The network for 'dna methylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna methylation

The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.

Mus musculus
Name Description Probability Func Analog Organism
Rnf2 ring finger protein 2 1.000
Rybp RING1 and YY1 binding protein 0.999
Pou5f1 POU domain, class 5, transcription factor 1 0.987
Arid1a AT rich interactive domain 1A (SWI-like) 0.987
Dnmt3a DNA methyltransferase 3A 0.978
Dnmt3b DNA methyltransferase 3B 0.977
Hdac1 histone deacetylase 1 0.963
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.938
Trim28 tripartite motif-containing 28 0.921
Tcfcp2l1 transcription factor CP2-like 1 0.906
Mta1 metastasis associated 1 0.895
Kdm2b lysine (K)-specific demethylase 2B 0.893
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.800
Trp53 transformation related protein 53 0.798
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.789
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.787
Jarid2 jumonji, AT rich interactive domain 2 0.781
Eed embryonic ectoderm development 0.770
Crebbp CREB binding protein 0.762
Mll3 myeloid/lymphoid or mixed-lineage leukemia 3 0.762
L3mbtl2 l(3)mbt-like 2 (Drosophila) 0.758
Runx1 runt related transcription factor 1 0.730
Arid1b AT rich interactive domain 1B (SWI-like) 0.686
Nanog Nanog homeobox 0.670
Hells helicase, lymphoid specific 0.636
Sall4 sal-like 4 (Drosophila) 0.617
Apc adenomatosis polyposis coli 0.613
Ncoa3 nuclear receptor coactivator 3 0.586
Bptf bromodomain PHD finger transcription factor 0.568
Trim24 tripartite motif-containing 24 0.542
Stat3 signal transducer and activator of transcription 3 0.537
Cbx1 chromobox homolog 1 (Drosophila HP1 beta) 0.463
Stk38 serine/threonine kinase 38 0.455
Cbl Casitas B-lineage lymphoma 0.407
Ptgs2 prostaglandin-endoperoxide synthase 2 0.398
Pcgf6 polycomb group ring finger 6 0.393
Mga MAX gene associated 0.376
Rbbp4 retinoblastoma binding protein 4 0.374
Brd4 bromodomain containing 4 0.361
Chd4 chromodomain helicase DNA binding protein 4 0.359
Dnmt3l DNA (cytosine-5-)-methyltransferase 3-like 0.328
Ubtf upstream binding transcription factor, RNA polymerase I 0.319
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.311
Ncor1 nuclear receptor co-repressor 1 0.285
Ring1 ring finger protein 1 0.261
Cbx8 chromobox homolog 8 (Drosophila Pc class) 0.252
Zbtb33 zinc finger and BTB domain containing 33 0.244
Pias1 protein inhibitor of activated STAT 1 0.236
Ehmt2 euchromatic histone lysine N-methyltransferase 2 0.216
Bcl6 B-cell leukemia/lymphoma 6 0.215
Cbx5 chromobox homolog 5 (Drosophila HP1a) 0.214
Mtf2 metal response element binding transcription factor 2 0.205
Kdm1a lysine (K)-specific demethylase 1A 0.199
Arid2 AT rich interactive domain 2 (ARID, RFX-like) 0.197
Cbx7 chromobox homolog 7 0.194
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.193
A530054K11Rik RIKEN cDNA A530054K11 gene 0.191
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.182
Ep300 E1A binding protein p300 0.179
Phc1 polyhomeotic-like 1 (Drosophila) 0.179
Brca2 breast cancer 2 0.176
Gsk3b glycogen synthase kinase 3 beta 0.174
Tnrc6b trinucleotide repeat containing 6b 0.173
Pcgf2 polycomb group ring finger 2 0.173
Cbx3 chromobox homolog 3 (Drosophila HP1 gamma) 0.173
Sin3a transcriptional regulator, SIN3A (yeast) 0.171
Piwil1 piwi-like homolog 1 (Drosophila) 0.171
Cav1 caveolin 1, caveolae protein 0.169
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.168
Ehmt1 euchromatic histone methyltransferase 1 0.160
