IMP

Process View

Homo sapiens

25 genes annotated in human

response to dsrna

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to dsrna"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to dsrna" (in gray)

Name	Description	Probability	Func Analog Organism
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.999
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.989	Human Mouse
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.987
IFIT1	interferon-induced protein with tetratricopeptide repeats 1	0.975
IFIT3	interferon-induced protein with tetratricopeptide repeats 3	0.918	Human
IFIT5	interferon-induced protein with tetratricopeptide repeats 5	0.862	Human
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.818	Human Fly
IFI44	interferon-induced protein 44	0.793
DICER1	dicer 1, ribonuclease type III	0.769
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.667
BIRC3	baculoviral IAP repeat containing 3	0.621
TNRC6A	trinucleotide repeat containing 6A	0.585
HERC5	hect domain and RLD 5	0.442
EIF2C4	eukaryotic translation initiation factor 2C, 4	0.426	Human
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.365
IFIT2	interferon-induced protein with tetratricopeptide repeats 2	0.333	Human
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.330
SLC7A5	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	0.304
DGCR8	DiGeorge syndrome critical region gene 8	0.283
IL1R1	interleukin 1 receptor, type I	0.255
EIF2C3	eukaryotic translation initiation factor 2C, 3	0.241	Human
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.235
OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa	0.217
SAMD9L	sterile alpha motif domain containing 9-like	0.215
ISG15	ISG15 ubiquitin-like modifier	0.209
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.206
IFI44L	interferon-induced protein 44-like	0.201
DLG4	discs, large homolog 4 (Drosophila)	0.179
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.176
DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.173
PLSCR1	phospholipid scramblase 1	0.146
SP100	SP100 nuclear antigen	0.144
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.134
TOP1	topoisomerase (DNA) I	0.133
PABPC1	poly(A) binding protein, cytoplasmic 1	0.132
TARBP2	TAR (HIV-1) RNA binding protein 2	0.105
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.104
SP110	SP110 nuclear body protein	0.103
PIAS4	protein inhibitor of activated STAT, 4	0.099
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.097
MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	0.096	Zebrafish
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.091
MAVS	mitochondrial antiviral signaling protein	0.090
CYLD	cylindromatosis (turban tumor syndrome)	0.090
RTP4	receptor (chemosensory) transporter protein 4	0.086
MOV10	Mov10, Moloney leukemia virus 10, homolog (mouse)	0.070
IFIH1	interferon induced with helicase C domain 1	0.066	Human
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.065
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.063
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.063
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.061
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.060
ZNFX1	zinc finger, NFX1-type containing 1	0.060
OAS3	2'-5'-oligoadenylate synthetase 3, 100kDa	0.056
PARP9	poly (ADP-ribose) polymerase family, member 9	0.056
MAPK14	mitogen-activated protein kinase 14	0.055
C17orf85	chromosome 17 open reading frame 85	0.054
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.054
IFI6	interferon, alpha-inducible protein 6	0.053
ELK1	ELK1, member of ETS oncogene family	0.052
EPSTI1	epithelial stromal interaction 1 (breast)	0.049
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.049
HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	0.047
OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.047
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.046
APOL6	apolipoprotein L, 6	0.043
TLR2	toll-like receptor 2	0.042
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.041
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.041
RSAD2	radical S-adenosyl methionine domain containing 2	0.040
PARP12	poly (ADP-ribose) polymerase family, member 12	0.040
CCL20	chemokine (C-C motif) ligand 20	0.038
EIF2S1	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	0.038
ADAR	adenosine deaminase, RNA-specific	0.038
TNIP2	TNFAIP3 interacting protein 2	0.036
FTSJD2	FtsJ methyltransferase domain containing 2	0.035
OASL	2'-5'-oligoadenylate synthetase-like	0.033
LUC7L	LUC7-like (S. cerevisiae)	0.033
TMEM173	transmembrane protein 173	0.032
TRIM71	tripartite motif containing 71	0.032
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.032
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.032
MBOAT7	membrane bound O-acyltransferase domain containing 7	0.031
SAMD9	sterile alpha motif domain containing 9	0.031
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.031
DROSHA	drosha, ribonuclease type III	0.030
CXCL2	chemokine (C-X-C motif) ligand 2	0.030
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.029
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.029	Mouse
TNRC6B	trinucleotide repeat containing 6B	0.027
HTT	huntingtin	0.027
DUSP1	dual specificity phosphatase 1	0.026
SRSF7	serine/arginine-rich splicing factor 7	0.026
FUS	fused in sarcoma	0.026
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.025
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.025
IRF7	interferon regulatory factor 7	0.024
BCL3	B-cell CLL/lymphoma 3	0.023
TDRD7	tudor domain containing 7	0.023
IL8	interleukin 8	0.023
MX2	myxovirus (influenza virus) resistance 2 (mouse)	0.022	Zebrafish
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.022
RBM8A	RNA binding motif protein 8A	0.022
TRIM22	tripartite motif containing 22	0.022
TRAF6	TNF receptor-associated factor 6	0.021
NOD1	nucleotide-binding oligomerization domain containing 1	0.021
PARN	poly(A)-specific ribonuclease (deadenylation nuclease)	0.020
LYAR	Ly1 antibody reactive homolog (mouse)	0.020
XAF1	XIAP associated factor 1	0.020
NOD2	nucleotide-binding oligomerization domain containing 2	0.019
IRAK2	interleukin-1 receptor-associated kinase 2	0.019
PHF11	PHD finger protein 11	0.019
IK	IK cytokine, down-regulator of HLA II	0.018
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.018
CUL2	cullin 2	0.018
MAP2K1	mitogen-activated protein kinase kinase 1	0.018
BRF2	BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like	0.018
IFNA10	interferon, alpha 10	0.018	Human
SPRR2A	small proline-rich protein 2A	0.017
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.017
CALCOCO2	calcium binding and coiled-coil domain 2	0.016
CCNL1	cyclin L1	0.016
ACIN1	apoptotic chromatin condensation inducer 1	0.016
TNIP1	TNFAIP3 interacting protein 1	0.016
CMPK2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.016
GNL3	guanine nucleotide binding protein-like 3 (nucleolar)	0.016
BAX	BCL2-associated X protein	0.015
LAP3	leucine aminopeptidase 3	0.015
IRF9	interferon regulatory factor 9	0.015
TRIM25	tripartite motif containing 25	0.015
DUSP3	dual specificity phosphatase 3	0.014
NCL	nucleolin	0.014
GTPBP4	GTP binding protein 4	0.014
RARS	arginyl-tRNA synthetase	0.014
PRRC2C	proline-rich coiled-coil 2C	0.014
DDX60L	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	0.013
IL1RAP	interleukin 1 receptor accessory protein	0.013
CD14	CD14 molecule	0.013
MFAP1	microfibrillar-associated protein 1	0.013
DHX58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.013	Human
HERC6	hect domain and RLD 6	0.013
IPO8	importin 8	0.013
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.013
UBE4A	ubiquitination factor E4A (UFD2 homolog, yeast)	0.013
YARS	tyrosyl-tRNA synthetase	0.012
IL4R	interleukin 4 receptor	0.012
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.012
IFNA4	interferon, alpha 4	0.012
SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)	0.012
SETX	senataxin	0.011
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.011
NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive	0.011
C12orf35	chromosome 12 open reading frame 35	0.011
SLC7A1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	0.011
TRIM5	tripartite motif containing 5	0.011
FNIP1	folliculin interacting protein 1	0.011
IFNA16	interferon, alpha 16	0.011	Human
TMEM140	transmembrane protein 140	0.011
NLGN1	neuroligin 1	0.011
GBP4	guanylate binding protein 4	0.010
ZFP28	zinc finger protein 28 homolog (mouse)	0.010
ZNF746	zinc finger protein 746	0.010
USP18	ubiquitin specific peptidase 18	0.010
SGTA	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	0.010