The network for 'positive regulation of mesenchymal cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of mesenchymal cell proliferation

The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.

Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 1.000
Shh sonic hedgehog 1.000
Bmp4 bone morphogenetic protein 4 1.000
Pax3 paired box gene 3 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Pitx2 paired-like homeodomain transcription factor 2 0.999
Fgf10 fibroblast growth factor 10 0.999
Tbx3 T-box 3 0.998
Sox9 SRY-box containing gene 9 0.998
Gli2 GLI-Kruppel family member GLI2 0.997
Fgf8 fibroblast growth factor 8 0.996
Foxc1 forkhead box C1 0.995
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.992
Meox2 mesenchyme homeobox 2 0.988
Otx2 orthodenticle homolog 2 (Drosophila) 0.985
Tgfb2 transforming growth factor, beta 2 0.984
Nos3 nitric oxide synthase 3, endothelial cell 0.984
Zeb1 zinc finger E-box binding homeobox 1 0.973
Pax2 paired box gene 2 0.972
Chrd chordin 0.971
Prrx1 paired related homeobox 1 0.969
Fgfr1 fibroblast growth factor receptor 1 0.967
Rarg retinoic acid receptor, gamma 0.964
Wnt3a wingless-related MMTV integration site 3A 0.959
Trp53 transformation related protein 53 0.947
Tgfbr2 transforming growth factor, beta receptor II 0.947
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.943
Nodal nodal 0.935
Sox7 SRY-box containing gene 7 0.923
Foxc2 forkhead box C2 0.923
Pten phosphatase and tensin homolog 0.907
Twist2 twist homolog 2 (Drosophila) 0.899
Hoxa1 homeobox A1 0.899
Pitx1 paired-like homeodomain transcription factor 1 0.888
Ctnnb1 catenin (cadherin associated protein), beta 1 0.880
Isl1 ISL1 transcription factor, LIM/homeodomain 0.860
Prrx2 paired related homeobox 2 0.855
Tbx1 T-box 1 0.829
Sox2 SRY-box containing gene 2 0.824
Vegfa vascular endothelial growth factor A 0.822
Msx1 homeobox, msh-like 1 0.817
Wt1 Wilms tumor 1 homolog 0.810
Apc adenomatosis polyposis coli 0.809
Dlx5 distal-less homeobox 5 0.794
Pax6 paired box gene 6 0.793
Smad6 MAD homolog 6 (Drosophila) 0.788
Col1a1 collagen, type I, alpha 1 0.766
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.763
Msx2 homeobox, msh-like 2 0.751
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.739
Ret ret proto-oncogene 0.738
Bmp7 bone morphogenetic protein 7 0.727
Alx4 aristaless-like homeobox 4 0.719
Acvr1 activin A receptor, type 1 0.715
Hand1 heart and neural crest derivatives expressed transcript 1 0.696
Smo smoothened homolog (Drosophila) 0.684
Foxf1a forkhead box F1a 0.679
Eya1 eyes absent 1 homolog (Drosophila) 0.675
Lrp6 low density lipoprotein receptor-related protein 6 0.670
Wnt4 wingless-related MMTV integration site 4 0.656
Tcfap2a transcription factor AP-2, alpha 0.652
Eng endoglin 0.646
Gata4 GATA binding protein 4 0.645
Gsc goosecoid homeobox 0.602
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.592
Sox11 SRY-box containing gene 11 0.583
Pou3f3 POU domain, class 3, transcription factor 3 0.573
Zic3 zinc finger protein of the cerebellum 3 0.563
Ptprb protein tyrosine phosphatase, receptor type, B 0.563
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.562
Runx2 runt related transcription factor 2 0.556
Flt4 FMS-like tyrosine kinase 4 0.553
Gdnf glial cell line derived neurotrophic factor 0.550
Gata6 GATA binding protein 6 0.547
Snai1 snail homolog 1 (Drosophila) 0.543
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.541
Tbx15 T-box 15 0.528
Tbx2 T-box 2 0.515
Rarb retinoic acid receptor, beta 0.505
Egfr epidermal growth factor receptor 0.499
Hand2 heart and neural crest derivatives expressed transcript 2 0.496
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.490
Pkd1 polycystic kidney disease 1 homolog 0.488
Kdr kinase insert domain protein receptor 0.482
Sox18 SRY-box containing gene 18 0.478
Bmpr1a bone morphogenetic protein receptor, type 1A 0.462
Hoxd11 homeobox D11 0.458
Pax7 paired box gene 7 0.457
Hoxa13 homeobox A13 0.438
Rara retinoic acid receptor, alpha 0.415
Lef1 lymphoid enhancer binding factor 1 0.405
Lhx1 LIM homeobox protein 1 0.402
Foxb1 forkhead box B1 0.393
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.391
Wnt11 wingless-related MMTV integration site 11 0.381
Ptch1 patched homolog 1 0.379
Ntf3 neurotrophin 3 0.370
Bdnf brain derived neurotrophic factor 0.359
Trp63 transformation related protein 63 0.348
She src homology 2 domain-containing transforming protein E 0.344
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
shha sonic hedgehog a 0.910
boc brother of CDO 0.910
ptch1 patched 1 0.875
tbx1 T-box 1 0.803
smo smoothened homolog (Drosophila) 0.774
gli1 GLI-Kruppel family member 1 0.710
ptch2 patched 2 0.677
ihha Indian hedgehog homolog a 0.634
twist3 twist3 0.603
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.597
hoxd4a homeo box D4a 0.574
sulf1 sulfatase 1 0.569
dlx5a distal-less homeobox gene 5a 0.452
bmp4 bone morphogenetic protein 4 0.440
prrx1a paired related homeobox 1a 0.411
grem2 gremlin 2, cysteine knot superfamily 0.409
chd chordin 0.408
wu:fv91b12 wu:fv91b12 0.400
ndr2 nodal-related 2 0.394
gli2a GLI-Kruppel family member GLI2a 0.372
bmp2b bone morphogenetic protein 2b 0.368
sema3aa semaphorin 3aa 0.366
dlx3b distal-less homeobox gene 3b 0.338
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.305
flh floating head 0.302
fn1 fibronectin 1 0.291
atoh1a atonal homolog 1a 0.286
jag1b jagged 1b 0.284
hoxb5b homeo box B5b 0.277
wif1 wnt inhibitory factor 1 0.276
eya1 eyes absent homolog 1 0.270
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.269
foxa1 forkhead box A1 0.259
col8a1a collagen, type VIII, alpha 1a 0.253
foxi1 forkhead box I1 0.242
mib mind bomb 0.235
npnt nephronectin 0.227
fgf3 fibroblast growth factor 3 0.221
edn1 endothelin 1 0.217
alpi alkaline phosphatase, intestinal 0.214
notch3 notch homolog 3 0.207
nkx3.2 NK3 homeobox 2 0.206
plcg1 phospholipase C, gamma 1 0.189
fgf10a fibroblast growth factor 10a 0.188
pitx3 paired-like homeodomain transcription factor 3 0.182
twist1a twist1a 0.174
barx1 BarH-like homeobox 1 0.173
fgfr4 fibroblast growth factor receptor 4 0.169
wnt8b wingless-type MMTV integration site family, member 8b 0.155
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.155
hoxb6a homeo box B6a 0.150
rarga retinoic acid receptor gamma a 0.149
lef1 lymphocyte enhancer binding factor 1 0.147
pmp22a peripheral myelin protein 22a 0.144
mab21l2 mab-21-like 2 0.140
vangl2 vang-like 2 (van gogh, Drosophila) 0.139
hoxa5a homeo box A5a 0.137
dlx1a distal-less homeobox gene 1a 0.134
nkx2.3 NK2 transcription factor related 3 0.133
meis3 myeloid ecotropic viral integration site 3 0.132
smad1 MAD homolog 1 (Drosophila) 0.127
myod1 myogenic differentiation 1 0.121
dcn decorin 0.121
hand2 heart and neural crest derivatives expressed transcript 2 0.116
mych myelocytomatosis oncogene homolog 0.116
notch2 notch homolog 2 0.113
six2a sine oculis-related homeobox 2a 0.113
wnt5b wingless-type MMTV integration site family, member 5b 0.109
gpc4 glypican 4 0.108
snai1b snail homolog 1b (Drosophila) 0.106
ptgs1 prostaglandin-endoperoxide synthase 1 0.105
hoxc1a homeo box C1a 0.104
fli1a friend leukemia integration 1a 0.104
hoxc4a homeo box C4a 0.100
hoxa9b homeo box A9b 0.100
tp73 tumor protein p73 0.097
pcdh18a protocadherin 18a 0.095
notch1b notch homolog 1b 0.094
six4b sine oculis homeobox homolog 4b 0.093
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.088
acvr1l activin A receptor, type I like 0.087
mef2ca myocyte enhancer factor 2ca 0.086
tnfsf10l3 tumor necrosis factor (ligand) superfamily, member 10 like 3 0.085
satb2 SATB homeobox 2 0.083
bmp2a bone morphogenetic protein 2a 0.082
wnt4a wingless-type MMTV integration site family, member 4a 0.082
irx5a iroquois homeobox protein 5a 0.081
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.080
hoxb4a homeo box B4a 0.080
nkx2.1a NK2 homeobox 1a 0.079
zgc:158345 zgc:158345 0.079
hoxa13b homeo box A13b 0.079
sox1a SRY-box containing gene 1a 0.076
pdzrn3 PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3 0.076
prrx1b paired related homeobox 1b 0.076
hoxd11a homeo box D11a 0.076
mef2d myocyte enhancer factor 2d 0.074
mmp15b matrix metallopeptidase 15b 0.073
tbx18 T-box 18 0.072
hoxa2b homeo box A2b 0.070
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 1.000
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.000
INSR insulin receptor 0.999
PLCG1 phospholipase C, gamma 1 0.997
IGF1R insulin-like growth factor 1 receptor 0.994
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.981
GRB10 growth factor receptor-bound protein 10 0.978
BMP2 bone morphogenetic protein 2 0.975
FGF1 fibroblast growth factor 1 (acidic) 0.967
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.945
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.812
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.785