Dcaf7 DDB1 and CUL4 associated factor 7 0.157
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.157
Mbd3 methyl-CpG binding domain protein 3 0.155
Rbbp7 retinoblastoma binding protein 7 0.155
Axin1 axin 1 0.150
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.143
Btk Bruton agammaglobulinemia tyrosine kinase 0.130
Arid4a AT rich interactive domain 4A (RBP1-like) 0.124
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.118
Setdb1 SET domain, bifurcated 1 0.117
Parp1 poly (ADP-ribose) polymerase family, member 1 0.115
Braf Braf transforming gene 0.112
Msl1 male-specific lethal 1 homolog (Drosophila) 0.108
Akt1 thymoma viral proto-oncogene 1 0.106
Thra thyroid hormone receptor alpha 0.105
Piwil2 piwi-like homolog 2 (Drosophila) 0.102
Bcor BCL6 interacting corepressor 0.100
Numa1 nuclear mitotic apparatus protein 1 0.100
Zfp748 zinc finger protein 748 0.098
Pcp2 Purkinje cell protein 2 (L7) 0.096
Cbx2 chromobox homolog 2 (Drosophila Pc class) 0.093
Smad4 MAD homolog 4 (Drosophila) 0.089
Tbl1xr1 transducin (beta)-like 1X-linked receptor 1 0.089
Mllt1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.088
Duox2 dual oxidase 2 0.086
Dnmt1 DNA methyltransferase (cytosine-5) 1 0.086
Igh immunoglobulin heavy chain complex 0.086
Chaf1a chromatin assembly factor 1, subunit A (p150) 0.085
Cxcr4 chemokine (C-X-C motif) receptor 4 0.085
Zfp418 zinc finger protein 418 0.084
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.275
usp1 ubiquitin specific protease 1 0.212
suv39h1a suppressor of variegation 3-9 homolog 1a 0.135
suv39h1b suppressor of variegation 3-9 homolog 1b 0.125
marcksb myristoylated alanine rich protein kinase C substrate b 0.112
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.109
si:ch211-1n9.7 si:ch211-1n9.7 0.108
pola1 polymerase (DNA directed), alpha 1 0.089
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.086
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.077
ascl1a achaete-scute complex-like 1a (Drosophila) 0.053
ndr1 nodal-related 1 0.051
lcp1 lymphocyte cytosolic plastin 1 0.048
org oogenesis-related gene 0.046
mmp9 matrix metalloproteinase 9 0.041
lhx3 LIM homeobox 3 0.040
smc3 structural maintenance of chromosomes 3 0.038
drd2l dopamine receptor D2 like 0.035
coro1a coronin, actin binding protein, 1A 0.034
ssrp1a structure specific recognition protein 1a 0.034
ahctf1 AT hook containing transcription factor 1 0.034
cbx2 chromobox homolog 2 (Drosophila Pc class) 0.032
eomesa eomesodermin homolog a 0.031
sass6 spindle assembly 6 homolog (C. elegans) 0.031
chek2 CHK2 checkpoint homolog (S. pombe) 0.031
tra2b transformer 2 beta homolog (Drosophila) 0.030
dazl daz-like gene 0.030
olig4 oligodendrocyte transcription factor 4 0.029
drl draculin 0.028
dnmt3 DNA (cytosine-5-)-methyltransferase 3 0.027
dnmt5 DNA (cytosine-5-)-methyltransferase 5 0.024
prim1 primase polypeptide 1 0.024
otx1b orthodenticle homolog 1b 0.024
crb2a crumbs homolog 2a 0.023
mpx myeloid-specific peroxidase 0.022
setd8a SET domain containing (lysine methyltransferase) 8a 0.022
pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.021
sephs1 selenophosphate synthetase 1 0.021
orc1 origin recognition complex, subunit 1 0.020
otpb orthopedia homolog b 0.020
mos v-mos Moloney murine sarcoma viral oncogene homolog 0.019
hhex hematopoietically expressed homeobox 0.019
atoh1a atonal homolog 1a 0.018
si:dkey-265a7.2 si:dkey-265a7.2 0.018
ezh2 enhancer of zeste homolog 2 (Drosophila) 0.018
