IMP

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Homo sapiens

18 genes annotated in human

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regulation of notch signaling pathway

GO:0008593

Any process that modulates the frequency, rate or extent of the Notch signaling pathway.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of notch signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of notch signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
GRB2	growth factor receptor-bound protein 2	0.945
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.673
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.552
NOTCH1	notch 1	0.449	Fly
HDAC1	histone deacetylase 1	0.442	Worm
TAL1	T-cell acute lymphocytic leukemia 1	0.422
EGFR	epidermal growth factor receptor	0.384
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.375
CREBBP	CREB binding protein	0.356
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.326
SNX9	sorting nexin 9	0.315
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.276	Fly
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.236
SH3KBP1	SH3-domain kinase binding protein 1	0.224
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.204
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.161
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.160
DNM2	dynamin 2	0.148	Fly
LAT	linker for activation of T cells	0.137
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.136
SOS1	son of sevenless homolog 1 (Drosophila)	0.133
NOTCH3	notch 3	0.114	Fly
RHOXF2	Rhox homeobox family, member 2	0.111
JAG1	jagged 1	0.109	Mouse Fly
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.100
MAGEA3	melanoma antigen family A, 3	0.091
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.089
SNIP1	Smad nuclear interacting protein 1	0.087
NCOR1	nuclear receptor corepressor 1	0.085
WASL	Wiskott-Aldrich syndrome-like	0.081
SYK	spleen tyrosine kinase	0.076
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.073	Fly
NAP1L5	nucleosome assembly protein 1-like 5	0.072
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.066	Fly
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.066
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.065
EP300	E1A binding protein p300	0.061
GDA	guanine deaminase	0.061
NSMCE4A	non-SMC element 4 homolog A (S. cerevisiae)	0.059
XIAP	X-linked inhibitor of apoptosis	0.057
CTAG1B	cancer/testis antigen 1B	0.056
MAGEA6	melanoma antigen family A, 6	0.054	Human
CREB1	cAMP responsive element binding protein 1	0.053
MAGEA12	melanoma antigen family A, 12	0.053	Human
NCK1	NCK adaptor protein 1	0.052
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.050
RALBP1	ralA binding protein 1	0.049
RNF11	ring finger protein 11	0.046
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.045
ZNF496	zinc finger protein 496	0.045
GRB7	growth factor receptor-bound protein 7	0.043
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.042
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.042	Fly
SKIL	SKI-like oncogene	0.041
JAG2	jagged 2	0.040	Fly
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.039
FAF1	Fas (TNFRSF6) associated factor 1	0.038
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.038
JAK2	Janus kinase 2	0.037
SH3BP2	SH3-domain binding protein 2	0.037
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.037
PTCH1	patched 1	0.037
EPS15	epidermal growth factor receptor pathway substrate 15	0.036	Fly
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.035
RADIL	Ras association and DIL domains	0.034
MAGEA1	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	0.033
FOXD3	forkhead box D3	0.032
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.032
ATP6V1B2	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	0.031
BBS1	Bardet-Biedl syndrome 1	0.031
MMS22L	MMS22-like, DNA repair protein	0.031
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.030
DLL1	delta-like 1 (Drosophila)	0.030	Zebrafish Mouse
ABI1	abl-interactor 1	0.030
LNX1	ligand of numb-protein X 1	0.029
PML	promyelocytic leukemia	0.028
ATP13A2	ATPase type 13A2	0.028
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.028
PITX1	paired-like homeodomain 1	0.028
CSNK1E	casein kinase 1, epsilon	0.028
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.028
ADAM17	ADAM metallopeptidase domain 17	0.027
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.027
CHMP1A	chromatin modifying protein 1A	0.027
BTRC	beta-transducin repeat containing	0.027
CTTN	cortactin	0.026
TLK1	tousled-like kinase 1	0.026
MAGEA2	melanoma antigen family A, 2	0.026	Human
WDR20	WD repeat domain 20	0.026
GFI1B	growth factor independent 1B transcription repressor	0.026
TRIM28	tripartite motif containing 28	0.026
PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	0.025
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.024
RAB5A	RAB5A, member RAS oncogene family	0.024
POU5F1	POU class 5 homeobox 1	0.024
LCK	lymphocyte-specific protein tyrosine kinase	0.023
UBQLN1	ubiquilin 1	0.023
WIPF1	WAS/WASL interacting protein family, member 1	0.023
DNM1	dynamin 1	0.023	Fly
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.022
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.022
NUMB	numb homolog (Drosophila)	0.021	Mouse
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.021
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.021
EID2	EP300 interacting inhibitor of differentiation 2	0.021
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.021
DCAF7	DDB1 and CUL4 associated factor 7	0.021
HDAC3	histone deacetylase 3	0.021
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.020
IFNGR1	interferon gamma receptor 1	0.020
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.020
CSNK1D	casein kinase 1, delta	0.019
SMAD3	SMAD family member 3	0.019
PTK2	PTK2 protein tyrosine kinase 2	0.019
PJA1	praja ring finger 1	0.019
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.019
MAGEA4	melanoma antigen family A, 4	0.019	Human
WWOX	WW domain containing oxidoreductase	0.019
STAT2	signal transducer and activator of transcription 2, 113kDa	0.019
DAXX	death-domain associated protein	0.019
STON2	stonin 2	0.018
AGFG1	ArfGAP with FG repeats 1	0.018
VPS25	vacuolar protein sorting 25 homolog (S. cerevisiae)	0.017	Fly
FZD1	frizzled homolog 1 (Drosophila)	0.017
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.017
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.016
RBPMS	RNA binding protein with multiple splicing	0.016
MTMR4	myotubularin related protein 4	0.016
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.016
KAT2B	K(lysine) acetyltransferase 2B	0.016
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.016
NCOR2	nuclear receptor corepressor 2	0.015
HTT	huntingtin	0.015
PTK6	PTK6 protein tyrosine kinase 6	0.015
TP73	tumor protein p73	0.015	Human
SP1	Sp1 transcription factor	0.015
CDAN1	congenital dyserythropoietic anemia, type I	0.015
REPS2	RALBP1 associated Eps domain containing 2	0.015
ITSN1	intersectin 1 (SH3 domain protein)	0.015	Fly
RB1	retinoblastoma 1	0.015
FAM156A	family with sequence similarity 156, member A	0.015
FGF18	fibroblast growth factor 18	0.015
SH3GL2	SH3-domain GRB2-like 2	0.015
PARP14	poly (ADP-ribose) polymerase family, member 14	0.015
KITLG	KIT ligand	0.015
SMAD9	SMAD family member 9	0.014
HMGA1	high mobility group AT-hook 1	0.014
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.014
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.014
HDAC6	histone deacetylase 6	0.014
PSEN2	presenilin 2 (Alzheimer disease 4)	0.014
PICALM	phosphatidylinositol binding clathrin assembly protein	0.014
SCARB2	scavenger receptor class B, member 2	0.014
BBS2	Bardet-Biedl syndrome 2	0.014
FBXW11	F-box and WD repeat domain containing 11	0.014
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.014
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.014
RBBP4	retinoblastoma binding protein 4	0.014
SMAD4	SMAD family member 4	0.013
AXIN1	axin 1	0.013
MAGEA5	melanoma antigen family A, 5	0.013
CUL7	cullin 7	0.013
CHD6	chromodomain helicase DNA binding protein 6	0.013
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.013
TCF4	transcription factor 4	0.013
SCAMP1	secretory carrier membrane protein 1	0.013
PLOD3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	0.013
CHAC1	ChaC, cation transport regulator homolog 1 (E. coli)	0.013
AP2M1	adaptor-related protein complex 2, mu 1 subunit	0.013
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.013
BIRC6	baculoviral IAP repeat containing 6	0.013
KLHL12	kelch-like 12 (Drosophila)	0.013
C20orf20	chromosome 20 open reading frame 20	0.013
CBX5	chromobox homolog 5	0.013
CDK2	cyclin-dependent kinase 2	0.013
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.013
CXXC5	CXXC finger protein 5	0.013
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.013
SGSM2	small G protein signaling modulator 2	0.013
ELL	elongation factor RNA polymerase II	0.013
KRT5	keratin 5	0.012
RUNX1	runt-related transcription factor 1	0.012
EXOC7	exocyst complex component 7	0.012
AMPH	amphiphysin	0.012
FYN	FYN oncogene related to SRC, FGR, YES	0.012
CLDN7	claudin 7	0.012
CCND1	cyclin D1	0.012
WT1	Wilms tumor 1	0.012
PARP9	poly (ADP-ribose) polymerase family, member 9	0.012
CCND3	cyclin D3	0.012
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.012
TBL1X	transducin (beta)-like 1X-linked	0.012	Fly
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.012
ATXN3	ataxin 3	0.012
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.012
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.012
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.012
RAB10	RAB10, member RAS oncogene family	0.012
DLG4	discs, large homolog 4 (Drosophila)	0.011	Fly
ZMYND8	zinc finger, MYND-type containing 8	0.011
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.011
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.011
IRS1	insulin receptor substrate 1	0.011
MTF1	metal-regulatory transcription factor 1	0.011
ANKRD13A	ankyrin repeat domain 13A	0.011
TRIM27	tripartite motif containing 27	0.011
SATB2	SATB homeobox 2	0.011
E2F1	E2F transcription factor 1	0.011
MAGEC1	melanoma antigen family C, 1	0.011	Human
TMED10	transmembrane emp24-like trafficking protein 10 (yeast)	0.011
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	0.011
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.011
TBX5	T-box 5	0.011
ASB13	ankyrin repeat and SOCS box containing 13	0.011
RBM11	RNA binding motif protein 11	0.011
CCDC6	coiled-coil domain containing 6	0.011
CPD	carboxypeptidase D	0.011
CABLES1	Cdk5 and Abl enzyme substrate 1	0.010
UBE2N	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	0.010
MCM2	minichromosome maintenance complex component 2	0.010
TOX4	TOX high mobility group box family member 4	0.010
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.010
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.010
PIAS4	protein inhibitor of activated STAT, 4	0.010