The network for 'hexose metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

hexose metabolic process

The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule.

Mus musculus
Name Description Probability Func Analog Organism
Lep leptin 0.999
Lepr leptin receptor 0.997
Insr insulin receptor 0.975
Igf1r insulin-like growth factor I receptor 0.965
Pparg peroxisome proliferator activated receptor gamma 0.955
Clock circadian locomotor output cycles kaput 0.952
Mapk14 mitogen-activated protein kinase 14 0.937
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.935
Onecut1 one cut domain, family member 1 0.929
Fos FBJ osteosarcoma oncogene 0.923
Aldoa aldolase A, fructose-bisphosphate 0.887
Pdx1 pancreatic and duodenal homeobox 1 0.883
Per2 period homolog 2 (Drosophila) 0.875
Npy1r neuropeptide Y receptor Y1 0.870
Ldha lactate dehydrogenase A 0.860
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.837
Tpi1 triosephosphate isomerase 1 0.836
Nos1 nitric oxide synthase 1, neuronal 0.823
Pten phosphatase and tensin homolog 0.819
Gm5506 predicted gene 5506 0.809
Cry2 cryptochrome 2 (photolyase-like) 0.803
Pkm2 pyruvate kinase, muscle 0.794
C1qc complement component 1, q subcomponent, C chain 0.794
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.788
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.784
Prlr prolactin receptor 0.780
Hnf4a hepatic nuclear factor 4, alpha 0.758
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.739
Stat5a signal transducer and activator of transcription 5A 0.699
Clk1 CDC-like kinase 1 0.690
Zeb1 zinc finger E-box binding homeobox 1 0.683
Jun Jun oncogene 0.650
Pgk1 phosphoglycerate kinase 1 0.620
Gpi1 glucose phosphate isomerase 1 0.618
Dusp1 dual specificity phosphatase 1 0.598
Otp orthopedia homolog (Drosophila) 0.595
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.586
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.585
Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.581
Mup5 major urinary protein 5 0.573
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.572
Clk4 CDC like kinase 4 0.543
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.527
Btk Bruton agammaglobulinemia tyrosine kinase 0.527
Drd2 dopamine receptor D2 0.519
Nr1h4 nuclear receptor subfamily 1, group H, member 4 0.511
Kiss1 KiSS-1 metastasis-suppressor 0.509
Tcf7 transcription factor 7, T-cell specific 0.486
Pim1 proviral integration site 1 0.470
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.456
S100a5 S100 calcium binding protein A5 0.456
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.450
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.440
Ins2 insulin II 0.428
Pgam1 phosphoglycerate mutase 1 0.428
F2 coagulation factor II 0.420
Irs2 insulin receptor substrate 2 0.418
Agrp agouti related protein 0.416
Ccnl2 cyclin L2 0.406
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.403
Foxa2 forkhead box A2 0.402
Hoxd3 homeobox D3 0.399
Lrp6 low density lipoprotein receptor-related protein 6 0.395
Pgls 6-phosphogluconolactonase 0.383
Esr1 estrogen receptor 1 (alpha) 0.380
D4Wsu53e DNA segment, Chr 4, Wayne State University 53, expressed 0.373
Trib3 tribbles homolog 3 (Drosophila) 0.365
Ep300 E1A binding protein p300 0.355
Eda ectodysplasin-A 0.355
Axin1 axin 1 0.351
Cidec cell death-inducing DFFA-like effector c 0.345
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.342
Atf2 activating transcription factor 2 0.337
Zfp36 zinc finger protein 36 0.334
Pthlh parathyroid hormone-like peptide 0.334
Vdr vitamin D receptor 0.326
Rxra retinoid X receptor alpha 0.320
Cfd complement factor D (adipsin) 0.316
Asgr2 asialoglycoprotein receptor 2 0.313
Tox thymocyte selection-associated high mobility group box 0.313
Usp2 ubiquitin specific peptidase 2 0.313
Fgfr1 fibroblast growth factor receptor 1 0.313
Mup9 major urinary protein 9 0.312
Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C 0.310
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.309
Gcgr glucagon receptor 0.307
Mc5r melanocortin 5 receptor 0.307
Fgf5 fibroblast growth factor 5 0.303
Gpr27 G protein-coupled receptor 27 0.299
Thra thyroid hormone receptor alpha 0.297
Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 0.291
Crhr1 corticotropin releasing hormone receptor 1 0.290
Bmp4 bone morphogenetic protein 4 0.290
Prkce protein kinase C, epsilon 0.288
Pim3 proviral integration site 3 0.288
Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic 0.278
Plin1 perilipin 1 0.278
Hoxd1 homeobox D1 0.274
Mup10 major urinary protein 10 0.271
Prpf39 PRP39 pre-mRNA processing factor 39 homolog (yeast) 0.270
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Pgk Phosphoglycerate kinase 0.082
Got2 Glutamate oxaloacetate transaminase 2 0.050
Pgm Phosphogluconate mutase 0.043
Gpdh Glycerol 3 phosphate dehydrogenase 0.033
Pgd Phosphogluconate dehydrogenase 0.027
Thor CG8846 gene product from transcript CG8846-RA 0.022
CG8036 CG8036 gene product from transcript CG8036-RB 0.020
Ca-P60A Calcium ATPase at 60A 0.019
Adh Alcohol dehydrogenase 0.019
CG7998 CG7998 gene product from transcript CG7998-RA 0.015
Gapdh1 Glyceraldehyde 3 phosphate dehydrogenase 1 0.014
GlyP Glycogen phosphorylase 0.014
S6k RPS6-p70-protein kinase 0.013
Atg9 Autophagy-specific gene 9 0.013
foxo forkhead box, sub-group O 0.011
Akt1 CG4006 gene product from transcript CG4006-RA 0.010
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
INSR insulin receptor 0.998
CREBBP CREB binding protein 0.997
ESR1 estrogen receptor 1 0.974
NCOA1 nuclear receptor coactivator 1 0.960
RXRA retinoid X receptor, alpha 0.928
RARA retinoic acid receptor, alpha 0.893
AR androgen receptor 0.765
EP300 E1A binding protein p300 0.737
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.715
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.701
KAT2B K(lysine) acetyltransferase 2B 0.700
ALDOA aldolase A, fructose-bisphosphate 0.700
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.694
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 0.674
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.659
HIPK2 homeodomain interacting protein kinase 2 0.654
TADA3 transcriptional adaptor 3 0.619
TPI1 triosephosphate isomerase 1 0.617
IRS1 insulin receptor substrate 1 0.549
SIRT1 sirtuin 1 0.463
PGK1 phosphoglycerate kinase 1 0.461
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.461
NCOA3 nuclear receptor coactivator 3 0.460
NCOA6 nuclear receptor coactivator 6 0.451
GRB10 growth factor receptor-bound protein 10 0.413
PRKCZ protein kinase C, zeta 0.394
GHR growth hormone receptor 0.390
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.378