lyz lysozyme 0.017
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.017
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.017
lhx1b LIM homeobox 1b 0.016
anp32a acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.016
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.015
atad5a ATPase family, AAA domain containing 5a 0.015
rif1 RAP1 interacting factor homolog (yeast) 0.015
chaf1b chromatin assembly factor 1, subunit B 0.015
pax6a paired box gene 6a 0.015
tbpl2 TATA box binding protein like 2 0.014
msh2 mutS homolog 2 (E. coli) 0.014
sulf2 sulfatase 2 0.014
asz1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 0.014
hcfc1a host cell factor C1a 0.013
polr2a polymerase (RNA) II (DNA directed) polypeptide A 0.013
ssbp3b single stranded DNA binding protein 3b 0.013
epb4.1l4 erythrocyte protein band 4.1-like 4 0.013
h3f3c H3 histone, family 3C 0.013
slbp stem-loop binding protein 0.013
prdm9 PR domain containing 9 0.012
zgc:110113 zgc:110113 0.012
ek1 eph-like kinase 1 0.012
st8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.012
si:dkey-97o5.1 si:dkey-97o5.1 0.012
LOC100151157 similar to bin3, bicoid-interacting 3 0.012
ehmt2 euchromatic histone-lysine N-methyltransferase 2 0.011
zgc:55468 zgc:55468 0.011
gmcl1 germ cell-less homolog 1 (Drosophila) 0.011
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.011
pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.011
cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.010
her2 hairy-related 2 0.010
cep70 centrosomal protein 70 0.010
si:ch211-81a5.5 si:ch211-81a5.5 0.010
otul OTU like protein 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
egg eggless 0.530
Su(var)3-7 Suppressor of variegation 3-7 0.457
Chro Chromator 0.378
Su(var)205 Suppressor of variegation 205 0.209
ash1 absent, small, or homeotic discs 1 0.203
trx trithorax 0.116
piwi CG6122 gene product from transcript CG6122-RA 0.113
Pc Polycomb 0.110
vas vasa 0.093
east enhanced adult sensory threshold 0.092
stwl stonewall 0.083
Snr1 Snf5-related 1 0.081
spn-E spindle E 0.077
gpp grappa 0.077
MED24 Mediator complex subunit 24 0.074
Su(var)3-3 Suppressor of variegation 3-3 0.073
otu ovarian tumor 0.072
Scm Sex comb on midleg 0.069
CTCF CG8591 gene product from transcript CG8591-RA 0.067
E(var)3-9 Enhancer of variegation 3-9 0.064
lid little imaginal discs 0.063
Rpd3 CG7471 gene product from transcript CG7471-RA 0.062
Acf1 ATP-dependent chromatin assembly factor large subunit 0.061
pUf68 poly U binding factor 68kD 0.058
Su(var)2-HP2 CG12864 gene product from transcript CG12864-RB 0.052
kis kismet 0.051
Cap-G CG34438 gene product from transcript CG34438-RF 0.046
dhd deadhead 0.042
JIL-1 CG6297 gene product from transcript CG6297-RA 0.041
pzg putzig 0.040
Trl Trithorax-like 0.040
orb oo18 RNA-binding protein 0.040
wapl wings apart-like 0.039
msl-3 male-specific lethal 3 0.039
Ets97D Ets at 97D 0.037
enok enoki mushroom 0.035
mael maelstrom 0.032
krimp krimper 0.031
zpg zero population growth 0.030
CG4771 CG4771 gene product from transcript CG4771-RA 0.028
CG13581 CG13581 gene product from transcript CG13581-RA 0.027
D19A CG10269 gene product from transcript CG10269-RA 0.027
fs(1)Yb female sterile (1) Yb 0.027
CG12256 CG12256 gene product from transcript CG12256-RA 0.026
aub aubergine 0.025
mus301 mutagen-sensitive 301 0.025
CG14625 CG14625 gene product from transcript CG14625-RB 0.025
bw brown 0.024
ewg erect wing 0.024
rhi rhino 0.023
CG5146 CG5146 gene product from transcript CG5146-RA 0.023
