IMP

Process View

Homo sapiens

1 genes annotated in human

convergent extension involved in gastrulation

The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "convergent extension involved in gastrulation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "convergent extension involved in gastrulation" (in gray)

Name	Description	Probability	Func Analog Organism
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	1.000
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.994
BCAR1	breast cancer anti-estrogen resistance 1	0.971
BMPR1A	bone morphogenetic protein receptor, type IA	0.553
PTK2	PTK2 protein tyrosine kinase 2	0.537
FYN	FYN oncogene related to SRC, FGR, YES	0.533	Zebrafish
GRB2	growth factor receptor-bound protein 2	0.528
MED28	mediator complex subunit 28	0.492
CAV1	caveolin 1, caveolae protein, 22kDa	0.391
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.270
TRIP6	thyroid hormone receptor interactor 6	0.254
DSG2	desmoglein 2	0.238
SMAD1	SMAD family member 1	0.194
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.188
BMP1	bone morphogenetic protein 1	0.174
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.171
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.156
BBS2	Bardet-Biedl syndrome 2	0.137
PCM1	pericentriolar material 1	0.128
SRCIN1	SRC kinase signaling inhibitor 1	0.108
BBS9	Bardet-Biedl syndrome 9	0.108
TNK2	tyrosine kinase, non-receptor, 2	0.102
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.087
CTTN	cortactin	0.085
BBS1	Bardet-Biedl syndrome 1	0.081
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.077
DST	dystonin	0.075
FRS2	fibroblast growth factor receptor substrate 2	0.075
APC	adenomatous polyposis coli	0.072
TJP2	tight junction protein 2 (zona occludens 2)	0.070
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.067
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	0.066
STAT5A	signal transducer and activator of transcription 5A	0.061
ZMYND11	zinc finger, MYND-type containing 11	0.060
SPRR2A	small proline-rich protein 2A	0.060
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.057
RPL10	ribosomal protein L10	0.057
SOCS1	suppressor of cytokine signaling 1	0.057
DCTN1	dynactin 1	0.056
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.054
PXN	paxillin	0.052
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.052
LCK	lymphocyte-specific protein tyrosine kinase	0.051
IFNGR1	interferon gamma receptor 1	0.051
EXOC7	exocyst complex component 7	0.050
STAT5B	signal transducer and activator of transcription 5B	0.049
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.049
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.049
FYB	FYN binding protein	0.048
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.046
SMAD3	SMAD family member 3	0.044
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.044
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.043
FZD1	frizzled homolog 1 (Drosophila)	0.043
LUM	lumican	0.041
PDCD6IP	programmed cell death 6 interacting protein	0.040
SMAD9	SMAD family member 9	0.040
QKI	quaking homolog, KH domain RNA binding (mouse)	0.039
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.039
TTC8	tetratricopeptide repeat domain 8	0.037
UNC119B	unc-119 homolog B (C. elegans)	0.036
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.036
DSP	desmoplakin	0.035
RPL13	ribosomal protein L13	0.035
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.034
RPL18	ribosomal protein L18	0.033
SPTBN1	spectrin, beta, non-erythrocytic 1	0.033
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.033
SH2D1A	SH2 domain containing 1A	0.032
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.032
SOCS3	suppressor of cytokine signaling 3	0.032
GLTSCR2	glioma tumor suppressor candidate region gene 2	0.031
MAP2	microtubule-associated protein 2	0.030
MBNL1	muscleblind-like (Drosophila)	0.029
PPIL4	peptidylprolyl isomerase (cyclophilin)-like 4	0.029
FSTL1	follistatin-like 1	0.029
CSK	c-src tyrosine kinase	0.029
ARHGAP32	Rho GTPase activating protein 32	0.028
CXXC5	CXXC finger protein 5	0.027
INPPL1	inositol polyphosphate phosphatase-like 1	0.027
JUP	junction plakoglobin	0.026
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.026
RBM4	RNA binding motif protein 4	0.026
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.026
SH3KBP1	SH3-domain kinase binding protein 1	0.025
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.025
NOG	noggin	0.025
CAV2	caveolin 2	0.024
PRKCQ	protein kinase C, theta	0.024
TIMP2	TIMP metallopeptidase inhibitor 2	0.024
MAP4K5	mitogen-activated protein kinase kinase kinase kinase 5	0.024
EIF3L	eukaryotic translation initiation factor 3, subunit L	0.024
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.023
SCAMP1	secretory carrier membrane protein 1	0.023
MAPT	microtubule-associated protein tau	0.022
IFNAR1	interferon (alpha, beta and omega) receptor 1	0.022
HIPK2	homeodomain interacting protein kinase 2	0.022
CPSF1	cleavage and polyadenylation specific factor 1, 160kDa	0.022
CEP164	centrosomal protein 164kDa	0.021
ANKRD13A	ankyrin repeat domain 13A	0.021
MARCKS	myristoylated alanine-rich protein kinase C substrate	0.021
ZFYVE9	zinc finger, FYVE domain containing 9	0.021
SKAP1	src kinase associated phosphoprotein 1	0.021
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.021
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.020
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.020
STAM2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	0.020
DPYSL2	dihydropyrimidinase-like 2	0.020
HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	0.020
PTBP2	polypyrimidine tract binding protein 2	0.020
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.020
ALDOB	aldolase B, fructose-bisphosphate	0.019
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.019
EEF1B2	eukaryotic translation elongation factor 1 beta 2	0.019
FURIN	furin (paired basic amino acid cleaving enzyme)	0.019
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.019
GJA1	gap junction protein, alpha 1, 43kDa	0.019
ERBB2IP	erbb2 interacting protein	0.019
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.019
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.019
ADRB2	adrenergic, beta-2-, receptor, surface	0.018
SHANK3	SH3 and multiple ankyrin repeat domains 3	0.018
PRPF6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)	0.018
FOXP1	forkhead box P1	0.018
RNF11	ring finger protein 11	0.018
FAS	Fas (TNF receptor superfamily, member 6)	0.018
FAM134C	family with sequence similarity 134, member C	0.018
HSCB	HscB iron-sulfur cluster co-chaperone homolog (E. coli)	0.018
SMAD2	SMAD family member 2	0.018
HCK	hemopoietic cell kinase	0.018
JAG1	jagged 1	0.018
CBX7	chromobox homolog 7	0.018
GLIS2	GLIS family zinc finger 2	0.017
RYK	RYK receptor-like tyrosine kinase	0.017	Zebrafish
IL6R	interleukin 6 receptor	0.017
PPP1R16A	protein phosphatase 1, regulatory (inhibitor) subunit 16A	0.017
MPZL1	myelin protein zero-like 1	0.017
IRS1	insulin receptor substrate 1	0.016
ARL6	ADP-ribosylation factor-like 6	0.016
CELF2	CUGBP, Elav-like family member 2	0.016
VHL	von Hippel-Lindau tumor suppressor	0.016
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.016
CAT	catalase	0.015
SLC25A6	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	0.015
TRIM32	tripartite motif containing 32	0.015
PDCD6	programmed cell death 6	0.015
PKP2	plakophilin 2	0.015
MTMR10	myotubularin related protein 10	0.015
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.015
GAB1	GRB2-associated binding protein 1	0.015
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.015
WDR83	WD repeat domain 83	0.015
DGCR14	DiGeorge syndrome critical region gene 14	0.015
GRB10	growth factor receptor-bound protein 10	0.014
DOCK1	dedicator of cytokinesis 1	0.014
HRG	histidine-rich glycoprotein	0.014
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.014
RPL32	ribosomal protein L32	0.014
INSR	insulin receptor	0.014
FRA10AC1	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1	0.014
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.014
RPL3	ribosomal protein L3	0.014
PTPRG	protein tyrosine phosphatase, receptor type, G	0.014
EFS	embryonal Fyn-associated substrate	0.014
FNBP1	formin binding protein 1	0.014
ZHX2	zinc fingers and homeoboxes 2	0.014
SVIL	supervillin	0.014
SOX7	SRY (sex determining region Y)-box 7	0.014
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.014
FZD6	frizzled homolog 6 (Drosophila)	0.013
ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	0.013
UTRN	utrophin	0.013
MACF1	microtubule-actin crosslinking factor 1	0.013
CD2AP	CD2-associated protein	0.013
SMAD6	SMAD family member 6	0.013
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.013
MCC	mutated in colorectal cancers	0.013
GSK3B	glycogen synthase kinase 3 beta	0.013
LEPR	leptin receptor	0.013
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.013
SFTPC	surfactant protein C	0.013
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.013
LTBP1	latent transforming growth factor beta binding protein 1	0.013
MIB1	mindbomb homolog 1 (Drosophila)	0.013
FERMT2	fermitin family member 2	0.013
DNM2	dynamin 2	0.013
GOLM1	golgi membrane protein 1	0.013
ADAM15	ADAM metallopeptidase domain 15	0.012
PTHLH	parathyroid hormone-like hormone	0.012
MYO1E	myosin IE	0.012
ACTN1	actinin, alpha 1	0.012
TCF4	transcription factor 4	0.012
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.012
RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.012
PRRC1	proline-rich coiled-coil 1	0.012
GAS7	growth arrest-specific 7	0.012
DACT1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)	0.012
SH2B1	SH2B adaptor protein 1	0.012
FOXN3	forkhead box N3	0.012
PAX2	paired box 2	0.012
ZBTB20	zinc finger and BTB domain containing 20	0.012
TBC1D5	TBC1 domain family, member 5	0.012
CHERP	calcium homeostasis endoplasmic reticulum protein	0.012
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.012
VCL	vinculin	0.012
KIAA0174	KIAA0174	0.012
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.012	Zebrafish
CSGALNACT2	chondroitin sulfate N-acetylgalactosaminyltransferase 2	0.012
CFL2	cofilin 2 (muscle)	0.012
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.012
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.012
AHR	aryl hydrocarbon receptor	0.012
HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')	0.011
ABCC10	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	0.011
KRT5	keratin 5	0.011
KIAA2026	KIAA2026	0.011
RBPMS	RNA binding protein with multiple splicing	0.011
ZHX1	zinc fingers and homeoboxes 1	0.011
EIF2C4	eukaryotic translation initiation factor 2C, 4	0.011
VPS24	vacuolar protein sorting 24 homolog (S. cerevisiae)	0.011
ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	0.011
PALLD	palladin, cytoskeletal associated protein	0.011
PTPRK	protein tyrosine phosphatase, receptor type, K	0.011
PRKCA	protein kinase C, alpha	0.011
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.011
HOXA9	homeobox A9	0.011
WWTR1	WW domain containing transcription regulator 1	0.011
SOX9	SRY (sex determining region Y)-box 9	0.011
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.011
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.011
SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.011
TNRC6B	trinucleotide repeat containing 6B	0.011
RPL27A	ribosomal protein L27a	0.011
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.011
CIRBP	cold inducible RNA binding protein	0.011
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.011
F2R	coagulation factor II (thrombin) receptor	0.011
REPS2	RALBP1 associated Eps domain containing 2	0.011
WNT5A	wingless-type MMTV integration site family, member 5A	0.011	Zebrafish
DSG3	desmoglein 3	0.011
ZCCHC24	zinc finger, CCHC domain containing 24	0.011
NLK	nemo-like kinase	0.010
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.010
UVRAG	UV radiation resistance associated gene	0.010
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.010
CDCP1	CUB domain containing protein 1	0.010
ANXA3	annexin A3	0.010
FLNA	filamin A, alpha	0.010
NCKAP1	NCK-associated protein 1	0.010
CREB5	cAMP responsive element binding protein 5	0.010
FRK	fyn-related kinase	0.010
GHR	growth hormone receptor	0.010
SFN	stratifin	0.010
AP1G2	adaptor-related protein complex 1, gamma 2 subunit	0.010
ZEB1	zinc finger E-box binding homeobox 1	0.010
C5orf55	chromosome 5 open reading frame 55	0.010
TRIM2	tripartite motif containing 2	0.010
CCDC92	coiled-coil domain containing 92	0.010
DENND5A	DENN/MADD domain containing 5A	0.010
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.010
SNAPC4	small nuclear RNA activating complex, polypeptide 4, 190kDa	0.010
ACSL4	acyl-CoA synthetase long-chain family member 4	0.010
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.010
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.010
TRPS1	trichorhinophalangeal syndrome I	0.010
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.010
ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	0.010
SMAD7	SMAD family member 7	0.010