IRS2 insulin receptor substrate 2 0.368
LIN7B lin-7 homolog B (C. elegans) 0.357
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.346
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.344
CREB1 cAMP responsive element binding protein 1 0.329
IGF1R insulin-like growth factor 1 receptor 0.316
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.301
TTR transthyretin 0.275
GPI glucose-6-phosphate isomerase 0.274
TKT transketolase 0.272
SMAD3 SMAD family member 3 0.265
LDHA lactate dehydrogenase A 0.244
C1QC complement component 1, q subcomponent, C chain 0.223
LRRK2 leucine-rich repeat kinase 2 0.219
MED25 mediator complex subunit 25 0.216
NCF1 neutrophil cytosolic factor 1 0.214
GSK3B glycogen synthase kinase 3 beta 0.209
NCOR2 nuclear receptor corepressor 2 0.207
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0.195
NOXA1 NADPH oxidase activator 1 0.189
PKM2 pyruvate kinase, muscle 0.179
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.176
ACACA acetyl-CoA carboxylase alpha 0.174
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.169
DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.169
HNF4A hepatocyte nuclear factor 4, alpha 0.165
SORBS3 sorbin and SH3 domain containing 3 0.163
C1QA complement component 1, q subcomponent, A chain 0.153
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.147
ARF4 ADP-ribosylation factor 4 0.136
MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) 0.135
PPARG peroxisome proliferator-activated receptor gamma 0.135
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.133
JUN jun proto-oncogene 0.130
BCAR1 breast cancer anti-estrogen resistance 1 0.121
RAB5A RAB5A, member RAS oncogene family 0.117
SH2B1 SH2B adaptor protein 1 0.114
ARIH1 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila) 0.109
DDIT3 DNA-damage-inducible transcript 3 0.107
ATF2 activating transcription factor 2 0.104
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.100
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.100
NEU1 sialidase 1 (lysosomal sialidase) 0.097
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.093
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.092
PPARA peroxisome proliferator-activated receptor alpha 0.092
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.091
FOXO3 forkhead box O3 0.090
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.090
AGXT2 alanine--glyoxylate aminotransferase 2 0.089
SQSTM1 sequestosome 1 0.087
TRIB3 tribbles homolog 3 (Drosophila) 0.087
SESN2 sestrin 2 0.086
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.081
CREBZF CREB/ATF bZIP transcription factor 0.081
DCN decorin 0.080
FHL2 four and a half LIM domains 2 0.077
ENO1 enolase 1, (alpha) 0.075
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.074
SORBS1 sorbin and SH3 domain containing 1 0.072
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.071
OASL 2'-5'-oligoadenylate synthetase-like 0.071
STAT5B signal transducer and activator of transcription 5B 0.071
TALDO1 transaldolase 1 0.067
ZNF746 zinc finger protein 746 0.067
SH3KBP1 SH3-domain kinase binding protein 1 0.067
LTBP4 latent transforming growth factor beta binding protein 4 0.067
USP22 ubiquitin specific peptidase 22 0.066
TRIM23 tripartite motif containing 23 0.065
SREBF2 sterol regulatory element binding transcription factor 2 0.062
ESRRG estrogen-related receptor gamma 0.061
APC adenomatous polyposis coli 0.061
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Eno1 enolase 1, (alpha) 0.830
Ldha lactate dehydrogenase A 0.788
Aldoa aldolase A, fructose-bisphosphate 0.521
Gpi glucose phosphate isomerase 0.354
Pgam1 phosphoglycerate mutase 1 (brain) 0.311
Cpt2 carnitine palmitoyltransferase 2 0.285
G6pc glucose-6-phosphatase, catalytic subunit 0.279
Tpi1 triosephosphate isomerase 1 0.276
Etfdh electron-transferring-flavoprotein dehydrogenase 0.187
Rab1b RAB1B, member RAS oncogene family 0.163
Nfib nuclear factor I/B 0.153
Met met proto-oncogene 0.150
Dbp D site of albumin promoter (albumin D-box) binding protein 0.145
Aldob aldolase B, fructose-bisphosphate 0.112
Ubtf upstream binding transcription factor, RNA polymerase I 0.110
Apoa4 apolipoprotein A-IV 0.100
Mlxipl MLX interacting protein-like 0.097
Ldhd lactate dehydrogenase D 0.095
Fbp1 fructose-1,6-bisphosphatase 1 0.094
Tuba1c tubulin, alpha 1C 0.093
Faah fatty acid amide hydrolase 0.091
Pfkm phosphofructokinase, muscle 0.090
Pgm1 phosphoglucomutase 1 0.090
Igfals insulin-like growth factor binding protein, acid labile subunit 0.089
Mif macrophage migration inhibitory factor 0.088
Dck deoxycytidine kinase 0.087
Hmox1 heme oxygenase (decycling) 1 0.080
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.075
Irs1 insulin receptor substrate 1 0.074
PVR poliovirus receptor 0.072
Ptprs protein tyrosine phosphatase, receptor type, S 0.071
Acads acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain 0.071
Galnt10 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) 0.070
Ccl2 chemokine (C-C motif) ligand 2 0.070
LOC100363662 6-phosphogluconate dehydrogenase, decarboxylating-like 0.069
Pgk1 phosphoglycerate kinase 1 0.067
A1cf APOBEC1 complementation factor 0.067
Zadh2 zinc binding alcohol dehydrogenase, domain containing 2 0.066
Asph aspartate-beta-hydroxylase 0.061
B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.060
Irs3 insulin receptor substrate 3 0.060
Tshr thyroid stimulating hormone receptor 0.059
Pygl phosphorylase, glycogen, liver 0.058
Acot2 acyl-CoA thioesterase 2 0.058
Eef2 eukaryotic translation elongation factor 2 0.058
Acadl acyl-Coenzyme A dehydrogenase, long-chain 0.057
Vipr1 vasoactive intestinal peptide receptor 1 0.055
Ccl3 chemokine (C-C motif) ligand 3 0.053
Ccnd3 cyclin D3 0.053
Hist1h2ba histone cluster 1, H2ba 0.053
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.053
Plaur plasminogen activator, urokinase receptor 0.052
LOC100366119 Mpv17 transgene, kidney disease mutant-like (predicted)-like 0.052
Mgat3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 0.051
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.051
Inhbe inhibin beta E 0.049
Tkt transketolase 0.049
RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase 0.049
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.049
Grinl1a glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A 0.049
Pkm2 pyruvate kinase, muscle 0.048
Glud1 glutamate dehydrogenase 1 0.048
Litaf lipopolysaccharide-induced TNF factor 0.048
Rara retinoic acid receptor, alpha 0.048
Mylk2 myosin light chain kinase 2 0.047
Creb1 cAMP responsive element binding protein 1 0.047
Ap2m1 adaptor-related protein complex 2, mu 1 subunit 0.047
St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 0.047
Oaz2 ornithine decarboxylase antizyme 2 0.047
Casp2 caspase 2 0.047
Pygm phosphorylase, glycogen, muscle 0.046
Acacb acetyl-Coenzyme A carboxylase beta 0.045
Foxa3 forkhead box A3 0.045
Dhrs7c dehydrogenase/reductase (SDR family) member 7C 0.044
Alb albumin 0.044
Pgam2 phosphoglycerate mutase 2 (muscle) 0.044
Tgfbr2 transforming growth factor, beta receptor II 0.044
Fabp5 fatty acid binding protein 5, epidermal 0.043
Ampd1 adenosine monophosphate deaminase 1 (isoform M) 0.043
Serinc1 serine incorporator 1 0.043
Akap8l A kinase (PRKA) anchor protein 8-like 0.043
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.043
Macrod1 MACRO domain containing 1 0.042
Slc20a2 solute carrier family 20 (phosphate transporter), member 2 0.042
Cxcl10 chemokine (C-X-C motif) ligand 10 0.041
Fn3k fructosamine 3 kinase 0.041
Obp3 alpha-2u globulin PGCL4 0.041
Ppp1r3c protein phosphatase 1, regulatory (inhibitor) subunit 3C 0.041
Slc25a42 solute carrier family 25, member 42 0.040
Impdh2 IMP (inosine monophosphate) dehydrogenase 2 0.040
Taldo1 transaldolase 1 0.040
Myo9a myosin IXA 0.040
Akap1 A kinase (PRKA) anchor protein 1 0.040
Aprt adenine phosphoribosyl transferase 0.039
Ndrg2 N-myc downstream regulated gene 2 0.039
Runx1 runt-related transcription factor 1 0.039
Angptl4 angiopoietin-like 4 0.038
Lypla1 lysophospholipase 1 0.038
Vdac1 voltage-dependent anion channel 1 0.038
Apoa1 apolipoprotein A-I 0.038
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
SOR1 Sor1p 0.982
FYV10 Fyv10p 0.977
ADH1 Adh1p 0.955
GAL1 Gal1p 0.939
ENO1 Eno1p 0.917
GND2 Gnd2p 0.912
ENO2 Eno2p 0.884
GAL10 Gal10p 0.884
FBA1 Fba1p 0.882
UGP1 Ugp1p 0.829
TDH2 Tdh2p 0.827
PGK1 Pgk1p 0.821
PDC1 Pdc1p 0.781
GAL4 Gal4p 0.756
ERR3 Err3p 0.694
CAK1 Cak1p 0.685
GAL3 Gal3p 0.669
PGI1 Pgi1p 0.626
GND1 Gnd1p 0.593
PYC2 Pyc2p 0.557
ALD6 Ald6p 0.548
VID30 Vid30p 0.539
RMD5 Rmd5p 0.534
MTH1 Mth1p 0.533
TDH3 Tdh3p 0.532
TAL1 Tal1p 0.530
MOH1 Moh1p 0.525
TPI1 Tpi1p 0.502
GID8 Gid8p 0.478
GAL7 Gal7p 0.477
HXK2 Hxk2p 0.460
ERR1 Err1p 0.456
GPM1 Gpm1p 0.447
PFK1 Pfk1p 0.440
HXT2 Hxt2p 0.439
CMK2 Cmk2p 0.424
SNF3 Snf3p 0.422
GID7 Gid7p 0.421
SOR2 Sor2p 0.417
BDH1 Bdh1p 0.397
POT1 Pot1p 0.392
ERR2 Err2p 0.386
HXT16 Hxt16p 0.386
CAT8 Cat8p 0.380
GIP2 Gip2p 0.374
IMA4 Ima4p 0.351
GLO1 Glo1p 0.349
GPM2 Gpm2p 0.338
NQM1 Nqm1p 0.333
SDS24 Sds24p 0.326
VID28 Vid28p 0.323
MLS1 Mls1p 0.305
AIM17 Aim17p 0.302
SNF1 Snf1p 0.286
YAP6 Yap6p 0.275
ROD1 Rod1p 0.274
ADH3 Adh3p 0.270
GAL83 Gal83p 0.260
TDH1 Tdh1p 0.260
MPH3 Mph3p 0.254
HXT10 Hxt10p 0.252
RDS2 Rds2p 0.240
YLR345W hypothetical protein 0.228
GLG2 Glg2p 0.227
SPE3 Spe3p 0.224
CIT2 Cit2p 0.219
GPD1 Gpd1p 0.207
RTC3 Rtc3p 0.194
YNR073C hypothetical protein 0.187
GRE3 Gre3p 0.186
NDE2 Nde2p 0.186
HXT3 Hxt3p 0.183
GSY2 Gsy2p 0.183
MIG1 Mig1p 0.171
SIP4 Sip4p 0.170
CKA2 Cka2p 0.167
ZWF1 Zwf1p 0.164
MSH6 Msh6p 0.162
YMR291W hypothetical protein 0.161
PIG2 Pig2p 0.151
GAL80 Gal80p 0.150
RAD30 Rad30p 0.149
THI3 Thi3p 0.149
WWM1 Wwm1p 0.146
THO2 Tho2p 0.144
HXT15 Hxt15p 0.143
KIN1 Kin1p 0.142
TPS1 Tps1p 0.142
TKL2 Tkl2p 0.141
ALD4 Ald4p 0.141
AZF1 Azf1p 0.139
YGR126W hypothetical protein 0.133
GAL2 Gal2p 0.132
HRK1 Hrk1p 0.124
YAR028W hypothetical protein 0.123
BNA5 Bna5p 0.122
NCE103 Nce103p 0.122
VID24 Vid24p 0.122
FBP1 Fbp1p 0.119
HOM6 Hom6p 0.117