APC adenomatous polyposis coli 0.765
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.703
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.690
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.670
APP amyloid beta (A4) precursor protein 0.665
MAX MYC associated factor X 0.664
FGF10 fibroblast growth factor 10 0.637
BMP1 bone morphogenetic protein 1 0.618
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.615
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.599
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.598
VEGFA vascular endothelial growth factor A 0.565
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.539
CDH5 cadherin 5, type 2 (vascular endothelium) 0.528
PDGFC platelet derived growth factor C 0.498
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.497
SATB2 SATB homeobox 2 0.493
SMAD7 SMAD family member 7 0.453
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.433
NRP1 neuropilin 1 0.424
CAV1 caveolin 1, caveolae protein, 22kDa 0.407
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.373
CAV2 caveolin 2 0.360
FGFR2 fibroblast growth factor receptor 2 0.353
FGF2 fibroblast growth factor 2 (basic) 0.320
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.311
HOXD9 homeobox D9 0.285
KRT5 keratin 5 0.281
FGF7 fibroblast growth factor 7 0.272
PSEN1 presenilin 1 0.264
CTNND1 catenin (cadherin-associated protein), delta 1 0.243
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.217
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.211
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.211
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.199
FSTL1 follistatin-like 1 0.199
SMAD3 SMAD family member 3 0.199
CAPRIN2 caprin family member 2 0.190
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.186
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.184
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.165
FZD1 frizzled homolog 1 (Drosophila) 0.162
KRT6C keratin 6C 0.154
BTRC beta-transducin repeat containing 0.154
GAB1 GRB2-associated binding protein 1 0.148
TGFB3 transforming growth factor, beta 3 0.147
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.146
PGF placental growth factor 0.145
ZMYND11 zinc finger, MYND-type containing 11 0.144
FRS2 fibroblast growth factor receptor substrate 2 0.139
SMAD2 SMAD family member 2 0.138
AXIN1 axin 1 0.135
GAB2 GRB2-associated binding protein 2 0.126
YAP1 Yes-associated protein 1 0.120
PRKCA protein kinase C, alpha 0.116
PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.116
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.101
SMAD6 SMAD family member 6 0.101
GSK3B glycogen synthase kinase 3 beta 0.099
LRRK2 leucine-rich repeat kinase 2 0.096
ENG endoglin 0.092
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.091
EPAS1 endothelial PAS domain protein 1 0.090
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) 0.087
MDFI MyoD family inhibitor 0.082
BIN1 bridging integrator 1 0.082
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.078
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.072
FGFR1 fibroblast growth factor receptor 1 0.071
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 0.069
WNT3A wingless-type MMTV integration site family, member 3A 0.069
PID1 phosphotyrosine interaction domain containing 1 0.067
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.067
JAG1 jagged 1 0.066
FZD7 frizzled homolog 7 (Drosophila) 0.064
SH2B1 SH2B adaptor protein 1 0.064
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.062
SIRT1 sirtuin 1 0.062
SOCS5 suppressor of cytokine signaling 5 0.061
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.061
TCF4 transcription factor 4 0.061
EYA1 eyes absent homolog 1 (Drosophila) 0.060
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.059
SHB Src homology 2 domain containing adaptor protein B 0.058
TGFB1 transforming growth factor, beta 1 0.058
BMP4 bone morphogenetic protein 4 0.057
STAT5B signal transducer and activator of transcription 5B 0.056
HSPG2 heparan sulfate proteoglycan 2 0.055
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Rattus norvegicus
Name Description Probability Func Analog Organism
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.599
Myh9 myosin, heavy chain 9, non-muscle 0.541
Myo1c myosin IC 0.533
Unc5b unc-5 homolog B (C. elegans) 0.517
LOC100365106 rCG32755-like 0.369
Akt2 v-akt murine thymoma viral oncogene homolog 2 0.353
Socs3 suppressor of cytokine signaling 3 0.341
Igfbp5 insulin-like growth factor binding protein 5 0.254
Tgfbr2 transforming growth factor, beta receptor II 0.252
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.229
Prrx1 paired related homeobox 1 0.220
Rxra retinoid X receptor alpha 0.210
Acvr1 activin A receptor, type I 0.201
Clic4 chloride intracellular channel 4 0.200
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.192
Efnb1 ephrin B1 0.188
Rnf213 ring finger protein 213 0.185
Met met proto-oncogene 0.180
Arnt aryl hydrocarbon receptor nuclear translocator 0.178
Smad1 SMAD family member 1 0.177
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.176
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.165
Smad7 SMAD family member 7 0.165
Thbd thrombomodulin 0.161
Timp3 TIMP metallopeptidase inhibitor 3 0.148
Notch2 Notch homolog 2 (Drosophila) 0.147
Utrn utrophin 0.144
Map3k3 mitogen activated protein kinase kinase kinase 3 0.143
LOC100362108 poly (ADP-ribose) polymerase family, member 10 0.136
Nab1 Ngfi-A binding protein 1 0.136
Sirpa signal-regulatory protein alpha 0.129
Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 0.109
Lamc1 laminin, gamma 1 0.109
Fgfr1 Fibroblast growth factor receptor 1 0.100
Flt1 FMS-related tyrosine kinase 1 0.099
Zfp36 zinc finger protein 36 0.096
Glg1 golgi apparatus protein 1 0.096
St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.084
Irs1 insulin receptor substrate 1 0.083
Ltbr lymphotoxin beta receptor (TNFR superfamily, member 3) 0.083
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.081
Myo1d myosin ID 0.080
Olfml2b olfactomedin-like 2B 0.076
LOC100360403 ATP-binding cassette, sub-family C, member 9-like 0.076
Scarf2 scavenger receptor class F, member 2 0.075
Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 0.073
Soat1 sterol O-acyltransferase 1 0.072
Cmklr1 chemokine-like receptor 1 0.072
Junb jun B proto-oncogene 0.070
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.068
Elf1 E74-like factor 1 0.066
Tcfe2a transcription factor E2a 0.064
Hdac7 histone deacetylase 7 0.062
Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.061
Calcrl calcitonin receptor-like 0.061
Lims1 LIM and senescent cell antigen-like domains 1 0.061
Ptma prothymosin alpha 0.059
Ifi35 interferon-induced protein 35 0.059
Nos3 nitric oxide synthase 3, endothelial cell 0.057
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.056
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.055
Icam1 intercellular adhesion molecule 1 0.055
Elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast) 0.055
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.055
Fnbp1 formin binding protein 1 0.054
Msn moesin 0.054
Anpep alanyl (membrane) aminopeptidase 0.054
Hnrnpk heterogeneous nuclear ribonucleoprotein K 0.052
Rara retinoic acid receptor, alpha 0.052
Il6st interleukin 6 signal transducer 0.052
Ece1 endothelin converting enzyme 1 0.051
Smo smoothened homolog (Drosophila) 0.050
A2m alpha-2-macroglobulin 0.049
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.049
Igf2 insulin-like growth factor 2 0.049
Stat1 signal transducer and activator of transcription 1 0.049
Runx1 runt-related transcription factor 1 0.048
Ptpn1 protein tyrosine phosphatase, non-receptor type 1 0.046
Pcna proliferating cell nuclear antigen 0.046
Itga6 integrin, alpha 6 0.046
Gdf11 growth differentiation factor 11 0.045
Sell selectin L 0.045
LOC100362331 rCG59612-like 0.045
Itgb4 integrin, beta 4 0.044
Litaf lipopolysaccharide-induced TNF factor 0.044
Rassf9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 0.043
Sp110 SP110 nuclear body protein 0.042
Abcc9 ATP-binding cassette, subfamily C (CFTR/MRP), member 9 0.042
Trim25 tripartite motif-containing 25 0.042
Frmd4b FERM domain containing 4B 0.042
Pcdhgc3 protocadherin gamma subfamily C, 3 0.042
S1pr2 sphingosine-1-phosphate receptor 2 0.041
Galr2 galanin receptor 2 0.040
Irf1 interferon regulatory factor 1 0.039
Zfp94 zinc finger protein 94 0.039
Casq1 calsequestrin 1 (fast-twitch, skeletal muscle) 0.038
Tceb3 transcription elongation factor B (SIII), polypeptide 3 0.038
Vipr1 vasoactive intestinal peptide receptor 1 0.037
Gpam glycerol-3-phosphate acyltransferase, mitochondrial 0.037
Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.037
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism