IMP

Process View

Homo sapiens

17 genes annotated in human

attachment of spindle microtubules to kinetochore

The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "attachment of spindle microtubules to kinetochore"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "attachment of spindle microtubules to kinetochore" (in gray)

Name	Description	Probability	Func Analog Organism
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.994
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.988
RB1	retinoblastoma 1	0.952
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.944
AURKB	aurora kinase B	0.912
RACGAP1	Rac GTPase activating protein 1	0.904
CBX5	chromobox homolog 5	0.862
ZWINT	ZW10 interactor	0.830
NCAPD2	non-SMC condensin I complex, subunit D2	0.689
NUF2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.673
CCNB1	cyclin B1	0.611
CENPE	centromere protein E, 312kDa	0.608	Mouse
RBL1	retinoblastoma-like 1 (p107)	0.510	Human
CCNA2	cyclin A2	0.491
PRC1	protein regulator of cytokinesis 1	0.455
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.377
TTK	TTK protein kinase	0.371	Yeast
CASC5	cancer susceptibility candidate 5	0.355
BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	0.346
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.324
CDCA8	cell division cycle associated 8	0.311
CDK1	cyclin-dependent kinase 1	0.306
SPC25	SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.283
KIF20A	kinesin family member 20A	0.256
KIF23	kinesin family member 23	0.255
CKS2	CDC28 protein kinase regulatory subunit 2	0.241
CDK2	cyclin-dependent kinase 2	0.225
NCAPG2	non-SMC condensin II complex, subunit G2	0.224
INCENP	inner centromere protein antigens 135/155kDa	0.215
VCP	valosin containing protein	0.196	Yeast
PLK1	polo-like kinase 1	0.193
KIF14	kinesin family member 14	0.162
ECT2	epithelial cell transforming sequence 2 oncogene	0.149
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.130
CDKN3	cyclin-dependent kinase inhibitor 3	0.125
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.121
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.117
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.110
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.110
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.101
NSL1	NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.098
KIF18A	kinesin family member 18A	0.094	Fly
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.093
DSN1	DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.087
SPC24	SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.084
KIF1B	kinesin family member 1B	0.080
MPHOSPH9	M-phase phosphoprotein 9	0.069
CDCA2	cell division cycle associated 2	0.057
NUP85	nucleoporin 85kDa	0.052
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.050
TUBB2C	tubulin, beta 2C	0.049
NUP133	nucleoporin 133kDa	0.049
CEBPE	CCAAT/enhancer binding protein (C/EBP), epsilon	0.048
SKA1	spindle and kinetochore associated complex subunit 1	0.048
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.048
ZW10	ZW10, kinetochore associated, homolog (Drosophila)	0.047
AURKA	aurora kinase A	0.047	Yeast
YTHDC2	YTH domain containing 2	0.047
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.047
SGOL2	shugoshin-like 2 (S. pombe)	0.043
CEP55	centrosomal protein 55kDa	0.041
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.041
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.040
MIS12	MIS12, MIND kinetochore complex component, homolog (S. pombe)	0.038
MKI67	antigen identified by monoclonal antibody Ki-67	0.037
CKAP5	cytoskeleton associated protein 5	0.033
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.033
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.033
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.032
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.031
ZNF207	zinc finger protein 207	0.031
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.029	Human
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.029
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.029
RANBP9	RAN binding protein 9	0.028
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.028
STIL	SCL/TAL1 interrupting locus	0.027
CCNB2	cyclin B2	0.027	Human Fly
TRIP13	thyroid hormone receptor interactor 13	0.026
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.026
E2F5	E2F transcription factor 5, p130-binding	0.026
DNA2	DNA replication helicase 2 homolog (yeast)	0.026
ANAPC1	anaphase promoting complex subunit 1	0.026
RRM2	ribonucleotide reductase M2	0.025
TMEM48	transmembrane protein 48	0.024
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.024
NCAPD3	non-SMC condensin II complex, subunit D3	0.023	Worm
WDR67	WD repeat domain 67	0.023
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.023
TDP1	tyrosyl-DNA phosphodiesterase 1	0.023
AXIN1	axin 1	0.022
LIN54	lin-54 homolog (C. elegans)	0.022
SMC2	structural maintenance of chromosomes 2	0.022
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.022
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.022
RBBP8	retinoblastoma binding protein 8	0.021
GPSM2	G-protein signaling modulator 2	0.021
WDHD1	WD repeat and HMG-box DNA binding protein 1	0.021
SMC4	structural maintenance of chromosomes 4	0.020
CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3	0.020
CLSPN	claspin	0.020
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.019	Human
ATXN3	ataxin 3	0.019
GSK3B	glycogen synthase kinase 3 beta	0.019
MIS18BP1	MIS18 binding protein 1	0.018
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.018
FAM54A	family with sequence similarity 54, member A	0.018
MZT1	mitotic spindle organizing protein 1	0.018
CDC23	cell division cycle 23 homolog (S. cerevisiae)	0.017
TTF2	transcription termination factor, RNA polymerase II	0.017
FANCI	Fanconi anemia, complementation group I	0.017
TMEM194A	transmembrane protein 194A	0.017
UBE4B	ubiquitination factor E4B (UFD2 homolog, yeast)	0.017
CENPF	centromere protein F, 350/400kDa (mitosin)	0.016	Worm
ANLN	anillin, actin binding protein	0.016
ZFYVE9	zinc finger, FYVE domain containing 9	0.016
C13orf34	chromosome 13 open reading frame 34	0.016
LBR	lamin B receptor	0.015
C1orf112	chromosome 1 open reading frame 112	0.015
CDC7	cell division cycle 7 homolog (S. cerevisiae)	0.014
NUP43	nucleoporin 43kDa	0.013
FBXO5	F-box protein 5	0.013
MSN	moesin	0.013
SKP2	S-phase kinase-associated protein 2 (p45)	0.013
NCF2	neutrophil cytosolic factor 2	0.013
MELK	maternal embryonic leucine zipper kinase	0.012
LARS2	leucyl-tRNA synthetase 2, mitochondrial	0.012
PRIM2	primase, DNA, polypeptide 2 (58kDa)	0.012
HDAC6	histone deacetylase 6	0.012
BIRC5	baculoviral IAP repeat containing 5	0.012
HJURP	Holliday junction recognition protein	0.012
DEPDC1	DEP domain containing 1	0.012
PPP2R5E	protein phosphatase 2, regulatory subunit B', epsilon isoform	0.012
RBL2	retinoblastoma-like 2 (p130)	0.012	Human
ACLY	ATP citrate lyase	0.011
SPAG5	sperm associated antigen 5	0.011
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.011
POGZ	pogo transposable element with ZNF domain	0.011
ATAD2	ATPase family, AAA domain containing 2	0.011
NSFL1C	NSFL1 (p97) cofactor (p47)	0.011	Yeast
ANAPC7	anaphase promoting complex subunit 7	0.011
EMP3	epithelial membrane protein 3	0.011
POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	0.011
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.011
MCC	mutated in colorectal cancers	0.011
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.011
GINS1	GINS complex subunit 1 (Psf1 homolog)	0.011
NCAPH	non-SMC condensin I complex, subunit H	0.010
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.010
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	0.010
SMC1A	structural maintenance of chromosomes 1A	0.010
ZMYND8	zinc finger, MYND-type containing 8	0.010
CSNK1E	casein kinase 1, epsilon	0.010	Yeast