stil stand still 0.022
CG2469 CG2469 gene product from transcript CG2469-RB 0.022
Dap160 Dynamin associated protein 160 0.022
sbb scribbler 0.022
CG14183 CG14183 gene product from transcript CG14183-RA 0.022
e(y)3 enhancer of yellow 3 0.021
Dcr-1 Dicer-1 0.021
Wnt5 Wnt oncogene analog 5 0.021
Fs(2)Ket Female sterile (2) Ketel 0.020
Mekk1 CG7717 gene product from transcript CG7717-RB 0.020
polybromo CG11375 gene product from transcript CG11375-RA 0.020
Nf-YA Nuclear factor Y-box A 0.020
CG16742 CG16742 gene product from transcript CG16742-RA 0.019
Ino80 CG31212 gene product from transcript CG31212-RA 0.019
hyd hyperplastic discs 0.019
DnaJ-1 DnaJ-like-1 0.019
pie pineapple eye 0.019
Rbf Retinoblastoma-family protein 0.019
Nf-YB Nuclear factor Y-box B 0.018
Hira CG12153 gene product from transcript CG12153-RA 0.018
Su(z)2 Suppressor of zeste 2 0.018
Dhc64C Dynein heavy chain 64C 0.018
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.018
ph-d polyhomeotic distal 0.018
wts warts 0.018
ovo CG6824 gene product from transcript CG6824-RE 0.017
por porcupine 0.017
Sir2 CG5216 gene product from transcript CG5216-RA 0.016
Hcf Host cell factor 0.016
tna tonalli 0.016
ftz-f1 ftz transcription factor 1 0.016
mtrm matrimony 0.016
l(2)05714 lethal (2) 05714 0.016
Taf1 TBP-associated factor 1 0.016
CG12253 CG12253 gene product from transcript CG12253-RA 0.016
Ravus CG15889 gene product from transcript CG15889-RA 0.015
CG13472 CG13472 gene product from transcript CG13472-RA 0.015
ranshi CG9793 gene product from transcript CG9793-RA 0.015
Hr39 Hormone receptor-like in 39 0.015
Taf4 TBP-associated factor 4 0.015
Adf1 Adh transcription factor 1 0.015
fend forked end 0.015
abo abnormal oocyte 0.015
CG9925 CG9925 gene product from transcript CG9925-RA 0.014
Rbp1 RNA-binding protein 1 0.014
CG8079 CG8079 gene product from transcript CG8079-RA 0.014
His2Av Histone H2A variant 0.014
simj simjang 0.014
mor moira 0.014
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Homo sapiens
Name Description Probability Func Analog Organism
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.777
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.710
CBX1 chromobox homolog 1 0.195
SP1 Sp1 transcription factor 0.134
EED embryonic ectoderm development 0.110
CBX5 chromobox homolog 5 0.107
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.060
RERE arginine-glutamic acid dipeptide (RE) repeats 0.048
LBR lamin B receptor 0.035
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.032
MEN1 multiple endocrine neoplasia I 0.032
EZH2 enhancer of zeste homolog 2 (Drosophila) 0.032
CHD4 chromodomain helicase DNA binding protein 4 0.024
MBD1 methyl-CpG binding domain protein 1 0.019
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.017
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.016
HIST1H3B histone cluster 1, H3b 0.014
SETD1A SET domain containing 1A 0.014
SMC1A structural maintenance of chromosomes 1A 0.013
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.013
HDAC1 histone deacetylase 1 0.011
DUT deoxyuridine triphosphatase 0.011
ADNP activity-dependent neuroprotector homeobox 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ssrp1 structure specific recognition protein 1 0.039
Bat1 HLA-B associated transcript 1 0.021
Errfi1 ERBB receptor feedback inhibitor 1 0.014
Rbm42 RNA binding motif protein 42 0.013
Hnrnpr heterogeneous nuclear ribonucleoprotein R 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism