin-like growth factor 1b receptor 0.154
ctgf connective tissue growth factor 0.152
smad5 MAD homolog 5 (Drosophila) 0.151
notch3 notch homolog 3 0.151
zgc:158603 zgc:158603 0.123
ldb2a LIM-domain binding factor 2a 0.123
dlx3b distal-less homeobox gene 3b 0.121
cdh1 cadherin 1, epithelial 0.118
twist3 twist3 0.118
efnb2a ephrin B2a 0.118
myf6 myogenic factor 6 0.115
matn4 matrilin 4 0.113
sulf1 sulfatase 1 0.107
pitx2 paired-like homeodomain transcription factor 2 0.101
epha4a eph receptor A4a 0.100
fgfr3 fibroblast growth factor receptor 3 0.100
apoeb apolipoprotein Eb 0.100
kdrl kinase insert domain receptor like 0.098
si:ch211-173b8.2 si:ch211-173b8.2 0.097
zgc:85866 zgc:85866 0.094
fgf4 fibroblast growth factor 4 0.093
wnt3 wingless-type MMTV integration site family, member 3 0.089
bmp3 bone morphogenetic protein 3 0.089
edn1 endothelin 1 0.088
six1b sine oculis homeobox homolog 1b 0.087
tlr3 toll-like receptor 3 0.087
dag1 dystroglycan 1 0.086
plod1a procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a 0.086
thrb thyroid hormone receptor beta 0.085
runx3 runt-related transcription factor 3 0.084
smad1 MAD homolog 1 (Drosophila) 0.083
tll1 tolloid-like 1 0.083
egr2b early growth response 2b 0.078
ptgs2a prostaglandin-endoperoxide synthase 2a 0.078
bmp1a bone morphogenetic protein 1a 0.078
kdelr2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.076
lef1 lymphocyte enhancer binding factor 1 0.071
fstl1b follistatin-like 1b 0.071
fgf17 fibroblast growth factor 17 0.069
col27a1a collagen, type XXVII, alpha 1a 0.068
sox11b SRY-box containing gene 11b 0.068
runx1 runt-related transcription factor 1 0.068
stc1l stanniocalcin 1, like 0.067
dlx2a distal-less homeobox gene 2a 0.067
bmper BMP binding endothelial regulator 0.067
ptch2 patched 2 0.064
gli1 GLI-Kruppel family member 1 0.060
aldob aldolase b, fructose-bisphosphate 0.060
cmyb transcription factor cmyb 0.057
aldh1a3 aldehyde dehydrogenase 1 family, member A3 0.057
fam20b family with sequence similarity 20, member B (H. sapiens) 0.056
sufu suppressor of fused homolog (Drosophila) 0.056
acvr1l activin A receptor, type I like 0.056
gli2a GLI-Kruppel family member GLI2a 0.055
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
COL1A1 collagen, type I, alpha 1 0.999
FN1 fibronectin 1 0.997
FHL2 four and a half LIM domains 2 0.980
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.967
SMAD4 SMAD family member 4 0.964
COL6A1 collagen, type VI, alpha 1 0.935
FBLN1 fibulin 1 0.934
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.932
CCR5 chemokine (C-C motif) receptor 5 0.926
SMAD2 SMAD family member 2 0.919
COL1A2 collagen, type I, alpha 2 0.896
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.877
DCN decorin 0.860
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.839
COL3A1 collagen, type III, alpha 1 0.824
FBN1 fibrillin 1 0.799
HIPK2 homeodomain interacting protein kinase 2 0.797
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.747
SKIL SKI-like oncogene 0.735
JUN jun proto-oncogene 0.714
EGR1 early growth response 1 0.705
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.705
PRKD2 protein kinase D2 0.695
DDR2 discoidin domain receptor tyrosine kinase 2 0.695
BMP1 bone morphogenetic protein 1 0.692
CCL5 chemokine (C-C motif) ligand 5 0.685
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.683
COL5A1 collagen, type V, alpha 1 0.673
BCAR1 breast cancer anti-estrogen resistance 1 0.651
COL4A1 collagen, type IV, alpha 1 0.646
VCAN versican 0.636
THBS1 thrombospondin 1 0.615
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.578
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.574
EFTUD2 elongation factor Tu GTP binding domain containing 2 0.573
IFITM3 interferon induced transmembrane protein 3 (1-8U) 0.566
COL4A2 collagen, type IV, alpha 2 0.564
ENG endoglin 0.564
SMAD7 SMAD family member 7 0.557
DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 0.556
AXIN1 axin 1 0.540
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.530
GSK3B glycogen synthase kinase 3 beta 0.530
IGFBP5 insulin-like growth factor binding protein 5 0.528
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.510
FGF1 fibroblast growth factor 1 (acidic) 0.507
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.477
SFRP1 secreted frizzled-related protein 1 0.475
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.469
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.451
TP53 tumor protein p53 0.445
RXRA retinoid X receptor, alpha 0.443
COL6A2 collagen, type VI, alpha 2 0.442
TGFB3 transforming growth factor, beta 3 0.438
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.428
NCOR2 nuclear receptor corepressor 2 0.426
RCN3 reticulocalbin 3, EF-hand calcium binding domain 0.417
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.411
SMAD9 SMAD family member 9 0.410
POU3F2 POU class 3 homeobox 2 0.409
BMP2 bone morphogenetic protein 2 0.407
NOTCH1 notch 1 0.391
MXRA5 matrix-remodelling associated 5 0.388
ZHX1 zinc fingers and homeoboxes 1 0.384
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.383
ADAM12 ADAM metallopeptidase domain 12 0.383
FLNA filamin A, alpha 0.377
PTK2 PTK2 protein tyrosine kinase 2 0.376
RUNX1 runt-related transcription factor 1 0.368
RPL18A ribosomal protein L18a 0.367
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.367
PRELP proline/arginine-rich end leucine-rich repeat protein 0.366
TGFB1 transforming growth factor, beta 1 0.361
TM4SF1 transmembrane 4 L six family member 1 0.360
JAG1 jagged 1 0.355
SUFU suppressor of fused homolog (Drosophila) 0.354
SMAD3 SMAD family member 3 0.345
PTGIS prostaglandin I2 (prostacyclin) synthase 0.341
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.339
NOTCH3 notch 3 0.338
POSTN periostin, osteoblast specific factor 0.314
LTBP2 latent transforming growth factor beta binding protein 2 0.313
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.309
FKBP1A FK506 binding protein 1A, 12kDa 0.307
PECAM1 platelet/endothelial cell adhesion molecule 0.306
FOXF2 forkhead box F2 0.304
THBS2 thrombospondin 2 0.303
SOCS3 suppressor of cytokine signaling 3 0.302
PLXND1 plexin D1 0.299
NCOR1 nuclear receptor corepressor 1 0.296
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.294
PTCH1 patched 1 0.287
ATF3 activating transcription factor 3 0.285
FZD1 frizzled homolog 1 (Drosophila) 0.280
ACAN aggrecan 0.278
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.276
MRC2 mannose receptor, C type 2 0.269
CCL2 chemokine (C-C motif) ligand 2 0.263
FBLN2 fibulin 2 0.262
LAMB1 laminin, beta 1 0.262
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Rattus norvegicus
Name Description Probability Func Analog Organism
Vcan versican 0.456
Col1a1 collagen, type I, alpha 1 0.434
Eln elastin 0.380
Sycp1 synaptonemal complex protein 1 0.365
Prl prolactin 0.357
Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.308
C1qtnf6 C1q and tumor necrosis factor related protein 6 0.253
Prrx1 paired related homeobox 1 0.244
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.233
Igfbp5 insulin-like growth factor binding protein 5 0.227
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.218
Col5a2 collagen, type V, alpha 2 0.216
Crtap cartilage associated protein 0.205
Capn6 calpain 6 0.199
Crisp1 cysteine-rich secretory protein 1 0.198
Lox lysyl oxidase 0.197
Hapln1 hyaluronan and proteoglycan link protein 1 0.195
Grin3a glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.192
