The network for 'citrate metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

citrate metabolic process

The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle.

Mus musculus
Name Description Probability Func Analog Organism
Stat5a signal transducer and activator of transcription 5A 1.000
Stat5b signal transducer and activator of transcription 5B 0.999
Cyc1 cytochrome c-1 0.993
Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 0.992
Mdh2 malate dehydrogenase 2, NAD (mitochondrial) 0.989
Cs citrate synthase 0.988
Aco2 aconitase 2, mitochondrial 0.981
Irf9 interferon regulatory factor 9 0.978
Ndufa9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 0.970
Ndufv1 NADH dehydrogenase (ubiquinone) flavoprotein 1 0.957
Stat3 signal transducer and activator of transcription 3 0.952
Esr1 estrogen receptor 1 (alpha) 0.882
Lepr leptin receptor 0.868
Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit 0.826
Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 0.805
Fh1 fumarate hydratase 1 0.797
Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 0.786
Stat1 signal transducer and activator of transcription 1 0.698
Uqcrc2 ubiquinol cytochrome c reductase core protein 2 0.661
Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.657
Ghr growth hormone receptor 0.631
Il6st interleukin 6 signal transducer 0.574
Sdhd succinate dehydrogenase complex, subunit D, integral membrane protein 0.561
Ndufb6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 0.548
Suclg1 succinate-CoA ligase, GDP-forming, alpha subunit 0.528
Foxp3 forkhead box P3 0.512
Trp53 transformation related protein 53 0.504
Ar androgen receptor 0.496
Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.482
Ndufs7 NADH dehydrogenase (ubiquinone) Fe-S protein 7 0.477
Ndufs2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 0.453
Lep leptin 0.440
Kit kit oncogene 0.422
Ndufb5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 0.347
Atp5o ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 0.344
Trim21 tripartite motif-containing 21 0.339
Stat6 signal transducer and activator of transcription 6 0.327
Ogdh oxoglutarate dehydrogenase (lipoamide) 0.321
Stat2 signal transducer and activator of transcription 2 0.259
Il1r1 interleukin 1 receptor, type I 0.249
Tgfb1 transforming growth factor, beta 1 0.205
Idh3a isocitrate dehydrogenase 3 (NAD+) alpha 0.199
Sdhc succinate dehydrogenase complex, subunit C, integral membrane protein 0.198
Ahr aryl-hydrocarbon receptor 0.195
Sin3a transcriptional regulator, SIN3A (yeast) 0.188
Samm50 sorting and assembly machinery component 50 homolog (S. cerevisiae) 0.184
Ndufv2 NADH dehydrogenase (ubiquinone) flavoprotein 2 0.170
Trap1 TNF receptor-associated protein 1 0.166
Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 0.160
Ndufa10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10 0.160
Irgm2 immunity-related GTPase family M member 2 0.159
Il4ra interleukin 4 receptor, alpha 0.158
Ndufab1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 0.151
Tapbp TAP binding protein 0.134
Egln3 EGL nine homolog 3 (C. elegans) 0.128
Myd88 myeloid differentiation primary response gene 88 0.118
Idh3b isocitrate dehydrogenase 3 (NAD+) beta 0.116
Cox15 COX15 homolog, cytochrome c oxidase assembly protein (yeast) 0.112
1300001I01Rik RIKEN cDNA 1300001I01 gene 0.110
Idh3g isocitrate dehydrogenase 3 (NAD+), gamma 0.103
Lgals9 lectin, galactose binding, soluble 9 0.103
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.101
Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.099
Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 0.098
Coq7 demethyl-Q 7 0.097
Pparg peroxisome proliferator activated receptor gamma 0.096
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.094
Parp14 poly (ADP-ribose) polymerase family, member 14 0.093
Il10 interleukin 10 0.091
Igtp interferon gamma induced GTPase 0.089
Ifnar2 interferon (alpha and beta) receptor 2 0.089
Prlr prolactin receptor 0.086
Nckap1l NCK associated protein 1 like 0.085
Vdac1 voltage-dependent anion channel 1 0.083
Igf1 insulin-like growth factor 1 0.082
Tsc2 tuberous sclerosis 2 0.078
Afg3l2 AFG3(ATPase family gene 3)-like 2 (yeast) 0.076
Uba7 ubiquitin-like modifier activating enzyme 7 0.075
Adar adenosine deaminase, RNA-specific 0.073
Coq5 coenzyme Q5 homolog, methyltransferase (yeast) 0.073
Ncoa3 nuclear receptor coactivator 3 0.071
Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.068
Irgm1 immunity-related GTPase family M member 1 0.068
Nfil3 nuclear factor, interleukin 3, regulated 0.068
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.067
Siah2 seven in absentia 2 0.064
Il6 interleukin 6 0.064
Gnrh1 gonadotropin releasing hormone 1 0.064
Usp18 ubiquitin specific peptidase 18 0.063
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.062
Pnpla2 patatin-like phospholipase domain containing 2 0.062
Ndufs3 NADH dehydrogenase (ubiquinone) Fe-S protein 3 0.061
Mavs mitochondrial antiviral signaling protein 0.061
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.060
Cav1 caveolin 1, caveolae protein 0.058
H2-K1 histocompatibility 2, K1, K region 0.055
Cd28 CD28 antigen 0.055
Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 0.054
Cox5a cytochrome c oxidase, subunit Va 0.054
Acat1 acetyl-Coenzyme A acetyltransferase 1 0.052
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
PyK Pyruvate kinase 0.124
blw bellwether 0.069
CG3731 CG3731 gene product from transcript CG3731-RA 0.063
l(1)G0334 lethal (1) G0334 0.061
CG6439 CG6439 gene product from transcript CG6439-RA 0.054
ND42 NADH:ubiquinone reductase 42kD subunit precursor 0.049
CG5261 CG5261 gene product from transcript CG5261-RB 0.040
Acon Aconitase 0.037
CG8036 CG8036 gene product from transcript CG8036-RB 0.034
Mpcp Mitochondrial phosphate carrier protein 0.034
ND75 NADH:ubiquinone reductase 75kD subunit precursor 0.031
l(1)G0156 lethal (1) G0156 0.030
skap skpA associated protein 0.029
VhaSFD Vacuolar H[+]-ATPase SFD subunit 0.028
Eno Enolase 0.025
e(y)3 enhancer of yellow 3 0.023
CG5214 CG5214 gene product from transcript CG5214-RA 0.021
CG7920 CG7920 gene product from transcript CG7920-RA 0.021
CG7430 CG7430 gene product from transcript CG7430-RA 0.019
CG1746 CG1746 gene product from transcript CG1746-RA 0.017
CG9140 CG9140 gene product from transcript CG9140-RA 0.017
vig vasa intronic gene 0.016
ttk tramtrack 0.015
CG14290 CG14290 gene product from transcript CG14290-RB 0.015
CycG Cyclin G 0.015
Cortactin CG3637 gene product from transcript CG3637-RA 0.015
CG9399 CG9399 gene product from transcript CG9399-RC 0.014
inx2 innexin 2 0.014
sea scheggia 0.014
CG12140 CG12140 gene product from transcript CG12140-RA 0.014
CG5028 CG5028 gene product from transcript CG5028-RB 0.014
CG11876 CG11876 gene product from transcript CG11876-RA 0.013
SdhB Succinate dehydrogenase B 0.013
CG9090 CG9090 gene product from transcript CG9090-RA 0.013
ATPsyn-gamma ATP synthase-gamma chain 0.013
gt giant 0.013
CG12091 CG12091 gene product from transcript CG12091-RA 0.013
cno canoe 0.013
CG5703 CG5703 gene product from transcript CG5703-RA 0.013
Alas Aminolevulinate synthase 0.013
CG12162 CG12162 gene product from transcript CG12162-RA 0.012
CG4774 CG4774 gene product from transcript CG4774-RB 0.012
Gdh Glutamate dehydrogenase 0.011
CG4538 CG4538 gene product from transcript CG4538-RA 0.011
Cap-G CG34438 gene product from transcript CG34438-RF 0.011
Dp1 Dodeca-satellite-binding protein 1 0.011
Act79B Actin 79B 0.011
CG5903 CG5903 gene product from transcript CG5903-RA 0.011
SuUR Suppressor of Under-Replication 0.011
SdhA Succinate dehydrogenase A 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
HDAC2 histone deacetylase 2 0.999
HDAC1 histone deacetylase 1 0.998
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 0.823
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 0.778
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.712
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.494
NCAPG non-SMC condensin I complex, subunit G 0.457
ACO2 aconitase 2, mitochondrial 0.414
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) 0.387
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.366
DLAT dihydrolipoamide S-acetyltransferase 0.357
INSR insulin receptor 0.312
PFDN1 prefoldin subunit 1 0.293
PDHX pyruvate dehydrogenase complex, component X 0.275
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.275
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 0.271
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.266
USPL1 ubiquitin specific peptidase like 1 0.265
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.252
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.244
NCAPD2 non-SMC condensin I complex, subunit D2 0.243
PDHB pyruvate dehydrogenase (lipoamide) beta 0.236
FH fumarate hydratase 0.213
C3orf15 chromosome 3 open reading frame 15 0.210
GOT1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 0.210
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.168
EGFR epidermal growth factor receptor 0.160
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 0.159
PTPRB protein tyrosine phosphatase, receptor type, B 0.152
RBBP4 retinoblastoma binding protein 4 0.129
HDAC3 histone deacetylase 3 0.121
JAK2 Janus kinase 2 0.119
AFG3L2 AFG3 ATPase family gene 3-like 2 (S. cerevisiae) 0.106
HADH hydroxyacyl-CoA dehydrogenase 0.106
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.094
BCAR1 breast cancer anti-estrogen resistance 1 0.091
SUCLG1 succinate-CoA ligase, alpha subunit 0.086
MTA3 metastasis associated 1 family, member 3 0.078
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.077
STAP2 signal transducing adaptor family member 2 0.069
IL2RB interleukin 2 receptor, beta 0.068
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.060
OXA1L oxidase (cytochrome c) assembly 1-like 0.060
TUBA1A tubulin, alpha 1a 0.055
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.053
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 0.051
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.050
CUX1 cut-like homeobox 1 0.049
PTPN9 protein tyrosine phosphatase, non-receptor type 9 0.049
GPI glucose-6-phosphate isomerase 0.048
C21orf33 chromosome 21 open reading frame 33 0.045
MTA2 metastasis associated 1 family, member 2 0.045
CHD4 chromodomain helicase DNA binding protein 4 0.044
PRKCA protein kinase C, alpha 0.042
NFS1 NFS1 nitrogen fixation 1 homolog (S. cerevisiae) 0.037
JAK1 Janus kinase 1 0.036
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.036
COQ9 coenzyme Q9 homolog (S. cerevisiae) 0.033
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.032
CTTN cortactin 0.031
SOCS2 suppressor of cytokine signaling 2 0.031
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.030
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 0.029
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.029
RBBP7 retinoblastoma binding protein 7 0.027
TXN2 thioredoxin 2 0.026
PRMT2 protein arginine methyltransferase 2 0.026
FAF1 Fas (TNFRSF6) associated factor 1 0.024
ADRBK1 adrenergic, beta, receptor kinase 1 0.024
MYCBP c-myc binding protein 0.024
PURA purine-rich element binding protein A 0.024
STARD7 StAR-related lipid transfer (START) domain containing 7 0.023
SAMM50 sorting and assembly machinery component 50 homolog (S. cerevisiae) 0.022
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.022
IRS1 insulin receptor substrate 1 0.021
SIRT2 sirtuin 2 0.021
MIPEP mitochondrial intermediate peptidase 0.021
DUSP7 dual specificity phosphatase 7 0.021
ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) 0.021
MECR mitochondrial trans-2-enoyl-CoA reductase 0.021
LRRC47 leucine rich repeat containing 47 0.021
EPOR erythropoietin receptor 0.020
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.020
EXT2 exostosin 2 0.020
GATAD2A GATA zinc finger domain containing 2A 0.019
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.019
E2F3 E2F transcription factor 3 0.019
GHR growth hormone receptor 0.019
E2F2 E2F transcription factor 2 0.018
MFN2 mitofusin 2 0.018
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.018
GPD1L glycerol-3-phosphate dehydrogenase 1-like 0.018
UQCRC1 ubiquinol-cytochrome c reductase core protein I 0.018
UQCRC2 ubiquinol-cytochrome c reductase core protein II 0.017
RCOR1 REST corepressor 1 0.017
KAT2B K(lysine) acetyltransferase 2B 0.017
AHR aryl hydrocarbon receptor 0.016
LAT linker for activation of T cells 0.016
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.016
GATAD2B GATA zinc finger domain containing 2B 0.016
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Rattus norvegicus
Name Description Probability Func Analog Organism
Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 0.938
Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.919
Idh3B isocitrate dehydrogenase 3 (NAD+) beta 0.897
Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.651
Cyc1 cytochrome c-1 0.555
Aco2 aconitase 2, mitochondrial 0.477
Fh1 fumarate hydratase 1 0.448
Timm17a translocase of inner mitochondrial membrane 17 homolog A (yeast) 0.386
Ndufv1 NADH dehydrogenase (ubiquinone) flavoprotein 1 0.332
Ndufs2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 0.278
Atp5b ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.197
Mdh2 malate dehydrogenase 2, NAD (mitochondrial) 0.189
Slc25a3 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 0.138
Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 0.096
Adk adenosine kinase 0.092
Sdhd succinate dehydrogenase complex, subunit D, integral membrane protein 0.078
Ndufs3 NADH dehydrogenase (ubiquinone) Fe-S protein 3 0.075
Gfm1 G elongation factor, mitochondrial 1 0.073
Idh3g isocitrate dehydrogenase 3 (NAD), gamma 0.062
Sdhc succinate dehydrogenase complex, subunit C, integral membrane protein 0.054
Acat1 acetyl-coenzyme A acetyltransferase 1 0.049
Mdh1 malate dehydrogenase 1, NAD (soluble) 0.045
Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 0.044
Slc25a11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 0.039
Acat3 acetyl-Coenzyme A acetyltransferase 3 0.039
Ghitm growth hormone inducible transmembrane protein 0.033
Vdac2 voltage-dependent anion channel 2 0.031
Fasn fatty acid synthase 0.031
Pfkm phosphofructokinase, muscle 0.028
Auh AU RNA binding protein/enoyl-coenzyme A hydratase 0.027
Ndufb8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8 0.027
Hadhb hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit 0.025
Aldh6a1 aldehyde dehydrogenase 6 family, member A1 0.021
Vdac1 voltage-dependent anion channel 1 0.020
Mccc2 methylcrotonoyl-Coenzyme A carboxylase 2 (beta) 0.018
Cs citrate synthase 0.018
Dlst dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 0.018
RGD1302996 hypothetical protein MGC:15854 0.017
Akr1c14 aldo-keto reductase family 1, member C14 0.015
Got1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 0.015
Ociad1 OCIA domain containing 1 0.014
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.014
Suclg1 succinate-CoA ligase, alpha subunit 0.014
Tecr trans-2,3-enoyl-CoA reductase 0.014
Gpam glycerol-3-phosphate acyltransferase, mitochondrial 0.014
Pde4dip phosphodiesterase 4D interacting protein 0.013
Slc25a4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 0.013
Vegfa vascular endothelial growth factor A 0.013
Atp5g3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9) 0.012
Atp6v1e1 ATPase, H+ transporting, lysosomal V1 subunit E1 0.011
Slc25a12 solute carrier family 25 (mitochondrial carrier, Aralar), member 12 0.011
Isoc1 isochorismatase domain containing 1 0.011
Nnt nicotinamide nucleotide transhydrogenase 0.010
Sqle squalene epoxidase 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism