IMP
Process View
regulation of release of cytochrome c from mitochondria
Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
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Click on a gene's description to view its network relationships with genes known to be involved in "regulation of release of cytochrome c from mitochondria"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| BCL2 | B-cell CLL/lymphoma 2 | 1.000 | Human | |
| BCL2L1 | BCL2-like 1 | 1.000 | ||
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 1.000 | ||
| BAD | BCL2-associated agonist of cell death | 1.000 | ||
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.999 | ||
| BAX | BCL2-associated X protein | 0.996 | ||
| BID | BH3 interacting domain death agonist | 0.977 | ||
| BAK1 | BCL2-antagonist/killer 1 | 0.933 | Human Rat | |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.919 | ||
| TP53BP2 | tumor protein p53 binding protein, 2 | 0.879 | ||
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.872 | ||
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.785 | ||
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.773 | ||
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.770 | ||
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.758 | ||
| FAS | Fas (TNF receptor superfamily, member 6) | 0.754 | ||
| FADD | Fas (TNFRSF6)-associated via death domain | 0.726 | ||
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.631 | ||
| BBC3 | BCL2 binding component 3 | 0.369 | ||
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.352 | Human | |
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.341 | ||
| BECN1 | beclin 1, autophagy related | 0.321 | ||
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | 0.305 | ||
| FKBP8 | FK506 binding protein 8, 38kDa | 0.294 | ||
| VDAC2 | voltage-dependent anion channel 2 | 0.288 | ||
| MCL1 | myeloid cell leukemia sequence 1 (BCL2-related) | 0.246 | Human | |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | 0.237 | ||
| MET | met proto-oncogene (hepatocyte growth factor receptor) | 0.229 | ||
| NLRC4 | NLR family, CARD domain containing 4 | 0.159 | ||
| ZNF746 | zinc finger protein 746 | 0.157 | ||
| ARRB1 | arrestin, beta 1 | 0.142 | ||
| PSMD6 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 0.140 | ||
| FBXO7 | F-box protein 7 | 0.123 | ||
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.119 | ||
| MAPK8 | mitogen-activated protein kinase 8 | 0.112 | ||
| SMCR7 | Smith-Magenis syndrome chromosome region, candidate 7 | 0.112 | ||
| ZFYVE1 | zinc finger, FYVE domain containing 1 | 0.111 | ||
| WWOX | WW domain containing oxidoreductase | 0.108 | ||
| KRT5 | keratin 5 | 0.101 | ||
| GRPEL1 | GrpE-like 1, mitochondrial (E. coli) | 0.082 | ||
| HUWE1 | HECT, UBA and WWE domain containing 1 | 0.076 | ||
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 0.074 | ||
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.073 | ||
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.065 | ||
| PSEN2 | presenilin 2 (Alzheimer disease 4) | 0.058 | ||
| H2AFX | H2A histone family, member X | 0.058 | ||
| APOH | apolipoprotein H (beta-2-glycoprotein I) | 0.053 | ||
| MDM4 | Mdm4 p53 binding protein homolog (mouse) | 0.051 | ||
| PDPK1 | 3-phosphoinositide dependent protein kinase-1 | 0.051 | ||
| PSMC2 | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | 0.049 | ||
| MEFV | Mediterranean fever | 0.049 | ||
| BCL2L2 | BCL2-like 2 | 0.048 | Human | |
| VDAC1 | voltage-dependent anion channel 1 | 0.042 | ||
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 0.041 | ||
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.040 | ||
| ACTB | actin, beta | 0.040 | ||
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.039 | ||
| HRK | harakiri, BCL2 interacting protein (contains only BH3 domain) | 0.038 | ||
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.037 | ||
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.037 | ||
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.035 | ||
| MAPK1 | mitogen-activated protein kinase 1 | 0.034 | ||
| AMBRA1 | autophagy/beclin-1 regulator 1 | 0.032 | ||
| ZHX1 | zinc fingers and homeoboxes 1 | 0.032 | ||
| TAGLN2 | transgelin 2 | 0.031 | ||
| CLU | clusterin | 0.031 | ||
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 0.031 | ||
| SMCR7L | Smith-Magenis syndrome chromosome region, candidate 7-like | 0.031 | ||
| PSMC5 | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | 0.031 | ||
| TSPO | translocator protein (18kDa) | 0.027 | ||
| YPEL5 | yippee-like 5 (Drosophila) | 0.027 | ||
| MAGEH1 | melanoma antigen family H, 1 | 0.027 | ||
| AMT | aminomethyltransferase | 0.027 | ||
| SPNS1 | spinster homolog 1 (Drosophila) | 0.027 | ||
| ORM1 | orosomucoid 1 | 0.027 | ||
| RNF144B | ring finger protein 144B | 0.027 | ||
| C1orf93 | chromosome 1 open reading frame 93 | 0.026 | ||
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.023 | ||
| SQSTM1 | sequestosome 1 | 0.022 | ||
| YAP1 | Yes-associated protein 1 | 0.022 | ||
| TMEM11 | transmembrane protein 11 | 0.021 | ||
| PSEN1 | presenilin 1 | 0.021 | ||
| CDKN2A | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 0.021 | ||
| PPP1CA | protein phosphatase 1, catalytic subunit, alpha isozyme | 0.020 | ||
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.019 | ||
| PPHLN1 | periphilin 1 | 0.018 | ||
| MAP2K4 | mitogen-activated protein kinase kinase 4 | 0.017 | ||
| ARPC4 | actin related protein 2/3 complex, subunit 4, 20kDa | 0.017 | ||
| C4orf14 | chromosome 4 open reading frame 14 | 0.017 | ||
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 0.017 | ||
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.016 | ||
| KRT6C | keratin 6C | 0.016 | ||
| MAP1LC3A | microtubule-associated protein 1 light chain 3 alpha | 0.016 | ||
| FLNA | filamin A, alpha | 0.016 | ||
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.016 | ||
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.015 | ||
| VTN | vitronectin | 0.015 | ||
| LRRK2 | leucine-rich repeat kinase 2 | 0.015 | ||
| FLNB | filamin B, beta | 0.015 | ||
| BCAP31 | B-cell receptor-associated protein 31 | 0.015 | ||
| ALOX12 | arachidonate 12-lipoxygenase | 0.015 | ||
| METTL23 | methyltransferase like 23 | 0.015 | ||
| TUBB6 | tubulin, beta 6 | 0.015 | ||
| PACRG | PARK2 co-regulated | 0.015 | ||
| PACSIN1 | protein kinase C and casein kinase substrate in neurons 1 | 0.015 | ||
| RAB5C | RAB5C, member RAS oncogene family | 0.014 | ||
| HIPK2 | homeodomain interacting protein kinase 2 | 0.014 | ||
| SERPINF2 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 | 0.014 | ||
| GCGR | glucagon receptor | 0.014 | ||
| S1PR5 | sphingosine-1-phosphate receptor 5 | 0.014 | ||
| NAF1 | nuclear assembly factor 1 homolog (S. cerevisiae) | 0.014 | ||
| TKT | transketolase | 0.014 | ||
| ACTN1 | actinin, alpha 1 | 0.014 | ||
| S100A4 | S100 calcium binding protein A4 | 0.014 | ||
| IKBKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 0.014 | ||
| NAP1L5 | nucleosome assembly protein 1-like 5 | 0.013 | ||
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | 0.013 | ||
| PPIF | peptidylprolyl isomerase F | 0.013 | ||
| AMOTL1 | angiomotin like 1 | 0.013 | ||
| KNG1 | kininogen 1 | 0.013 | ||
| MTFP1 | mitochondrial fission process 1 | 0.013 | ||
| HNRNPCL1 | heterogeneous nuclear ribonucleoprotein C-like 1 | 0.013 | ||
| FES | feline sarcoma oncogene | 0.013 | ||
| CCDC86 | coiled-coil domain containing 86 | 0.013 | ||
| F10 | coagulation factor X | 0.012 | ||
| PGAM1 | phosphoglycerate mutase 1 (brain) | 0.012 | ||
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.012 | ||
| PSMC4 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | 0.012 | ||
| ZNF219 | zinc finger protein 219 | 0.012 | ||
| PPP1R13B | protein phosphatase 1, regulatory (inhibitor) subunit 13B | 0.012 | ||
| S100A10 | S100 calcium binding protein A10 | 0.012 | ||
| ITGB7 | integrin, beta 7 | 0.012 | ||
| CLTB | clathrin, light chain B | 0.012 | ||
| MAPK9 | mitogen-activated protein kinase 9 | 0.012 | ||
| SERPINC1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 0.012 | ||
| CFL1 | cofilin 1 (non-muscle) | 0.012 | ||
| DBN1 | drebrin 1 | 0.011 | ||
| RNR2 | l-rRNA | 0.011 | ||
| MYH9 | myosin, heavy chain 9, non-muscle | 0.011 | ||
| TSPYL4 | TSPY-like 4 | 0.011 | ||
| IGFALS | insulin-like growth factor binding protein, acid labile subunit | 0.010 | ||
| PAAF1 | proteasomal ATPase-associated factor 1 | 0.010 | ||
| HPX | hemopexin | 0.010 | ||
| PKM2 | pyruvate kinase, muscle | 0.010 | ||
| FYCO1 | FYVE and coiled-coil domain containing 1 | 0.010 | ||
| TNFRSF14 | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) | 0.010 |