IMP

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Homo sapiens

20 genes annotated in human

lymphocyte activation involved in immune response

A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lymphocyte activation involved in immune response"

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Name	Description	Probability	Func Analog Organism
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.950
FHL2	four and a half LIM domains 2	0.854
IL4R	interleukin 4 receptor	0.424	Mouse
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.330
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.232
PILRA	paired immunoglobin-like type 2 receptor alpha	0.228
GRAP2	GRB2-related adaptor protein 2	0.166
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.151	Human
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.150
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.149
MDC1	mediator of DNA-damage checkpoint 1	0.137
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.132	Mouse
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.127
APLF	aprataxin and PNKP like factor	0.123
ENG	endoglin	0.112
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.107	Human
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.097
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.095
RXRA	retinoid X receptor, alpha	0.088
BRCA1	breast cancer 1, early onset	0.085
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.085
LIN9	lin-9 homolog (C. elegans)	0.081
TGIF1	TGFB-induced factor homeobox 1	0.076
H2AFX	H2A histone family, member X	0.076
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.069
BIRC3	baculoviral IAP repeat containing 3	0.066
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.064
FLNA	filamin A, alpha	0.060
CALCOCO2	calcium binding and coiled-coil domain 2	0.058
MSH6	mutS homolog 6 (E. coli)	0.057	Mouse
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.056
THOC5	THO complex 5	0.055
SIGLEC7	sialic acid binding Ig-like lectin 7	0.050
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.048
CD22	CD22 molecule	0.048
PTPRC	protein tyrosine phosphatase, receptor type, C	0.047	Mouse
PECAM1	platelet/endothelial cell adhesion molecule	0.047
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.046	Mouse
THOC4	THO complex 4	0.045
IL23A	interleukin 23, alpha subunit p19	0.043	Mouse
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.043
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.040	Human
ESR1	estrogen receptor 1	0.039
LIG4	ligase IV, DNA, ATP-dependent	0.039	Mouse
CD86	CD86 molecule	0.038	Rat
NCSTN	nicastrin	0.037
PLEK	pleckstrin	0.037
IL2RG	interleukin 2 receptor, gamma	0.036
NOD2	nucleotide-binding oligomerization domain containing 2	0.036
GBA	glucosidase, beta, acid	0.035
RUNX1	runt-related transcription factor 1	0.033
BCL3	B-cell CLL/lymphoma 3	0.033	Mouse
MSH3	mutS homolog 3 (E. coli)	0.030
ICAM1	intercellular adhesion molecule 1	0.029
NCOR2	nuclear receptor corepressor 2	0.028
PML	promyelocytic leukemia	0.028
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	0.028
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.028
CD1C	CD1c molecule	0.026
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.026
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.026
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.026
HDAC9	histone deacetylase 9	0.026
SOCS3	suppressor of cytokine signaling 3	0.025
RAB14	RAB14, member RAS oncogene family	0.025
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.024
PDZD11	PDZ domain containing 11	0.024
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.023
RAD50	RAD50 homolog (S. cerevisiae)	0.022
TLN1	talin 1	0.022
CD33	CD33 molecule	0.022
IL4	interleukin 4	0.021	Mouse
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.021
TGFB1	transforming growth factor, beta 1	0.021
TYMP	thymidine phosphorylase	0.021
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.021
IL6R	interleukin 6 receptor	0.021
LAPTM5	lysosomal protein transmembrane 5	0.020
MICA	MHC class I polypeptide-related sequence A	0.020
PPARA	peroxisome proliferator-activated receptor alpha	0.020
EMP3	epithelial membrane protein 3	0.018
HCK	hemopoietic cell kinase	0.018
TRAF3	TNF receptor-associated factor 3	0.018
CCR2	chemokine (C-C motif) receptor 2	0.017
CD40	CD40 molecule, TNF receptor superfamily member 5	0.017	Mouse Rat
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.017
PTAFR	platelet-activating factor receptor	0.017
FLNB	filamin B, beta	0.017
HK3	hexokinase 3 (white cell)	0.017
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.017
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.016
FRA10AC1	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1	0.016
CD1B	CD1b molecule	0.016	Human
PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	0.016
TICAM2	toll-like receptor adaptor molecule 2	0.015
LY96	lymphocyte antigen 96	0.015
TMSB10	thymosin beta 10	0.015
CCL22	chemokine (C-C motif) ligand 22	0.015
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.015
LIN54	lin-54 homolog (C. elegans)	0.014
CD80	CD80 molecule	0.014
MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	0.014	Mouse
CD1A	CD1a molecule	0.014	Human
CCR7	chemokine (C-C motif) receptor 7	0.014
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.014
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.013
PLXND1	plexin D1	0.013
MLPH	melanophilin	0.013
CD1D	CD1d molecule	0.013	Human
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.013
XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	0.013	Mouse
IRF4	interferon regulatory factor 4	0.013	Mouse
PLAUR	plasminogen activator, urokinase receptor	0.013
SYK	spleen tyrosine kinase	0.013
SH3BP2	SH3-domain binding protein 2	0.013
IL21R	interleukin 21 receptor	0.013
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.012
CD44	CD44 molecule (Indian blood group)	0.012
SFPQ	splicing factor proline/glutamine-rich	0.012
CCR1	chemokine (C-C motif) receptor 1	0.012
IRF8	interferon regulatory factor 8	0.012
PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0.012
ITGB7	integrin, beta 7	0.012
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.011
CLEC10A	C-type lectin domain family 10, member A	0.011
CYTH4	cytohesin 4	0.011
ZBTB16	zinc finger and BTB domain containing 16	0.011
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.011
SIRPB1	signal-regulatory protein beta 1	0.011
DDIT3	DNA-damage-inducible transcript 3	0.011
MATK	megakaryocyte-associated tyrosine kinase	0.011
TANK	TRAF family member-associated NFKB activator	0.011
ZNF830	zinc finger protein 830	0.011
IL2RA	interleukin 2 receptor, alpha	0.011
FOSL2	FOS-like antigen 2	0.011
DTL	denticleless homolog (Drosophila)	0.011
TGFBR1	transforming growth factor, beta receptor 1	0.011
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.010
IL13RA1	interleukin 13 receptor, alpha 1	0.010
C1orf38	chromosome 1 open reading frame 38	0.010
NHEJ1	nonhomologous end-joining factor 1	0.010
IL7R	interleukin 7 receptor	0.010