IMP

Process View

Homo sapiens

27 genes annotated in human

regulation of generation of precursor metabolites and energy

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of generation of precursor metabolites and energy"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of generation of precursor metabolites and energy" (in gray)

Name	Description	Probability	Func Analog Organism
INSR	insulin receptor	0.994
PGK1	phosphoglycerate kinase 1	0.830
PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.712
GRB10	growth factor receptor-bound protein 10	0.683	Rat
IGF1R	insulin-like growth factor 1 receptor	0.644	Human
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.617	Mouse Rat
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	0.450
HIPK2	homeodomain interacting protein kinase 2	0.415
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.377	Human
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.343	Human
TP53	tumor protein p53	0.330
RXRA	retinoid X receptor, alpha	0.269
PRKCZ	protein kinase C, zeta	0.265	Human
IRS1	insulin receptor substrate 1	0.259
NCF1	neutrophil cytosolic factor 1	0.255
IRS2	insulin receptor substrate 2	0.235
EEF2	eukaryotic translation elongation factor 2	0.220
TPI1	triosephosphate isomerase 1	0.210
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.201
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.176
PPARG	peroxisome proliferator-activated receptor gamma	0.138	Human
RARA	retinoic acid receptor, alpha	0.131
RB1	retinoblastoma 1	0.126
NCOR2	nuclear receptor corepressor 2	0.115	Human
DCAF7	DDB1 and CUL4 associated factor 7	0.109
QARS	glutaminyl-tRNA synthetase	0.108
PPARA	peroxisome proliferator-activated receptor alpha	0.108
ESR1	estrogen receptor 1	0.108
HNF4A	hepatocyte nuclear factor 4, alpha	0.106
PPP2R5B	protein phosphatase 2, regulatory subunit B', beta	0.101
PDZD11	PDZ domain containing 11	0.089
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.087
NOXA1	NADPH oxidase activator 1	0.086
EP300	E1A binding protein p300	0.080
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.080
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.078
NFYA	nuclear transcription factor Y, alpha	0.075
GSK3B	glycogen synthase kinase 3 beta	0.073
SP1	Sp1 transcription factor	0.069
ITGB1BP3	integrin beta 1 binding protein 3	0.064
PPP1R2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.064
CCND1	cyclin D1	0.055
VHL	von Hippel-Lindau tumor suppressor	0.052
LZTS2	leucine zipper, putative tumor suppressor 2	0.050
CCND3	cyclin D3	0.049
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.048
NCOR1	nuclear receptor corepressor 1	0.048
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.046
HDAC1	histone deacetylase 1	0.044
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.043
DYRK4	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	0.042	Human
PDPK1	3-phosphoinositide dependent protein kinase-1	0.042
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.041
CDK5	cyclin-dependent kinase 5	0.040
ENO1	enolase 1, (alpha)	0.040
SH3RF1	SH3 domain containing ring finger 1	0.038
IGBP1	immunoglobulin (CD79A) binding protein 1	0.037
FAF1	Fas (TNFRSF6) associated factor 1	0.036
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.036
STAT5B	signal transducer and activator of transcription 5B	0.036
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.036
PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	0.036
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.035
SIRT1	sirtuin 1	0.035
BAD	BCL2-associated agonist of cell death	0.035
SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.034
ACTB	actin, beta	0.034
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.033
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	0.032
DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	0.031
BCL3	B-cell CLL/lymphoma 3	0.031
AKIP1	A kinase (PRKA) interacting protein 1	0.028
RYR2	ryanodine receptor 2 (cardiac)	0.028
RAB6A	RAB6A, member RAS oncogene family	0.027
ACACA	acetyl-CoA carboxylase alpha	0.027
HDAC3	histone deacetylase 3	0.026
EXOSC5	exosome component 5	0.026
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.025
GOT2	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	0.025
NUMB	numb homolog (Drosophila)	0.025
CFL1	cofilin 1 (non-muscle)	0.025
CLTC	clathrin, heavy chain (Hc)	0.025
BOK	BCL2-related ovarian killer	0.025
IGF2R	insulin-like growth factor 2 receptor	0.024
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.024
ESRRG	estrogen-related receptor gamma	0.024
PICK1	protein interacting with PRKCA 1	0.024
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.024
HDAC5	histone deacetylase 5	0.024
SIGMAR1	sigma non-opioid intracellular receptor 1	0.023
NCOA1	nuclear receptor coactivator 1	0.023
SOCS1	suppressor of cytokine signaling 1	0.023
SETDB1	SET domain, bifurcated 1	0.022
ARF1	ADP-ribosylation factor 1	0.022
VEGFA	vascular endothelial growth factor A	0.022
EIF2D	eukaryotic translation initiation factor 2D	0.022
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.022
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.022	Rat
PRKCB	protein kinase C, beta	0.021
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.021
PRKAA2	protein kinase, AMP-activated, alpha 2 catalytic subunit	0.021	Rat
OSBP	oxysterol binding protein	0.021
BCL2L1	BCL2-like 1	0.021
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.021
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.020
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.020
RAB8A	RAB8A, member RAS oncogene family	0.020
PGR	progesterone receptor	0.020
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.020
EIF3D	eukaryotic translation initiation factor 3, subunit D	0.019
HR	hairless homolog (mouse)	0.018
KAT2B	K(lysine) acetyltransferase 2B	0.018
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.018
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.017
CUX1	cut-like homeobox 1	0.017
CDCP1	CUB domain containing protein 1	0.017
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.017	Rat
INPPL1	inositol polyphosphate phosphatase-like 1	0.017
PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	0.016
SLC25A6	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	0.016
NCOA6	nuclear receptor coactivator 6	0.016
EIF3L	eukaryotic translation initiation factor 3, subunit L	0.016
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.016	Rat
MEF2A	myocyte enhancer factor 2A	0.016
RUNX1	runt-related transcription factor 1	0.015
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.014
UBQLN4	ubiquilin 4	0.014
PILRA	paired immunoglobin-like type 2 receptor alpha	0.014
C11orf2	chromosome 11 open reading frame 2	0.014
PPP1R10	protein phosphatase 1, regulatory (inhibitor) subunit 10	0.014
MIF4GD	MIF4G domain containing	0.014
EPOR	erythropoietin receptor	0.014
SESN2	sestrin 2	0.014
SH2B1	SH2B adaptor protein 1	0.014
GRB14	growth factor receptor-bound protein 14	0.013
HDAC7	histone deacetylase 7	0.013
LDHA	lactate dehydrogenase A	0.013
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.013
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.013
MLX	MAX-like protein X	0.013
USMG5	up-regulated during skeletal muscle growth 5 homolog (mouse)	0.013
FAM117B	family with sequence similarity 117, member B	0.013
MED25	mediator complex subunit 25	0.013
AK2	adenylate kinase 2	0.013
MRPL14	mitochondrial ribosomal protein L14	0.013
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.013
SOD1	superoxide dismutase 1, soluble	0.012
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.012
CDK6	cyclin-dependent kinase 6	0.012
HDAC4	histone deacetylase 4	0.012	Mouse
MAPKAP1	mitogen-activated protein kinase associated protein 1	0.012
GHR	growth hormone receptor	0.012
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.012
FOXO3	forkhead box O3	0.012
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.012
JAK2	Janus kinase 2	0.012
CYBA	cytochrome b-245, alpha polypeptide	0.012
PKM2	pyruvate kinase, muscle	0.012
DAXX	death-domain associated protein	0.012
BCL6	B-cell CLL/lymphoma 6	0.012
MGEA5	meningioma expressed antigen 5 (hyaluronidase)	0.012
FXN	frataxin	0.012
SMAD3	SMAD family member 3	0.012
SH3RF3	SH3 domain containing ring finger 3	0.012
SETD7	SET domain containing (lysine methyltransferase) 7	0.012
AKAP8L	A kinase (PRKA) anchor protein 8-like	0.011
PPIF	peptidylprolyl isomerase F	0.011	Mouse
SPRED1	sprouty-related, EVH1 domain containing 1	0.011
HSPA13	heat shock protein 70kDa family, member 13	0.011
GCKR	glucokinase (hexokinase 4) regulator	0.011
PSEN2	presenilin 2 (Alzheimer disease 4)	0.011
SORBS2	sorbin and SH3 domain containing 2	0.011
HMOX2	heme oxygenase (decycling) 2	0.011
CDK4	cyclin-dependent kinase 4	0.011
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.011
SEC24D	SEC24 family, member D (S. cerevisiae)	0.011
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.011
C20orf24	chromosome 20 open reading frame 24	0.011
BMX	BMX non-receptor tyrosine kinase	0.010
IGFBP3	insulin-like growth factor binding protein 3	0.010
ARFGAP3	ADP-ribosylation factor GTPase activating protein 3	0.010
EEF1D	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	0.010
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.010
MRPS12	mitochondrial ribosomal protein S12	0.010
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.010
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.010
FBP2	fructose-1,6-bisphosphatase 2	0.010	Human
TXNIP	thioredoxin interacting protein	0.010