IMP

Process View

Homo sapiens

19 genes annotated in human

protein k48 linked deubiquitination

A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein k48 linked deubiquitination"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "protein k48 linked deubiquitination" (in gray)

Name	Description	Probability	Func Analog Organism
RAD23B	RAD23 homolog B (S. cerevisiae)	0.621
USP15	ubiquitin specific peptidase 15	0.339
UBQLN1	ubiquilin 1	0.237
UBC	ubiquitin C	0.228
NBR1	neighbor of BRCA1 gene 1	0.223
VCP	valosin containing protein	0.160
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.149
TNIP1	TNFAIP3 interacting protein 1	0.085
DAXX	death-domain associated protein	0.084
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.074
TRAF6	TNF receptor-associated factor 6	0.069
TADA3	transcriptional adaptor 3	0.069
USP25	ubiquitin specific peptidase 25	0.054
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.054
STAMBP	STAM binding protein	0.046
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.044
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.043
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.042
C16orf70	chromosome 16 open reading frame 70	0.040
TRIM33	tripartite motif containing 33	0.040
HUWE1	HECT, UBA and WWE domain containing 1	0.031
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.029
ATM	ataxia telangiectasia mutated	0.028
BIRC2	baculoviral IAP repeat containing 2	0.027
RYBP	RING1 and YY1 binding protein	0.027
KLF5	Kruppel-like factor 5 (intestinal)	0.026
FUNDC2	FUN14 domain containing 2	0.026
USP21	ubiquitin specific peptidase 21	0.026	Human Fly
CHMP1B	chromatin modifying protein 1B	0.026
TNIP2	TNFAIP3 interacting protein 2	0.026
HGS	hepatocyte growth factor-regulated tyrosine kinase substrate	0.025
ZRANB1	zinc finger, RAN-binding domain containing 1	0.024	Human
SQSTM1	sequestosome 1	0.024
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.024
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.023
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.023
EPS15	epidermal growth factor receptor pathway substrate 15	0.023
USP28	ubiquitin specific peptidase 28	0.022	Human
UBXN2A	UBX domain protein 2A	0.022
POLH	polymerase (DNA directed), eta	0.021
CEP350	centrosomal protein 350kDa	0.020
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.020
ARIH1	ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)	0.020
MARK2	MAP/microtubule affinity-regulating kinase 2	0.020
PHIP	pleckstrin homology domain interacting protein	0.018
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.018
KDM6A	lysine (K)-specific demethylase 6A	0.017
RNF11	ring finger protein 11	0.017
XIAP	X-linked inhibitor of apoptosis	0.017
BIRC6	baculoviral IAP repeat containing 6	0.017
MARCH5	membrane-associated ring finger (C3HC4) 5	0.016
ASXL1	additional sex combs like 1 (Drosophila)	0.016
HECTD1	HECT domain containing 1	0.015
USP5	ubiquitin specific peptidase 5 (isopeptidase T)	0.015
TP53BP1	tumor protein p53 binding protein 1	0.015
MYCBP2	MYC binding protein 2	0.014
UBE3A	ubiquitin protein ligase E3A	0.014
SOD1	superoxide dismutase 1, soluble	0.014
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.014
ADRBK1	adrenergic, beta, receptor kinase 1	0.014
NDUFA4	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa	0.014
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.014
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.013
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.013
USP20	ubiquitin specific peptidase 20	0.013
HDAC6	histone deacetylase 6	0.013
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.013
ZNF148	zinc finger protein 148	0.013
ZFR	zinc finger RNA binding protein	0.013
FOXK2	forkhead box K2	0.013
UBE4B	ubiquitination factor E4B (UFD2 homolog, yeast)	0.013
FTH1	ferritin, heavy polypeptide 1	0.013
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.012
EIF2C3	eukaryotic translation initiation factor 2C, 3	0.012
EIF1	eukaryotic translation initiation factor 1	0.012
ZFAND5	zinc finger, AN1-type domain 5	0.012
VPS13A	vacuolar protein sorting 13 homolog A (S. cerevisiae)	0.012
RICTOR	RPTOR independent companion of MTOR, complex 2	0.012
NIPBL	Nipped-B homolog (Drosophila)	0.012
PSMC2	proteasome (prosome, macropain) 26S subunit, ATPase, 2	0.012
CYLD	cylindromatosis (turban tumor syndrome)	0.012
TRAPPC8	trafficking protein particle complex 8	0.011
DYNC2H1	dynein, cytoplasmic 2, heavy chain 1	0.011
USP9X	ubiquitin specific peptidase 9, X-linked	0.011	Human
UBASH3B	ubiquitin associated and SH3 domain containing B	0.011
ZNF282	zinc finger protein 282	0.011
APC	adenomatous polyposis coli	0.011
UBB	ubiquitin B	0.011
JUN	jun proto-oncogene	0.010
ATXN3	ataxin 3	0.010
DDX3Y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked	0.010
RHOA	ras homolog gene family, member A	0.010
UBE2O	ubiquitin-conjugating enzyme E2O	0.010
ZC3H12A	zinc finger CCCH-type containing 12A	0.010