Col5a1 collagen, type V, alpha 1 0.192
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.192
Igfbp3 insulin-like growth factor binding protein 3 0.192
Col12a1 collagen, type XII, alpha 1 0.187
Col3a1 collagen, type III, alpha 1 0.182
Phkg1 phosphorylase kinase, gamma 1 0.181
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.174
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.173
Calcr calcitonin receptor 0.165
Col1a2 collagen, type I, alpha 2 0.165
Srpx sushi-repeat-containing protein, X-linked 0.156
Folh1 folate hydrolase 1 0.153
Scn9a sodium channel, voltage-gated, type IX, alpha 0.151
Bcl2 B-cell CLL/lymphoma 2 0.149
Fgf10 fibroblast growth factor 10 0.142
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.138
Mmp13 matrix metallopeptidase 13 0.136
Il2ra interleukin 2 receptor, alpha 0.135
Enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 0.131
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.126
Tas2r126 taste receptor, type 2, member 126 0.125
Slc34a1 solute carrier family 34 (sodium phosphate), member 1 0.123
Prss1 protease, serine, 1 (trypsin 1) 0.119
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.118
Tgfb2 transforming growth factor, beta 2 0.117
Vim vimentin 0.112
Galntl1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1 0.112
Glycam1 glycosylation dependent cell adhesion molecule 1 0.109
Hspa1l heat shock protein 1-like 0.107
Fn1 fibronectin 1 0.106
Sstr1 somatostatin receptor 1 0.104
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.103
Olr1500 olfactory receptor 1500 0.103
Accn3 amiloride-sensitive cation channel 3 0.101
Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 0.100
Agtr1a angiotensin II receptor, type 1a 0.100
Mmp3 matrix metallopeptidase 3 0.098
Arc activity-regulated cytoskeleton-associated protein 0.098
Lum lumican 0.098
LOC312273 Trypsin V-A 0.095
Sfrp4 secreted frizzled-related protein 4 0.095
Gfra1 GDNF family receptor alpha 1 0.093
Sostdc1 sclerostin domain containing 1 0.093
Prol1 proline rich, lacrimal 1 0.092
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.092
Six1 SIX homeobox 1 0.092
Mafb v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) 0.091
Kl Klotho 0.091
Padi2 peptidyl arginine deiminase, type II 0.091
Vom1r105 vomeronasal 1 receptor 105 0.089
Dchs1 dachsous 1 (Drosophila) 0.088
Has2 hyaluronan synthase 2 0.087
Necab1 N-terminal EF-hand calcium binding protein 1 0.086
Mas1 MAS1 oncogene 0.086
Mmp10 matrix metallopeptidase 10 0.086
Hoxb8 homeo box B8 0.086
Uox urate oxidase 0.085
Plagl1 pleiomorphic adenoma gene-like 1 0.084
Serpinb12 serpin peptidase inhibitor, clade B (ovalbumin), member 12 0.084
Rgs8 regulator of G-protein signaling 8 0.083
Gpr12 G protein-coupled receptor 12 0.083
Fam38b family with sequence similarity 38, member B 0.082
Acrv1 acrosomal vesicle protein 1 0.082
Asb9 ankyrin repeat and SOCS box-containing 9 0.081
LOC679840 similar to germinal histone H4 gene 0.080
Csf3 colony stimulating factor 3 (granulocyte) 0.079
Sod3 superoxide dismutase 3, extracellular 0.078
Plxdc2 plexin domain containing 2 0.078
Spta1 spectrin, alpha, erythrocytic 1 (elliptocytosis 2) 0.078
Olr1496 olfactory receptor 1496 0.077
Myog myogenin 0.076
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.076
Nkx6-1 NK6 homeobox 1 0.076
Reg3a regenerating islet-derived 3 alpha 0.075
Fev FEV (ETS oncogene family) 0.075
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.075
Loxl1 lysyl oxidase-like 1 0.074
Ddn dendrin 0.074
Arhgap28 Rho GTPase activating protein 28 0.074
Vom2r40 vomeronasal 2 receptor, 40 0.073
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.073
Bgn biglycan 0.073
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism