The network for 'morphogenesis of a branching epithelium' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

morphogenesis of a branching epithelium

The process in which the anatomical structures of a branched epithelium are generated and organized.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Fgfr1 fibroblast growth factor receptor 1 1.000
Pax2 paired box gene 2 1.000
Rarg retinoic acid receptor, gamma 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Foxc1 forkhead box C1 0.999
Zeb1 zinc finger E-box binding homeobox 1 0.999
Pax8 paired box gene 8 0.999
Bmp4 bone morphogenetic protein 4 0.999
Eya1 eyes absent 1 homolog (Drosophila) 0.999
Foxc2 forkhead box C2 0.999
Hoxd11 homeobox D11 0.998
Bcl2 B-cell leukemia/lymphoma 2 0.998
Prrx1 paired related homeobox 1 0.997
Pitx2 paired-like homeodomain transcription factor 2 0.996
Pten phosphatase and tensin homolog 0.996
Ret ret proto-oncogene 0.995
Pbx1 pre B-cell leukemia transcription factor 1 0.995
Efnb2 ephrin B2 0.995
Rarb retinoic acid receptor, beta 0.995
Apc adenomatosis polyposis coli 0.995
Vegfa vascular endothelial growth factor A 0.995
Wt1 Wilms tumor 1 homolog 0.994
Ctnnb1 catenin (cadherin associated protein), beta 1 0.994
Pax3 paired box gene 3 0.994
Rara retinoic acid receptor, alpha 0.994
Fgf10 fibroblast growth factor 10 0.994
Trp53 transformation related protein 53 0.993
Fgfr3 fibroblast growth factor receptor 3 0.992
Ednra endothelin receptor type A 0.991
Gli2 GLI-Kruppel family member GLI2 0.991
Lef1 lymphoid enhancer binding factor 1 0.986
Fgf8 fibroblast growth factor 8 0.982
Hes1 hairy and enhancer of split 1 (Drosophila) 0.981
Sox7 SRY-box containing gene 7 0.981
Esr1 estrogen receptor 1 (alpha) 0.981
Nog noggin 0.979
Tcf21 transcription factor 21 0.979
Tgfb2 transforming growth factor, beta 2 0.978
Lhx1 LIM homeobox protein 1 0.978
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.977
Vangl2 vang-like 2 (van gogh, Drosophila) 0.977
Tgfbr2 transforming growth factor, beta receptor II 0.976
Dlx5 distal-less homeobox 5 0.974
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.971
Msx1 homeobox, msh-like 1 0.971
Sox2 SRY-box containing gene 2 0.970
Hoxa11 homeobox A11 0.967
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.967
Bmp7 bone morphogenetic protein 7 0.966
Gdnf glial cell line derived neurotrophic factor 0.962
Jag1 jagged 1 0.961
Hand2 heart and neural crest derivatives expressed transcript 2 0.961
Trp63 transformation related protein 63 0.960
Hoxa1 homeobox A1 0.959
Gbx2 gastrulation brain homeobox 2 0.955
Tbx3 T-box 3 0.954
Hoxd13 homeobox D13 0.944
Hand1 heart and neural crest derivatives expressed transcript 1 0.943
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.943
Epha4 Eph receptor A4 0.942
Ptk2 PTK2 protein tyrosine kinase 2 0.938
Hoxa3 homeobox A3 0.937
Hoxb3 homeobox B3 0.937
Fzd1 frizzled homolog 1 (Drosophila) 0.934
Hoxa5 homeobox A5 0.933
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.932
Smad6 MAD homolog 6 (Drosophila) 0.932
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.930
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.927
Wnt5a wingless-related MMTV integration site 5A 0.924
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.915
Rxra retinoid X receptor alpha 0.914
Emx2 empty spiracles homolog 2 (Drosophila) 0.912
Lamc1 laminin, gamma 1 0.910
Nkx2-1 NK2 homeobox 1 0.910
Egfr epidermal growth factor receptor 0.905
Meox2 mesenchyme homeobox 2 0.904
Tcfap2a transcription factor AP-2, alpha 0.904
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.903
Hoxa2 homeobox A2 0.900
Axl AXL receptor tyrosine kinase 0.889
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.883
Acvr1 activin A receptor, type 1 0.881
Vdr vitamin D receptor 0.880
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.878
Smad3 MAD homolog 3 (Drosophila) 0.877
Gas1 growth arrest specific 1 0.873
Lepr leptin receptor 0.867
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.866
Col4a2 collagen, type IV, alpha 2 0.864
Pou3f3 POU domain, class 3, transcription factor 3 0.863
Hoxd3 homeobox D3 0.861
Prrx2 paired related homeobox 2 0.860
Snai1 snail homolog 1 (Drosophila) 0.859
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.857
Phox2b paired-like homeobox 2b 0.853
Tbx1 T-box 1 0.852
Msx2 homeobox, msh-like 2 0.850
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
shha sonic hedgehog a 0.985
notch3 notch homolog 3 0.876
kdrl kinase insert domain receptor like 0.865
bmp4 bone morphogenetic protein 4 0.811
tbx1 T-box 1 0.764
wu:fv91b12 wu:fv91b12 0.690
traf4a tnf receptor-associated factor 4a 0.626
fn1 fibronectin 1 0.622
fbn2b fibrillin 2b 0.618
jag2 jagged 2 0.589
foxd3 forkhead box D3 0.552
hnf1ba HNF1 homeobox Ba 0.540
foxa2 forkhead box A2 0.409
hoxa13b homeo box A13b 0.390
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.376
jag1b jagged 1b 0.366
osr2 odd-skipped related 2 (Drosophila) 0.361
boc brother of CDO 0.350
aplnra apelin receptor a 0.342
dll4 delta-like 4 (Drosophila) 0.332
pitx3 paired-like homeodomain transcription factor 3 0.313
cxcr4a chemokine (C-X-C motif) receptor 4a 0.312
wnt5b wingless-type MMTV integration site family, member 5b 0.311
cdh1 cadherin 1, epithelial 0.279
wnt10a wingless-type MMTV integration site family, member 10a 0.276
wnt11 wingless-type MMTV integration site family, member 11 0.254
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.242
dlx2a distal-less homeobox gene 2a 0.234
sulf1 sulfatase 1 0.233
tp53 tumor protein p53 0.230
nrarpa notch-regulated ankyrin repeat protein a 0.226
pax2a paired box gene 2a 0.214
gli1 GLI-Kruppel family member 1 0.206
mmp2 matrix metalloproteinase 2 0.202
ptgs1 prostaglandin-endoperoxide synthase 1 0.200
mecom MDS1 and EVI1 complex locus 0.199
dld deltaD 0.199
myog myogenin 0.195
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.187
hs6st1a heparan sulfate 6-O-sulfotransferase 1a 0.181
fgfr2 fibroblast growth factor receptor 2 0.181
nrp1a neuropilin 1a 0.175
met met proto-oncogene (hepatocyte growth factor receptor) 0.173
pea3 ETS-domain transcription factor pea3 0.171
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.170
wnt3a wingless-type MMTV integration site family, member 3A 0.168
alcamb activated leukocyte cell adhesion molecule b 0.157
dlc deltaC 0.155
nrp2a neuropilin 2a 0.148
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.138
tll1 tolloid-like 1 0.134
hoxa9a homeo box A9a 0.130
wls wntless homolog (Drosophila) 0.128
sox2 SRY-box containing gene 2 0.127
cdh2 cadherin 2, neuronal 0.126
pax7a paired box gene 7a 0.121
twist1a twist1a 0.121
sfrp1a secreted frizzled-related protein 1a 0.119
efnb2a ephrin B2a 0.118
wnt3 wingless-type MMTV integration site family, member 3 0.111
hhex hematopoietically expressed homeobox 0.104
plcg1 phospholipase C, gamma 1 0.102
eng1a engrailed 1a 0.102
wt1a wilms tumor 1a 0.096
pdgfaa platelet-derived growth factor alpha a 0.094
elmo1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) 0.093
sema3fa semaphorin 3fa 0.091
hoxb3a homeo box B3a 0.089
hoxa11a homeo box A11a 0.088
slit3 slit (Drosophila) homolog 3 0.088
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.087
nkx2.2a NK2 transcription factor related 2a 0.087
hoxd10a homeo box D10a 0.081
edn1 endothelin 1 0.079
foxa3 forkhead box A3 0.077
evx2 even-skipped homeobox 2 0.077
cdx4 caudal type homeo box transcription factor 4 0.075
si:ch73-60e21.1 si:ch73-60e21.1 0.075
bmp2a bone morphogenetic protein 2a 0.074
igfbp3 insulin-like growth factor binding protein 3 0.073
wnt4a wingless-type MMTV integration site family, member 4a 0.073
smo smoothened homolog (Drosophila) 0.071
lef1 lymphocyte enhancer binding factor 1 0.070
twist3 twist3 0.070
gli2a GLI-Kruppel family member GLI2a 0.068
runx3 runt-related transcription factor 3 0.067
grem2 gremlin 2, cysteine knot superfamily 0.066
dusp6 dual specificity phosphatase 6 0.061
scube2 signal peptide, CUB domain, EGF-like 2 0.061
sema3aa semaphorin 3aa 0.057
dag1 dystroglycan 1 0.055
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.054
jam2b junctional adhesion molecule 2b 0.053
hoxd12a homeo box D12a 0.053
bmp2b bone morphogenetic protein 2b 0.053
she Src homology 2 domain containing E 0.053
rargb retinoic acid receptor, gamma b 0.052
acvrl1 activin A receptor type II-like 1 0.051
hoxd11a homeo box D11a 0.051
chd chordin 0.051
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Drosophila melanogaster
Name Description Probability Func Analog Organism
btl breathless 0.996
dpp decapentaplegic 0.993
arm armadillo 0.992
tkv thickveins 0.989
ptc patched 0.965
salm spalt major 0.956
pnt pointed 0.952
baz bazooka 0.929
Mad Mothers against dpp 0.910
wg wingless 0.905
stumps CG31317 gene product from transcript CG31317-RC 0.904
vvl ventral veins lacking 0.807
sd scalloped 0.788
mew multiple edematous wings 0.753
sr stripe 0.725
shi shibire 0.724
pio piopio 0.719
argos CG4531 gene product from transcript CG4531-RA 0.704
tgo tango 0.697
fu fused 0.694
rst roughest 0.665
shg shotgun 0.636
Fas2 Fasciclin 2 0.635
sgg shaggy 0.625
elB elbow B 0.607
Nsf2 NEM-sensitive fusion protein 2 0.591
jing CG9397 gene product from transcript CG9397-RI 0.558
spi spitz 0.556
ap apterous 0.552
sfl sulfateless 0.524
Egfr Epidermal growth factor receptor 0.503
ci cubitus interruptus 0.465
GckIII Germinal centre kinase III 0.460
msn misshapen 0.442
kni knirps 0.427
p120ctn Adherens junction protein p120 0.418
BicD Bicaudal D 0.388
lea leak 0.381
wkd whacked 0.363
put punt 0.358
Sra-1 specifically Rac1-associated protein 1 0.358
Cctgamma CG8977 gene product from transcript CG8977-RC 0.342
InR Insulin-like receptor 0.323
wdb widerborst 0.323
rl rolled 0.314
bsk basket 0.313
Adar Adenosine deaminase acting on RNA 0.308
Fhos CG42610 gene product from transcript CG42610-RC 0.300
pyd polychaetoid 0.296
DAAM Dishevelled Associated Activator of Morphogenesis 0.296
robo roundabout 0.288
shn schnurri 0.266
Moe Moesin 0.263
ex expanded 0.262
Hs6st Heparan sulfate 6-O-sulfotransferase 0.255
CG31048 CG31048 gene product from transcript CG31048-RB 0.252
dally division abnormally delayed 0.243
luna CG33473 gene product from transcript CG33473-RB 0.233
lola longitudinals lacking 0.232
eya eyes absent 0.231
sli slit 0.214
Rac1 CG2248 gene product from transcript CG2248-RA 0.209
per period 0.206
Mrtf Myocardin-related transcription factor 0.205
Gyc76C Guanylyl cyclase at 76C 0.203
aop anterior open 0.201
grh grainy head 0.200
Src42A Src oncogene at 42A 0.186
ik2 IkappaB kinase-like 2 0.183
osa CG7467 gene product from transcript CG7467-RD 0.183
sns sticks and stones 0.177
dsh dishevelled 0.177
vari varicose 0.174
Vhl von Hippel-Lindau 0.171
knk knickkopf 0.171
slou slouch 0.167
bnl branchless 0.164
H Hairless 0.161
Dad Daughters against dpp 0.159
cora coracle 0.153
Abl Abl tyrosine kinase 0.151
disco disconnected 0.149
beta-Spec beta Spectrin 0.146
sty sprouty 0.142
nkd naked cuticle 0.141
CtBP C-terminal Binding Protein 0.140
Ptp69D Protein tyrosine phosphatase 69D 0.140
ara araucan 0.135
fs(1)M3 female sterile (1) M3 0.133
smo smoothened 0.133
crb crumbs 0.132
dm diminutive 0.130
dp dumpy 0.129
par-6 CG5884 gene product from transcript CG5884-RA 0.128
LanB2 Laminin B2 0.124
trx trithorax 0.118
par-1 CG8201 gene product from transcript CG8201-RA 0.117
Pten CG5671 gene product from transcript CG5671-RB 0.116
Ser Serrate 0.108
Dll Distal-less 0.107
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 0.972
VEGFA vascular endothelial growth factor A 0.955
RARA retinoic acid receptor, alpha 0.943
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.931
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.849
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.838
FGF1 fibroblast growth factor 1 (acidic) 0.752
NRP1 neuropilin 1 0.694
CREBBP CREB binding protein 0.615
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.595
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.569
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.548
THBS1 thrombospondin 1 0.536
COL4A2 collagen, type IV, alpha 2 0.500
BMPR1A bone morphogenetic protein receptor, type IA 0.491
COL4A1 collagen, type IV, alpha 1 0.457
BCL2L1 BCL2-like 1 0.439
TIMP3 TIMP metallopeptidase inhibitor 3 0.426
FGFR1 fibroblast growth factor receptor 1 0.351
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.325
COL2A1 collagen, type II, alpha 1 0.311
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.303
TBX5 T-box 5 0.293
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.246
FGF10 fibroblast growth factor 10 0.245
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.237
FN1 fibronectin 1 0.230
NKX2-1 NK2 homeobox 1 0.213
GAS6 growth arrest-specific 6 0.212
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.211
JAG1 jagged 1 0.200
FGF2 fibroblast growth factor 2 (basic) 0.189
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.151
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.148
HNF4A hepatocyte nuclear factor 4, alpha 0.146
HOXA10 homeobox A10 0.145
RUNX1 runt-related transcription factor 1 0.140
NCOR2 nuclear receptor corepressor 2 0.137
PTK2 PTK2 protein tyrosine kinase 2 0.137
ITGB4 integrin, beta 4 0.136
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.135
MEIS1 Meis homeobox 1 0.124
COL4A4 collagen, type IV, alpha 4 0.120
PAX8 paired box 8 0.120
BMP7 bone morphogenetic protein 7 0.118
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.116
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.115
COL5A1 collagen, type V, alpha 1 0.112
SMN1 survival of motor neuron 1, telomeric 0.111
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.110
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.109
PGF placental growth factor 0.105
EFNA1 ephrin-A1 0.102
FSTL1 follistatin-like 1 0.102
MEIS2 Meis homeobox 2 0.102
PARVA parvin, alpha 0.101
FGF8 fibroblast growth factor 8 (androgen-induced) 0.098
GAB1 GRB2-associated binding protein 1 0.098
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.095
JDP2 Jun dimerization protein 2 0.088
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.079
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.078
EGR1 early growth response 1 0.078
FBXW11 F-box and WD repeat domain containing 11 0.077
TGFB2 transforming growth factor, beta 2 0.076
COL4A6 collagen, type IV, alpha 6 0.076
TM4SF1 transmembrane 4 L six family member 1 0.076
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.075
IQGAP1 IQ motif containing GTPase activating protein 1 0.073
PDGFC platelet derived growth factor C 0.071
MYOD1 myogenic differentiation 1 0.070
AR androgen receptor 0.070
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.069
STK3 serine/threonine kinase 3 0.066
PLAUR plasminogen activator, urokinase receptor 0.065
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.065
GSK3B glycogen synthase kinase 3 beta 0.064
FGF4 fibroblast growth factor 4 0.063
RB1 retinoblastoma 1 0.063
DUSP6 dual specificity phosphatase 6 0.063
HOXB5 homeobox B5 0.059
GATA4 GATA binding protein 4 0.059
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.058
BMPR1B bone morphogenetic protein receptor, type IB 0.057
LUM lumican 0.056
APC adenomatous polyposis coli 0.054
TGFB3 transforming growth factor, beta 3 0.054
STC1 stanniocalcin 1 0.051
PTPRB protein tyrosine phosphatase, receptor type, B 0.051
EGFR epidermal growth factor receptor 0.051
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.050
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.050
IGFBP5 insulin-like growth factor binding protein 5 0.048
PLAT plasminogen activator, tissue 0.047
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.046
IL8 interleukin 8 0.045
NOTCH3 notch 3 0.045
EGR3 early growth response 3 0.045
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.044
TNC tenascin C 0.044
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Rattus norvegicus
Name Description Probability Func Analog Organism
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.107
Unc5b unc-5 homolog B (C. elegans) 0.078
Fgfr2 fibroblast growth factor receptor 2 0.043
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.034
Myh9 myosin, heavy chain 9, non-muscle 0.028
Flt1 FMS-related tyrosine kinase 1 0.028
Gja5 gap junction protein, alpha 5 0.026
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.025
Utrn utrophin 0.024
Smad7 SMAD family member 7 0.024
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.021
Nos2 nitric oxide synthase 2, inducible 0.020
Ednra endothelin receptor type A 0.019
Foxe3 forkhead box E3 0.019
Irs1 insulin receptor substrate 1 0.017
Gata6 GATA binding protein 6 0.015
Nos3 nitric oxide synthase 3, endothelial cell 0.014
RGD1564327 similar to integrin alpha 8 0.014
Notch2 Notch homolog 2 (Drosophila) 0.013
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.013
LOC64038 sertolin 0.013
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.013
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.012
Mapk9 mitogen-activated protein kinase 9 0.012
Bmp6 bone morphogenetic protein 6 0.012
Mcam melanoma cell adhesion molecule 0.012
Prrx1 paired related homeobox 1 0.012
Lhx5 LIM homeobox 5 0.012
Tgfbr2 transforming growth factor, beta receptor II 0.011
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.011
Met met proto-oncogene 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism